BRPI0409436A - compostos de 4-fenil-piperidina e a sua utilização como moduladores de receptores de opióides - Google Patents
compostos de 4-fenil-piperidina e a sua utilização como moduladores de receptores de opióidesInfo
- Publication number
- BRPI0409436A BRPI0409436A BRPI0409436-0A BRPI0409436A BRPI0409436A BR PI0409436 A BRPI0409436 A BR PI0409436A BR PI0409436 A BRPI0409436 A BR PI0409436A BR PI0409436 A BRPI0409436 A BR PI0409436A
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- opioid receptor
- disorders
- conditions
- disease states
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
"COMPOSTOS DE 4-FENIL-PIPERIDINA E A SUA UTILIZAçãO COMO MODULADORES DE RECEPTORES DE OPIóIDES". A presente invenção refere-se a derivados de 4-fenil-piperidina de fórmula (I) a composições farmacêuticas contendo esses derivados e a métodos de se utilizarem esses derivados para tratar estados de doença, distúrbios e condições mediados por um receptor de opióides. A invenção particularmente também refere-se à utilização de tais derivados para tratar determinados estados de doença, distúrbios e condições, por exemplo, a síndrome de intestino irritável, a adicção ou dependência de drogas, incluindo a adicção do álcool, a depressão, a ansiedade, a esquizofrenia, a ansiedade, a esquizofrenia e distúrbios de alimentação, entre muitos outros estados de doença, distúrbios e condições que são descritos mais detalhadamente neste documento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46265103P | 2003-04-14 | 2003-04-14 | |
PCT/IB2004/001161 WO2004089370A1 (en) | 2003-04-14 | 2004-04-01 | 4-phenyl-piperidine compounds and their use as modulators of opioid receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0409436A true BRPI0409436A (pt) | 2006-04-18 |
Family
ID=33159858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0409436-0A BRPI0409436A (pt) | 2003-04-14 | 2004-04-01 | compostos de 4-fenil-piperidina e a sua utilização como moduladores de receptores de opióides |
Country Status (16)
Country | Link |
---|---|
US (2) | US20040204453A1 (pt) |
EP (1) | EP1615643A1 (pt) |
JP (1) | JP2006522792A (pt) |
AR (1) | AR044016A1 (pt) |
BR (1) | BRPI0409436A (pt) |
CA (1) | CA2522214A1 (pt) |
CL (1) | CL2004000695A1 (pt) |
DO (1) | DOP2004000876A (pt) |
GT (1) | GT200400064A (pt) |
MX (1) | MXPA05011018A (pt) |
NL (1) | NL1025933C2 (pt) |
PA (1) | PA8600001A1 (pt) |
PE (1) | PE20050416A1 (pt) |
TW (1) | TW200423934A (pt) |
UY (1) | UY28263A1 (pt) |
WO (1) | WO2004089370A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100621292B1 (ko) * | 2001-10-22 | 2006-09-13 | 화이자 프로덕츠 인코포레이티드 | 오피오이드 수용체 길항제로서의3-아자비사이클로[3.1.0]헥산 유도체 |
US7381721B2 (en) * | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
WO2004089908A2 (en) | 2003-04-14 | 2004-10-21 | Pfizer Products Inc. | 3-azabicyclo[3.2.1]octane derivatives |
US6992090B2 (en) * | 2003-06-16 | 2006-01-31 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
AR057061A1 (es) * | 2005-06-16 | 2007-11-14 | Altana Pharma Ag | Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos |
MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | 8-氮雜雙環〔3.2.1〕辛烷化合物之結晶型 |
EP2195313B1 (en) * | 2007-08-27 | 2014-04-02 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
US7947710B2 (en) | 2007-08-27 | 2011-05-24 | Theravance, Inc. | Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
TWI423801B (zh) * | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之8-氮雜雙環〔3.2.1〕辛基-2-羥基苯甲醯胺化合物 |
ES2390195T3 (es) * | 2007-08-27 | 2012-11-07 | Theravance, Inc. | Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu |
US9512105B2 (en) | 2011-12-09 | 2016-12-06 | Research Triangle Institute | 1-substituted 4-arylpiperazine as kappa opioid receptor antagonists |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
CN107530186A (zh) | 2015-01-27 | 2018-01-02 | 梅迪万斯股份有限公司 | 用于热疗的改进的医疗垫和系统 |
EP3512832B1 (en) | 2016-09-16 | 2021-05-19 | Research Triangle Institute | Tetrahydroisoquinoline kappa opioid antagonists |
EP3555072A1 (en) * | 2016-12-16 | 2019-10-23 | Esteve Pharmaceuticals, S.A. | Tetrahydropyran and tetrahydrothiopyran amide derivatives having multimodal activity against pain |
CA3050515A1 (en) * | 2017-01-17 | 2018-07-26 | Mebias Discovery, Inc. | Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same |
EP3595661A4 (en) * | 2017-03-12 | 2020-08-19 | Xiaodong Wang | POLYCYCLIC AMINES USED AS MODULATORS OF OPIOID RECEPTOR |
US11584765B2 (en) | 2017-03-12 | 2023-02-21 | Ecstasy LLC | Polycyclic amines as sigma receptor modulators |
CA3188131A1 (en) | 2020-07-01 | 2022-01-06 | Ecstasy LLC | Polycyclic amines for opioid receptor modulation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4891379A (en) * | 1987-04-16 | 1990-01-02 | Kabushiki Kaisha Kobe Seikosho | Piperidine opioid antagonists |
GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
EP1513813B1 (en) * | 2002-05-30 | 2005-11-02 | Eli Lilly And Company | Opioid receptor antagonists |
US7381721B2 (en) * | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
-
2004
- 2004-01-22 US US10/762,447 patent/US20040204453A1/en not_active Abandoned
- 2004-03-31 CL CL200400695A patent/CL2004000695A1/es unknown
- 2004-04-01 JP JP2006506479A patent/JP2006522792A/ja not_active Abandoned
- 2004-04-01 CA CA002522214A patent/CA2522214A1/en not_active Abandoned
- 2004-04-01 EP EP04725122A patent/EP1615643A1/en not_active Withdrawn
- 2004-04-01 MX MXPA05011018A patent/MXPA05011018A/es unknown
- 2004-04-01 WO PCT/IB2004/001161 patent/WO2004089370A1/en active Application Filing
- 2004-04-01 BR BRPI0409436-0A patent/BRPI0409436A/pt not_active IP Right Cessation
- 2004-04-02 DO DO2004000876A patent/DOP2004000876A/es unknown
- 2004-04-06 GT GT200400064A patent/GT200400064A/es unknown
- 2004-04-12 PA PA20048600001A patent/PA8600001A1/es unknown
- 2004-04-12 PE PE2004000363A patent/PE20050416A1/es not_active Application Discontinuation
- 2004-04-12 UY UY28263A patent/UY28263A1/es not_active Application Discontinuation
- 2004-04-13 TW TW093110285A patent/TW200423934A/zh unknown
- 2004-04-13 NL NL1025933A patent/NL1025933C2/nl not_active IP Right Cessation
- 2004-04-13 US US10/823,026 patent/US20050032837A1/en not_active Abandoned
- 2004-04-13 AR ARP040101234A patent/AR044016A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
NL1025933A1 (nl) | 2004-10-18 |
EP1615643A1 (en) | 2006-01-18 |
TW200423934A (en) | 2004-11-16 |
WO2004089370A1 (en) | 2004-10-21 |
CL2004000695A1 (es) | 2005-02-04 |
UY28263A1 (es) | 2004-11-30 |
MXPA05011018A (es) | 2005-12-12 |
DOP2004000876A (es) | 2004-10-15 |
AR044016A1 (es) | 2005-08-24 |
PE20050416A1 (es) | 2005-06-13 |
JP2006522792A (ja) | 2006-10-05 |
US20040204453A1 (en) | 2004-10-14 |
US20050032837A1 (en) | 2005-02-10 |
GT200400064A (es) | 2004-11-30 |
NL1025933C2 (nl) | 2005-11-23 |
CA2522214A1 (en) | 2004-10-21 |
PA8600001A1 (es) | 2004-12-16 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |