ATE266655T1 - Dibenzopyrane als glucocorticoid-rezeptor- antagonisten für die behandlung von zuckerkrankheit - Google Patents
Dibenzopyrane als glucocorticoid-rezeptor- antagonisten für die behandlung von zuckerkrankheitInfo
- Publication number
- ATE266655T1 ATE266655T1 AT00959835T AT00959835T ATE266655T1 AT E266655 T1 ATE266655 T1 AT E266655T1 AT 00959835 T AT00959835 T AT 00959835T AT 00959835 T AT00959835 T AT 00959835T AT E266655 T1 ATE266655 T1 AT E266655T1
- Authority
- AT
- Austria
- Prior art keywords
- dibenzopyrane
- treatment
- receptor antagonists
- glucocorticoid receptor
- subject disease
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003850 glucocorticoid receptor antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38825199A | 1999-09-01 | 1999-09-01 | |
| PCT/US2000/024234 WO2001016128A1 (en) | 1999-09-01 | 2000-09-01 | Dibenzopyrans as glucocorticoid receptor antagonists for treatment of diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE266655T1 true ATE266655T1 (de) | 2004-05-15 |
Family
ID=23533319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00959835T ATE266655T1 (de) | 1999-09-01 | 2000-09-01 | Dibenzopyrane als glucocorticoid-rezeptor- antagonisten für die behandlung von zuckerkrankheit |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1208095B1 (de) |
| JP (1) | JP2003508393A (de) |
| AR (1) | AR034096A1 (de) |
| AT (1) | ATE266655T1 (de) |
| AU (1) | AU7109000A (de) |
| BR (1) | BR0009320A (de) |
| CA (1) | CA2381239A1 (de) |
| CO (1) | CO5180649A1 (de) |
| DE (1) | DE60010722T2 (de) |
| DK (1) | DK1208095T3 (de) |
| ES (1) | ES2220529T3 (de) |
| HK (1) | HK1047580B (de) |
| MX (1) | MXPA02002110A (de) |
| PT (1) | PT1208095E (de) |
| WO (1) | WO2001016128A1 (de) |
Families Citing this family (60)
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| US6593480B2 (en) | 1999-09-01 | 2003-07-15 | Abbott Laboratories | Glucocorticoid receptor antagonists for treatment of diabetes |
| US7235662B2 (en) | 2003-06-11 | 2007-06-26 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
| GB0316290D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
| TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
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| MY145343A (en) | 2005-03-25 | 2012-01-31 | Glaxo Group Ltd | Novel compounds |
| PE20061193A1 (es) | 2005-03-25 | 2006-12-02 | Glaxo Group Ltd | DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38 |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| TW200730498A (en) | 2005-12-20 | 2007-08-16 | Glaxo Group Ltd | Compounds |
| KR20090003349A (ko) | 2006-04-20 | 2009-01-09 | 글락소 그룹 리미티드 | 화합물 |
| GB0611587D0 (en) | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
| TW200820977A (en) | 2006-08-08 | 2008-05-16 | Organon Nv | Use of glucocorticoid receptor antagonists for treatment of infectious conditions |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| BRPI0912267A2 (pt) | 2008-05-23 | 2015-10-13 | Amira Pharmaceuticals Inc | sal farmaceuticamente aceitável, composição farmacêutica, artigo de fabricação, métodos para tratar asma, rinite alérgica, doença, lesões gástricas e dor, métodos para prevenir broncoconstrição e rinite alérgica, uso de um sal farmaceuticamente aceitável, e, processo para a preparação de um sal farmaceuticamente aceitável. |
| JP5502077B2 (ja) | 2008-06-05 | 2014-05-28 | グラクソ グループ リミテッド | 新規な化合物 |
| ES2566339T3 (es) | 2008-06-05 | 2016-04-12 | Glaxo Group Limited | Derivados de 4-carboxamida indazol útiles como inhibidores de PI3-quinasas |
| ES3050068T3 (en) | 2008-11-07 | 2025-12-19 | Univ Sheffield | Medicament and method of diagnosis |
| WO2010094643A1 (en) | 2009-02-17 | 2010-08-26 | Glaxo Group Limited | Quinoline derivatives and their uses for rhinitis and urticaria |
| US8524751B2 (en) | 2009-03-09 | 2013-09-03 | GlaxoSmithKline Intellecutual Property Development | 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases |
| JP2012520257A (ja) | 2009-03-10 | 2012-09-06 | グラクソ グループ リミテッド | Ikk2阻害剤としてのインドール誘導体 |
| EP2408769A1 (de) | 2009-03-17 | 2012-01-25 | Glaxo Group Limited | Als itk-inhibitoren verwendete pyrimidinderivate |
| EP2408916A2 (de) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | Rna-interferenz-vermittelte hemmung der genexpression von ctgf (connective tissue growth factor) unter verwendung von sina (short interfering nucleic acid) |
| EA201171144A1 (ru) | 2009-03-19 | 2012-04-30 | Мерк Шарп Энд Домэ Корп. | ОПОСРЕДОВАННОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНА ГОМОЛОГА 1 BTB И CNC, ОСНОВНОГО ФАКТОРА ТРАНСКРИПЦИИ С ЛЕЙЦИНОВОЙ МОЛНИЕЙ 1 (Bach1) С ИСПОЛЬЗОВАНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК) |
| JP2012520685A (ja) | 2009-03-19 | 2012-09-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いたGATA結合タンパク質3(GATA3)遺伝子発現のRNA干渉媒介性阻害 |
| WO2010107958A1 (en) | 2009-03-19 | 2010-09-23 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6 (STAT6) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| KR20110138223A (ko) | 2009-03-27 | 2011-12-26 | 머크 샤프 앤드 돔 코포레이션 | 짧은 간섭 핵산 (siNA)을 사용한 세포간 부착 분자 1 (ICAM-1) 유전자 발현의 RNA 간섭 매개 억제 |
| JP2012521760A (ja) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いたアポトーシスシグナル調節キナーゼ1(ASK1)遺伝子発現のRNA干渉媒介性阻害 |
| US20120022143A1 (en) | 2009-03-27 | 2012-01-26 | Merck Sharp & Dohme Corp | RNA Interference Mediated Inhibition of the Thymic Stromal Lymphopoietin (TSLP) Gene Expression Using Short Interfering Nucliec Acid (siNA) |
| WO2010111468A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF THE NERVE GROWTH FACTOR BETA CHAIN (NGFß) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) |
| US20120022142A1 (en) | 2009-03-27 | 2012-01-26 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| EP2421834A1 (de) | 2009-04-24 | 2012-02-29 | Glaxo Group Limited | Pyrazol- und triazolcarbonsäureamide als inhibitoren des crac-kanals |
| US20100273744A1 (en) | 2009-04-24 | 2010-10-28 | Paul Martin Gore | Compounds |
| CN102459253B (zh) | 2009-04-30 | 2015-03-25 | 葛兰素集团有限公司 | 作为pi3-激酶抑制剂的*唑取代的吲唑化合物 |
| WO2011067366A1 (en) | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Indazole derivatives as pi 3 - kinase inhibitors |
| US20120238559A1 (en) | 2009-12-03 | 2012-09-20 | Glaxo Group Limited | Novel compounds |
| EP2507223A1 (de) | 2009-12-03 | 2012-10-10 | Glaxo Group Limited | Benzpyrazolderivate als p13-kinasehemmer |
| US20120272951A1 (en) | 2009-12-16 | 2012-11-01 | 3M Innovative Properties Company | Formulations and methods for controlling mdi particle size delivery |
| WO2011110575A1 (en) | 2010-03-11 | 2011-09-15 | Glaxo Group Limited | Derivatives of 2-[2-(benzo- or pyrido-) thiazolylamino]-6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases |
| GB201007203D0 (en) | 2010-04-29 | 2010-06-16 | Glaxo Group Ltd | Novel compounds |
| JP5965402B2 (ja) | 2010-09-08 | 2016-08-03 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | N−[5−[4−(5−{[(2r,6s)−2,6−ジメチル−4−モルホリニル]メチル}−1,3−オキサゾール−2−イル)−1h−インダゾール−6−イル]−2−(メチルオキシ)−3−ピリジニル]メタンスルホンアミドの多形体および塩 |
| WO2012032065A1 (en) | 2010-09-08 | 2012-03-15 | Glaxo Group Limited | Indazole derivatives for use in the treatment of influenza virus infection |
| WO2012035055A1 (en) | 2010-09-17 | 2012-03-22 | Glaxo Group Limited | Novel compounds |
| EP2630126B1 (de) | 2010-10-21 | 2015-01-07 | Glaxo Group Limited | Pyrazolverbindungen gegen allergie-, immun- und entzündungserkrankungen |
| EP2630127A1 (de) | 2010-10-21 | 2013-08-28 | Glaxo Group Limited | Pyrazolverbindungen, gegen allergie-, entzündungs- und immunerkrankungen |
| GB201018124D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
| US20140005188A1 (en) | 2011-03-11 | 2014-01-02 | Glaxo Group Limited | Pyrido[3,4-b]pyrazine derivatives as syk inhibitors |
| GB201104153D0 (en) | 2011-03-11 | 2011-04-27 | Glaxo Group Ltd | Novel compounds |
| KR20160060100A (ko) | 2013-09-22 | 2016-05-27 | 칼리토르 사이언시즈, 엘엘씨 | 치환된 아미노피리미딘 화합물 및 이용 방법 |
| WO2015055691A1 (en) | 2013-10-17 | 2015-04-23 | Glaxosmithkline Intellectual Property Development Limited | Pi3k inhibitor for treatment of respiratory disease |
| EP3057587A1 (de) | 2013-10-17 | 2016-08-24 | GlaxoSmithKline Intellectual Property Development Limited | Pi3k-hemmers zur behandlung von atemwegserkrankungen |
| WO2015148868A1 (en) | 2014-03-28 | 2015-10-01 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| TW201625247A (zh) | 2014-05-12 | 2016-07-16 | 葛蘭素史密斯克藍智慧財產權有限公司 | 用於治療傳染性疾病之醫藥組合物 |
| US9938257B2 (en) | 2015-09-11 | 2018-04-10 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| GB201602527D0 (en) | 2016-02-12 | 2016-03-30 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| JP2019524792A (ja) | 2016-08-08 | 2019-09-05 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 化合物 |
| GB201706102D0 (en) | 2017-04-18 | 2017-05-31 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| GB201712081D0 (en) | 2017-07-27 | 2017-09-13 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| US10683297B2 (en) | 2017-11-19 | 2020-06-16 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| EP4125919A1 (de) | 2020-03-26 | 2023-02-08 | GlaxoSmithKline Intellectual Property Development Limited | Cathepsinhemmer zur vorbeugung oder behandlung von virusinfektionen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2091721B (en) * | 1980-10-20 | 1984-02-15 | Erba Farmitalia | 6-substituted 6h-dibezo(b,d)pyran derivatives and process for their preparation |
| CN1119348C (zh) * | 1998-02-13 | 2003-08-27 | 艾博特公司 | 糖皮质激素衍生物,其组合物和用途 |
-
2000
- 2000-08-30 CO CO00065017A patent/CO5180649A1/es not_active Application Discontinuation
- 2000-08-31 AR ARP000104550A patent/AR034096A1/es not_active Application Discontinuation
- 2000-09-01 BR BR0009320-3A patent/BR0009320A/pt not_active IP Right Cessation
- 2000-09-01 DE DE60010722T patent/DE60010722T2/de not_active Expired - Lifetime
- 2000-09-01 EP EP00959835A patent/EP1208095B1/de not_active Expired - Lifetime
- 2000-09-01 DK DK00959835T patent/DK1208095T3/da active
- 2000-09-01 JP JP2001519695A patent/JP2003508393A/ja not_active Withdrawn
- 2000-09-01 AT AT00959835T patent/ATE266655T1/de not_active IP Right Cessation
- 2000-09-01 CA CA002381239A patent/CA2381239A1/en not_active Abandoned
- 2000-09-01 HK HK02107584.5A patent/HK1047580B/en not_active IP Right Cessation
- 2000-09-01 AU AU71090/00A patent/AU7109000A/en not_active Abandoned
- 2000-09-01 ES ES00959835T patent/ES2220529T3/es not_active Expired - Lifetime
- 2000-09-01 WO PCT/US2000/024234 patent/WO2001016128A1/en not_active Ceased
- 2000-09-01 PT PT00959835T patent/PT1208095E/pt unknown
- 2000-09-01 MX MXPA02002110A patent/MXPA02002110A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02002110A (es) | 2002-11-07 |
| ES2220529T3 (es) | 2004-12-16 |
| JP2003508393A (ja) | 2003-03-04 |
| HK1047580A1 (en) | 2003-02-28 |
| AU7109000A (en) | 2001-03-26 |
| DE60010722T2 (de) | 2005-05-12 |
| WO2001016128A1 (en) | 2001-03-08 |
| CO5180649A1 (es) | 2002-07-30 |
| AR034096A1 (es) | 2004-02-04 |
| CA2381239A1 (en) | 2001-03-08 |
| EP1208095B1 (de) | 2004-05-12 |
| HK1047580B (en) | 2005-04-01 |
| BR0009320A (pt) | 2002-02-05 |
| EP1208095A1 (de) | 2002-05-29 |
| PT1208095E (pt) | 2004-09-30 |
| DK1208095T3 (da) | 2004-09-20 |
| DE60010722D1 (de) | 2004-06-17 |
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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| REN | Ceased due to non-payment of the annual fee |