NZ326283A - Diphenyl stilbenes as prodrugs to cox-2 inhibitors - Google Patents
Diphenyl stilbenes as prodrugs to cox-2 inhibitorsInfo
- Publication number
- NZ326283A NZ326283A NZ326283A NZ32628397A NZ326283A NZ 326283 A NZ326283 A NZ 326283A NZ 326283 A NZ326283 A NZ 326283A NZ 32628397 A NZ32628397 A NZ 32628397A NZ 326283 A NZ326283 A NZ 326283A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cox
- prodrugs
- inhibitors
- diphenyl stilbenes
- stilbenes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1095096P | 1996-02-01 | 1996-02-01 | |
| GBGB9605647.8A GB9605647D0 (en) | 1996-03-18 | 1996-03-18 | Diphenyl stilbenes as prodrugs to cox-2 inhibitors |
| PCT/CA1997/000063 WO1997028120A1 (en) | 1996-02-01 | 1997-01-29 | Diphenyl stilbenes as prodrugs to cox-2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ326283A true NZ326283A (en) | 1998-12-23 |
Family
ID=26308949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ326283A NZ326283A (en) | 1996-02-01 | 1997-01-29 | Diphenyl stilbenes as prodrugs to cox-2 inhibitors |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0882015B1 (es) |
| JP (1) | JP3662936B2 (es) |
| KR (1) | KR19990082260A (es) |
| CN (1) | CN1214677A (es) |
| AT (1) | ATE198323T1 (es) |
| AU (1) | AU707199B2 (es) |
| CA (1) | CA2244134C (es) |
| CZ (1) | CZ241698A3 (es) |
| DE (1) | DE69703791T2 (es) |
| EA (1) | EA199800675A1 (es) |
| EE (1) | EE9800230A (es) |
| ES (1) | ES2152648T3 (es) |
| HU (1) | HUP9902119A3 (es) |
| IL (1) | IL125441A0 (es) |
| NO (1) | NO983511L (es) |
| NZ (1) | NZ326283A (es) |
| PL (1) | PL328225A1 (es) |
| SK (1) | SK102698A3 (es) |
| WO (1) | WO1997028120A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635417B1 (en) | 1996-07-31 | 2003-10-21 | California Institute Of Technology | Complex formation between DSDNA and oligomer of cyclic heterocycles |
| US5998140A (en) * | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| JP2003523958A (ja) | 1999-12-23 | 2003-08-12 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法 |
| AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| EP1527045A1 (en) * | 2002-07-26 | 2005-05-04 | Merck Frosst Canada & Co. | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors |
| US7244753B2 (en) | 2002-07-29 | 2007-07-17 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| DE602004021238D1 (de) | 2003-03-05 | 2009-07-09 | Merck Frosst Company | Stickstoffmonoxid freisetzende prodrugs von diaryl-2-(5h)-furanonen als inhibitoren von cyclooxygenase-2 |
| WO2005070883A1 (en) * | 2004-01-27 | 2005-08-04 | Merck Frosst Company | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors |
| CN1914151A (zh) * | 2004-01-27 | 2007-02-14 | 默克弗罗斯特公司 | 作为环氧合酶－2抑制剂的二芳基－2(5h)－呋喃酮类的释放一氧化氮的前药 |
| WO2006029436A1 (de) * | 2004-09-17 | 2006-03-23 | Universität Wien | Cox-ii-inhibitorverbindungen |
| CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990012786A1 (fr) * | 1989-04-24 | 1990-11-01 | Otsuka Pharmaceutical Factory, Inc. | Derive de 3-halogeno-2,3-diphenylacrylaldehyde, son procede de fabrication et agent de traitement de l'hyperlipidemie |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5393790A (en) * | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
-
1997
- 1997-01-29 PL PL97328225A patent/PL328225A1/xx unknown
- 1997-01-29 NZ NZ326283A patent/NZ326283A/xx unknown
- 1997-01-29 ES ES97900915T patent/ES2152648T3/es not_active Expired - Lifetime
- 1997-01-29 SK SK1026-98A patent/SK102698A3/sk unknown
- 1997-01-29 JP JP52720397A patent/JP3662936B2/ja not_active Expired - Fee Related
- 1997-01-29 EA EA199800675A patent/EA199800675A1/ru unknown
- 1997-01-29 EE EE9800230A patent/EE9800230A/xx unknown
- 1997-01-29 CA CA002244134A patent/CA2244134C/en not_active Expired - Fee Related
- 1997-01-29 KR KR1019980705989A patent/KR19990082260A/ko not_active Application Discontinuation
- 1997-01-29 HU HU9902119A patent/HUP9902119A3/hu unknown
- 1997-01-29 WO PCT/CA1997/000063 patent/WO1997028120A1/en not_active Application Discontinuation
- 1997-01-29 CN CN97193332A patent/CN1214677A/zh active Pending
- 1997-01-29 CZ CZ982416A patent/CZ241698A3/cs unknown
- 1997-01-29 IL IL12544197A patent/IL125441A0/xx unknown
- 1997-01-29 AU AU14346/97A patent/AU707199B2/en not_active Ceased
- 1997-01-29 EP EP97900915A patent/EP0882015B1/en not_active Expired - Lifetime
- 1997-01-29 AT AT97900915T patent/ATE198323T1/de not_active IP Right Cessation
- 1997-01-29 DE DE69703791T patent/DE69703791T2/de not_active Expired - Fee Related
-
1998
- 1998-07-30 NO NO983511A patent/NO983511L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2244134C (en) | 2005-04-26 |
| NO983511L (no) | 1998-09-30 |
| JP3662936B2 (ja) | 2005-06-22 |
| AU707199B2 (en) | 1999-07-08 |
| ATE198323T1 (de) | 2001-01-15 |
| KR19990082260A (ko) | 1999-11-25 |
| CZ241698A3 (cs) | 1998-12-16 |
| EP0882015B1 (en) | 2000-12-27 |
| DE69703791T2 (de) | 2001-06-21 |
| HUP9902119A3 (en) | 2001-08-28 |
| AU1434697A (en) | 1997-08-22 |
| NO983511D0 (no) | 1998-07-30 |
| PL328225A1 (en) | 1999-01-18 |
| MX9806213A (es) | 1998-12-31 |
| CA2244134A1 (en) | 1997-08-07 |
| ES2152648T3 (es) | 2001-02-01 |
| CN1214677A (zh) | 1999-04-21 |
| HUP9902119A2 (hu) | 2001-04-28 |
| SK102698A3 (en) | 1999-04-13 |
| DE69703791D1 (de) | 2001-02-01 |
| WO1997028120A1 (en) | 1997-08-07 |
| EE9800230A (et) | 1998-12-15 |
| IL125441A0 (en) | 1999-03-12 |
| EP0882015A1 (en) | 1998-12-09 |
| JP2000504332A (ja) | 2000-04-11 |
| EA199800675A1 (ru) | 1999-02-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LU91145I9 (es) | ||
| ZA944501B (en) | Phenyl heterocycles as cox-2 inhibitors | |
| ES2171723T3 (es) | 3,4-diaril-2-hidroxi-2,5-dihidrofuranos como profarmacos de inhibidores de cox-2. | |
| NZ326283A (en) | Diphenyl stilbenes as prodrugs to cox-2 inhibitors | |
| DE69702182D1 (de) | Alkylierte styrole als prodrugs zu cox-2-inhibitoren | |
| DE69715173D1 (en) | Bisarylcyclobutenderivate als cyclooxygenasehemmer | |
| MY119407A (en) | 3-phenyl-4-(4(methylsulfonyl)phenyl)-2-(5h)-furanone as a cox-2 inhibitor. | |
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