PT1246809E - Compostos de 5-aril-1h-1,2,4-triazole como inibidores de ciclooxigenase-2 e composicoes farmaceuticas que os contem - Google Patents

Compostos de 5-aril-1h-1,2,4-triazole como inibidores de ciclooxigenase-2 e composicoes farmaceuticas que os contem

Info

Publication number
PT1246809E
PT1246809E PT00983110T PT00983110T PT1246809E PT 1246809 E PT1246809 E PT 1246809E PT 00983110 T PT00983110 T PT 00983110T PT 00983110 T PT00983110 T PT 00983110T PT 1246809 E PT1246809 E PT 1246809E
Authority
PT
Portugal
Prior art keywords
inhibitors
aryl
pharmaceutical compositions
ciclooxygenase
contain
Prior art date
Application number
PT00983110T
Other languages
English (en)
Inventor
Jean-Claude Pascal
Denis Carniato
Original Assignee
Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramex filed Critical Theramex
Publication of PT1246809E publication Critical patent/PT1246809E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT00983110T 1999-11-09 2000-11-06 Compostos de 5-aril-1h-1,2,4-triazole como inibidores de ciclooxigenase-2 e composicoes farmaceuticas que os contem PT1246809E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99402784A EP1099695A1 (en) 1999-11-09 1999-11-09 5-aryl-1H-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
PT1246809E true PT1246809E (pt) 2003-11-28

Family

ID=8242172

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00983110T PT1246809E (pt) 1999-11-09 2000-11-06 Compostos de 5-aril-1h-1,2,4-triazole como inibidores de ciclooxigenase-2 e composicoes farmaceuticas que os contem

Country Status (24)

Country Link
US (1) US6803380B1 (pt)
EP (2) EP1099695A1 (pt)
JP (1) JP4786846B2 (pt)
CN (1) CN1198807C (pt)
AT (1) ATE245148T1 (pt)
AU (1) AU778819B2 (pt)
BR (1) BR0015440A (pt)
CA (1) CA2390649C (pt)
CZ (1) CZ20021591A3 (pt)
DE (1) DE60003949T2 (pt)
DK (1) DK1246809T3 (pt)
ES (1) ES2203538T3 (pt)
HU (1) HUP0203376A3 (pt)
IL (2) IL149370A0 (pt)
MX (1) MXPA01012903A (pt)
NO (1) NO328008B1 (pt)
NZ (1) NZ518682A (pt)
PL (1) PL204230B1 (pt)
PT (1) PT1246809E (pt)
RU (1) RU2249588C2 (pt)
SI (1) SI1246809T1 (pt)
TW (1) TWI268925B (pt)
WO (1) WO2001034577A1 (pt)
ZA (1) ZA200203165B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2390181A1 (en) * 2001-07-05 2003-01-05 Andrei Shavnya Sulfonyl aryl triazoles as anti-inflammatory/analgesic agents
EP1273580B1 (en) 2001-07-05 2005-06-15 Pfizer Products Inc. Sulfonyl heteroaryl triazoles as anti-inflammatory and analgesic agents
ES2241964T3 (es) 2001-07-05 2005-11-01 Pfizer Products Inc. Heterocicloalquilsulfufonilpirazoles como agentes antiinflamatorios/abnalgesicos.
KR100824233B1 (ko) * 2001-10-10 2008-04-24 씨제이제일제당 (주) 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난3,4-디하이드로-1ｈ-나프탈렌 유도체
WO2003037336A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
AUPR878201A0 (en) 2001-11-09 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. New compounds
KR100686537B1 (ko) 2001-12-28 2007-02-27 씨제이 주식회사 사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
US6797722B2 (en) * 2002-05-03 2004-09-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
KR100467668B1 (ko) * 2002-08-07 2005-01-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470075B1 (ko) * 2002-11-21 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100491317B1 (ko) * 2002-11-26 2005-05-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470076B1 (ko) * 2002-11-27 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
WO2004060367A1 (en) * 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Imidazole and triazole derivatives useful as selective cox-1 inhibitors
US9113536B2 (en) * 2005-04-28 2015-08-18 Basf Se Electroluminescent device
US20100256357A1 (en) * 2006-08-09 2010-10-07 Agouron Pharmaceuticals, Inc. Heterocycles useful as inhibitors of carbonic anhydrase
CN103347886A (zh) * 2010-11-26 2013-10-09 株式会社半导体能源研究所 有机金属配合物、发光元件、发光装置、电子设备以及照明装置
WO2012170839A2 (en) * 2011-06-09 2012-12-13 Cardeus Pharmaceuticals, Inc. Treatment of neuroinflammatory disease with selective cox1 inhibitors
US8853248B2 (en) * 2012-04-05 2014-10-07 Hubert Maehr (1,2,3-triazolyl)sulfonyl derivatives
CN104693133A (zh) * 2015-02-16 2015-06-10 广州市盈宇医药科技有限公司 一种环氧化酶-2选择性抑制剂及其制备方法和应用
US20200404919A1 (en) 2018-03-08 2020-12-31 Bayer Aktiengesellschaft Use of heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides in plant protection
KR20200143367A (ko) 2018-04-12 2020-12-23 바이엘 악티엔게젤샤프트 살충제로서의 ｎ-（시클로프로필메틸）-５-（메틸술포닐）-ｎ-｛１-［１-（피리미딘-２-일）-１ｈ-１,２,４-트리아졸-５-일］에틸｝벤즈아미드 유도체 및 상응하는 피리딘-카르복스아미드 유도체
CA3098061A1 (en) 2018-04-25 2019-10-31 Bayer Aktiengesellschaft Novel heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides
KR20220038403A (ko) 2019-07-23 2022-03-28 바이엘 악티엔게젤샤프트 살충제로서의 신규 헤테로아릴-트리아졸 화합물
UY38794A (es) 2019-07-23 2021-02-26 Bayer Ag Novedosos compuestos de heteroaril-triazol como plaguicidas
EP4041393A1 (en) 2019-10-09 2022-08-17 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
TW202134226A (zh) 2019-11-18 2021-09-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
CN115551839A (zh) 2020-02-18 2022-12-30 拜耳公司 作为农药的杂芳基-三唑化合物
TWI754474B (zh) * 2020-11-30 2022-02-01 翁豐富 具選擇性第二型環氧合酶抑制活性之1,2,4-三氮唑衍生物及其用途
CN112480073B (zh) * 2020-12-02 2022-03-22 武汉药明康德新药开发有限公司 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW226993B (pt) * 1992-05-29 1994-07-21 Kumiai Chemical Industry Co
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
JPH0776577A (ja) * 1993-07-14 1995-03-20 Kumiai Chem Ind Co Ltd ジフェニルトリアゾール誘導体及び殺虫、殺ダニ剤
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation

Also Published As

Publication number Publication date
CN1387517A (zh) 2002-12-25
AU778819B2 (en) 2004-12-23
EP1246809B1 (en) 2003-07-16
IL149370A0 (en) 2002-11-10
ES2203538T3 (es) 2004-04-16
CN1198807C (zh) 2005-04-27
JP4786846B2 (ja) 2011-10-05
PL204230B1 (pl) 2009-12-31
HUP0203376A2 (hu) 2003-01-28
MXPA01012903A (es) 2002-11-07
PL356120A1 (en) 2004-06-14
IL149370A (en) 2007-06-17
DE60003949D1 (de) 2003-08-21
RU2249588C2 (ru) 2005-04-10
NZ518682A (en) 2003-07-25
EP1246809A1 (en) 2002-10-09
NO20022202L (no) 2002-05-08
BR0015440A (pt) 2002-07-02
EP1099695A1 (en) 2001-05-16
NO20022202D0 (no) 2002-05-08
AU1998501A (en) 2001-06-06
ATE245148T1 (de) 2003-08-15
JP2003513961A (ja) 2003-04-15
NO328008B1 (no) 2009-11-09
US6803380B1 (en) 2004-10-12
TWI268925B (en) 2006-12-21
DK1246809T3 (da) 2003-10-20
SI1246809T1 (en) 2004-02-29
WO2001034577A1 (en) 2001-05-17
CA2390649A1 (en) 2001-05-17
CA2390649C (en) 2008-05-06
HUP0203376A3 (en) 2004-12-28
DE60003949T2 (de) 2004-05-27
CZ20021591A3 (cs) 2002-07-17
ZA200203165B (en) 2003-06-25

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