IL125441A0 - Novel diphenyl stilbenes and pharmaceutical compositions thereof for treatment of cox-2 mediated diseases - Google Patents

Novel diphenyl stilbenes and pharmaceutical compositions thereof for treatment of cox-2 mediated diseases

Info

Publication number
IL125441A0
IL125441A0 IL12544197A IL12544197A IL125441A0 IL 125441 A0 IL125441 A0 IL 125441A0 IL 12544197 A IL12544197 A IL 12544197A IL 12544197 A IL12544197 A IL 12544197A IL 125441 A0 IL125441 A0 IL 125441A0
Authority
IL
Israel
Prior art keywords
treatment
mediated diseases
pharmaceutical compositions
cox
novel diphenyl
Prior art date
Application number
IL12544197A
Other languages
English (en)
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605647.8A external-priority patent/GB9605647D0/en
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Publication of IL125441A0 publication Critical patent/IL125441A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/095Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10Sulfides; Sulfoxides; Sulfones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/16Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/24Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pyridine Compounds (AREA)
IL12544197A 1996-02-01 1997-01-29 Novel diphenyl stilbenes and pharmaceutical compositions thereof for treatment of cox-2 mediated diseases IL125441A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1095096P 1996-02-01 1996-02-01
GBGB9605647.8A GB9605647D0 (en) 1996-03-18 1996-03-18 Diphenyl stilbenes as prodrugs to cox-2 inhibitors
PCT/CA1997/000063 WO1997028120A1 (en) 1996-02-01 1997-01-29 Diphenyl stilbenes as prodrugs to cox-2 inhibitors

Publications (1)

Publication Number Publication Date
IL125441A0 true IL125441A0 (en) 1999-03-12

Family

ID=26308949

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12544197A IL125441A0 (en) 1996-02-01 1997-01-29 Novel diphenyl stilbenes and pharmaceutical compositions thereof for treatment of cox-2 mediated diseases

Country Status (19)

Country Link
EP (1) EP0882015B1 (xx)
JP (1) JP3662936B2 (xx)
KR (1) KR19990082260A (xx)
CN (1) CN1214677A (xx)
AT (1) ATE198323T1 (xx)
AU (1) AU707199B2 (xx)
CA (1) CA2244134C (xx)
CZ (1) CZ241698A3 (xx)
DE (1) DE69703791T2 (xx)
EA (1) EA199800675A1 (xx)
EE (1) EE9800230A (xx)
ES (1) ES2152648T3 (xx)
HU (1) HUP9902119A3 (xx)
IL (1) IL125441A0 (xx)
NO (1) NO983511L (xx)
NZ (1) NZ326283A (xx)
PL (1) PL328225A1 (xx)
SK (1) SK102698A3 (xx)
WO (1) WO1997028120A1 (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635417B1 (en) 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
US5998140A (en) * 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
JP2003523958A (ja) 1999-12-23 2003-08-12 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−2の阻害剤、組成物ならびに使用法
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
WO2004011421A1 (en) * 2002-07-26 2004-02-05 Merck Frosst Canada & Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
EP1542972A4 (en) 2002-07-29 2008-01-23 Nitromed Inc CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITION AND METHOD OF USE
ATE432258T1 (de) 2003-03-05 2009-06-15 Merck Frosst Company Stickstoffmonoxid freisetzende prodrugs von diaryl-2-(5h)-furanonen als inhibitoren von cyclooxygenase-2
JP2007520483A (ja) 2004-01-27 2007-07-26 メルク フロスト カンパニー シクロオキシゲナーゼ−2インヒビターとしてのジアリール−2−(5h)−フラノンの一酸化窒素放出プロドラッグ
US7622502B2 (en) 2004-01-27 2009-11-24 Merck Frosst Canada & Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
WO2006029436A1 (de) * 2004-09-17 2006-03-23 Universität Wien Cox-ii-inhibitorverbindungen
CA3209491A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5082974A (en) * 1989-04-24 1992-01-21 Otsuka Pharaceutical Factory, Inc. 3-halogeno-2,3-diphenylacrylaldehyde derivatives, process for preparing the same and a pharmaceutical composition for treating hyperlipidemi
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5393790A (en) * 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation

Also Published As

Publication number Publication date
DE69703791D1 (de) 2001-02-01
EP0882015B1 (en) 2000-12-27
ATE198323T1 (de) 2001-01-15
CA2244134C (en) 2005-04-26
JP2000504332A (ja) 2000-04-11
EP0882015A1 (en) 1998-12-09
AU707199B2 (en) 1999-07-08
ES2152648T3 (es) 2001-02-01
PL328225A1 (en) 1999-01-18
NO983511L (no) 1998-09-30
AU1434697A (en) 1997-08-22
HUP9902119A3 (en) 2001-08-28
CA2244134A1 (en) 1997-08-07
KR19990082260A (ko) 1999-11-25
CZ241698A3 (cs) 1998-12-16
WO1997028120A1 (en) 1997-08-07
EA199800675A1 (ru) 1999-02-25
MX9806213A (es) 1998-12-31
DE69703791T2 (de) 2001-06-21
JP3662936B2 (ja) 2005-06-22
HUP9902119A2 (hu) 2001-04-28
SK102698A3 (en) 1999-04-13
NO983511D0 (no) 1998-07-30
EE9800230A (et) 1998-12-15
NZ326283A (en) 1998-12-23
CN1214677A (zh) 1999-04-21

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