EA200000842A1 - Бицикло [2.2.1] гептаны и родственные соединения - Google Patents

Бицикло [2.2.1] гептаны и родственные соединения

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Publication number
EA200000842A1
EA200000842A1 EA200000842A EA200000842A EA200000842A1 EA 200000842 A1 EA200000842 A1 EA 200000842A1 EA 200000842 A EA200000842 A EA 200000842A EA 200000842 A EA200000842 A EA 200000842A EA 200000842 A1 EA200000842 A1 EA 200000842A1
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EA
Eurasian Patent Office
Prior art keywords
alkyl
aryl
compounds
optionally substituted
heteroaryl
Prior art date
Application number
EA200000842A
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English (en)
Other versions
EA003946B1 (ru
Inventor
Бертранд Лео Ченард
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200000842A1 publication Critical patent/EA200000842A1/ru
Publication of EA003946B1 publication Critical patent/EA003946B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/08Vasodilators for multiple indications
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/36Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы I, в которых n принимает значения от 0 до 6; X обозначает CH, CHCHили кислород; Z обозначает CHRили NR, Rи Rвыбирают независимо из водорода, (C-C) алкила, арила и гетероарила, при этом указанный арил выбирают из фенила и нафтила и указанный гетероарил выбирают из 5- и 6-членных ароматических гетероциклических колец, которые содержат от одного до четырех гетероатомов, выбранных независимо из азота, кислорода и серы, и при этом указанные арильная и гетероарильная группировки могут быть необязательно замещены одним или большим количеством заместителей, которые выбирают независимо из галогена, -S(C-C)алкила, -S(O)(C-C)алкила, -S(O)(C-C)алкила, (C-C)алкила, необязательно замещенного от одного до семи атомами фтора, (C-C)алкокси, необязательно замещенного от одного до семи атомами фтора, амино, нитро, циано, карбокси, -CO(C-C)алкила, (C-C)алкиламино, ди-[(C-C)алкил] аминофенокси, анилино и фенилтио; к фармацевтическим композициям, содержащим такие соединения (I), и к использованию таких соединений (I) для лечения неврологических и психических заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000842A 1998-03-17 1999-03-04 Бицикло[2.2.1]гептаны и родственные соединения EA003946B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7834698P 1998-03-17 1998-03-17
PCT/IB1999/000376 WO1999047490A1 (en) 1998-03-17 1999-03-04 Bicyclo[2.2.1]heptanes and related compounds

Publications (2)

Publication Number Publication Date
EA200000842A1 true EA200000842A1 (ru) 2001-04-23
EA003946B1 EA003946B1 (ru) 2003-10-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000842A EA003946B1 (ru) 1998-03-17 1999-03-04 Бицикло[2.2.1]гептаны и родственные соединения

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US (1) US6136861A (ru)
EP (1) EP1064256B1 (ru)
JP (1) JP3665567B2 (ru)
KR (1) KR100372981B1 (ru)
CN (1) CN1231461C (ru)
AP (1) AP1116A (ru)
AR (1) AR017236A1 (ru)
AT (1) ATE272608T1 (ru)
AU (1) AU753422B2 (ru)
BG (1) BG104837A (ru)
BR (1) BR9908850A (ru)
CA (1) CA2321639C (ru)
CO (1) CO5090835A1 (ru)
CZ (1) CZ20003355A3 (ru)
DE (1) DE69919142T2 (ru)
DZ (1) DZ2745A1 (ru)
EA (1) EA003946B1 (ru)
ES (1) ES2224604T3 (ru)
GT (1) GT199900040A (ru)
HR (1) HRP20000611A2 (ru)
HU (1) HUP0101031A3 (ru)
ID (1) ID25651A (ru)
IL (1) IL138342A0 (ru)
IS (1) IS5592A (ru)
MA (1) MA26614A1 (ru)
MY (1) MY121047A (ru)
NO (1) NO20004626L (ru)
NZ (1) NZ506227A (ru)
OA (1) OA11488A (ru)
PE (1) PE20000339A1 (ru)
PL (1) PL343278A1 (ru)
PT (1) PT1064256E (ru)
SK (1) SK13532000A3 (ru)
TN (1) TNSN99039A1 (ru)
TR (1) TR200002671T2 (ru)
TW (1) TW509667B (ru)
UA (1) UA53781C2 (ru)
WO (1) WO1999047490A1 (ru)
YU (1) YU53700A (ru)
ZA (1) ZA992094B (ru)

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ES2224604T3 (es) 2005-03-01
BG104837A (bg) 2001-07-31
CZ20003355A3 (cs) 2002-05-15
SK13532000A3 (sk) 2002-07-02
KR100372981B1 (ko) 2003-02-25
IL138342A0 (en) 2001-10-31
US6136861A (en) 2000-10-24
YU53700A (sh) 2002-11-15
GT199900040A (es) 2000-09-06
CN1231461C (zh) 2005-12-14
TR200002671T2 (tr) 2000-12-21
OA11488A (en) 2004-05-07
TNSN99039A1 (fr) 2005-11-10
HUP0101031A2 (hu) 2001-08-28
TW509667B (en) 2002-11-11
EA003946B1 (ru) 2003-10-30
JP2002506847A (ja) 2002-03-05
AP1116A (en) 2002-10-21
ATE272608T1 (de) 2004-08-15
AU2540999A (en) 1999-10-11
AP9901482A0 (en) 1999-03-31
NO20004626L (no) 2000-11-13
NO20004626D0 (no) 2000-09-15
AU753422B2 (en) 2002-10-17
UA53781C2 (ru) 2003-02-17
NZ506227A (en) 2003-06-30
CO5090835A1 (es) 2001-10-30
KR20010041951A (ko) 2001-05-25
HRP20000611A2 (en) 2001-04-30
MY121047A (en) 2005-12-30
DE69919142D1 (de) 2004-09-09
PL343278A1 (en) 2001-08-13
HUP0101031A3 (en) 2003-05-28
BR9908850A (pt) 2000-11-21
CN1293655A (zh) 2001-05-02
PT1064256E (pt) 2004-10-29
MA26614A1 (fr) 2004-12-20
IS5592A (is) 2000-08-18
PE20000339A1 (es) 2000-05-13
DZ2745A1 (fr) 2003-09-08
EP1064256A1 (en) 2001-01-03
JP3665567B2 (ja) 2005-06-29
AR017236A1 (es) 2001-08-22
CA2321639C (en) 2005-08-02
DE69919142T2 (de) 2005-01-20
ID25651A (id) 2000-10-19
ZA992094B (en) 2000-11-28
EP1064256B1 (en) 2004-08-04
CA2321639A1 (en) 1999-09-23
WO1999047490A1 (en) 1999-09-23

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