EP0898564A1 - Method of preparing phosphodiesterase iv inhibitors - Google Patents

Method of preparing phosphodiesterase iv inhibitors

Info

Publication number
EP0898564A1
EP0898564A1 EP97920379A EP97920379A EP0898564A1 EP 0898564 A1 EP0898564 A1 EP 0898564A1 EP 97920379 A EP97920379 A EP 97920379A EP 97920379 A EP97920379 A EP 97920379A EP 0898564 A1 EP0898564 A1 EP 0898564A1
Authority
EP
European Patent Office
Prior art keywords
alkyl
phenyl
alkenyl
inhibitors
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97920379A
Other languages
German (de)
English (en)
French (fr)
Inventor
Ioannis Houpis
Audrey Molina
Ralph P. Volante
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9612083.7A external-priority patent/GB9612083D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0898564A1 publication Critical patent/EP0898564A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Definitions

  • the starting material, 2 is obtained according to the following reaction scheme:

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP97920379A 1996-04-17 1997-04-14 Method of preparing phosphodiesterase iv inhibitors Withdrawn EP0898564A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1568796P 1996-04-17 1996-04-17
US15687 1996-04-17
GB9612083 1996-06-10
GBGB9612083.7A GB9612083D0 (en) 1996-06-10 1996-06-10 Method of preparing phosphodiesterase IV inhibitors
PCT/US1997/006131 WO1997038976A1 (en) 1996-04-17 1997-04-14 Method of preparing phosphodiesterase iv inhibitors

Publications (1)

Publication Number Publication Date
EP0898564A1 true EP0898564A1 (en) 1999-03-03

Family

ID=26309476

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97920379A Withdrawn EP0898564A1 (en) 1996-04-17 1997-04-14 Method of preparing phosphodiesterase iv inhibitors

Country Status (10)

Country Link
EP (1) EP0898564A1 (ru)
CN (1) CN1216532A (ru)
AR (1) AR006550A1 (ru)
AU (1) AU2459297A (ru)
BR (1) BR9708684A (ru)
CZ (1) CZ333298A3 (ru)
EA (1) EA000877B1 (ru)
SK (1) SK143198A3 (ru)
TW (1) TW426669B (ru)
WO (1) WO1997038976A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0931066B1 (en) * 1996-09-17 2002-05-15 Merck & Co., Inc. Method of preparing phosphodiesterase iv inhibitors
TW508353B (en) * 1996-09-17 2002-11-01 Merck & Co Inc Method of preparing phosphodiesterase IV inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW263495B (ru) * 1992-12-23 1995-11-21 Celltech Ltd
GB9326173D0 (en) * 1993-12-22 1994-02-23 Celltech Ltd Chemical compounds and process

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9738976A1 *

Also Published As

Publication number Publication date
CN1216532A (zh) 1999-05-12
TW426669B (en) 2001-03-21
WO1997038976A1 (en) 1997-10-23
BR9708684A (pt) 1999-08-03
EA199800931A1 (ru) 1999-04-29
AR006550A1 (es) 1999-09-08
AU2459297A (en) 1997-11-07
EA000877B1 (ru) 2000-06-26
SK143198A3 (en) 1999-06-11
CZ333298A3 (cs) 1999-03-17

Similar Documents

Publication Publication Date Title
Khan et al. Iodine catalyzed one-pot five-component reactions for direct synthesis of densely functionalized piperidines
Hao et al. Homogeneous catalytic hydrosilylation of pyridines
EP0770065B1 (en) Tri-substituted phenyl derivates useful as pde iv inhibitors
Weinreb et al. Total synthesis of the antitumor antibiotic streptonigrin
Hartung et al. Selectivity in the chemistry of oxygen-centered radicals-the formation of carbon-oxygen bonds
Seebach et al. Secondary and Tertiary Phenylthio- and Phenylselenoalkyllithium Compounds as Novel Reagents for the Formation of C C Bonds
CA2005206A1 (en) Substituted 2-pyridones and pyrid-2-thiones, processes for their preparation and their use in medicaments
Seashore‐Ludlow et al. Domino carbopalladation‐carbonylation: investigation of substrate scope
CA2134096C (en) Enantioselective oxazaborolidine catalysts
NZ262945A (en) Chiral oxazaborolidine derivatives; use as enantioselective catalysts for reduction of prochiral ketones to chiral alcohols
Chadwick et al. The protecting–directing role of the trityl group in syntheses of pyrrole derivatives: efficient preparations of 1-H-pyrrole-3-carboxylic acid and 3-acyl-, 3-amino-, and 3-bromo-1-tritylpyrroles
US4413127A (en) Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles
Wybrow et al. A diastereoselective tandem RCM approach to spiropiperidines
EP0898564A1 (en) Method of preparing phosphodiesterase iv inhibitors
KR20000071138A (ko) 치환 티아졸리딘디온의 제조방법
US5728838A (en) Method of preparing phosphodiesterase IV inhibitors
Hudlicky et al. Studies in the regioselectivity of the vinylogous Reformatsky reaction with ambident electrophiles: reversibility, mechanism, and synthetic utility
Chou et al. One-pot sequential acylation/alkylation reactions of 3-sulfolenes
Aumann et al. Vinyl‐and Divinylcyclopentadienes by Rhodium‐Catalyzed Condensation of Alkynes with Cross‐Conjugated Amino Metallahexatrienes [=(1‐Amino‐1, 3‐butadien‐2‐yl) carbene Complexes](M= Cr, W)
Righi et al. Linear aminopolyhydroxylated structures through rapid domino assembly of a highly functionalized heterotricyclic system and its selective cleavage
EP0354418A2 (de) 6-Fluor-3,5-dihydroxycarbonsäuren und deren Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, pharmazeutische Präparate und Zwischenprodukte
Rudler et al. Tungsten (0) alkylidene complexes stabilized as pyridinium ylides: new aspects of their synthesis and reactivity
US6632947B2 (en) Process for the preparation of substituted thiazolidinedione
Bell et al. Metalation and alkylation of 3, 6-dihydrothiazine 1-oxides prepared via Diels-Alder cycloadditions of N-sulfinyl dienophiles
EP0931066B1 (en) Method of preparing phosphodiesterase iv inhibitors

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19981117

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

AX Request for extension of the european patent

Free format text: RO PAYMENT 981117

17Q First examination report despatched

Effective date: 19990720

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20021101