ATE224872T1 - Azetidinonderivate zur behandlung von hcmv entzündungen - Google Patents
Azetidinonderivate zur behandlung von hcmv entzündungenInfo
- Publication number
- ATE224872T1 ATE224872T1 AT98947256T AT98947256T ATE224872T1 AT E224872 T1 ATE224872 T1 AT E224872T1 AT 98947256 T AT98947256 T AT 98947256T AT 98947256 T AT98947256 T AT 98947256T AT E224872 T1 ATE224872 T1 AT E224872T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- het
- hydrogen
- optionally substituted
- phenyl
- Prior art date
Links
- 241000701024 Human betaherpesvirus 5 Species 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 title 1
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 206010011831 Cytomegalovirus infection Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- -1 methoxy, ethoxy Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6154497P | 1997-10-07 | 1997-10-07 | |
| PCT/CA1998/000953 WO1999018072A1 (en) | 1997-10-07 | 1998-10-06 | Azetidinone derivatives for the treatment of hcmv infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE224872T1 true ATE224872T1 (de) | 2002-10-15 |
Family
ID=22036448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98947256T ATE224872T1 (de) | 1997-10-07 | 1998-10-06 | Azetidinonderivate zur behandlung von hcmv entzündungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6242439B1 (de) |
| EP (1) | EP1021405B1 (de) |
| JP (1) | JP2001519329A (de) |
| AT (1) | ATE224872T1 (de) |
| AU (1) | AU9426098A (de) |
| CA (1) | CA2301543C (de) |
| DE (1) | DE69808326T2 (de) |
| DK (1) | DK1021405T3 (de) |
| ES (1) | ES2180201T3 (de) |
| PT (1) | PT1021405E (de) |
| WO (1) | WO1999018072A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| KR20070120617A (ko) | 2001-01-26 | 2007-12-24 | 쉐링 코포레이션 | 치환된 아제티딘온 화합물을 포함하는 약제학적 조성물 |
| IL156445A0 (en) | 2001-01-26 | 2004-01-04 | Schering Corp | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| BRPI0208384B1 (pt) | 2001-03-28 | 2016-05-31 | Merck Sharp & Dohme | síntese enantiosseletiva de compostos intermediários de azetidinona |
| DE10134478B4 (de) * | 2001-07-16 | 2007-10-31 | Priaton Gmbh | Verfahren zur Darstellung von thiazolsubstituierten β-Lactamen |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| EP1429756B1 (de) | 2001-09-21 | 2006-11-22 | Schering Corporation | Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption |
| CA2504916A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
| DE602004018617D1 (de) | 2003-03-07 | 2009-02-05 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| WO2004081002A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| WO2004081004A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| AU2005329094A1 (en) * | 2005-03-09 | 2006-09-21 | Carrier Commercial Refrigeration, Inc. | Cold room with roof-top support platform |
| CA2735811A1 (en) * | 2008-09-02 | 2010-03-11 | Susan L. Uprichard | Compositions and methods for inhibiting entry of a hepatic virus |
| US11072610B2 (en) | 2018-09-12 | 2021-07-27 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| CN114667285B (zh) | 2019-09-26 | 2025-08-08 | 诺华股份有限公司 | 抗病毒吡唑并吡啶酮化合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680391A (en) | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US5229381A (en) * | 1983-12-01 | 1993-07-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| NZ228600A (en) * | 1988-04-11 | 1992-02-25 | Merck & Co Inc | 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives |
| DE377549T1 (de) | 1989-01-03 | 1990-11-08 | Marcos Y. Southbridge Mass. Kleinerman | Fernmessung physikalischer variablen mit faseroptischen systemen. |
| US5104862A (en) | 1991-03-20 | 1992-04-14 | Merck & Co., Inc. | Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
| US5100880A (en) | 1991-03-20 | 1992-03-31 | Merck & Co., Inc. | Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
| US5229831A (en) | 1991-09-20 | 1993-07-20 | The Charles Stark Draper Laboratory, Inc. | Ultraminiature tactical grade cryogenic RFOG |
| GB2266527A (en) * | 1992-03-17 | 1993-11-03 | Merck & Co Inc | Substituted azetidinones useful in the treatment of leukemia |
| GB9314350D0 (en) | 1993-07-12 | 1993-08-25 | Zeneca Ltd | Armide derivatives |
| HUT75660A (en) * | 1994-03-23 | 1997-05-28 | Tokyo Tanabe Co | Novel remedy for respiratory-tract viral disease |
-
1998
- 1998-10-06 EP EP98947256A patent/EP1021405B1/de not_active Expired - Lifetime
- 1998-10-06 JP JP2000514884A patent/JP2001519329A/ja not_active Ceased
- 1998-10-06 AU AU94260/98A patent/AU9426098A/en not_active Abandoned
- 1998-10-06 US US09/167,143 patent/US6242439B1/en not_active Expired - Lifetime
- 1998-10-06 DK DK98947256T patent/DK1021405T3/da active
- 1998-10-06 PT PT98947256T patent/PT1021405E/pt unknown
- 1998-10-06 WO PCT/CA1998/000953 patent/WO1999018072A1/en not_active Ceased
- 1998-10-06 CA CA002301543A patent/CA2301543C/en not_active Expired - Fee Related
- 1998-10-06 ES ES98947256T patent/ES2180201T3/es not_active Expired - Lifetime
- 1998-10-06 DE DE69808326T patent/DE69808326T2/de not_active Expired - Lifetime
- 1998-10-06 AT AT98947256T patent/ATE224872T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2180201T3 (es) | 2003-02-01 |
| US6242439B1 (en) | 2001-06-05 |
| PT1021405E (pt) | 2003-02-28 |
| CA2301543A1 (en) | 1999-04-15 |
| DK1021405T3 (da) | 2003-02-03 |
| EP1021405B1 (de) | 2002-09-25 |
| WO1999018072A1 (en) | 1999-04-15 |
| DE69808326T2 (de) | 2003-05-22 |
| CA2301543C (en) | 2005-05-17 |
| EP1021405A1 (de) | 2000-07-26 |
| AU9426098A (en) | 1999-04-27 |
| DE69808326D1 (de) | 2002-10-31 |
| JP2001519329A (ja) | 2001-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69808326D1 (de) | Azetidinonderivate zur behandlung von hcmv entzündungen | |
| ATE186909T1 (de) | Cyclische fungizide amide | |
| DE69930947D1 (de) | Piperazin-4-phenyl-derivate als inhibitoren der wechselwirkung zwischen mdm2 und mdm2 | |
| AU2910600A (en) | Phenyl urea and phenyl thiourea derivatives | |
| DE69902634D1 (de) | Substituierte aminophenylisoxazolinderivate verwendbar als antimikrobielle agenzien | |
| CA2230082A1 (en) | Amide compounds and use thereof | |
| DE69725151D1 (de) | Purinderivate und ihre anwendung als anticoagulante | |
| DE60005504D1 (de) | Chinolinderivate als mek enzym-inhibitoren | |
| DE3853577D1 (de) | Benzyliden-Malononitril-Derivate zur Hemmung von proliferativen Prozessen in Säugetierzellen. | |
| MY111814A (en) | Watersoluble azole antifungals | |
| DE69924292D1 (de) | Pyrazol verbindungen und ihre verwendung | |
| ATE263771T1 (de) | Totalsynthese von acylfulvenen mit antitumorwirkung | |
| AP9901578A0 (en) | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents. | |
| CA2152902A1 (fr) | Ligands selectifs des recepteurs 5-ht1d-5ht1b derives d'indole-piperazine utiles comme medicaments | |
| TW429255B (en) | Pyrazine compounds having treatment of central nervous system diseases and disorders | |
| DK1202954T3 (da) | Nye aminobenzophenoner | |
| ATE231124T1 (de) | Azetidinonderivate zur behandlung von hcmv entzündungen | |
| ATE178319T1 (de) | Indol-7-carboxamide derivate als analgetika | |
| NZ337749A (en) | Benzimidazole derivative and their use in allergy-related disease | |
| ATE230725T1 (de) | Azetidinonderivate zur behandlung von hcmv entzündungen | |
| ES479110A1 (es) | Procedimiento para preparar derivados de benzamidina. | |
| DK1049672T3 (da) | Azetidincarboxamid-derivater til behandling af CNS-lidelser | |
| ATE264840T1 (de) | Azetidincarboxamid-derivate zur behandlung von zns störungen | |
| DK1049670T3 (da) | Azetidincarboxamidderivater til behandling af CNS-lidelser | |
| ATE223406T1 (de) | 1,4-disubstitutierte cyclohexanderivate zur behandlung von depression |