ES2220529T3 - Dibenzopiranos utiles como antagonistas del receptor de los glucocorticoides, en el tratamiento de la diabetes. - Google Patents

Dibenzopiranos utiles como antagonistas del receptor de los glucocorticoides, en el tratamiento de la diabetes.

Info

Publication number
ES2220529T3
ES2220529T3 ES00959835T ES00959835T ES2220529T3 ES 2220529 T3 ES2220529 T3 ES 2220529T3 ES 00959835 T ES00959835 T ES 00959835T ES 00959835 T ES00959835 T ES 00959835T ES 2220529 T3 ES2220529 T3 ES 2220529T3
Authority
ES
Spain
Prior art keywords
carbon
aryl
dibenzopirans
antagonists
diabetes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00959835T
Other languages
English (en)
Inventor
Philip R. Kym
Benjamin C. Lane
John K. Pratt
Tom Von Geldern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2220529T3 publication Critical patent/ES2220529T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Un compuesto de fórmula I **(Fórmula)** o una sal o profármaco del mismo farmacéuticamente aceptable, donde R1 es L1-RA, R2, R3, R4, R7, R8, y R9 se seleccionan independientemente entre -1-RA o H, L1 se selecciona entre: (1) un enlace covalente, (2) -O-, 35 (3) -S(O)t-, donde t es 0, 1, o 2, (4) -C(X)-, donde X es O o S, (5) -NR12-, donde R12 se selecciona entre (a) hidrógeno, (b) arilo, (c) cicloalquilo C3-C12, (d) alcanoílo C1-C12, (e) alcoxi(C1-C12)carbonilo, (f) alcoxi(C1-C12)carbonilo sustituido con 1 a 2 grupos arilo, (g) alquilo C1-C12, (h) alquilo C1-C12 sustituido con 1 ó 2 sustituyentes seleccionados independientemente entre arilo o cicloalquilo C3-C12, (i) alquenilo C3-C12, siempre que un carbono del doble enlace carbono-carbono no esté anclado directamente a nitrógeno, (j) alquinilo C3-C12, siempre que un carbono del triple enlace carbono-carbono no esté anclado directamente a nitrógeno, (6) -NR13C(X)NR14- donde X es O o S y o S y R13 y R14 se seleccionan independientemente entre (a) hidrógeno, (b) arilo.
ES00959835T 1999-09-01 2000-09-01 Dibenzopiranos utiles como antagonistas del receptor de los glucocorticoides, en el tratamiento de la diabetes. Expired - Lifetime ES2220529T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38825199A 1999-09-01 1999-09-01
US388251 1999-09-01

Publications (1)

Publication Number Publication Date
ES2220529T3 true ES2220529T3 (es) 2004-12-16

Family

ID=23533319

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00959835T Expired - Lifetime ES2220529T3 (es) 1999-09-01 2000-09-01 Dibenzopiranos utiles como antagonistas del receptor de los glucocorticoides, en el tratamiento de la diabetes.

Country Status (15)

Country Link
EP (1) EP1208095B1 (es)
JP (1) JP2003508393A (es)
AR (1) AR034096A1 (es)
AT (1) ATE266655T1 (es)
AU (1) AU7109000A (es)
BR (1) BR0009320A (es)
CA (1) CA2381239A1 (es)
CO (1) CO5180649A1 (es)
DE (1) DE60010722T2 (es)
DK (1) DK1208095T3 (es)
ES (1) ES2220529T3 (es)
HK (1) HK1047580B (es)
MX (1) MXPA02002110A (es)
PT (1) PT1208095E (es)
WO (1) WO2001016128A1 (es)

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EP2408458A1 (en) 2009-03-19 2012-01-25 Merck Sharp&Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6 (STAT6) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP2411517A2 (en) 2009-03-27 2012-02-01 Merck Sharp&Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF THE INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1)GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20120004281A1 (en) 2009-03-27 2012-01-05 Merck Sharp & Dohme Corp RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA)
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Also Published As

Publication number Publication date
AU7109000A (en) 2001-03-26
DE60010722T2 (de) 2005-05-12
HK1047580A1 (en) 2003-02-28
CA2381239A1 (en) 2001-03-08
DK1208095T3 (da) 2004-09-20
JP2003508393A (ja) 2003-03-04
HK1047580B (zh) 2005-04-01
DE60010722D1 (de) 2004-06-17
CO5180649A1 (es) 2002-07-30
EP1208095B1 (en) 2004-05-12
MXPA02002110A (es) 2002-11-07
WO2001016128A1 (en) 2001-03-08
EP1208095A1 (en) 2002-05-29
ATE266655T1 (de) 2004-05-15
AR034096A1 (es) 2004-02-04
PT1208095E (pt) 2004-09-30
BR0009320A (pt) 2002-02-05

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