ES2152648T3 - Difenilestilbenos como profarmacos inhibidores de la cox-2. - Google Patents

Difenilestilbenos como profarmacos inhibidores de la cox-2.

Info

Publication number
ES2152648T3
ES2152648T3 ES97900915T ES97900915T ES2152648T3 ES 2152648 T3 ES2152648 T3 ES 2152648T3 ES 97900915 T ES97900915 T ES 97900915T ES 97900915 T ES97900915 T ES 97900915T ES 2152648 T3 ES2152648 T3 ES 2152648T3
Authority
ES
Spain
Prior art keywords
propharmaces
difenylestilben
cox
inhibiting
cyclooxygenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97900915T
Other languages
English (en)
Inventor
Cameron Black
Mario Girard
Daniel Guay
Zhaoyin Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605647.8A external-priority patent/GB9605647D0/en
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Application granted granted Critical
Publication of ES2152648T3 publication Critical patent/ES2152648T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

LA INVENCION SE REFIERE AL NUEVO COMPUESTO DE FORMULA (I), UTIL PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR LA CICLOOXIGENASA-2. ASIMISMO, SE DESCRIBEN CIERTAS COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR LA CICLOOXIGENASA-2, QUE COMPRENDEN COMPUESTOS DE FORMULA (I).
ES97900915T 1996-02-01 1997-01-29 Difenilestilbenos como profarmacos inhibidores de la cox-2. Expired - Lifetime ES2152648T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1095096P 1996-02-01 1996-02-01
GBGB9605647.8A GB9605647D0 (en) 1996-03-18 1996-03-18 Diphenyl stilbenes as prodrugs to cox-2 inhibitors

Publications (1)

Publication Number Publication Date
ES2152648T3 true ES2152648T3 (es) 2001-02-01

Family

ID=26308949

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97900915T Expired - Lifetime ES2152648T3 (es) 1996-02-01 1997-01-29 Difenilestilbenos como profarmacos inhibidores de la cox-2.

Country Status (19)

Country Link
EP (1) EP0882015B1 (es)
JP (1) JP3662936B2 (es)
KR (1) KR19990082260A (es)
CN (1) CN1214677A (es)
AT (1) ATE198323T1 (es)
AU (1) AU707199B2 (es)
CA (1) CA2244134C (es)
CZ (1) CZ241698A3 (es)
DE (1) DE69703791T2 (es)
EA (1) EA199800675A1 (es)
EE (1) EE9800230A (es)
ES (1) ES2152648T3 (es)
HU (1) HUP9902119A3 (es)
IL (1) IL125441A0 (es)
NO (1) NO983511L (es)
NZ (1) NZ326283A (es)
PL (1) PL328225A1 (es)
SK (1) SK102698A3 (es)
WO (1) WO1997028120A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635417B1 (en) 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
US5998140A (en) * 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
WO2001045703A1 (en) 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
CA2493082A1 (en) 2002-07-26 2004-02-05 Merck Frosst Canada & Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
CA2493156A1 (en) 2002-07-29 2004-02-05 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
CA2517490A1 (en) * 2003-03-05 2004-12-02 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
EP1711457A4 (en) 2004-01-27 2008-01-09 Merck Frosst Company NITROGEN MONOXIDE RELEASING PRODRUGS OF DIARYL-2- (5H) FURANOES AS INHIBITORS OF CYCLOOXYGENASE-2
WO2005070883A1 (en) * 2004-01-27 2005-08-04 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
WO2006029436A1 (de) * 2004-09-17 2006-03-23 Universität Wien Cox-ii-inhibitorverbindungen
CA3209491A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU625123B2 (en) * 1989-04-24 1992-07-02 Otsuka Pharmaceutical Factory, Inc. 3-halogeno-2,3-diphenylacrylaldehyde derivative, method of production thereof and curing agent for hyperlipidemia
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5393790A (en) * 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation

Also Published As

Publication number Publication date
NO983511D0 (no) 1998-07-30
NO983511L (no) 1998-09-30
CA2244134C (en) 2005-04-26
CZ241698A3 (cs) 1998-12-16
SK102698A3 (en) 1999-04-13
IL125441A0 (en) 1999-03-12
EP0882015A1 (en) 1998-12-09
JP2000504332A (ja) 2000-04-11
EE9800230A (et) 1998-12-15
DE69703791T2 (de) 2001-06-21
JP3662936B2 (ja) 2005-06-22
EP0882015B1 (en) 2000-12-27
DE69703791D1 (de) 2001-02-01
CN1214677A (zh) 1999-04-21
HUP9902119A3 (en) 2001-08-28
WO1997028120A1 (en) 1997-08-07
AU707199B2 (en) 1999-07-08
KR19990082260A (ko) 1999-11-25
AU1434697A (en) 1997-08-22
MX9806213A (es) 1998-12-31
PL328225A1 (en) 1999-01-18
CA2244134A1 (en) 1997-08-07
NZ326283A (en) 1998-12-23
EA199800675A1 (ru) 1999-02-25
HUP9902119A2 (hu) 2001-04-28
ATE198323T1 (de) 2001-01-15

Similar Documents

Publication Publication Date Title
ES2187675T3 (es) (metilsulfonil)fenil-2-(5h)-furanonas como inhibidores de cox-2.
ES2115237T3 (es) Fenil heterociclos como inhibidores de la ciclooxigenasa-2.
ES2139959T3 (es) Derivados de estilbeno utiles como inhibidores de la ciclooxigenasa-2.
HN2003000417A (es) Intermedio de formulacion aceptablemente no higroscopico que comprende un farmaco higroscopico
ES2171723T3 (es) 3,4-diaril-2-hidroxi-2,5-dihidrofuranos como profarmacos de inhibidores de cox-2.
ATE433447T1 (de) Pyrimiidinverbindungen
ES2144623T3 (es) Heterociclos diaril biciclicos como inhibidores de la ciclooxigenasa-2.
EA200900828A1 (ru) Соединения и композиции в качестве ингибиторов активности каннабиноидного рецептора 1
BR0313676A (pt) Derivados de pirimidina e uso destes como moduladores cb2
MA30427B1 (fr) Derives bicycliques utilises comme inhibiteurs de cetp
GT200600327A (es) Ciclohexilaminoisoquinolona
PT1246809E (pt) Compostos de 5-aril-1h-1,2,4-triazole como inibidores de ciclooxigenase-2 e composicoes farmaceuticas que os contem
CR9223A (es) 18-metil-19-nor-17-pregn-4-en-21, 17-carbolactonas,asi como preparaciones farmaceuticas que las contienen
EA200700166A1 (ru) 4-замещённые производные хинолина, способ получения и промежуточные вещества для их приготовления и содержащие их фармацевтические композиции
BRPI0806789B8 (pt) composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto ou de um sal farmaceuticamente aceitável do mesmo
BRPI0519198A2 (pt) moduladores de delta-opiàide tricÍclicos
DOP2006000175A (es) Heterociclos de 1,4-dihidropiridina condensados, procesos para preparar los mismos, uso y composiciones que los contienen
ES2243579T3 (es) Derivados de pirazolopirideno.
ES2152648T3 (es) Difenilestilbenos como profarmacos inhibidores de la cox-2.
DK1831239T5 (da) Fremgangsmåde til fremstilling af 17-hydroxy-6 beta, 7 beta, 15 beta, 16 beta -bismethylen-17alpha-pregn-4-en-3-on-21-carboxylsyre-gamma-lacton og nøgle-mellemprodukter til denne fremgangsmåde
DK1817326T3 (da) Industriel fremgangsmåde til fremstilling af 17-hydroxy-6-beta, 7-beta, 15-beta, 16-beta-bismethylen-3-oxo-17-alpha-pregn-4-en-21-carboxylsyre-gamma-lacton og nøglemellemprodukter for denne fremgangsmåde
DE60221425D1 (de) Substituierte tetrazyklische pyprolochinolonderivate als phosphodiesterase-inhibitoren
ES2166977T3 (es) Nuevo procedimiento para preparar compuestos intermedios de plaguicidas.
BRPI0412843A (pt) lactamas substituìdas e uso das mesmas como agentes anticáncer
ES2147973T3 (es) Estirenos alquilatados como profarmacos de inhibidores de cox-2.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 882015

Country of ref document: ES