NZ179139A - Piperidylidene derivatives of xanthene, thioxanthene and dibenzoxepin and pharmaceutical compositions - Google Patents

Piperidylidene derivatives of xanthene, thioxanthene and dibenzoxepin and pharmaceutical compositions

Info

Publication number
NZ179139A
NZ179139A NZ179139A NZ17913975A NZ179139A NZ 179139 A NZ179139 A NZ 179139A NZ 179139 A NZ179139 A NZ 179139A NZ 17913975 A NZ17913975 A NZ 17913975A NZ 179139 A NZ179139 A NZ 179139A
Authority
NZ
New Zealand
Prior art keywords
dibenzoxepin
thioxanthene
xanthene
pharmaceutical compositions
piperidylidene
Prior art date
Application number
NZ179139A
Inventor
C Zirkle
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of NZ179139A publication Critical patent/NZ179139A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82Xanthenes
    • C07D311/84Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NZ179139A 1974-11-06 1975-11-03 Piperidylidene derivatives of xanthene, thioxanthene and dibenzoxepin and pharmaceutical compositions NZ179139A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52121674A 1974-11-06 1974-11-06

Publications (1)

Publication Number Publication Date
NZ179139A true NZ179139A (en) 1978-04-28

Family

ID=24075868

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ179139A NZ179139A (en) 1974-11-06 1975-11-03 Piperidylidene derivatives of xanthene, thioxanthene and dibenzoxepin and pharmaceutical compositions

Country Status (17)

Country Link
JP (1) JPS5826754B2 (en)
AU (1) AU498298B2 (en)
BE (1) BE835224A (en)
CA (1) CA1055945A (en)
CH (1) CH624403A5 (en)
DE (1) DE2549841A1 (en)
DK (1) DK139429B (en)
ES (1) ES442357A1 (en)
FR (1) FR2290202A1 (en)
HU (1) HU174639B (en)
IE (1) IE42137B1 (en)
IL (1) IL48400A (en)
LU (1) LU73714A1 (en)
NL (1) NL7512974A (en)
NZ (1) NZ179139A (en)
PH (1) PH12158A (en)
ZA (1) ZA756550B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2357251A1 (en) * 1976-07-09 1978-02-03 Merck & Co Inc Carboxy-thioxanthenylidene-piperidine - useful as appetite stimulants and antiallergics
US4073912A (en) * 1976-10-12 1978-02-14 Smithkline Corporation Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof
US4089961A (en) * 1976-11-08 1978-05-16 Smithkline Corporation Antipsychotically useful quinolizidylidene derivatives of xanthenes, thioxanthenes and dibenzoxepins
NZ189108A (en) * 1977-12-29 1982-02-23 Kefalas As 2-methylthio-6-fluoro-9-(1-methyl-4-piperidylidene)-thioxanthene and pharmaceutical compositions intermediate 2-methylthio-6-fluoro-9-(1-methyl-4-piperidyl)-thioxanthen-9-ol
US4777177A (en) * 1984-10-19 1988-10-11 Ciba-Geigy Corporation Pesticidal thioxanthen-9-ylidenepiperidines
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
CA2004211A1 (en) * 1988-11-30 1990-05-31 Masataka Syoji Piperidine derivatives and hyportensives containing the same
EP1306376A1 (en) * 2001-10-25 2003-05-02 Biofrontera Pharmaceuticals AG Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
US7060711B2 (en) 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
CA2530444C (en) * 2003-06-27 2012-03-13 Janssen Pharmaceutica, N.V. Tricyclic .delta. opioid modulators
CN101039940A (en) 2004-08-05 2007-09-19 詹森药业有限公司 Tricyclic delta-opioid modulators
CA2592462A1 (en) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
EA011674B1 (en) 2004-12-22 2009-04-28 Янссен Фармацевтика Н.В. TRICYCLIC δ-OPIOID MODULATORS
BRPI0519201A2 (en) 2004-12-22 2008-12-30 Janssen Pharmaceutica Nv tricyclic delta-opioid modulators
JP2008526878A (en) 2005-01-06 2008-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Tricyclic δ-opioid regulator
BRPI0611885A2 (en) 2005-06-16 2010-10-05 Janssen Pharmaceutica Nv tricyclic opioid modulators
EP2067777B1 (en) 2006-09-29 2013-08-14 Nippon Zoki Pharmaceutical Co., Ltd. Oxepin derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL260070A (en) * 1960-02-25
NL122808C (en) * 1961-09-29
DE1670118A1 (en) * 1966-07-22 1970-11-05 Boehringer Mannheim Gmbh Process for the preparation of new derivatives of 6,11-dihydro-dibenz [b, e] oxepins and their salts
US3470188A (en) * 1967-01-05 1969-09-30 Smithkline Corp 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes
JPS5018478A (en) * 1973-05-17 1975-02-26

Also Published As

Publication number Publication date
CA1055945A (en) 1979-06-05
AU8624775A (en) 1977-05-05
HU174639B (en) 1980-02-28
DK139429C (en) 1979-08-06
BE835224A (en) 1976-05-04
IL48400A0 (en) 1976-01-30
NL7512974A (en) 1976-05-10
ES442357A1 (en) 1977-04-01
FR2290202A1 (en) 1976-06-04
ZA756550B (en) 1976-09-29
FR2290202B1 (en) 1980-05-23
JPS5170768A (en) 1976-06-18
DE2549841C2 (en) 1988-07-07
IL48400A (en) 1979-01-31
DK139429B (en) 1979-02-19
DK495775A (en) 1976-05-07
CH624403A5 (en) 1981-07-31
PH12158A (en) 1978-11-10
IE42137B1 (en) 1980-06-04
DE2549841A1 (en) 1976-05-13
IE42137L (en) 1976-05-06
AU498298B2 (en) 1979-03-01
LU73714A1 (en) 1976-06-11
JPS5826754B2 (en) 1983-06-04

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