ATE216233T1 - Indolditerpen alkaloide - Google Patents
Indolditerpen alkaloideInfo
- Publication number
- ATE216233T1 ATE216233T1 AT95908099T AT95908099T ATE216233T1 AT E216233 T1 ATE216233 T1 AT E216233T1 AT 95908099 T AT95908099 T AT 95908099T AT 95908099 T AT95908099 T AT 95908099T AT E216233 T1 ATE216233 T1 AT E216233T1
- Authority
- AT
- Austria
- Prior art keywords
- indolditerpene
- alkaloids
- useful
- formula
- channel antagonists
- Prior art date
Links
- 229930013930 alkaloid Natural products 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000016469 Large-Conductance Calcium-Activated Potassium Channels Human genes 0.000 abstract 1
- 108010092555 Large-Conductance Calcium-Activated Potassium Channels Proteins 0.000 abstract 1
- 229940127316 Potassium Channel Antagonists Drugs 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/186,197 US5541208A (en) | 1994-01-24 | 1994-01-24 | Indole diterpene alkaloid compounds |
| PCT/US1995/000861 WO1995019771A1 (en) | 1994-01-24 | 1995-01-20 | Indole diterpene alkaloid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE216233T1 true ATE216233T1 (de) | 2002-05-15 |
Family
ID=22684018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95908099T ATE216233T1 (de) | 1994-01-24 | 1995-01-20 | Indolditerpen alkaloide |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5541208A (de) |
| EP (1) | EP0804186B1 (de) |
| JP (1) | JP3689108B2 (de) |
| AT (1) | ATE216233T1 (de) |
| AU (1) | AU689207B2 (de) |
| CA (1) | CA2181371A1 (de) |
| DE (1) | DE69526452T2 (de) |
| DK (1) | DK0804186T3 (de) |
| ES (1) | ES2173177T3 (de) |
| PT (1) | PT804186E (de) |
| WO (1) | WO1995019771A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997005780A1 (en) * | 1995-08-08 | 1997-02-20 | The University Of Alabama At Birmingham Research Foundation | Regulation of alzheimer's disease related proteins and uses thereof |
| ES2258799T3 (es) * | 1996-12-23 | 2006-09-01 | MERCK & CO., INC. | Agentes antidiabeticos. |
| US6160000A (en) * | 1996-12-23 | 2000-12-12 | Merck & Co., Inc. | Antidiabetic agents based on aryl and heteroarylacetic acids |
| US6090839A (en) * | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
| EP1487438A4 (de) * | 2002-03-15 | 2007-08-15 | Merck & Co Inc | Zusammensetzungen und verfahren zur behandlung von glaukom und okularer hypertonie |
| JP2005533055A (ja) * | 2002-06-17 | 2005-11-04 | メルク エンド カムパニー インコーポレーテッド | 新規マキシｋチャンネルブロッカー、その使用方法および製造方法 |
| CN110872338B (zh) * | 2018-09-04 | 2021-04-09 | 中国海洋大学 | 一种吲哚二萜类化合物及其制备方法和用途 |
| CN110105422B (zh) * | 2019-06-12 | 2020-03-27 | 扬州工业职业技术学院 | 一种钩藤吲哚二萜生物碱及其制备方法与应用 |
| CN121160824A (zh) * | 2024-07-16 | 2025-12-19 | 中国科学院沈阳应用生态研究所 | 一种蛋白酪氨酸磷酸酶1b抑制活性吲哚二萜类化合物的制备方法与应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4374132A (en) * | 1979-12-10 | 1983-02-15 | Sterling Drug Inc. | Plasma uric acid lowering method |
| US4560558A (en) * | 1983-05-16 | 1985-12-24 | Abbott Laboratories | 3-Alkyl-8-chloro-5,6-dihydrofuro-[3,2-f]-1,2-benzisoxazole-6-carboxylic acids |
| US4812447A (en) * | 1985-10-22 | 1989-03-14 | City Of Hope | Method for the treatment of nervous system degeneration |
| US4960867A (en) * | 1987-10-01 | 1990-10-02 | Merck & Co., Inc. | Leiurus quinquestriatus venom peptide inhibitor of calcium activated potassium channels |
| US5006512A (en) * | 1987-10-02 | 1991-04-09 | Tsuyoshi Ohnishi | Therapeutic usages of inhibitors for a potassium efflux channel |
| US5006529A (en) * | 1988-05-27 | 1991-04-09 | Lever Brothers Company | Soap compositions of enhanced antimicrobial effectiveness |
| US4973601A (en) * | 1988-06-01 | 1990-11-27 | The United States Of America, As Represented By The Secretary Of Agriculture | Control of insects by fungal tremorgenic mycotoxins |
| US5223430A (en) * | 1988-08-04 | 1993-06-29 | American Cyanamid Company | Subspecies of micromonospora citrea which produces antibiotic ll-e19085 alpha |
| JPH05331146A (ja) * | 1991-07-16 | 1993-12-14 | Tsumura & Co | 新規ジテルペンアルカロイド及びジテルペンアルカロイド類を有効成分とする心疾患治療薬 |
| US5300495A (en) * | 1991-07-19 | 1994-04-05 | The United States Of America, As Represented By The Secretary Of Agriculture | Indole antiinsectan metabolites |
| US5130326A (en) * | 1991-07-19 | 1992-07-14 | The United States Of America As Represented By The Secretary Of Agriculture | Sulpinine, secopenitrem B and aflatrem B antiinsectan metabolites |
| US5158969A (en) * | 1991-08-21 | 1992-10-27 | Neurosearch A/S | Indole derivatives as potassium channel blockers |
| WO1994009004A1 (en) * | 1992-10-22 | 1994-04-28 | The Kitasato Institute | Fo-2546 substance, its production and its use as inhibitor of acyl-coa cholesterol acyltransferase |
| US5399582A (en) * | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
-
1994
- 1994-01-24 US US08/186,197 patent/US5541208A/en not_active Expired - Fee Related
-
1995
- 1995-01-20 WO PCT/US1995/000861 patent/WO1995019771A1/en not_active Ceased
- 1995-01-20 CA CA002181371A patent/CA2181371A1/en not_active Abandoned
- 1995-01-20 ES ES95908099T patent/ES2173177T3/es not_active Expired - Lifetime
- 1995-01-20 PT PT95908099T patent/PT804186E/pt unknown
- 1995-01-20 JP JP51970095A patent/JP3689108B2/ja not_active Expired - Fee Related
- 1995-01-20 EP EP95908099A patent/EP0804186B1/de not_active Expired - Lifetime
- 1995-01-20 DK DK95908099T patent/DK0804186T3/da active
- 1995-01-20 DE DE69526452T patent/DE69526452T2/de not_active Expired - Fee Related
- 1995-01-20 AU AU16058/95A patent/AU689207B2/en not_active Ceased
- 1995-01-20 AT AT95908099T patent/ATE216233T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP3689108B2 (ja) | 2005-08-31 |
| US5541208A (en) | 1996-07-30 |
| DK0804186T3 (da) | 2002-06-17 |
| JPH09508271A (ja) | 1997-08-26 |
| AU689207B2 (en) | 1998-03-26 |
| AU1605895A (en) | 1995-08-08 |
| EP0804186A4 (de) | 1998-04-22 |
| DE69526452T2 (de) | 2002-11-14 |
| ES2173177T3 (es) | 2002-10-16 |
| EP0804186B1 (de) | 2002-04-17 |
| CA2181371A1 (en) | 1995-07-27 |
| DE69526452D1 (de) | 2002-05-23 |
| WO1995019771A1 (en) | 1995-07-27 |
| EP0804186A1 (de) | 1997-11-05 |
| PT804186E (pt) | 2002-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |