SK143198A3 - Method of preparing phosphodiesterase iv inhibitors - Google Patents

Method of preparing phosphodiesterase iv inhibitors Download PDF

Info

Publication number
SK143198A3
SK143198A3 SK1431-98A SK143198A SK143198A3 SK 143198 A3 SK143198 A3 SK 143198A3 SK 143198 A SK143198 A SK 143198A SK 143198 A3 SK143198 A3 SK 143198A3
Authority
SK
Slovakia
Prior art keywords
alkyl
phenyl
alkenyl
thf
compound
Prior art date
Application number
SK1431-98A
Other languages
English (en)
Slovak (sk)
Inventor
Ioannis Houpis
Audrey Molina
Ralph P Volante
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9612083.7A external-priority patent/GB9612083D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SK143198A3 publication Critical patent/SK143198A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SK1431-98A 1996-04-17 1997-04-14 Method of preparing phosphodiesterase iv inhibitors SK143198A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1568796P 1996-04-17 1996-04-17
GBGB9612083.7A GB9612083D0 (en) 1996-06-10 1996-06-10 Method of preparing phosphodiesterase IV inhibitors
PCT/US1997/006131 WO1997038976A1 (en) 1996-04-17 1997-04-14 Method of preparing phosphodiesterase iv inhibitors

Publications (1)

Publication Number Publication Date
SK143198A3 true SK143198A3 (en) 1999-06-11

Family

ID=26309476

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1431-98A SK143198A3 (en) 1996-04-17 1997-04-14 Method of preparing phosphodiesterase iv inhibitors

Country Status (10)

Country Link
EP (1) EP0898564A1 (ru)
CN (1) CN1216532A (ru)
AR (1) AR006550A1 (ru)
AU (1) AU2459297A (ru)
BR (1) BR9708684A (ru)
CZ (1) CZ333298A3 (ru)
EA (1) EA000877B1 (ru)
SK (1) SK143198A3 (ru)
TW (1) TW426669B (ru)
WO (1) WO1997038976A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0931066B1 (en) * 1996-09-17 2002-05-15 Merck & Co., Inc. Method of preparing phosphodiesterase iv inhibitors
TW508353B (en) * 1996-09-17 2002-11-01 Merck & Co Inc Method of preparing phosphodiesterase IV inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW263495B (ru) * 1992-12-23 1995-11-21 Celltech Ltd
GB9326173D0 (en) * 1993-12-22 1994-02-23 Celltech Ltd Chemical compounds and process

Also Published As

Publication number Publication date
CN1216532A (zh) 1999-05-12
TW426669B (en) 2001-03-21
WO1997038976A1 (en) 1997-10-23
BR9708684A (pt) 1999-08-03
EA199800931A1 (ru) 1999-04-29
AR006550A1 (es) 1999-09-08
AU2459297A (en) 1997-11-07
EA000877B1 (ru) 2000-06-26
CZ333298A3 (cs) 1999-03-17
EP0898564A1 (en) 1999-03-03

Similar Documents

Publication Publication Date Title
US4613610A (en) Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
US5196440A (en) Compounds active as inhibitors of the cholesterol biosynthesis
CA2005206A1 (en) Substituted 2-pyridones and pyrid-2-thiones, processes for their preparation and their use in medicaments
PL140278B1 (en) Method of obtaining novel derivatives of 1,4-dihydropyridine
NZ277529A (en) Enantioselective preparation of chiral triaryl (where aryl is either carbocyclic or heterocyclic) derivatives, chiral intermediates
EP0307342A2 (de) 3-Desmethyl-mevalonsäurederivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen, ihre Verwendung sowie Zwischenprodukte
CZ307821B6 (ru)
BG60409B2 (bg) 4-арил-1,4-дихидропиридин-3,5-дикарбоксилни производни
Uneyama et al. Tandem alkylation-defluorination reaction: Synthesis of 2-(N-alkyl-N-aryl) amino-3, 3-difluoropropenoates from 2-(N-aryl) imino-3, 3, 3-trifluoropropanoates
EP0249950B1 (en) Aromatic compounds
WO1988001997A2 (en) Azaindole and indolizine derivatives, processes for their production and their use as pharmaceuticals
PH26148A (en) 3-5-dihydroxy carboxylic acids
US4851427A (en) Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use
CA2107150C (fr) Nouveaux derives chromeniques a chaine laterale trienique, leur procede de preparation et les compositions pharmaceutiques les renfermant
SK143198A3 (en) Method of preparing phosphodiesterase iv inhibitors
BG60346B2 (bg) Метод за получаване на z-2-ациламино-3-монозаместени пропеноати
WO2008103382A1 (en) Method for assembling high-purity chemical libraries, compounds suppressing acetyl coenzyme a carboxylase activities discovered by same
EP1050531B1 (fr) Composés pyridiniques ou pipéridiniques substitués pour le traitement des maladies neurodégénératives
US5347039A (en) Process for the preparation of derivatives of 3,5-dihydroxypentanoic acid
US5656656A (en) Tartronic acids, their acetalic ethers and O-esters
EP0354418A2 (de) 6-Fluor-3,5-dihydroxycarbonsäuren und deren Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, pharmazeutische Präparate und Zwischenprodukte
US5728838A (en) Method of preparing phosphodiesterase IV inhibitors
EP1607388A1 (en) An improved manufacturing process for methylphenidate and intermediates thereof
JP2559814B2 (ja) カテコール誘導体及びこれを含有する医薬製剤
CS277498B6 (en) Process for preparing esters of beta-carboline-3-carboxylic acids being substituted in position 5 or 6