DE69703791D1 - Diphenylstibene als prodrugs zu cox-2-inhibitoren - Google Patents

Diphenylstibene als prodrugs zu cox-2-inhibitoren

Info

Publication number
DE69703791D1
DE69703791D1 DE69703791T DE69703791T DE69703791D1 DE 69703791 D1 DE69703791 D1 DE 69703791D1 DE 69703791 T DE69703791 T DE 69703791T DE 69703791 T DE69703791 T DE 69703791T DE 69703791 D1 DE69703791 D1 DE 69703791D1
Authority
DE
Germany
Prior art keywords
diphenylstibene
cox
prodrugs
inhibitors
cyclooxygenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69703791T
Other languages
English (en)
Other versions
DE69703791T2 (de
Inventor
Cameron Black
Mario Girard
Daniel Guay
Zhaoyin Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605647.8A external-priority patent/GB9605647D0/en
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Application granted granted Critical
Publication of DE69703791D1 publication Critical patent/DE69703791D1/de
Publication of DE69703791T2 publication Critical patent/DE69703791T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE69703791T 1996-02-01 1997-01-29 Diphenylstibene als prodrugs zu cox-2-inhibitoren Expired - Fee Related DE69703791T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1095096P 1996-02-01 1996-02-01
GBGB9605647.8A GB9605647D0 (en) 1996-03-18 1996-03-18 Diphenyl stilbenes as prodrugs to cox-2 inhibitors
PCT/CA1997/000063 WO1997028120A1 (en) 1996-02-01 1997-01-29 Diphenyl stilbenes as prodrugs to cox-2 inhibitors

Publications (2)

Publication Number Publication Date
DE69703791D1 true DE69703791D1 (de) 2001-02-01
DE69703791T2 DE69703791T2 (de) 2001-06-21

Family

ID=26308949

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69703791T Expired - Fee Related DE69703791T2 (de) 1996-02-01 1997-01-29 Diphenylstibene als prodrugs zu cox-2-inhibitoren

Country Status (19)

Country Link
EP (1) EP0882015B1 (de)
JP (1) JP3662936B2 (de)
KR (1) KR19990082260A (de)
CN (1) CN1214677A (de)
AT (1) ATE198323T1 (de)
AU (1) AU707199B2 (de)
CA (1) CA2244134C (de)
CZ (1) CZ241698A3 (de)
DE (1) DE69703791T2 (de)
EA (1) EA199800675A1 (de)
EE (1) EE9800230A (de)
ES (1) ES2152648T3 (de)
HU (1) HUP9902119A3 (de)
IL (1) IL125441A0 (de)
NO (1) NO983511L (de)
NZ (1) NZ326283A (de)
PL (1) PL328225A1 (de)
SK (1) SK102698A3 (de)
WO (1) WO1997028120A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635417B1 (en) 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
US5998140A (en) * 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
NZ519781A (en) 1999-12-23 2004-04-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
AU2003252515A1 (en) * 2002-07-26 2004-02-16 Merck Frosst Canada And Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
DE602004021238D1 (de) * 2003-03-05 2009-07-09 Merck Frosst Company Stickstoffmonoxid freisetzende prodrugs von diaryl-2-(5h)-furanonen als inhibitoren von cyclooxygenase-2
WO2005070883A1 (en) * 2004-01-27 2005-08-04 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
JP2007520484A (ja) 2004-01-27 2007-07-26 メルク フロスト カンパニー シクロオキシゲナーゼ−２インヒビターとしてのジアリール−２−（５ｈ）−フラノンの一酸化窒素放出プロドラッグ
WO2006029436A1 (de) * 2004-09-17 2006-03-23 Universität Wien Cox-ii-inhibitorverbindungen
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424541A4 (en) * 1989-04-24 1991-09-25 Otsuka Pharmaceutical Factory, Inc. 3-halogeno-2,3-diphenylacrylaldehyde derivative, method of production thereof and curing agent for hyperlipidemia
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5393790A (en) * 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation

Also Published As

Publication number Publication date
PL328225A1 (en) 1999-01-18
NO983511L (no) 1998-09-30
CA2244134A1 (en) 1997-08-07
MX9806213A (es) 1998-12-31
ES2152648T3 (es) 2001-02-01
EP0882015A1 (de) 1998-12-09
CN1214677A (zh) 1999-04-21
HUP9902119A2 (hu) 2001-04-28
ATE198323T1 (de) 2001-01-15
KR19990082260A (ko) 1999-11-25
AU707199B2 (en) 1999-07-08
NO983511D0 (no) 1998-07-30
JP2000504332A (ja) 2000-04-11
CA2244134C (en) 2005-04-26
HUP9902119A3 (en) 2001-08-28
WO1997028120A1 (en) 1997-08-07
IL125441A0 (en) 1999-03-12
CZ241698A3 (cs) 1998-12-16
EP0882015B1 (de) 2000-12-27
DE69703791T2 (de) 2001-06-21
EA199800675A1 (ru) 1999-02-25
JP3662936B2 (ja) 2005-06-22
AU1434697A (en) 1997-08-22
NZ326283A (en) 1998-12-23
SK102698A3 (en) 1999-04-13
EE9800230A (et) 1998-12-15

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ATE165825T1 (de) Phenyl heterocyclen als cyclooxygenase-2 inhibitoren
PT863891E (pt) (metilsulfonil)fenil-2-(5h)furanonas como inibidores de cox-2
ES2171723T3 (es) 3,4-diaril-2-hidroxi-2,5-dihidrofuranos como profarmacos de inhibidores de cox-2.
DE69529690D1 (de) Diaryl-2(5h)-fuaranone als cox-2-inhibitoren
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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK FROSST COMPANY, HALIFAX, NOVA SCOTIA, CA

8339 Ceased/non-payment of the annual fee