BRPI0409302A - derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos - Google Patents
derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmosInfo
- Publication number
- BRPI0409302A BRPI0409302A BRPI0409302-0A BRPI0409302A BRPI0409302A BR PI0409302 A BRPI0409302 A BR PI0409302A BR PI0409302 A BRPI0409302 A BR PI0409302A BR PI0409302 A BRPI0409302 A BR PI0409302A
- Authority
- BR
- Brazil
- Prior art keywords
- muscarinic receptor
- preparation
- pharmaceutical composition
- composition containing
- receptor antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
"DERIVADOS AZABICICLO COMO ANTAGONISTAS DE RECEPTORES MUSCARìNICOS, MéTODO PARA SUA PREPARAçãO E COMPOSIçãO FARMACêUTICA CONTENDO OS MESMOS". A presente invenção refere-se a antagonistas de receptores muscarínicos de Fórmula (I) que são úteis, entre outros usos, para o tratamento de várias doenças dos sistemas respiratório, urinário e gastrointestinal mediados através de receptores muscarínicos. Especificamente, a invenção refere-se a derivados de compostos azabicíclicos que incluem, por exemplo, 6-substituído azabiciclo ¢3.1.0! hexanos, bem como composições farmacêuticas contendo tais compostos e métodos de tratamento de doenças mediadas por receptores muscarínicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2003/001367 WO2004005252A1 (en) | 2002-07-08 | 2003-04-11 | Azabicyclo derivatives as muscarinic receptor antagonists |
PCT/IB2004/000008 WO2004089900A1 (en) | 2003-04-11 | 2004-01-06 | Azabicyclo derivatives as muscarinic receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0409302A true BRPI0409302A (pt) | 2006-04-11 |
Family
ID=33156169
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0409302-0A BRPI0409302A (pt) | 2003-04-11 | 2004-01-06 | derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos |
BRPI0409308-9A BRPI0409308A (pt) | 2003-04-11 | 2004-01-07 | derivados azabiciclo como antagonistas de receptores muscarìnicos, composição farmacêutica e processo para sua preparação |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0409308-9A BRPI0409308A (pt) | 2003-04-11 | 2004-01-07 | derivados azabiciclo como antagonistas de receptores muscarìnicos, composição farmacêutica e processo para sua preparação |
Country Status (10)
Country | Link |
---|---|
US (2) | US20070021487A1 (pt) |
EP (2) | EP1626957A1 (pt) |
JP (2) | JP2006522787A (pt) |
CN (2) | CN100436414C (pt) |
AU (2) | AU2004228452A1 (pt) |
BR (2) | BRPI0409302A (pt) |
CA (2) | CA2522071A1 (pt) |
EA (1) | EA009387B1 (pt) |
NZ (2) | NZ542952A (pt) |
WO (2) | WO2004089900A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004004629A2 (en) | 2002-07-08 | 2004-01-15 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
US7488748B2 (en) * | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
US7517905B2 (en) | 2003-04-09 | 2009-04-14 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
AU2004228452A1 (en) * | 2003-04-11 | 2004-10-21 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as muscarinic receptor antagonists |
KR20060095865A (ko) * | 2003-10-14 | 2006-09-04 | 화이자 프로덕츠 인크. | 글리신 수송 억제제로서의 비시클릭 [3.1.0] 유도체 |
EP1828126A1 (en) * | 2004-12-15 | 2007-09-05 | Ranbaxy Laboratories Limited | Acid addition salts of muscarinic receptor antagonists |
EP1888525A1 (en) * | 2005-05-03 | 2008-02-20 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives as muscarinic receptor antagonists |
EP1904446A2 (en) * | 2005-07-11 | 2008-04-02 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as muscarinic receptor antagonists |
EP1934184A1 (en) | 2005-10-05 | 2008-06-25 | Ranbaxy Laboratories, Ltd. | 3 -azabicyclooctane derivatives as muscarinic receptor antagonists |
WO2007045979A1 (en) * | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
US20090137623A1 (en) | 2005-12-30 | 2009-05-28 | Naresh Kumar | Muscarinic receptor antagonists |
EA200801591A1 (ru) | 2005-12-30 | 2008-12-30 | Рэнбакси Лабораториз Лимитед | Антагонисты мускаринового рецептора |
WO2008029349A2 (en) * | 2006-09-04 | 2008-03-13 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
US20090326004A1 (en) | 2008-06-03 | 2009-12-31 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
BR112013007566A2 (pt) | 2010-09-28 | 2016-08-02 | Panacea Biotec Ltd | novos compostos bicíclicos |
CN103772379B (zh) * | 2014-01-26 | 2016-06-15 | 寿光富康制药有限公司 | 一种曲司氯铵关键中间体的制备方法 |
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ATE396969T1 (de) | 2002-07-31 | 2008-06-15 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo (3.1.0)hexanderivate, die sich als muscarinrezeptorantagonisten eignen |
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US7501443B2 (en) | 2002-12-23 | 2009-03-10 | Ranbaxy Laboratories Limited | Flavaxate derivatives as muscarinic receptor antagonists |
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US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
AU2003205964A1 (en) | 2003-02-07 | 2004-08-30 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
US7517905B2 (en) * | 2003-04-09 | 2009-04-14 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
WO2004089363A1 (en) | 2003-04-10 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
EP1615887A1 (en) * | 2003-04-10 | 2006-01-18 | Ranbaxy Laboratories, Ltd. | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
AU2004228452A1 (en) | 2003-04-11 | 2004-10-21 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as muscarinic receptor antagonists |
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WO2005092341A1 (en) | 2004-03-22 | 2005-10-06 | Ranbaxy Laboratories Limited | Combination therapy for lower urinary tract symptoms |
EP1796667A2 (en) | 2004-09-27 | 2007-06-20 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
EP1828126A1 (en) | 2004-12-15 | 2007-09-05 | Ranbaxy Laboratories Limited | Acid addition salts of muscarinic receptor antagonists |
-
2004
- 2004-01-06 AU AU2004228452A patent/AU2004228452A1/en not_active Abandoned
- 2004-01-06 BR BRPI0409302-0A patent/BRPI0409302A/pt not_active IP Right Cessation
- 2004-01-06 EP EP04700287A patent/EP1626957A1/en not_active Withdrawn
- 2004-01-06 CN CNB2004800144712A patent/CN100436414C/zh not_active Expired - Fee Related
- 2004-01-06 US US10/552,503 patent/US20070021487A1/en not_active Abandoned
- 2004-01-06 CA CA002522071A patent/CA2522071A1/en not_active Abandoned
- 2004-01-06 JP JP2006506251A patent/JP2006522787A/ja not_active Withdrawn
- 2004-01-06 EA EA200501593A patent/EA009387B1/ru not_active IP Right Cessation
- 2004-01-06 WO PCT/IB2004/000008 patent/WO2004089900A1/en active Application Filing
- 2004-01-06 NZ NZ542952A patent/NZ542952A/en unknown
- 2004-01-07 EP EP04700488A patent/EP1620087A1/en not_active Withdrawn
- 2004-01-07 JP JP2006506252A patent/JP2006522788A/ja not_active Withdrawn
- 2004-01-07 WO PCT/IB2004/000012 patent/WO2004089364A1/en active Application Filing
- 2004-01-07 US US10/552,455 patent/US7446123B2/en not_active Expired - Fee Related
- 2004-01-07 BR BRPI0409308-9A patent/BRPI0409308A/pt not_active Application Discontinuation
- 2004-01-07 AU AU2004228760A patent/AU2004228760A1/en not_active Abandoned
- 2004-01-07 CN CNA2004800145024A patent/CN1794985A/zh active Pending
- 2004-01-07 CA CA002521989A patent/CA2521989A1/en not_active Abandoned
- 2004-01-07 NZ NZ542951A patent/NZ542951A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA200501593A1 (ru) | 2006-06-30 |
US7446123B2 (en) | 2008-11-04 |
NZ542952A (en) | 2008-11-28 |
CN1794985A (zh) | 2006-06-28 |
EA009387B1 (ru) | 2007-12-28 |
EP1626957A1 (en) | 2006-02-22 |
JP2006522787A (ja) | 2006-10-05 |
AU2004228452A2 (en) | 2004-10-21 |
CN1795176A (zh) | 2006-06-28 |
CA2521989A1 (en) | 2004-10-21 |
EP1620087A1 (en) | 2006-02-01 |
US20060287380A1 (en) | 2006-12-21 |
AU2004228452A1 (en) | 2004-10-21 |
WO2004089364A1 (en) | 2004-10-21 |
AU2004228760A1 (en) | 2004-10-21 |
WO2004089900A1 (en) | 2004-10-21 |
JP2006522788A (ja) | 2006-10-05 |
CA2522071A1 (en) | 2004-10-21 |
NZ542951A (en) | 2008-11-28 |
BRPI0409308A (pt) | 2006-05-02 |
US20070021487A1 (en) | 2007-01-25 |
CN100436414C (zh) | 2008-11-26 |
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