PT804186E - Compostos alcaloides diterpenicos de indole - Google Patents
Compostos alcaloides diterpenicos de indoleInfo
- Publication number
- PT804186E PT804186E PT95908099T PT95908099T PT804186E PT 804186 E PT804186 E PT 804186E PT 95908099 T PT95908099 T PT 95908099T PT 95908099 T PT95908099 T PT 95908099T PT 804186 E PT804186 E PT 804186E
- Authority
- PT
- Portugal
- Prior art keywords
- compounds
- alcaloid
- diterpenic
- indole
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/186,197 US5541208A (en) | 1994-01-24 | 1994-01-24 | Indole diterpene alkaloid compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PT804186E true PT804186E (pt) | 2002-08-30 |
Family
ID=22684018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95908099T PT804186E (pt) | 1994-01-24 | 1995-01-20 | Compostos alcaloides diterpenicos de indole |
Country Status (11)
Country | Link |
---|---|
US (1) | US5541208A (pt) |
EP (1) | EP0804186B1 (pt) |
JP (1) | JP3689108B2 (pt) |
AT (1) | ATE216233T1 (pt) |
AU (1) | AU689207B2 (pt) |
CA (1) | CA2181371A1 (pt) |
DE (1) | DE69526452T2 (pt) |
DK (1) | DK0804186T3 (pt) |
ES (1) | ES2173177T3 (pt) |
PT (1) | PT804186E (pt) |
WO (1) | WO1995019771A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU718462B2 (en) * | 1995-08-08 | 2000-04-13 | University Of Alabama At Birmingham Research Foundation, The | Regulation of alzheimer's disease related proteins and uses thereof |
US6090839A (en) * | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
DE69735442T2 (de) * | 1996-12-23 | 2006-11-16 | Merck & Co., Inc. | Antidiabetische mittel |
US6160000A (en) * | 1996-12-23 | 2000-12-12 | Merck & Co., Inc. | Antidiabetic agents based on aryl and heteroarylacetic acids |
WO2003077845A2 (en) * | 2002-03-15 | 2003-09-25 | Merck & Co., Inc. | Compositions and methods for treating glaucoma and ocular hypertension |
JP2005533055A (ja) * | 2002-06-17 | 2005-11-04 | メルク エンド カムパニー インコーポレーテッド | 新規マキシkチャンネルブロッカー、その使用方法および製造方法 |
CN110872338B (zh) * | 2018-09-04 | 2021-04-09 | 中国海洋大学 | 一种吲哚二萜类化合物及其制备方法和用途 |
CN110105422B (zh) * | 2019-06-12 | 2020-03-27 | 扬州工业职业技术学院 | 一种钩藤吲哚二萜生物碱及其制备方法与应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4374132A (en) * | 1979-12-10 | 1983-02-15 | Sterling Drug Inc. | Plasma uric acid lowering method |
US4560558A (en) * | 1983-05-16 | 1985-12-24 | Abbott Laboratories | 3-Alkyl-8-chloro-5,6-dihydrofuro-[3,2-f]-1,2-benzisoxazole-6-carboxylic acids |
US4812447A (en) * | 1985-10-22 | 1989-03-14 | City Of Hope | Method for the treatment of nervous system degeneration |
US4960867A (en) * | 1987-10-01 | 1990-10-02 | Merck & Co., Inc. | Leiurus quinquestriatus venom peptide inhibitor of calcium activated potassium channels |
US5006512A (en) * | 1987-10-02 | 1991-04-09 | Tsuyoshi Ohnishi | Therapeutic usages of inhibitors for a potassium efflux channel |
US5006529A (en) * | 1988-05-27 | 1991-04-09 | Lever Brothers Company | Soap compositions of enhanced antimicrobial effectiveness |
US4973601A (en) * | 1988-06-01 | 1990-11-27 | The United States Of America, As Represented By The Secretary Of Agriculture | Control of insects by fungal tremorgenic mycotoxins |
US5223430A (en) * | 1988-08-04 | 1993-06-29 | American Cyanamid Company | Subspecies of micromonospora citrea which produces antibiotic ll-e19085 alpha |
JPH05331146A (ja) * | 1991-07-16 | 1993-12-14 | Tsumura & Co | 新規ジテルペンアルカロイド及びジテルペンアルカロイド類を有効成分とする心疾患治療薬 |
US5300495A (en) * | 1991-07-19 | 1994-04-05 | The United States Of America, As Represented By The Secretary Of Agriculture | Indole antiinsectan metabolites |
US5130326A (en) * | 1991-07-19 | 1992-07-14 | The United States Of America As Represented By The Secretary Of Agriculture | Sulpinine, secopenitrem B and aflatrem B antiinsectan metabolites |
US5158969A (en) * | 1991-08-21 | 1992-10-27 | Neurosearch A/S | Indole derivatives as potassium channel blockers |
WO1994009004A1 (en) * | 1992-10-22 | 1994-04-28 | The Kitasato Institute | Fo-2546 substance, its production and its use as inhibitor of acyl-coa cholesterol acyltransferase |
US5399582A (en) * | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
-
1994
- 1994-01-24 US US08/186,197 patent/US5541208A/en not_active Expired - Fee Related
-
1995
- 1995-01-20 JP JP51970095A patent/JP3689108B2/ja not_active Expired - Fee Related
- 1995-01-20 ES ES95908099T patent/ES2173177T3/es not_active Expired - Lifetime
- 1995-01-20 DK DK95908099T patent/DK0804186T3/da active
- 1995-01-20 PT PT95908099T patent/PT804186E/pt unknown
- 1995-01-20 CA CA002181371A patent/CA2181371A1/en not_active Abandoned
- 1995-01-20 DE DE69526452T patent/DE69526452T2/de not_active Expired - Fee Related
- 1995-01-20 WO PCT/US1995/000861 patent/WO1995019771A1/en active IP Right Grant
- 1995-01-20 AU AU16058/95A patent/AU689207B2/en not_active Ceased
- 1995-01-20 EP EP95908099A patent/EP0804186B1/en not_active Expired - Lifetime
- 1995-01-20 AT AT95908099T patent/ATE216233T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH09508271A (ja) | 1997-08-26 |
DK0804186T3 (da) | 2002-06-17 |
EP0804186A4 (en) | 1998-04-22 |
ES2173177T3 (es) | 2002-10-16 |
DE69526452D1 (de) | 2002-05-23 |
ATE216233T1 (de) | 2002-05-15 |
JP3689108B2 (ja) | 2005-08-31 |
AU1605895A (en) | 1995-08-08 |
DE69526452T2 (de) | 2002-11-14 |
WO1995019771A1 (en) | 1995-07-27 |
AU689207B2 (en) | 1998-03-26 |
EP0804186A1 (en) | 1997-11-05 |
CA2181371A1 (en) | 1995-07-27 |
US5541208A (en) | 1996-07-30 |
EP0804186B1 (en) | 2002-04-17 |
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