HUP9902119A2 - Difenil-stilbén származékok, mint Cox-2 inhibitorok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Difenil-stilbén származékok, mint Cox-2 inhibitorok és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9902119A2
HUP9902119A2 HU9902119A HUP9902119A HUP9902119A2 HU P9902119 A2 HUP9902119 A2 HU P9902119A2 HU 9902119 A HU9902119 A HU 9902119A HU P9902119 A HUP9902119 A HU P9902119A HU P9902119 A2 HUP9902119 A2 HU P9902119A2
Authority
HU
Hungary
Prior art keywords
group
atom
hydrogen atom
cox
inhibitors
Prior art date
Application number
HU9902119A
Other languages
English (en)
Inventor
Cameron Black
Mario Girard
Daniel Guay
Zhaoyin Wang
Original Assignee
Merck Frosst Canada & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605647.8A external-priority patent/GB9605647D0/en
Application filed by Merck Frosst Canada & Co. filed Critical Merck Frosst Canada & Co.
Publication of HUP9902119A2 publication Critical patent/HUP9902119A2/hu
Publication of HUP9902119A3 publication Critical patent/HUP9902119A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

A találmány szerinti vegyületek (I) általános képletében X jelentése -CH2OH, -CHO, -CO2R4 vagy -CONR42 általános képletűcsoport, Y jelentése -CH3 vagy -CH2OR5 általános képletű csoport, R1 jelentése -S(O)2CH3, -S(O)2NH2, -S(O)2NHC(O)CF3, -S(O)(NH)CH3, -S(O)(NH)NH2, -S(O)(NH)NHC(O)CF3, -P(O)(CH3)OH vagy -P(O)(CH3)NH2képletű csoport, R2 és R3 jelentése egymástól függetlenül hidrogénatom, halogénatom,alkoxicsoport, alkil-tio-csoport, cianocsoport, trifluor-metil-csoport, alkilcsoport vagy azidocsoport, R4 jelentése hidrogénatom, alkilcsoport vagy mono- vagydiszubsztituált benzilcsoport, vagy azonos nitrogénatomhoz kapcsolódókét R4 jelentése együtt 5, 6 vagy 7 tagú telített gyűrű, amely adottesetben oxigénatomot vagy kénatomot, vagy további nitrogénatomottartalmazhat, ahol a nitrogénatom hidrogénatommal vagyalkoxicsoporttal szubsztituálva van, R5 jelentése alkilcsoport vagy mono- vagy diszubsztituáltbenzilcsoport. A találmány kiterjed a fenti vegyületeket tartalmazó -főleg gyulladások és fájdalom elleni - gyógykészítményekre. Ó
HU9902119A 1996-02-01 1997-01-29 Diphenyl stilbene derivatives as cox-2 inhibitors and pharmaceutical compositions of the same HUP9902119A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1095096P 1996-02-01 1996-02-01
GBGB9605647.8A GB9605647D0 (en) 1996-03-18 1996-03-18 Diphenyl stilbenes as prodrugs to cox-2 inhibitors
PCT/CA1997/000063 WO1997028120A1 (en) 1996-02-01 1997-01-29 Diphenyl stilbenes as prodrugs to cox-2 inhibitors

Publications (2)

Publication Number Publication Date
HUP9902119A2 true HUP9902119A2 (hu) 2001-04-28
HUP9902119A3 HUP9902119A3 (en) 2001-08-28

Family

ID=26308949

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902119A HUP9902119A3 (en) 1996-02-01 1997-01-29 Diphenyl stilbene derivatives as cox-2 inhibitors and pharmaceutical compositions of the same

Country Status (19)

Country Link
EP (1) EP0882015B1 (hu)
JP (1) JP3662936B2 (hu)
KR (1) KR19990082260A (hu)
CN (1) CN1214677A (hu)
AT (1) ATE198323T1 (hu)
AU (1) AU707199B2 (hu)
CA (1) CA2244134C (hu)
CZ (1) CZ241698A3 (hu)
DE (1) DE69703791T2 (hu)
EA (1) EA199800675A1 (hu)
EE (1) EE9800230A (hu)
ES (1) ES2152648T3 (hu)
HU (1) HUP9902119A3 (hu)
IL (1) IL125441A0 (hu)
NO (1) NO983511L (hu)
NZ (1) NZ326283A (hu)
PL (1) PL328225A1 (hu)
SK (1) SK102698A3 (hu)
WO (1) WO1997028120A1 (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635417B1 (en) 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
US5998140A (en) * 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
JP2003523958A (ja) 1999-12-23 2003-08-12 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
EP1527045A1 (en) * 2002-07-26 2005-05-04 Merck Frosst Canada & Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
US7244753B2 (en) 2002-07-29 2007-07-17 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
DE602004021238D1 (de) 2003-03-05 2009-07-09 Merck Frosst Company Stickstoffmonoxid freisetzende prodrugs von diaryl-2-(5h)-furanonen als inhibitoren von cyclooxygenase-2
WO2005070883A1 (en) * 2004-01-27 2005-08-04 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
CN1914151A (zh) * 2004-01-27 2007-02-14 默克弗罗斯特公司 作为环氧合酶－2抑制剂的二芳基－2(5h)－呋喃酮类的释放一氧化氮的前药
WO2006029436A1 (de) * 2004-09-17 2006-03-23 Universität Wien Cox-ii-inhibitorverbindungen
CA3209491A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012786A1 (fr) * 1989-04-24 1990-11-01 Otsuka Pharmaceutical Factory, Inc. Derive de 3-halogeno-2,3-diphenylacrylaldehyde, son procede de fabrication et agent de traitement de l'hyperlipidemie
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5393790A (en) * 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation

Also Published As

Publication number Publication date
CA2244134C (en) 2005-04-26
NZ326283A (en) 1998-12-23
NO983511L (no) 1998-09-30
JP3662936B2 (ja) 2005-06-22
AU707199B2 (en) 1999-07-08
ATE198323T1 (de) 2001-01-15
KR19990082260A (ko) 1999-11-25
CZ241698A3 (cs) 1998-12-16
EP0882015B1 (en) 2000-12-27
DE69703791T2 (de) 2001-06-21
HUP9902119A3 (en) 2001-08-28
AU1434697A (en) 1997-08-22
NO983511D0 (no) 1998-07-30
PL328225A1 (en) 1999-01-18
MX9806213A (es) 1998-12-31
CA2244134A1 (en) 1997-08-07
ES2152648T3 (es) 2001-02-01
CN1214677A (zh) 1999-04-21
SK102698A3 (en) 1999-04-13
DE69703791D1 (de) 2001-02-01
WO1997028120A1 (en) 1997-08-07
EE9800230A (et) 1998-12-15
IL125441A0 (en) 1999-03-12
EP0882015A1 (en) 1998-12-09
JP2000504332A (ja) 2000-04-11
EA199800675A1 (ru) 1999-02-25

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