ZA976705B - Process for the synthesis of protected esters of (S)-3,4-dihydroxybutric acid. - Google Patents
Process for the synthesis of protected esters of (S)-3,4-dihydroxybutric acid.Info
- Publication number
- ZA976705B ZA976705B ZA9706705A ZA976705A ZA976705B ZA 976705 B ZA976705 B ZA 976705B ZA 9706705 A ZA9706705 A ZA 9706705A ZA 976705 A ZA976705 A ZA 976705A ZA 976705 B ZA976705 B ZA 976705B
- Authority
- ZA
- South Africa
- Prior art keywords
- pct
- dihydroxybutric
- synthesis
- acid
- protected esters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2236996P | 1996-07-29 | 1996-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA976705B true ZA976705B (en) | 1998-02-10 |
Family
ID=21809241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9706705A ZA976705B (en) | 1996-07-29 | 1997-07-28 | Process for the synthesis of protected esters of (S)-3,4-dihydroxybutric acid. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5998633A (de) |
| EP (1) | EP0915866B1 (de) |
| JP (1) | JP2000515882A (de) |
| KR (1) | KR100447370B1 (de) |
| CN (1) | CN1093126C (de) |
| AT (1) | ATE215078T1 (de) |
| AU (1) | AU3515497A (de) |
| CO (1) | CO4950542A1 (de) |
| DE (1) | DE69711391T2 (de) |
| DK (1) | DK0915866T3 (de) |
| ES (1) | ES2176756T3 (de) |
| HK (1) | HK1020728A1 (de) |
| HU (1) | HU226465B1 (de) |
| IL (1) | IL127058A (de) |
| PT (1) | PT915866E (de) |
| TR (1) | TR199900191T2 (de) |
| WO (1) | WO1998004543A1 (de) |
| ZA (1) | ZA976705B (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093126C (zh) * | 1996-07-29 | 2002-10-23 | 沃尼尔·朗伯公司 | 合成被保护的(s)－3,4－二羟基丁酸酯的改进方法 |
| US6713290B2 (en) | 1998-07-24 | 2004-03-30 | Samsung Fine Chemicals Co., Ltd. | Process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone |
| EP1100953B1 (de) * | 1998-07-24 | 2002-10-09 | Samsung Fine Chemicals Co., Ltd. | Kontinuierliches Verfahren zur Herstellung von optisch reinem (S)-3-Hydroxy-gamma-Butyrolacton |
| KR100332703B1 (ko) * | 1998-07-24 | 2002-08-27 | 삼성정밀화학 주식회사 | 광학활성을갖는(s)-3,4-에폭시부티르산염의제조방법 |
| US6235930B1 (en) * | 1999-03-31 | 2001-05-22 | Board Of Trustees Operating Michigan State University | Process for the preparation of 3,4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars |
| HU227840B1 (en) * | 1999-05-06 | 2012-05-02 | Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag | Intermediates of atorvastatin synthesis and process for producing them |
| CA2391357C (en) * | 1999-12-17 | 2009-01-06 | Warner Lambert Research And Development Ireland Limited | A process for producing crystalline atorvastatin calcium |
| DE60024133T2 (de) | 1999-12-17 | 2006-08-03 | Pfizer Science And Technology Ireland Ltd., Dun Laoghaire | Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form |
| JP4598917B2 (ja) * | 2000-04-28 | 2010-12-15 | ダイセル化学工業株式会社 | ラクトンの製造方法 |
| KR100645665B1 (ko) | 2000-07-27 | 2006-11-13 | 에스케이 주식회사 | (ｓ)-베타-하이드록시-감마-부티로락톤의 연속 제조방법 |
| EP1734034A3 (de) | 2001-01-09 | 2007-01-03 | Warner-Lambert Company LLC | Carbonsäuresalze von beta-Alaninestern oder -Amiden |
| US6476235B2 (en) * | 2001-01-09 | 2002-11-05 | Warner-Lambert Company | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
| WO2002057229A1 (en) * | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
| RS100003A (en) | 2001-06-29 | 2007-02-05 | Warner-Lambert Company, | Crystalline forms of /r-(r*,r*)-2-(4- fluorphenyl)-beta,delta -dihydroxy-5(1- methylethyl)-phenyl-4-/phenylamino) carbonyl/-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin) |
| JP2004533482A (ja) * | 2001-07-06 | 2004-11-04 | テバ ファーマシューティカル インダストリーズ リミティド | ６−シアノ−ｓｙｎ−３，５−ジヒドロキシ・ヘキサン酸誘導体による７−アミノ−ｓｙｎ−３，５−ジヒドロキシ・ヘプタン酸誘導体の製法 |
| HUP0500125A3 (en) * | 2002-02-25 | 2008-03-28 | Biocon Ltd | Novel boronate esters and process for their preparation |
| GB0211716D0 (en) | 2002-05-22 | 2002-07-03 | Phoenix Chemicals Ltd | Process |
| WO2004014896A1 (en) * | 2002-08-06 | 2004-02-19 | Warner-Lambert Company Llc | Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide |
| WO2004026223A2 (en) * | 2002-09-18 | 2004-04-01 | Sk Corporation | CONTINUOUS PROCESS FOR THE PRODUCTION OF OPTICALLY PURE (S)-β HYDROXY-Ϝ-BUTYROLACTONE |
| JP2006512086A (ja) * | 2002-09-20 | 2006-04-13 | ダイヴァーサ コーポレイション | スタチンおよびスタチン中間体の合成のための酵素化学的方法 |
| US6713639B1 (en) | 2002-10-28 | 2004-03-30 | Council Of Scientific And Industrial Research | Process for preparing enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone |
| JP2006523670A (ja) * | 2003-04-14 | 2006-10-19 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | ５−（４−フルオロフェニル）−１−［２−（（２ｒ，４ｒ）−４−ヒドロキシ−６−オキソ−テトラヒドロ−ピラン−２−イル）エチル］−２−イソプロピル−４−フェニル−１ｈ−ピロール−３−カルボン酸フェニルアミドの調製方法 |
| AU2003231926A1 (en) * | 2003-04-22 | 2004-11-19 | Biocon Limited | NOVEL PROCESS FOR STEREOSELECTIVE REDUCTION OF ss-KETOESTERS |
| US7790197B2 (en) * | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
| US20050271717A1 (en) | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
| US20040253305A1 (en) * | 2003-06-12 | 2004-12-16 | Luner Paul E. | Pharmaceutical compositions of atorvastatin |
| US7655692B2 (en) * | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
| RU2315755C2 (ru) * | 2003-09-17 | 2008-01-27 | Уорнер-Ламберт Компани Ллс | Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1н-пиррол-1-гептановой кислоты |
| WO2005068642A2 (en) | 2003-10-01 | 2005-07-28 | Board Of Trustees Operating Michigan State University | Bacterial synthesis of 1,2,4-butanetriol enantiomers |
| KR100829268B1 (ko) * | 2004-04-16 | 2008-05-13 | 화이자 프로덕츠 인코포레이티드 | 비정질 아토바스타틴 칼슘의 제조 방법 |
| JP2007536373A (ja) | 2004-05-05 | 2007-12-13 | ファイザー・プロダクツ・インク | アトルバスタチンの塩形態 |
| MX2007000765A (es) | 2004-07-20 | 2007-03-28 | Warner Lambert Co | Formas cristalinas de sal de calcio del acido (r-(r*, r*))-2- (4-fluorofenil)- beta,gama- dihidroxi-5- (1-metiletil)-3 -fenil-4-((fenilamino) (carbonil)-1ih -pirrol-1- heptanoico (2:1). |
| JP2008517992A (ja) * | 2004-10-28 | 2008-05-29 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アモルファスのアトルバスタチンを形成する方法 |
| JP2008521878A (ja) * | 2004-12-02 | 2008-06-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 非晶質アトルバスタチンの医薬組成物及びその製造のための方法 |
| EP1887005B1 (de) * | 2005-05-31 | 2010-04-21 | Kowa Co., Ltd. | Verfahren zur herstellung von optisch aktiven ppar-aktivierenden verbindungen und zwischenprodukte für die herstellung |
| CA2547216A1 (en) | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Process for annealing amorphous atorvastatin |
| PT1957452E (pt) | 2005-11-21 | 2010-05-25 | Warner Lambert Co | Novas formas de ácido [r-(r*,r*)]-2-(4-fluorofenil)-b,b--di-hidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil]-1h-pirrole-1-heptanóico magnésico |
| US20110165641A1 (en) * | 2006-03-31 | 2011-07-07 | The Board Of Trustees Of Michigan State University | Synthesis of 1,2,4-Butanetriol Enantiomers from Carbohydrates |
| CN101512004A (zh) * | 2006-07-19 | 2009-08-19 | 密歇根州州立大学托管委员会 | D-1,2,4-丁三醇的微生物合成 |
| KR100850558B1 (ko) | 2008-01-02 | 2008-08-06 | 조동옥 | 아토르바스타틴의 효율적인 제조방법 |
| JP2009256316A (ja) | 2008-03-28 | 2009-11-05 | Daicel Chem Ind Ltd | β−ヒドロキシ−γ−ブチロラクトンの製造方法 |
| CN101337906B (zh) * | 2008-08-15 | 2012-06-27 | 河南豫辰精细化工有限公司 | 一种4-甲基-3-氧代-n-苯基戊酰胺的制备方法 |
| SI2373609T1 (sl) | 2008-12-19 | 2013-12-31 | Krka, D.D., Novo Mesto | Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov |
| EP2327682A1 (de) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Verwendung von amphiphilen Verbindungen zur gesteuerten Kristallisation von Statinen und Statin Zwischenprodukte. |
| MX2013015272A (es) | 2011-07-01 | 2014-04-14 | Dsm Sinochem Pharm Nl Bv | Cristales micronizados. |
| CN106397241A (zh) * | 2016-08-23 | 2017-02-15 | 杨锋 | 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法 |
| CN106588689A (zh) * | 2016-12-15 | 2017-04-26 | 河南豫辰药业股份有限公司 | 一种从结晶母液废液中回收阿托伐他汀中间体m4的方法 |
| CN112939901B (zh) * | 2021-02-09 | 2023-05-09 | 中国科学院福建物质结构研究所 | 一种α-羟基-γ-丁内酯的制备方法 |
| CN114195670B (zh) * | 2021-12-31 | 2024-03-15 | 河南豫辰药业股份有限公司 | 一种阿托伐他汀母核m4的精制方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2710688B2 (ja) * | 1990-10-09 | 1998-02-10 | 鐘淵化学工業株式会社 | ４―ブロモ―３―ヒドロキシ酪酸エステル誘導体の製造法 |
| CA2049536C (en) * | 1991-05-13 | 1999-07-06 | Rawle I. Hollingsworth | Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof |
| JP3351563B2 (ja) * | 1992-12-03 | 2002-11-25 | 鐘淵化学工業株式会社 | ３−ヒドロキシ酪酸誘導体の製造法 |
| CN1093126C (zh) * | 1996-07-29 | 2002-10-23 | 沃尼尔·朗伯公司 | 合成被保护的(s)－3,4－二羟基丁酸酯的改进方法 |
-
1997
- 1997-07-01 CN CN97195996A patent/CN1093126C/zh not_active Expired - Fee Related
- 1997-07-01 ES ES97931557T patent/ES2176756T3/es not_active Expired - Lifetime
- 1997-07-01 HU HU9904348A patent/HU226465B1/hu not_active IP Right Cessation
- 1997-07-01 IL IL12705897A patent/IL127058A/en not_active IP Right Cessation
- 1997-07-01 JP JP10508813A patent/JP2000515882A/ja not_active Ceased
- 1997-07-01 DE DE69711391T patent/DE69711391T2/de not_active Expired - Fee Related
- 1997-07-01 AT AT97931557T patent/ATE215078T1/de not_active IP Right Cessation
- 1997-07-01 DK DK97931557T patent/DK0915866T3/da active
- 1997-07-01 WO PCT/US1997/011654 patent/WO1998004543A1/en active IP Right Grant
- 1997-07-01 AU AU35154/97A patent/AU3515497A/en not_active Abandoned
- 1997-07-01 KR KR10-1999-7000721A patent/KR100447370B1/ko not_active IP Right Cessation
- 1997-07-01 EP EP97931557A patent/EP0915866B1/de not_active Expired - Lifetime
- 1997-07-01 TR TR1999/00191T patent/TR199900191T2/xx unknown
- 1997-07-01 PT PT97931557T patent/PT915866E/pt unknown
- 1997-07-01 US US09/230,397 patent/US5998633A/en not_active Expired - Fee Related
- 1997-07-28 ZA ZA9706705A patent/ZA976705B/xx unknown
- 1997-07-28 CO CO97042973A patent/CO4950542A1/es unknown
-
1999
- 1999-12-09 HK HK99105756A patent/HK1020728A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9904348A2 (hu) | 2000-04-28 |
| CN1093126C (zh) | 2002-10-23 |
| EP0915866A1 (de) | 1999-05-19 |
| HK1020728A1 (en) | 2000-05-19 |
| CN1223647A (zh) | 1999-07-21 |
| DE69711391D1 (de) | 2002-05-02 |
| ES2176756T3 (es) | 2002-12-01 |
| TR199900191T2 (xx) | 1999-04-21 |
| AU3515497A (en) | 1998-02-20 |
| JP2000515882A (ja) | 2000-11-28 |
| HUP9904348A3 (en) | 2004-03-01 |
| IL127058A0 (en) | 1999-09-22 |
| HU226465B1 (en) | 2008-12-29 |
| CO4950542A1 (es) | 2000-09-01 |
| KR20000029648A (ko) | 2000-05-25 |
| DE69711391T2 (de) | 2002-11-07 |
| KR100447370B1 (ko) | 2004-09-08 |
| IL127058A (en) | 2001-07-24 |
| DK0915866T3 (da) | 2002-06-10 |
| PT915866E (pt) | 2002-07-31 |
| ATE215078T1 (de) | 2002-04-15 |
| WO1998004543A1 (en) | 1998-02-05 |
| EP0915866B1 (de) | 2002-03-27 |
| US5998633A (en) | 1999-12-07 |
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