ATE299861T1 - Ppar-(gamma) agonisten zur behandlung von type ii diabetes - Google Patents

Ppar-(gamma) agonisten zur behandlung von type ii diabetes

Info

Publication number
ATE299861T1
ATE299861T1 AT00922297T AT00922297T ATE299861T1 AT E299861 T1 ATE299861 T1 AT E299861T1 AT 00922297 T AT00922297 T AT 00922297T AT 00922297 T AT00922297 T AT 00922297T AT E299861 T1 ATE299861 T1 AT E299861T1
Authority
AT
Austria
Prior art keywords
substituted
hydrogen
ppar
agonists
sulfonyl
Prior art date
Application number
AT00922297T
Other languages
English (en)
Inventor
Hartmuth C Kolb
Gerard Mcgeehan
Zhi-Cai Shi
Laxma Reddy Kolla
Cullen Cavallaro
Original Assignee
Coelacanth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coelacanth Corp filed Critical Coelacanth Corp
Application granted granted Critical
Publication of ATE299861T1 publication Critical patent/ATE299861T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
AT00922297T 1999-04-19 2000-04-18 Ppar-(gamma) agonisten zur behandlung von type ii diabetes ATE299861T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13001199P 1999-04-19 1999-04-19
US17552800P 2000-01-11 2000-01-11
PCT/US2000/010416 WO2000063161A1 (en) 1999-04-19 2000-04-18 Ppar-(gamma) agonists as agents for the treatment of type ii diabetes

Publications (1)

Publication Number Publication Date
ATE299861T1 true ATE299861T1 (de) 2005-08-15

Family

ID=26828115

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00922297T ATE299861T1 (de) 1999-04-19 2000-04-18 Ppar-(gamma) agonisten zur behandlung von type ii diabetes

Country Status (7)

Country Link
EP (1) EP1173408B1 (de)
JP (1) JP2002542224A (de)
AT (1) ATE299861T1 (de)
AU (1) AU4250200A (de)
CA (1) CA2370742A1 (de)
DE (1) DE60021368T2 (de)
WO (1) WO2000063161A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1911462A3 (de) 2001-01-26 2011-11-30 Schering Corporation Zusammensetzungen enthaltend einen Sterolabsorptionshemmer
KR100959356B1 (ko) 2001-06-12 2010-05-20 웰스테트 테라퓨틱스 코포레이션 대사 질환의 치료용 화합물
US6716842B2 (en) 2002-04-05 2004-04-06 Warner-Lambert Company, Llc Antidiabetic agents
KR20050057178A (ko) * 2002-09-05 2005-06-16 노보 노르디스크 에이/에스 신규 비닐 카르복실산 유도체 및 그들의 치료에의 사용
ES2344106T3 (es) * 2002-10-28 2010-08-18 High Point Pharmaceuticals, Llc Nuevos compuestos utiles en el tratamiento de enfermedades mediadas por ppar.
FR2850969B1 (fr) * 2003-02-12 2005-03-25 Genfit S A Aminopropanediols acyles et analogues et leurs utilisations therapeutiques
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
WO2019125878A1 (en) 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Conjugate based systems for controlled insulin delivery
WO2019125879A2 (en) 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Conjugate based systems for controlled insulin delivery

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3118738B2 (ja) * 1992-12-22 2000-12-18 小野薬品工業株式会社 （チオ）ウレア誘導体
IL109144A (en) * 1993-03-29 2000-02-29 Zeneca Ltd Glycoprotein IIB/IIIA inhibiting 4-pyridylamino heterocyclic derivatives process for their preparation and pharmaceutical compositions containing them
NZ262942A (en) * 1993-03-29 1997-07-27 Zeneca Ltd Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions
WO1997010813A1 (en) * 1995-09-18 1997-03-27 Ligand Pharmaceuticals Incorporated Ppar gamma antagonists for treating obesity
JPH0987291A (ja) * 1995-09-26 1997-03-31 Wakamoto Pharmaceut Co Ltd 新規なアラニン誘導体
GB9604242D0 (en) * 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
AU4050797A (en) * 1996-08-02 1998-02-25 Ligand Pharmaceuticals Incorporated Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators
US6482849B1 (en) * 1997-06-23 2002-11-19 Tanabe Seiyaku Co., Ltd. Inhibitors of α4β1 mediated cell adhesion
US6197794B1 (en) * 1998-01-08 2001-03-06 Celltech Therapeutics Limited Phenylalanine derivatives
US6329372B1 (en) * 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
US6555562B1 (en) * 1998-02-26 2003-04-29 Celltech R&D Limited Phenylalanine derivatives
TW591026B (en) * 1998-06-23 2004-06-11 Upjohn Co Inhibitors of alpha4beta1 mediated cell adhesion

Also Published As

Publication number Publication date
CA2370742A1 (en) 2000-10-26
DE60021368D1 (de) 2005-08-25
DE60021368T2 (de) 2006-07-27
WO2000063161A1 (en) 2000-10-26
EP1173408A1 (de) 2002-01-23
EP1173408B1 (de) 2005-07-20
JP2002542224A (ja) 2002-12-10
AU4250200A (en) 2000-11-02

Similar Documents

Publication Publication Date Title
DE3069408D1 (en) 5-oxo- and 5-thioxoproline derivatives, process for their production and pharmaceutical compositions containing them
PL274751A1 (en) Method of obtaining novel derivatives of benzimidazoline-2-oxo-carboxylic acid
YU32100A (sh) Derivati hidrosamske kiseline kao inhibitori matrične metaloproteaze (mmp)
ATE218141T1 (de) Erythromycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
BR9507106A (pt) Derivado de ácido fenilacético alfa-substituido sua produção e fungicida agricola contendo o mesmo
ES2124545T3 (es) Azolidindionas como agentes antihiperglucemicos.
DE60042496D1 (de) Verwendung von retinoid rezeptor antagonisten für die behandlung von knochen und knorpel pathologien
DE3876813D1 (de) 3(2h)pyridazinon, verfahren zu dessen herstellung und dieses enthaltendes mittel gegen srs-a.
ATE299861T1 (de) Ppar-(gamma) agonisten zur behandlung von type ii diabetes
DE69309454D1 (de) Pyridincarboximidamide und deren anwendung
FR2798126B1 (fr) Heteroaryloxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant
ES455741A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1,3-bencenodimetanol.
DK0573318T3 (da) 4-phenylcarbamoyl-3-isoxazolcarboxylsyreforbindelser, fremgangsmåde til deres fremstilling, farmaceutiske præparater med in
DK1205476T3 (da) Fremgangsmåde til syntese af N-(mercaptoacyl)-aminosyrederivater ud fra alfa-substituerede acrylsyrer
ATE2044T1 (de) 6h-1,2,4,6-thiatriazin-1,1-dioxide, herbizide, die diese verbindungen enthalten, ihre anwendung als herbizide und verfahren zu ihrer herstellung.
ATE259817T1 (de) Herstellung von einem clavulansäuresalz
AR010205A1 (es) Un compuesto farmaceutico
GB9929582D0 (en) Chemical compounds
DE2967648D1 (en) Utilisation of 2-(n-(2,6-dichloro-phenyl)-n-allyl-amino)-imidazoline-(2) for the production of bradycardiac drugs
DE69904940T2 (de) 6-deoxy-erythromycin-derivate, ihrer herstellung, und ihrer verwendung als arzneimitteln
HUP0203921A2 (hu) Diazepin-karboxamid-származékok, eljárás a vegyületek előállítására, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
ES8403899A1 (es) Un procedimiento para la preparacion de nuevos derivados de benzamida.
TH34907A (th) สารประกอบใหม่

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties