BRPI0519198A2 - moduladores de delta-opiàide tricÍclicos - Google Patents

moduladores de delta-opiàide tricÍclicos

Info

Publication number
BRPI0519198A2
BRPI0519198A2 BRPI0519198-0A BRPI0519198A BRPI0519198A2 BR PI0519198 A2 BRPI0519198 A2 BR PI0519198A2 BR PI0519198 A BRPI0519198 A BR PI0519198A BR PI0519198 A2 BRPI0519198 A2 BR PI0519198A2
Authority
BR
Brazil
Prior art keywords
opioid
tricyclic
modulators
delta
opioid modulators
Prior art date
Application number
BRPI0519198-0A
Other languages
English (en)
Inventor
John R Carson
Scott L Dax
Bart Decorte
Li Liu
James J Mcnally
Mark Mcdonnell
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0519198A2 publication Critical patent/BRPI0519198A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

MODULADORES DE DELTA-OPIàIDE TRICÍCLICOS. A invenção refere-se a moduladores de receptor deita opiálde da fórmula (1). Mais especificamente, a invenção refere-se a moduladores <sym>-opióide triçíclicos. Composições farmacêuticas e veterinárias para tratar dor branda a severa e várias doenças que são também descritas.
BRPI0519198-0A 2004-12-22 2005-12-21 moduladores de delta-opiàide tricÍclicos BRPI0519198A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63831404P 2004-12-22 2004-12-22
PCT/US2005/046690 WO2006069275A1 (en) 2004-12-22 2005-12-21 Tricyclic delta-opioid modulators

Publications (1)

Publication Number Publication Date
BRPI0519198A2 true BRPI0519198A2 (pt) 2008-12-30

Family

ID=36177990

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519198-0A BRPI0519198A2 (pt) 2004-12-22 2005-12-21 moduladores de delta-opiàide tricÍclicos

Country Status (10)

Country Link
US (2) US20060135522A1 (pt)
EP (1) EP1836196A1 (pt)
JP (1) JP2008525481A (pt)
KR (1) KR20070092286A (pt)
CN (1) CN101128458A (pt)
AU (1) AU2005319059A1 (pt)
BR (1) BRPI0519198A2 (pt)
CA (1) CA2592462A1 (pt)
MX (1) MX2007007625A (pt)
WO (1) WO2006069275A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4810423B2 (ja) * 2003-06-27 2011-11-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式デルタオピオイド調節剤
JP2008529971A (ja) * 2004-08-05 2008-08-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
WO2006069276A2 (en) 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. TRICYCLIC ō-OPIOID MODULATORS
US20060135522A1 (en) * 2004-12-22 2006-06-22 Carson John R Tricyclic delta-opioid modulators
US7589104B2 (en) * 2004-12-22 2009-09-15 Janssen Pharmaceutica Nv Tricyclic-bridged piperidinyline derivatives as §-opioid modulators
JP2008526878A (ja) * 2005-01-06 2008-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
AR057374A1 (es) * 2005-06-16 2007-11-28 Janssen Pharmaceutica Nv Moduladres opioides triciclicos y composiciones farmaceuticas y veterinarias
IT1396951B1 (it) * 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
KR101275092B1 (ko) * 2011-05-19 2013-06-17 한미정밀화학주식회사 아질사르탄의 개선된 제조방법
CN102680310A (zh) * 2012-03-20 2012-09-19 中国人民解放军第二军医大学 一种微波辅助血浆样品前处理方法及在血浆代谢组学分析中的应用
WO2016116527A1 (de) * 2015-01-20 2016-07-28 Cynora Gmbh Organische moleküle, insbesondere zur verwendung in optoelektronischen bauelementen
CN108069935A (zh) * 2017-12-25 2018-05-25 天津瑞岭化工有限公司 一种2,4-二乙基硫杂蒽酮的制备方法
CN115521319A (zh) * 2021-06-25 2022-12-27 沈阳兴齐眼药股份有限公司 2-(10-氧代-9-氧杂-1-氮杂蒽-6-基)丙酸酯类化合物的制备方法及用途
CN115521320B (zh) * 2021-06-25 2023-09-05 沈阳兴齐眼药股份有限公司 一种制备普拉洛芬的方法

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US4666907A (en) * 1983-10-05 1987-05-19 Merck Frosst Canada, Inc. Phenothiazine and derivatives and analogs and use as leukotriene biosynthesis inhibitors
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FR2689013B1 (fr) * 1992-03-30 1995-05-05 Rhone Poulenc Rorer Sa Nouvelle application thérapeutique des dérivés de la phénothiazine.
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JP2008529971A (ja) * 2004-08-05 2008-08-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
US20060135522A1 (en) * 2004-12-22 2006-06-22 Carson John R Tricyclic delta-opioid modulators
WO2006069276A2 (en) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. TRICYCLIC ō-OPIOID MODULATORS
US7589104B2 (en) * 2004-12-22 2009-09-15 Janssen Pharmaceutica Nv Tricyclic-bridged piperidinyline derivatives as §-opioid modulators
JP2008526878A (ja) * 2005-01-06 2008-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
AR057374A1 (es) * 2005-06-16 2007-11-28 Janssen Pharmaceutica Nv Moduladres opioides triciclicos y composiciones farmaceuticas y veterinarias

Also Published As

Publication number Publication date
KR20070092286A (ko) 2007-09-12
CA2592462A1 (en) 2006-06-29
MX2007007625A (es) 2008-01-28
AU2005319059A1 (en) 2006-06-29
EP1836196A1 (en) 2007-09-26
US20080306111A1 (en) 2008-12-11
JP2008525481A (ja) 2008-07-17
US20060135522A1 (en) 2006-06-22
WO2006069275A1 (en) 2006-06-29
CN101128458A (zh) 2008-02-20

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.