DE60042496D1 - Verwendung von retinoid rezeptor antagonisten für die behandlung von knochen und knorpel pathologien - Google Patents
Verwendung von retinoid rezeptor antagonisten für die behandlung von knochen und knorpel pathologienInfo
- Publication number
- DE60042496D1 DE60042496D1 DE60042496T DE60042496T DE60042496D1 DE 60042496 D1 DE60042496 D1 DE 60042496D1 DE 60042496 T DE60042496 T DE 60042496T DE 60042496 T DE60042496 T DE 60042496T DE 60042496 D1 DE60042496 D1 DE 60042496D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- bone
- cartil
- pathologies
- retinoid receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/464,344 US6313168B1 (en) | 1999-12-15 | 1999-12-15 | Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies |
PCT/US2000/033697 WO2001043732A2 (en) | 1999-12-15 | 2000-12-13 | Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60042496D1 true DE60042496D1 (de) | 2009-08-13 |
Family
ID=23843560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60042496T Expired - Lifetime DE60042496D1 (de) | 1999-12-15 | 2000-12-13 | Verwendung von retinoid rezeptor antagonisten für die behandlung von knochen und knorpel pathologien |
Country Status (8)
Country | Link |
---|---|
US (1) | US6313168B1 (de) |
EP (2) | EP1645271A1 (de) |
JP (1) | JP4808887B2 (de) |
AT (1) | ATE435010T1 (de) |
AU (1) | AU784189B2 (de) |
CA (1) | CA2394210A1 (de) |
DE (1) | DE60042496D1 (de) |
WO (1) | WO2001043732A2 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020111695A1 (en) * | 1995-11-06 | 2002-08-15 | Mount Sinai Hospital Corporation | Reconstituted mineralized cartilage tissue |
CA2402413A1 (en) * | 2000-03-14 | 2001-09-20 | The University Of Western Ontario | Compositions and methods for affecting osteogenesis |
US6503914B1 (en) * | 2000-10-23 | 2003-01-07 | Board Of Regents, The University Of Texas System | Thienopyrimidine-based inhibitors of the Src family |
AU2002325752A1 (en) * | 2001-09-17 | 2003-04-01 | The University Of Western Ontario | Retinoid receptor pan-antagonists for stimulating chondrogenesis |
US20040097587A1 (en) * | 2002-03-27 | 2004-05-20 | Arbiser Jack L | Compositions and methods of treatment of ulcerating diseases, burns, and related conditions |
AU2003302070A1 (en) * | 2002-11-15 | 2004-06-15 | Galderma Research And Development, S.N.C. | USE OF AN RAR RECEPTOR ANTAGONIST FOR POTENTIATING THE ACTION OF TGFBeta |
FR2847167A1 (fr) * | 2002-11-15 | 2004-05-21 | Galderma Res & Dev | UTILISATION D'UN ANTAGONISTE DES RECEPTEURS RARs POUR POTENTIALISER L'ACTION DU TGFb |
US7226951B2 (en) * | 2003-12-17 | 2007-06-05 | Allergan, Inc. | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same |
EP1701934B1 (de) * | 2003-12-26 | 2009-02-25 | Allergan, Inc. | DISUBSTITUIERTE CHALCOGENOXIME MIT ANTAGONISTISCHER WIRKUNG AM RAR(Gamma)-RETINOIDREZEPTOR |
US7476673B2 (en) * | 2003-12-30 | 2009-01-13 | Allergan, Inc. | Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors |
SI1937244T1 (sl) | 2005-09-30 | 2018-12-31 | Io Therapeutics, Llc | Zdravljenje raka s specifičnimi RXR agonisti |
DK2026778T3 (en) * | 2006-05-16 | 2019-01-07 | Io Therapeutics Llc | RAR ANTAGONIST OR INVERSE AGONIST FOR USE IN THE TREATMENT OF CHEMOTHERAPY AND / OR RADIATION THERAPY SIDE EFFECTS |
EP2613776B1 (de) | 2010-09-01 | 2020-07-29 | Thomas Jefferson University | Zusammensetzungen und verfahren zur muskelreparatur und -regeneration |
MX352727B (es) | 2011-12-13 | 2017-12-06 | Dartmouth College | Tratamiento de trastorno autoinmune al usar agonistas de rxr. |
EP2918290B1 (de) | 2012-11-08 | 2020-09-02 | Yamaguchi University | Therapeutikum für keratokonjunktivitis |
EP3446690A1 (de) | 2013-05-22 | 2019-02-27 | Yamaguchi University | Inhibitor für retinochoroidale erkrankungen |
PL3368080T3 (pl) | 2015-10-31 | 2023-09-11 | Io Therapeutics, Inc. | Leczenie zaburzeń układu nerwowego z zastosowaniem kombinacji agonistów rxr i hormonów tarczycy |
KR20230164204A (ko) | 2016-03-10 | 2023-12-01 | 아이오 테라퓨틱스, 인크. | Rxr 작용제 및 갑상선 호르몬의 조합을 사용한 자가면역 질환의 치료 |
EP3426303B1 (de) | 2016-03-10 | 2022-06-15 | IO Therapeutics, Inc. | Behandlung von muskelerkrankungen mit kombinationen von rxr-agonisten und schilddrüsenhormonen |
EP4249490A3 (de) | 2016-06-08 | 2023-12-13 | Clementia Pharmaceuticals Inc. | Verfahren zur behandlung von heterotopischer ossifikation |
KR20190100187A (ko) | 2016-11-16 | 2019-08-28 | 클레멘티아 파마슈티컬즈, 인크. | 다중 골연골종(mo)을 치료하는 방법 |
SG11202000230VA (en) | 2017-07-11 | 2020-02-27 | Vertex Pharma | Carboxamides as modulators of sodium channels |
CA3076373A1 (en) | 2017-09-20 | 2019-03-28 | Io Therapeutics, Inc. | Treatment of disease with esters of selective rxr agonists |
US10966950B2 (en) | 2019-06-11 | 2021-04-06 | Io Therapeutics, Inc. | Use of an RXR agonist in treating HER2+ cancers |
US11896558B2 (en) | 2021-12-07 | 2024-02-13 | Io Therapeutics, Inc. | Use of an RXR agonist and taxanes in treating Her2+ cancers |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993011755A1 (en) | 1991-12-18 | 1993-06-24 | The Salk Institute For Biological Studies | Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor |
US5977125A (en) * | 1994-10-31 | 1999-11-02 | Eisai Co., Ltd. | Mono-or polyenic carboxylic acid derivatives |
US5514825A (en) | 1994-12-29 | 1996-05-07 | Allergan, Inc. | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
US5648514A (en) | 1994-12-29 | 1997-07-15 | Allergan | Substituted acetylenes having retinoid-like biological activity |
DE19501032A1 (de) * | 1995-01-14 | 1996-07-18 | Max Delbrueck Centrum | Mittel zur Behandlung von rheumatischen Erkrankungen |
US5776699A (en) | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
US5877207A (en) | 1996-03-11 | 1999-03-02 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US5808124A (en) | 1996-06-21 | 1998-09-15 | Allergan | O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5763635A (en) | 1996-06-21 | 1998-06-09 | Allergan | Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity |
US5773594A (en) | 1996-06-21 | 1998-06-30 | Allergan | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5739338A (en) | 1996-11-05 | 1998-04-14 | Allergan | N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity |
US5728846A (en) | 1996-12-12 | 1998-03-17 | Allergan | Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives |
US5760276A (en) | 1997-03-06 | 1998-06-02 | Allergan | Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity |
CA2254429A1 (en) * | 1998-11-19 | 2000-05-19 | Tully Michael Underhill | Compositions for promoting chondrogenesis |
DE19910246A1 (de) * | 1999-03-08 | 2000-09-28 | Bayer Ag | Trennfreundliche Polyurethan-Formschaum-Systeme |
DK1161410T3 (da) * | 1999-03-08 | 2004-09-20 | Basilea Pharmaceutica Ag | Retinoidantagonister og anvendelse deraf |
-
1999
- 1999-12-15 US US09/464,344 patent/US6313168B1/en not_active Expired - Fee Related
-
2000
- 2000-12-13 EP EP05024409A patent/EP1645271A1/de not_active Withdrawn
- 2000-12-13 CA CA002394210A patent/CA2394210A1/en not_active Abandoned
- 2000-12-13 JP JP2001544671A patent/JP4808887B2/ja not_active Expired - Fee Related
- 2000-12-13 EP EP00986336A patent/EP1248602B1/de not_active Expired - Lifetime
- 2000-12-13 WO PCT/US2000/033697 patent/WO2001043732A2/en active Application Filing
- 2000-12-13 AU AU22593/01A patent/AU784189B2/en not_active Ceased
- 2000-12-13 DE DE60042496T patent/DE60042496D1/de not_active Expired - Lifetime
- 2000-12-13 AT AT00986336T patent/ATE435010T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU784189B2 (en) | 2006-02-16 |
CA2394210A1 (en) | 2001-06-21 |
EP1645271A1 (de) | 2006-04-12 |
WO2001043732A2 (en) | 2001-06-21 |
JP4808887B2 (ja) | 2011-11-02 |
US6313168B1 (en) | 2001-11-06 |
ATE435010T1 (de) | 2009-07-15 |
EP1248602A2 (de) | 2002-10-16 |
JP2003519103A (ja) | 2003-06-17 |
AU2259301A (en) | 2001-06-25 |
EP1248602B1 (de) | 2009-07-01 |
WO2001043732A3 (en) | 2002-03-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |