ZA756550B - Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms - Google Patents

Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms

Info

Publication number
ZA756550B
ZA756550B ZA00756550A ZA756550A ZA756550B ZA 756550 B ZA756550 B ZA 756550B ZA 00756550 A ZA00756550 A ZA 00756550A ZA 756550 A ZA756550 A ZA 756550A ZA 756550 B ZA756550 B ZA 756550B
Authority
ZA
South Africa
Prior art keywords
pharmaceutical compositions
antipsychotic activity
extrapyramidal symptoms
producing
producing antipsychotic
Prior art date
Application number
ZA00756550A
Inventor
C Zirkle
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Priority to US05/655,587 priority Critical patent/US4086350A/en
Publication of ZA756550B publication Critical patent/ZA756550B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82Xanthenes
    • C07D311/84Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA00756550A 1974-11-06 1975-10-16 Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms ZA756550B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US05/655,587 US4086350A (en) 1974-11-06 1976-02-05 Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52121674A 1974-11-06 1974-11-06

Publications (1)

Publication Number Publication Date
ZA756550B true ZA756550B (en) 1976-09-29

Family

ID=24075868

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00756550A ZA756550B (en) 1974-11-06 1975-10-16 Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms

Country Status (17)

Country Link
JP (1) JPS5826754B2 (en)
AU (1) AU498298B2 (en)
BE (1) BE835224A (en)
CA (1) CA1055945A (en)
CH (1) CH624403A5 (en)
DE (1) DE2549841A1 (en)
DK (1) DK139429B (en)
ES (1) ES442357A1 (en)
FR (1) FR2290202A1 (en)
HU (1) HU174639B (en)
IE (1) IE42137B1 (en)
IL (1) IL48400A (en)
LU (1) LU73714A1 (en)
NL (1) NL7512974A (en)
NZ (1) NZ179139A (en)
PH (1) PH12158A (en)
ZA (1) ZA756550B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2357251A1 (en) * 1976-07-09 1978-02-03 Merck & Co Inc Carboxy-thioxanthenylidene-piperidine - useful as appetite stimulants and antiallergics
US4073912A (en) * 1976-10-12 1978-02-14 Smithkline Corporation Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof
US4089961A (en) * 1976-11-08 1978-05-16 Smithkline Corporation Antipsychotically useful quinolizidylidene derivatives of xanthenes, thioxanthenes and dibenzoxepins
NZ189108A (en) * 1977-12-29 1982-02-23 Kefalas As 2-methylthio-6-fluoro-9-(1-methyl-4-piperidylidene)-thioxanthene and pharmaceutical compositions intermediate 2-methylthio-6-fluoro-9-(1-methyl-4-piperidyl)-thioxanthen-9-ol
US4777177A (en) * 1984-10-19 1988-10-11 Ciba-Geigy Corporation Pesticidal thioxanthen-9-ylidenepiperidines
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
CA2004211A1 (en) * 1988-11-30 1990-05-31 Masataka Syoji Piperidine derivatives and hyportensives containing the same
US7060711B2 (en) 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
EP1306376A1 (en) * 2001-10-25 2003-05-02 Biofrontera Pharmaceuticals AG Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
US7589103B2 (en) 2003-06-27 2009-09-15 Janssen Pharmaceutica N.V. Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators
EP1910353A1 (en) 2004-08-05 2008-04-16 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
JP2008525483A (en) 2004-12-22 2008-07-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Tricyclic δ-opioid regulator
BRPI0518563A2 (en) 2004-12-22 2008-11-25 Janssen Pharmaceutica Nv tricyclic delta-opioid modulators
CN101128458A (en) * 2004-12-22 2008-02-20 詹森药业有限公司 Tricyclic delta-opioid modulators
CN101128460A (en) 2005-01-06 2008-02-20 詹森药业有限公司 Tricyclic delta-opioid modulators
CA2612491A1 (en) 2005-06-16 2006-12-28 Janssen Pharmaceutica N.V. Tricyclic opioid modulators
JP5044562B2 (en) 2006-09-29 2012-10-10 日本臓器製薬株式会社 Oxepin derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL260070A (en) * 1960-02-25
NL283292A (en) * 1961-09-29
DE1670118A1 (en) * 1966-07-22 1970-11-05 Boehringer Mannheim Gmbh Process for the preparation of new derivatives of 6,11-dihydro-dibenz [b, e] oxepins and their salts
US3470188A (en) * 1967-01-05 1969-09-30 Smithkline Corp 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes
JPS5018478A (en) * 1973-05-17 1975-02-26

Also Published As

Publication number Publication date
PH12158A (en) 1978-11-10
JPS5826754B2 (en) 1983-06-04
NZ179139A (en) 1978-04-28
CA1055945A (en) 1979-06-05
HU174639B (en) 1980-02-28
NL7512974A (en) 1976-05-10
BE835224A (en) 1976-05-04
DK139429C (en) 1979-08-06
LU73714A1 (en) 1976-06-11
AU498298B2 (en) 1979-03-01
IE42137B1 (en) 1980-06-04
FR2290202A1 (en) 1976-06-04
IL48400A (en) 1979-01-31
DE2549841C2 (en) 1988-07-07
DK139429B (en) 1979-02-19
CH624403A5 (en) 1981-07-31
IL48400A0 (en) 1976-01-30
JPS5170768A (en) 1976-06-18
ES442357A1 (en) 1977-04-01
DK495775A (en) 1976-05-07
DE2549841A1 (en) 1976-05-13
FR2290202B1 (en) 1980-05-23
IE42137L (en) 1976-05-06
AU8624775A (en) 1977-05-05

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