DE60010722D1 - Dibenzopyrane als glucocorticoid-rezeptor-antagonisten für die behandlung von zuckerkrankheit - Google Patents

Dibenzopyrane als glucocorticoid-rezeptor-antagonisten für die behandlung von zuckerkrankheit

Info

Publication number
DE60010722D1
DE60010722D1 DE60010722T DE60010722T DE60010722D1 DE 60010722 D1 DE60010722 D1 DE 60010722D1 DE 60010722 T DE60010722 T DE 60010722T DE 60010722 T DE60010722 T DE 60010722T DE 60010722 D1 DE60010722 D1 DE 60010722D1
Authority
DE
Germany
Prior art keywords
dibenzopyrans
treatment
receptor antagonists
glucocorticoid receptor
sugar disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60010722T
Other languages
English (en)
Other versions
DE60010722T2 (de
Inventor
R Kym
C Lane
K Pratt
Geldern Tom Von
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Karo Pharma AB
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE60010722D1 publication Critical patent/DE60010722D1/de
Application granted granted Critical
Publication of DE60010722T2 publication Critical patent/DE60010722T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
DE60010722T 1999-09-01 2000-09-01 Dibenzopyrane als glucocorticoid-rezeptor-antagonisten für die behandlung von zuckerkrankheit Expired - Lifetime DE60010722T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38825199A 1999-09-01 1999-09-01
US388251 1999-09-01
PCT/US2000/024234 WO2001016128A1 (en) 1999-09-01 2000-09-01 Dibenzopyrans as glucocorticoid receptor antagonists for treatment of diabetes

Publications (2)

Publication Number Publication Date
DE60010722D1 true DE60010722D1 (de) 2004-06-17
DE60010722T2 DE60010722T2 (de) 2005-05-12

Family

ID=23533319

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60010722T Expired - Lifetime DE60010722T2 (de) 1999-09-01 2000-09-01 Dibenzopyrane als glucocorticoid-rezeptor-antagonisten für die behandlung von zuckerkrankheit

Country Status (15)

Country Link
EP (1) EP1208095B1 (de)
JP (1) JP2003508393A (de)
AR (1) AR034096A1 (de)
AT (1) ATE266655T1 (de)
AU (1) AU7109000A (de)
BR (1) BR0009320A (de)
CA (1) CA2381239A1 (de)
CO (1) CO5180649A1 (de)
DE (1) DE60010722T2 (de)
DK (1) DK1208095T3 (de)
ES (1) ES2220529T3 (de)
HK (1) HK1047580B (de)
MX (1) MXPA02002110A (de)
PT (1) PT1208095E (de)
WO (1) WO2001016128A1 (de)

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US20120016011A1 (en) 2009-03-19 2012-01-19 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA)
JP2012520685A (ja) 2009-03-19 2012-09-10 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いたＧＡＴＡ結合タンパク質３（ＧＡＴＡ３）遺伝子発現のＲＮＡ干渉媒介性阻害
WO2010111468A2 (en) 2009-03-27 2010-09-30 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF THE NERVE GROWTH FACTOR BETA CHAIN (NGFß) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
JP2012521764A (ja) 2009-03-27 2012-09-20 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いた胸腺間質性リンパ球新生因子（ＴＳＬＰ）遺伝子発現のＲＮＡ干渉媒介性阻害
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JP2013544794A (ja) 2010-10-21 2013-12-19 グラクソ グループ リミテッド アレルギー性障害、炎症性障害及び免疫障害に作用するピラゾール化合物
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GB201104153D0 (en) 2011-03-11 2011-04-27 Glaxo Group Ltd Novel compounds
WO2012123312A1 (en) 2011-03-11 2012-09-20 Glaxo Group Limited Pyrido[3,4-b]pyrazine derivatives as syk inhibitors
MY184292A (en) 2013-09-22 2021-03-30 Sunshine Lake Pharma Co Ltd Substituted aminopyrimidine compounds and methods of use
US20160256466A1 (en) 2013-10-17 2016-09-08 Glaxosmithkline Intellectual Property Development Limited Pi3k inhibitor for treatment of respiratory disease
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Also Published As

Publication number Publication date
PT1208095E (pt) 2004-09-30
WO2001016128A1 (en) 2001-03-08
DE60010722T2 (de) 2005-05-12
ATE266655T1 (de) 2004-05-15
EP1208095B1 (de) 2004-05-12
CO5180649A1 (es) 2002-07-30
BR0009320A (pt) 2002-02-05
MXPA02002110A (es) 2002-11-07
ES2220529T3 (es) 2004-12-16
DK1208095T3 (da) 2004-09-20
AU7109000A (en) 2001-03-26
HK1047580B (zh) 2005-04-01
AR034096A1 (es) 2004-02-04
JP2003508393A (ja) 2003-03-04
HK1047580A1 (en) 2003-02-28
EP1208095A1 (de) 2002-05-29
CA2381239A1 (en) 2001-03-08

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: KARO BIO AB, HUDDINGE, SE

8364 No opposition during term of opposition