UA42747C2 - Похідні пептиду,фармацевтична композиція та спосіб стимулювання секреції гормону росту - Google Patents
Похідні пептиду,фармацевтична композиція та спосіб стимулювання секреції гормону ростуInfo
- Publication number
- UA42747C2 UA42747C2 UA96062486A UA96062486A UA42747C2 UA 42747 C2 UA42747 C2 UA 42747C2 UA 96062486 A UA96062486 A UA 96062486A UA 96062486 A UA96062486 A UA 96062486A UA 42747 C2 UA42747 C2 UA 42747C2
- Authority
- UA
- Ukraine
- Prior art keywords
- growth hormone
- peptide derivatives
- pharmaceutical composition
- hormone releasing
- stimulating growth
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Винахід належить до нових пептидних похідних, композицій, що містять ці похідні, та їхнього застосування для лікування медичних порушень, що є результатом дефіциту гормону росту.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK143993A DK143993D0 (uk) | 1993-12-23 | 1993-12-23 | |
DK12194 | 1994-01-28 | ||
DK119194 | 1994-10-14 | ||
PCT/DK1994/000485 WO1995017423A1 (en) | 1993-12-23 | 1994-12-22 | Compounds with growth hormone releasing properties |
Publications (1)
Publication Number | Publication Date |
---|---|
UA42747C2 true UA42747C2 (uk) | 2001-11-15 |
Family
ID=27220421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA96062486A UA42747C2 (uk) | 1993-12-23 | 1994-12-22 | Похідні пептиду,фармацевтична композиція та спосіб стимулювання секреції гормону росту |
Country Status (27)
Country | Link |
---|---|
US (1) | US5767085A (uk) |
EP (1) | EP0736039B1 (uk) |
JP (1) | JP3181918B2 (uk) |
KR (1) | KR100354897B1 (uk) |
CN (1) | CN1052731C (uk) |
AT (1) | ATE197158T1 (uk) |
AU (1) | AU689181B2 (uk) |
BR (1) | BR9408377A (uk) |
CA (1) | CA2179597A1 (uk) |
CZ (1) | CZ293113B6 (uk) |
DE (1) | DE69426206T2 (uk) |
DK (1) | DK0736039T3 (uk) |
ES (1) | ES2153469T3 (uk) |
FI (1) | FI962584A0 (uk) |
GR (1) | GR3035150T3 (uk) |
HU (1) | HU224345B1 (uk) |
IL (1) | IL112112A (uk) |
MX (1) | MX9500072A (uk) |
NO (1) | NO315561B1 (uk) |
NZ (1) | NZ277486A (uk) |
PL (1) | PL181280B1 (uk) |
PT (1) | PT736039E (uk) |
RO (1) | RO115635B1 (uk) |
SG (1) | SG55069A1 (uk) |
SK (1) | SK281963B6 (uk) |
UA (1) | UA42747C2 (uk) |
WO (1) | WO1995017423A1 (uk) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995014666A1 (en) * | 1993-11-24 | 1995-06-01 | Merck & Co., Inc. | Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s) |
CN1052730C (zh) * | 1993-12-23 | 2000-05-24 | 诺沃挪第克公司 | 具有生长激素释放特性的化合物 |
US20020111461A1 (en) | 1999-05-21 | 2002-08-15 | Todd C. Somers | Low molecular weight peptidomimetic growth hormone secretagogues |
US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
EP0805816B1 (en) * | 1995-01-27 | 2004-07-28 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
CA2224434A1 (en) * | 1995-06-22 | 1997-01-09 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
US6531314B1 (en) | 1996-12-10 | 2003-03-11 | Merck & Co., Inc. | Growth hormone secretagogue receptor family |
ATE334394T1 (de) | 1995-12-13 | 2006-08-15 | Merck & Co Inc | Testverfahren für die sekretionsrezeptoren von wachstumshormonen |
GB2308362A (en) * | 1995-12-19 | 1997-06-25 | Lilly Industries Ltd | Pharmaceutical indole derivatives |
ATE424412T1 (de) * | 1995-12-22 | 2009-03-15 | Novo Nordisk As | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
CZ291982B6 (cs) * | 1996-04-24 | 2003-06-18 | Novo Nordisk A/S | Diamidový derivát uvolňující růstový hormon, jeho použití, farmaceutické prostředky ho obsahující a způsob stimulace uvolňování růstového hormonu |
US5919777A (en) * | 1996-04-24 | 1999-07-06 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
WO1998003473A1 (en) * | 1996-07-22 | 1998-01-29 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
WO1998008492A1 (en) * | 1996-08-29 | 1998-03-05 | Novo Nordisk A/S | Transdermal delivery of peptides |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6127341A (en) * | 1997-06-20 | 2000-10-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
JP4116097B2 (ja) | 1997-06-20 | 2008-07-09 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン放出特性をもつ化合物 |
HUP0100777A3 (en) | 1998-01-16 | 2001-12-28 | Novo Nordisk As | Tripeptides with growth hormone releasing properties, pharmaceutical compositions comprising thereof and their use |
US6919315B1 (en) | 1998-06-30 | 2005-07-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
US6682908B1 (en) | 1998-07-10 | 2004-01-27 | Merck & Co., Inc. | Mouse growth hormone secretagogue receptor |
JP2002520011A (ja) | 1998-07-13 | 2002-07-09 | メルク・アンド・カンパニー・インコーポレーテッド | 成長ホルモン分泌促進物質関連受容体および核酸 |
JP2002522058A (ja) | 1998-08-10 | 2002-07-23 | メルク・アンド・カンパニー・インコーポレーテッド | イヌ成長ホルモン分泌促進物質受容体 |
US6696063B1 (en) * | 1998-12-30 | 2004-02-24 | Applied Research Systems Ars Holding N.V. | Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy |
ATE284415T1 (de) | 1999-01-06 | 2004-12-15 | Genentech Inc | Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i) |
WO2000048623A1 (en) | 1999-02-18 | 2000-08-24 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
WO2000074702A1 (en) * | 1999-06-04 | 2000-12-14 | Novo Nordisk A/S | Compositions for the treatment of the catabolic state of prolonged critical illness |
DK1282437T3 (da) | 2000-05-16 | 2008-06-30 | Genentech Inc | Behandling af brusklidelser |
ATE446758T1 (de) | 2000-05-31 | 2009-11-15 | Pfizer Prod Inc | Verwendung von wachstumshormonsekretagoga zur förderung der beweglichkeit des verdauungstrakts |
TWI331922B (en) | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
US20040234591A1 (en) * | 2003-05-19 | 2004-11-25 | Takahisa Takubo | Hard gelatin capsule and process for producing the same |
US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
CN102861321A (zh) | 2003-09-12 | 2013-01-09 | 特西卡股份有限公司 | 胰岛素样生长因子-1(igf-1)缺陷的治疗方法 |
WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
JP2007531769A (ja) * | 2004-03-30 | 2007-11-08 | サファイア セラピューティクス インコーポレイテッド | 成長ホルモン分泌促進薬を使用したc−反応性蛋白質の低減方法 |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
KR101380200B1 (ko) * | 2004-08-12 | 2014-04-01 | 헬신 세라퓨틱스 (유.에스.) 인크. | 성장 호르몬 분비촉진제를 이용하여 위장관계의 운동성을촉진하는 방법 |
CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
WO2007127457A2 (en) * | 2006-04-28 | 2007-11-08 | The Administrators Of The Tulane Educational Fund | Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof |
CA2677399C (en) | 2007-02-09 | 2016-09-13 | Tranzyme Pharma, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
KR20090112720A (ko) * | 2007-02-13 | 2009-10-28 | 헬신 세라퓨틱스 (유.에스.) 인크. | 성장 호르몬 분비촉진제를 이용한 세포 증식 질환의 치료방법 |
TWI429436B (zh) * | 2007-04-10 | 2014-03-11 | Helsinn Therapeutics Us Inc | 使用生長激素促泌素治療或預防嘔吐之方法 |
EP2155769B1 (en) | 2007-05-04 | 2012-06-27 | Katholieke Universiteit Leuven KU Leuven Research & Development | Tissue degeneration protection |
WO2009079797A1 (en) | 2007-12-26 | 2009-07-02 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
EP3023426A1 (en) | 2008-07-17 | 2016-05-25 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
UA105657C2 (uk) * | 2009-02-27 | 2014-06-10 | Хелсінн Терапьютікс (Ю.Ес.), Інк. | Поліпшені способи лікування мігрені на основі анамореліну |
US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
WO2010144265A2 (en) * | 2009-06-12 | 2010-12-16 | Helsinn Therapeutics (U.S.), Inc. | Ipamorelin diacetate injection and infusion solutions |
CA2794952C (en) | 2010-04-01 | 2018-05-15 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
WO2013190520A2 (en) | 2012-06-22 | 2013-12-27 | The General Hospital Corporation | Gh-releasing agents in the treatment of vascular stenosis and associated conditions |
US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
CN106572997A (zh) | 2014-05-30 | 2017-04-19 | 辉瑞公司 | 作为选择性雄激素受体调节剂的腈衍生物 |
US20170121385A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4223019A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4223020A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4228156A (en) * | 1979-03-30 | 1980-10-14 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4410512A (en) * | 1981-12-28 | 1983-10-18 | Beckman Instruments, Inc. | Combinations having synergistic pituitary growth hormone releasing activity |
AU549053B2 (en) * | 1981-12-28 | 1986-01-09 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4803261A (en) * | 1986-06-27 | 1989-02-07 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide |
IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
EP0663834A4 (en) * | 1992-09-25 | 1996-01-24 | Smithkline Beecham Corp | GROWTH HORMONE RELEASING PEPTIDES. |
WO1995014666A1 (en) * | 1993-11-24 | 1995-06-01 | Merck & Co., Inc. | Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s) |
-
1994
- 1994-12-22 KR KR1019960703336A patent/KR100354897B1/ko not_active IP Right Cessation
- 1994-12-22 CA CA002179597A patent/CA2179597A1/en not_active Abandoned
- 1994-12-22 IL IL11211294A patent/IL112112A/xx not_active IP Right Cessation
- 1994-12-22 CN CN94194590A patent/CN1052731C/zh not_active Expired - Fee Related
- 1994-12-22 SK SK820-96A patent/SK281963B6/sk unknown
- 1994-12-22 DE DE69426206T patent/DE69426206T2/de not_active Expired - Lifetime
- 1994-12-22 HU HU9501947A patent/HU224345B1/hu not_active IP Right Cessation
- 1994-12-22 JP JP51710995A patent/JP3181918B2/ja not_active Expired - Lifetime
- 1994-12-22 AT AT95903774T patent/ATE197158T1/de not_active IP Right Cessation
- 1994-12-22 CZ CZ19961834A patent/CZ293113B6/cs not_active IP Right Cessation
- 1994-12-22 UA UA96062486A patent/UA42747C2/uk unknown
- 1994-12-22 ES ES95903774T patent/ES2153469T3/es not_active Expired - Lifetime
- 1994-12-22 EP EP95903774A patent/EP0736039B1/en not_active Expired - Lifetime
- 1994-12-22 AU AU12724/95A patent/AU689181B2/en not_active Ceased
- 1994-12-22 BR BR9408377A patent/BR9408377A/pt not_active Application Discontinuation
- 1994-12-22 RO RO96-01293A patent/RO115635B1/ro unknown
- 1994-12-22 WO PCT/DK1994/000485 patent/WO1995017423A1/en active IP Right Grant
- 1994-12-22 SG SG1996004604A patent/SG55069A1/en unknown
- 1994-12-22 DK DK95903774T patent/DK0736039T3/da active
- 1994-12-22 US US08/448,623 patent/US5767085A/en not_active Expired - Lifetime
- 1994-12-22 PL PL94315113A patent/PL181280B1/pl not_active IP Right Cessation
- 1994-12-22 NZ NZ277486A patent/NZ277486A/en unknown
- 1994-12-22 PT PT95903774T patent/PT736039E/pt unknown
-
1995
- 1995-01-02 MX MX9500072A patent/MX9500072A/es unknown
-
1996
- 1996-06-20 FI FI962584A patent/FI962584A0/fi not_active IP Right Cessation
- 1996-06-21 NO NO19962665A patent/NO315561B1/no not_active IP Right Cessation
-
2000
- 2000-12-27 GR GR20000402838T patent/GR3035150T3/el not_active IP Right Cessation
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