ES2087038B1 - Nuevas piperidinas con actividad antagonista del paf. - Google Patents
Nuevas piperidinas con actividad antagonista del paf.Info
- Publication number
- ES2087038B1 ES2087038B1 ES09402291A ES9402291A ES2087038B1 ES 2087038 B1 ES2087038 B1 ES 2087038B1 ES 09402291 A ES09402291 A ES 09402291A ES 9402291 A ES9402291 A ES 9402291A ES 2087038 B1 ES2087038 B1 ES 2087038B1
- Authority
- ES
- Spain
- Prior art keywords
- paf
- pct
- antagonist activity
- sec
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPUESTOS DE FORMULA I, DONDE M REPRESENTA 0,1 O 2; R1 REPRESENTA C1-4 ALQUILO; B REPRESENTA ZCR2R3-X-(CH2)N), CR2R3=CH- O R7N(Y)-CH2-; N REPRESENTA 0 O 1; X REPRESENTA NH O UN ENLACE SENCILLO; UNO DE R2 O R3 REPRESENTA C1-4 ALQUILO, C3-6 CICLOALQUILO O ARILO, Y EL OTRO REPRESENTA HIDROGENO, C1-4 ALQUILO, C1-4 HALOALQUILO, C3-6 CICLOALQUILO O ARILO; Z REPRESENTA HIDROGENO, C1-4 ALQUILO, (CH2-OR4, -COOR4 O -CONR4R5, Y CUANDO X REPRESENTA ENLACE SENCILLO, Z PUEDE SER TAMBIEN HIDROXI, (NR4R5, (NR6C(=O)OR4, -NR6C(=O)R4, -NR6C(=O)NR4R5, -N(OH)C(=O)NR4R5 O -NR6SO2R4; R4 REPRESENTA HIDROGENO, C1-4 ALQUILO, ARILO O ARIL-C1-4 ALQUILO; R5 Y R6 REPRESENTAN HIDROGENO O C1-4 ALQUILO; R7 REPRESENTA C1-4 ALQUILO, C3-6 CICIOALQUILO O ARILO; E Y REPRESENTA HIDROGENO, C1-4 ALQUILO, ARILO, ARIL-C1-4 ALQUILO, -C(=O)OR4, -C(=O)R4, -C(=O)NR4R5, O -SO2R4. ESTOS COMPUESTOS SON ANTAGONISTAS DEL PAF.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09402291A ES2087038B1 (es) | 1994-11-07 | 1994-11-07 | Nuevas piperidinas con actividad antagonista del paf. |
US08/669,440 US5705504A (en) | 1994-11-07 | 1995-09-05 | Piperidine derivatives with PAF antagonist activity |
PT95932668T PT738269E (pt) | 1994-11-07 | 1995-09-05 | Derivados de piperidina com actividade antagonista de paf |
PCT/EP1995/003487 WO1996014317A1 (en) | 1994-11-07 | 1995-09-05 | Novel piperidine derivatives with paf antagonist activity |
AU35636/95A AU3563695A (en) | 1994-11-07 | 1995-09-05 | Novel piperidine derivatives with paf antagonist activity |
DK95932668T DK0738269T5 (da) | 1994-11-07 | 1995-09-05 | Piperidinderivater med PAF-antagonistaktivitet |
ES95932668T ES2147616T3 (es) | 1994-11-07 | 1995-09-05 | Derivados de piperidina con actividad antagonista del paf. |
JP51497296A JP4018137B2 (ja) | 1994-11-07 | 1995-09-05 | Pafアンタゴニスト活性を有する新規ピぺリジン誘導体 |
CA002180660A CA2180660C (en) | 1994-11-07 | 1995-09-05 | Novel piperidine derivatives with paf antagonist activity |
MXPA/A/1996/002559A MXPA96002559A (es) | 1994-11-07 | 1995-09-05 | Nuevos derivados de piperidina con actividadantagonista del paf |
DE69516503T DE69516503T2 (de) | 1994-11-07 | 1995-09-05 | Piperidinderivate mit paf antagonistischer wirkung |
AT95932668T ATE192152T1 (de) | 1994-11-07 | 1995-09-05 | Piperidinderivate mit paf antagonistischer wirkung |
KR1019960703655A KR100514201B1 (ko) | 1994-11-07 | 1995-09-05 | 피에이에프길항활성을갖는피페리딘유도체 |
EP95932668A EP0738269B1 (en) | 1994-11-07 | 1995-09-05 | Piperidine derivatives with paf antagonist activity |
NO962855A NO306345B1 (no) | 1994-11-07 | 1996-07-05 | Piperidin-derivater med PAF antagonist-aktivitet, anvendelse derav og farmasöytisk blanding |
GR20000401219T GR3033528T3 (en) | 1994-11-07 | 2000-05-29 | Novel piperidine derivatives with paf antagonist activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09402291A ES2087038B1 (es) | 1994-11-07 | 1994-11-07 | Nuevas piperidinas con actividad antagonista del paf. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2087038A1 ES2087038A1 (es) | 1996-07-01 |
ES2087038B1 true ES2087038B1 (es) | 1997-03-16 |
Family
ID=8287905
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09402291A Expired - Fee Related ES2087038B1 (es) | 1994-11-07 | 1994-11-07 | Nuevas piperidinas con actividad antagonista del paf. |
ES95932668T Expired - Lifetime ES2147616T3 (es) | 1994-11-07 | 1995-09-05 | Derivados de piperidina con actividad antagonista del paf. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95932668T Expired - Lifetime ES2147616T3 (es) | 1994-11-07 | 1995-09-05 | Derivados de piperidina con actividad antagonista del paf. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5705504A (es) |
EP (1) | EP0738269B1 (es) |
JP (1) | JP4018137B2 (es) |
KR (1) | KR100514201B1 (es) |
AT (1) | ATE192152T1 (es) |
AU (1) | AU3563695A (es) |
DE (1) | DE69516503T2 (es) |
DK (1) | DK0738269T5 (es) |
ES (2) | ES2087038B1 (es) |
GR (1) | GR3033528T3 (es) |
NO (1) | NO306345B1 (es) |
PT (1) | PT738269E (es) |
WO (1) | WO1996014317A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2155621T3 (es) * | 1995-09-08 | 2001-05-16 | Uriach & Cia Sa J | Derivados azo del acido 5-aminosalicilico para el tratamiento de la enfermedad inflamatoria intestinal. |
ES2165803B1 (es) * | 2000-04-10 | 2003-09-16 | Uriach & Cia Sa J | Nueva sal de un derivado azo del acido 5-aminosalicilico |
GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
CA2413418A1 (en) | 2000-06-21 | 2001-12-27 | Joseph B. Santella | Piperidine amides as modulators of chemokine receptor activity |
AU7931301A (en) * | 2000-08-04 | 2002-02-18 | Dmi Biosciences Inc | Method of using diketopiperazines and composition containing them |
GB0021670D0 (en) | 2000-09-04 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
CA3050734A1 (en) | 2003-05-15 | 2004-12-02 | Ampio Pharmaceuticals, Inc. | Treatment of t-cell mediated diseases |
FR2860514A1 (fr) * | 2003-10-03 | 2005-04-08 | Sanofi Synthelabo | Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique |
WO2007101270A1 (en) * | 2006-03-02 | 2007-09-07 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
AU2007279092B2 (en) * | 2006-07-24 | 2012-12-13 | Ucb Pharma S.A. | Substituted aniline derivatives |
KR100737397B1 (ko) | 2007-01-31 | 2007-07-09 | 한국교세라정공(주) | 밀링 커터 |
US8217047B2 (en) | 2008-05-27 | 2012-07-10 | Dmi Acquisition Corp. | Therapeutic methods and compounds |
FR2962649A1 (fr) | 2010-07-19 | 2012-01-20 | Conservatoire Nat Arts Et Metiers | Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide |
GB201101517D0 (en) * | 2011-01-28 | 2011-03-16 | Proximagen Ltd | Receptor antagonists |
US8980834B2 (en) | 2011-10-10 | 2015-03-17 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
KR20140075772A (ko) | 2011-10-10 | 2014-06-19 | 앰피오 파마슈티컬스 인코퍼레이티드 | 면역 내성을 증가시킨 이식 의료 장비, 및 그의 제조 및 이식 방법 |
SG11201400283RA (en) | 2011-10-28 | 2014-03-28 | Ampio Pharmaceuticals Inc | Treatment of rhinitis |
MX2015010937A (es) | 2013-03-15 | 2015-10-29 | Ampio Pharmaceuticals Inc | Composiciones para la movilizacion, autodireccion, expansion y diferenciacion de celulas madre y metodos para usar las mismas. |
JP6723222B2 (ja) | 2014-08-18 | 2020-07-15 | アンピオ ファーマシューティカルズ,インコーポレイテッド | 関節病態の治療 |
WO2016209969A1 (en) | 2015-06-22 | 2016-12-29 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0029707B1 (en) * | 1979-11-21 | 1984-02-01 | Kyowa Hakko Kogyo Co., Ltd | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them |
IL85700A0 (en) * | 1987-03-24 | 1988-08-31 | Takeda Chemical Industries Ltd | 1,4-disubstituted piperazine compounds,their production and use |
EP0441226A1 (en) * | 1990-01-29 | 1991-08-14 | J. URIACH & CIA. S.A. | (cyanomethyl)pyridines useful as PAF antagonists |
GB9102997D0 (en) * | 1991-02-13 | 1991-03-27 | Pfizer Ltd | Therapeutic agents |
ES2036926B1 (es) * | 1991-08-08 | 1994-01-16 | Uriach & Cia Sa J | "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina". |
US5268376A (en) * | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
US5283242A (en) * | 1991-10-24 | 1994-02-01 | American Home Products Corporation | Substituted benzimidazoles and quinazolines as antihypertensives |
-
1994
- 1994-11-07 ES ES09402291A patent/ES2087038B1/es not_active Expired - Fee Related
-
1995
- 1995-09-05 US US08/669,440 patent/US5705504A/en not_active Expired - Lifetime
- 1995-09-05 EP EP95932668A patent/EP0738269B1/en not_active Expired - Lifetime
- 1995-09-05 DE DE69516503T patent/DE69516503T2/de not_active Expired - Lifetime
- 1995-09-05 WO PCT/EP1995/003487 patent/WO1996014317A1/en active IP Right Grant
- 1995-09-05 JP JP51497296A patent/JP4018137B2/ja not_active Expired - Fee Related
- 1995-09-05 PT PT95932668T patent/PT738269E/pt unknown
- 1995-09-05 AT AT95932668T patent/ATE192152T1/de not_active IP Right Cessation
- 1995-09-05 DK DK95932668T patent/DK0738269T5/da active
- 1995-09-05 ES ES95932668T patent/ES2147616T3/es not_active Expired - Lifetime
- 1995-09-05 AU AU35636/95A patent/AU3563695A/en not_active Abandoned
- 1995-09-05 KR KR1019960703655A patent/KR100514201B1/ko not_active IP Right Cessation
-
1996
- 1996-07-05 NO NO962855A patent/NO306345B1/no not_active IP Right Cessation
-
2000
- 2000-05-29 GR GR20000401219T patent/GR3033528T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100514201B1 (ko) | 2005-12-29 |
EP0738269B1 (en) | 2000-04-26 |
PT738269E (pt) | 2000-08-31 |
JP4018137B2 (ja) | 2007-12-05 |
DE69516503T2 (de) | 2001-03-15 |
US5705504A (en) | 1998-01-06 |
DK0738269T3 (da) | 2000-08-28 |
ES2087038A1 (es) | 1996-07-01 |
AU3563695A (en) | 1996-05-31 |
ATE192152T1 (de) | 2000-05-15 |
NO306345B1 (no) | 1999-10-25 |
GR3033528T3 (en) | 2000-09-29 |
ES2147616T3 (es) | 2000-09-16 |
JPH09507862A (ja) | 1997-08-12 |
NO962855D0 (no) | 1996-07-05 |
MX9602559A (es) | 1997-07-31 |
NO962855L (no) | 1996-07-05 |
DK0738269T5 (da) | 2000-12-18 |
WO1996014317A1 (en) | 1996-05-17 |
EP0738269A1 (en) | 1996-10-23 |
DE69516503D1 (de) | 2000-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19941107 Kind code of ref document: A1 Effective date: 19941107 |
|
FD1A | Patent lapsed |
Effective date: 20051108 |