DE69614491D1 - 5HT1Dalpha und 5HT2A Ligande - Google Patents

5HT1Dalpha und 5HT2A Ligande

Info

Publication number
DE69614491D1
DE69614491D1 DE69614491T DE69614491T DE69614491D1 DE 69614491 D1 DE69614491 D1 DE 69614491D1 DE 69614491 T DE69614491 T DE 69614491T DE 69614491 T DE69614491 T DE 69614491T DE 69614491 D1 DE69614491 D1 DE 69614491D1
Authority
DE
Germany
Prior art keywords
ligande
5ht1dalpha
5ht2a
5ht2a ligande
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69614491T
Other languages
English (en)
Other versions
DE69614491T2 (de
Inventor
Peter Thaddeus Gallagher
William Martin Owton
Colin William Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co Ltd
Eli Lilly and Co
Original Assignee
Eli Lilly and Co Ltd
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co Ltd, Eli Lilly and Co filed Critical Eli Lilly and Co Ltd
Publication of DE69614491D1 publication Critical patent/DE69614491D1/de
Application granted granted Critical
Publication of DE69614491T2 publication Critical patent/DE69614491T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
DE69614491T 1995-12-19 1996-12-17 5HT1Dalpha und 5HT2A Ligande Expired - Fee Related DE69614491T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9525963A GB2308362A (en) 1995-12-19 1995-12-19 Pharmaceutical indole derivatives

Publications (2)

Publication Number Publication Date
DE69614491D1 true DE69614491D1 (de) 2001-09-20
DE69614491T2 DE69614491T2 (de) 2002-04-18

Family

ID=10785702

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69614491T Expired - Fee Related DE69614491T2 (de) 1995-12-19 1996-12-17 5HT1Dalpha und 5HT2A Ligande

Country Status (27)

Country Link
US (1) US5773448A (de)
EP (1) EP0780388B1 (de)
JP (1) JPH09202784A (de)
KR (1) KR970042503A (de)
CN (1) CN1157822A (de)
AR (1) AR010205A1 (de)
AT (1) ATE204273T1 (de)
AU (1) AU720711B2 (de)
BR (1) BR9606066A (de)
CA (1) CA2193039C (de)
CZ (1) CZ372296A3 (de)
DE (1) DE69614491T2 (de)
DK (1) DK0780388T3 (de)
ES (1) ES2159693T3 (de)
GB (1) GB2308362A (de)
HU (1) HUP9603498A3 (de)
IL (1) IL119844A (de)
MX (1) MX9606531A (de)
NO (1) NO307512B1 (de)
NZ (1) NZ299959A (de)
PE (1) PE26198A1 (de)
PL (1) PL317526A1 (de)
PT (1) PT780388E (de)
SG (1) SG47206A1 (de)
TR (1) TR199601018A1 (de)
YU (1) YU67096A (de)
ZA (1) ZA9610589B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9810886D0 (en) * 1998-05-13 1998-07-22 Lilly Industries Ltd Pharmaceutical compounds
GB2362826A (en) * 2000-06-02 2001-12-05 Lilly Co Eli A pharmaceutical composition comprising a serotonin transport inhibitor and a serotonin recptor antagonist
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
CN106928122A (zh) * 2017-03-07 2017-07-07 贵州大学 3‑烷氧基季碳氧化吲哚及其制备方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411890A (en) * 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4035369A (en) * 1975-10-08 1977-07-12 Janssen Pharmaceutica N.V. 1-Benzazolylalkyl-4-substituted-piperidines
US4432978A (en) * 1979-07-30 1984-02-21 Pfizer Inc. Hexahydro-trans-pyridoindole
US4254127A (en) * 1980-04-03 1981-03-03 Janssen Pharmaceutica, N.V. 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives
FR2523964B1 (fr) * 1982-03-23 1985-09-27 Sanofi Sa Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation
IL69132A (en) * 1982-07-14 1986-02-28 Roussel Uclaf Benzo-and naphtho-thiopyranopyrimidinones,their preparation and pharmaceutical compositions containing them
US4658038A (en) * 1982-10-07 1987-04-14 Research Foundation For Mental Hygiene, Inc. N-acylated 5-hydroxytryptophan amide derivatives
US4608374A (en) * 1983-11-07 1986-08-26 Hoechst-Roussel Pharmaceuticals Inc. 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents
GB8332704D0 (en) * 1983-12-07 1984-01-11 Pfizer Ltd Growth promotants for animals
EP0181793B1 (de) * 1984-10-16 1988-07-27 Synthelabo Piperidinderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung
US4789676A (en) * 1986-03-05 1988-12-06 Merrell Dow Pharmaceuticals Inc. Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives, usefull as anxiolytic agents
FR2634207B1 (fr) * 1988-07-12 1990-09-07 Synthelabo Derives de ((piperidinyl-4)methyl) benzazepines, leur preparation et leur application en therapeutique
EP0351283A1 (de) * 1988-07-12 1990-01-17 Synthelabo 2-[(4-Piperidinyl)methyl]-2,3-dihydro-1H-isoindol- und 2,3,4,5-tetrahydro-1H-benzazepin-Derivate, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung
FR2635524B1 (fr) * 1988-08-19 1992-04-24 Adir Nouveaux derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermant
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
TW203049B (de) * 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
FR2661177A1 (fr) * 1990-04-23 1991-10-25 Rhone Poulenc Sante Derives du naphtosultame antagonistes de la serotonine, leur preparation et les medicaments les contenant.
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
FR2679561A1 (fr) * 1991-07-26 1993-01-29 Schneider Marc Nouveaux derives de l'(indolyl-1) alkylamine substituee par une chaine presentant des groupements carbonyles conjugues a un noyau aromatique.
SE9103752D0 (sv) 1991-12-18 1991-12-18 Astra Ab New compounds
TW218875B (de) * 1992-03-09 1994-01-11 Takeda Pharm Industry Co Ltd
CA2092112A1 (en) * 1992-03-23 1993-09-24 Nobuyoshi Iwata Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use
EP0572235A3 (en) * 1992-05-28 1994-06-01 Tanabe Seiyaku Co Beta-carboline derivatives with anticholecystoquinine activity
AU676525B2 (en) * 1992-11-06 1997-03-13 Merck & Co., Inc. Substituted dipeptide analogs promote release of growth hormone
PL176993B1 (pl) * 1992-12-11 1999-08-31 Merck & Co Inc Nowe związki spiropiperydynowe oraz sposób ich wytwarzania
US5578593A (en) * 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
CA2179597A1 (en) * 1993-12-23 1995-06-29 Nils Langeland Johansen Compounds with growth hormone releasing properties
RU2167881C2 (ru) * 1993-12-23 2001-05-27 Ново Нордиск А/С Соединения, способствующие высвобождению гормона роста
GB9418326D0 (en) * 1994-09-12 1994-11-02 Lilly Industries Ltd Pharmaceutical compounds
EP0705832B1 (de) * 1994-09-12 2003-08-13 Eli Lilly And Company Limited Serotonergische Modulatoren
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues

Also Published As

Publication number Publication date
MX9606531A (es) 1997-06-28
CA2193039A1 (en) 1997-06-20
HU9603498D0 (en) 1997-02-28
ZA9610589B (en) 1998-01-16
JPH09202784A (ja) 1997-08-05
AU720711B2 (en) 2000-06-08
BR9606066A (pt) 1998-09-01
NO307512B1 (no) 2000-04-17
NZ299959A (en) 1998-09-24
YU67096A (sh) 1999-03-04
IL119844A (en) 2000-12-06
EP0780388B1 (de) 2001-08-16
CN1157822A (zh) 1997-08-27
AR010205A1 (es) 2000-06-07
KR970042503A (ko) 1997-07-24
US5773448A (en) 1998-06-30
ES2159693T3 (es) 2001-10-16
EP0780388A1 (de) 1997-06-25
PT780388E (pt) 2001-12-28
AU7546096A (en) 1997-06-26
HUP9603498A2 (hu) 1998-09-28
CZ372296A3 (en) 1997-08-13
NO965448D0 (no) 1996-12-18
IL119844A0 (en) 1997-03-18
SG47206A1 (en) 1998-03-20
CA2193039C (en) 2006-04-04
TR199601018A1 (tr) 1997-07-21
ATE204273T1 (de) 2001-09-15
GB2308362A (en) 1997-06-25
HUP9603498A3 (en) 2001-04-28
DE69614491T2 (de) 2002-04-18
PL317526A1 (en) 1997-06-23
GB9525963D0 (en) 1996-02-21
DK0780388T3 (da) 2001-10-08
NO965448L (no) 1997-06-20
PE26198A1 (es) 1998-05-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee