IL125441A0 - Novel diphenyl stilbenes and pharmaceutical compositions thereof for treatment of cox-2 mediated diseases - Google Patents
Novel diphenyl stilbenes and pharmaceutical compositions thereof for treatment of cox-2 mediated diseasesInfo
- Publication number
- IL125441A0 IL125441A0 IL12544197A IL12544197A IL125441A0 IL 125441 A0 IL125441 A0 IL 125441A0 IL 12544197 A IL12544197 A IL 12544197A IL 12544197 A IL12544197 A IL 12544197A IL 125441 A0 IL125441 A0 IL 125441A0
- Authority
- IL
- Israel
- Prior art keywords
- treatment
- mediated diseases
- pharmaceutical compositions
- cox
- novel diphenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Polyesters Or Polycarbonates (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1095096P | 1996-02-01 | 1996-02-01 | |
| GBGB9605647.8A GB9605647D0 (en) | 1996-03-18 | 1996-03-18 | Diphenyl stilbenes as prodrugs to cox-2 inhibitors |
| PCT/CA1997/000063 WO1997028120A1 (en) | 1996-02-01 | 1997-01-29 | Diphenyl stilbenes as prodrugs to cox-2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL125441A0 true IL125441A0 (en) | 1999-03-12 |
Family
ID=26308949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12544197A IL125441A0 (en) | 1996-02-01 | 1997-01-29 | Novel diphenyl stilbenes and pharmaceutical compositions thereof for treatment of cox-2 mediated diseases |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0882015B1 (ru) |
| JP (1) | JP3662936B2 (ru) |
| KR (1) | KR19990082260A (ru) |
| CN (1) | CN1214677A (ru) |
| AT (1) | ATE198323T1 (ru) |
| AU (1) | AU707199B2 (ru) |
| CA (1) | CA2244134C (ru) |
| CZ (1) | CZ241698A3 (ru) |
| DE (1) | DE69703791T2 (ru) |
| EA (1) | EA199800675A1 (ru) |
| EE (1) | EE9800230A (ru) |
| ES (1) | ES2152648T3 (ru) |
| HU (1) | HUP9902119A3 (ru) |
| IL (1) | IL125441A0 (ru) |
| NO (1) | NO983511L (ru) |
| NZ (1) | NZ326283A (ru) |
| PL (1) | PL328225A1 (ru) |
| SK (1) | SK102698A3 (ru) |
| WO (1) | WO1997028120A1 (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635417B1 (en) | 1996-07-31 | 2003-10-21 | California Institute Of Technology | Complex formation between DSDNA and oligomer of cyclic heterocycles |
| US5998140A (en) * | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| IL150368A0 (en) | 1999-12-23 | 2002-12-01 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use |
| AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| AU2003252515A1 (en) | 2002-07-26 | 2004-02-16 | Merck Frosst Canada And Co. | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors |
| AU2003261281A1 (en) | 2002-07-29 | 2004-02-16 | Nicox S.A. | Cyclooxygenase- 2 selective inhibitors, compositions and methods of use |
| EP1601644B1 (en) * | 2003-03-05 | 2009-05-27 | Merck Frosst Company | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors |
| AU2005206228A1 (en) | 2004-01-27 | 2005-08-04 | Merck Frosst Company | Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors |
| CA2554333A1 (en) | 2004-01-27 | 2005-08-04 | Merck Frosst Company | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors |
| WO2006029436A1 (de) * | 2004-09-17 | 2006-03-23 | Universität Wien | Cox-ii-inhibitorverbindungen |
| CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990012786A1 (fr) * | 1989-04-24 | 1990-11-01 | Otsuka Pharmaceutical Factory, Inc. | Derive de 3-halogeno-2,3-diphenylacrylaldehyde, son procede de fabrication et agent de traitement de l'hyperlipidemie |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5393790A (en) * | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
-
1997
- 1997-01-29 PL PL97328225A patent/PL328225A1/xx unknown
- 1997-01-29 AU AU14346/97A patent/AU707199B2/en not_active Ceased
- 1997-01-29 WO PCT/CA1997/000063 patent/WO1997028120A1/en not_active Application Discontinuation
- 1997-01-29 EA EA199800675A patent/EA199800675A1/ru unknown
- 1997-01-29 EE EE9800230A patent/EE9800230A/xx unknown
- 1997-01-29 HU HU9902119A patent/HUP9902119A3/hu unknown
- 1997-01-29 IL IL12544197A patent/IL125441A0/xx unknown
- 1997-01-29 EP EP97900915A patent/EP0882015B1/en not_active Expired - Lifetime
- 1997-01-29 JP JP52720397A patent/JP3662936B2/ja not_active Expired - Fee Related
- 1997-01-29 CN CN97193332A patent/CN1214677A/zh active Pending
- 1997-01-29 AT AT97900915T patent/ATE198323T1/de not_active IP Right Cessation
- 1997-01-29 ES ES97900915T patent/ES2152648T3/es not_active Expired - Lifetime
- 1997-01-29 DE DE69703791T patent/DE69703791T2/de not_active Expired - Fee Related
- 1997-01-29 KR KR1019980705989A patent/KR19990082260A/ko not_active Application Discontinuation
- 1997-01-29 SK SK1026-98A patent/SK102698A3/sk unknown
- 1997-01-29 NZ NZ326283A patent/NZ326283A/xx unknown
- 1997-01-29 CZ CZ982416A patent/CZ241698A3/cs unknown
- 1997-01-29 CA CA002244134A patent/CA2244134C/en not_active Expired - Fee Related
-
1998
- 1998-07-30 NO NO983511A patent/NO983511L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ241698A3 (cs) | 1998-12-16 |
| SK102698A3 (en) | 1999-04-13 |
| HUP9902119A3 (en) | 2001-08-28 |
| EA199800675A1 (ru) | 1999-02-25 |
| DE69703791T2 (de) | 2001-06-21 |
| JP2000504332A (ja) | 2000-04-11 |
| CA2244134C (en) | 2005-04-26 |
| ATE198323T1 (de) | 2001-01-15 |
| AU1434697A (en) | 1997-08-22 |
| AU707199B2 (en) | 1999-07-08 |
| NO983511D0 (no) | 1998-07-30 |
| NO983511L (no) | 1998-09-30 |
| CN1214677A (zh) | 1999-04-21 |
| EE9800230A (et) | 1998-12-15 |
| JP3662936B2 (ja) | 2005-06-22 |
| EP0882015B1 (en) | 2000-12-27 |
| PL328225A1 (en) | 1999-01-18 |
| CA2244134A1 (en) | 1997-08-07 |
| DE69703791D1 (de) | 2001-02-01 |
| HUP9902119A2 (hu) | 2001-04-28 |
| MX9806213A (es) | 1998-12-31 |
| EP0882015A1 (en) | 1998-12-09 |
| ES2152648T3 (es) | 2001-02-01 |
| KR19990082260A (ko) | 1999-11-25 |
| NZ326283A (en) | 1998-12-23 |
| WO1997028120A1 (en) | 1997-08-07 |
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