MD663G2 - Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente - Google Patents

Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente

Info

Publication number
MD663G2
MD663G2 MD95-0431A MD950431A MD663G2 MD 663 G2 MD663 G2 MD 663G2 MD 950431 A MD950431 A MD 950431A MD 663 G2 MD663 G2 MD 663G2
Authority
MD
Moldova
Prior art keywords
compounds
heteroatoms
formula
saturated
possibly
Prior art date
Application number
MD95-0431A
Other languages
English (en)
Russian (ru)
Other versions
MD663F1 (ro
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD663F1 publication Critical patent/MD663F1/ro
Publication of MD663G2 publication Critical patent/MD663G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Compuşii cu formula generală (I):în care fie că R1 şi R2, care sunt identici sau diferiţi, reprezintă atom de hidrogen sau radical de hidrocarbură, saturat sau nesaturat, conţinând până la 24 atomi de carbon, fiind eventual întrerupt prin unul sau mai mulţi heteroatomi şi având una sau mai multe grupări funcţionale; fie că R1 şi R2, împreună cu atomul de azot, cuplat cu ei, formează un inel heterociclic, ce conţine eventual unul sau mai mulţi heteroatomi, selectaţi dintre azot, oxigen sau sulf; fie că R1 şi R2, luaţi împreună, formează un radical (a), în care R'1 şi R'2, care sunt identici sau diferiţi, reprezintă atom de hidrogen sau radical de hidrocarbură, saturat sau nesaturat, conţinând până la 23 atomi de carbon, fiind eventual întrerupt prin unul sau mai mulţi heteroatomi şi conţinând una sau mai multe grupări funcţionale, şi Z reprezintă un atom de hidrogen sau un rest de acid carboxilic, conţinând până la 18 atomi de carbon, precum şi sărurile lor aditive cu acizii compuşilor cu formula (I). Compuşii cu formula (I) posedă proprietăţi antibiotice valoroase.
MD95-0431A 1994-04-08 1995-04-06 Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente MD663G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
MD663F1 MD663F1 (ro) 1997-01-31
MD663G2 true MD663G2 (ro) 1997-07-31

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0431A MD663G2 (ro) 1994-04-08 1995-04-06 Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente

Country Status (49)

Country Link
US (2) US5656607A (ro)
EP (1) EP0676409B1 (ro)
JP (1) JP3000023B2 (ro)
KR (1) KR100317148B1 (ro)
CN (1) CN1059445C (ro)
AP (1) AP587A (ro)
AT (1) ATE234853T1 (ro)
AU (1) AU684939B2 (ro)
BG (1) BG61916B1 (ro)
BR (1) BR9506147A (ro)
CA (1) CA2164638C (ro)
CO (1) CO4370097A1 (ro)
CZ (1) CZ296005B6 (ro)
DE (1) DE69529934T2 (ro)
DK (1) DK0676409T3 (ro)
DZ (1) DZ1869A1 (ro)
EE (1) EE04498B1 (ro)
ES (1) ES2189820T3 (ro)
FI (1) FI111264B (ro)
FR (1) FR2718450B1 (ro)
GB (1) GB2288174A (ro)
GE (1) GEP19991836B (ro)
HR (1) HRP950217B1 (ro)
HU (1) HU215396B (ro)
IL (1) IL112954A (ro)
IS (1) IS1865B (ro)
JO (1) JO1850B1 (ro)
LV (1) LV11182B (ro)
MA (1) MA23501A1 (ro)
MD (1) MD663G2 (ro)
MY (1) MY114672A (ro)
NO (1) NO308361B1 (ro)
NZ (1) NZ284498A (ro)
OA (1) OA10200A (ro)
PE (1) PE2896A1 (ro)
PL (1) PL180837B1 (ro)
PT (1) PT676409E (ro)
RO (1) RO115634B1 (ro)
RU (1) RU2141965C1 (ro)
SA (1) SA97170757A (ro)
SI (1) SI0676409T1 (ro)
SK (1) SK284079B6 (ro)
SV (1) SV1995000018A (ro)
TN (1) TNSN95026A1 (ro)
TW (1) TW316908B (ro)
UA (1) UA44705C2 (ro)
WO (1) WO1995027720A1 (ro)
YU (1) YU49221B (ro)
ZA (1) ZA952059B (ro)

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FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
PT922050E (pt) * 1996-05-07 2003-12-31 Abbott Lab Derivados de 3-descladinose-2,3-anidroeritromicina
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
CN100460415C (zh) * 1996-09-04 2009-02-11 艾博特公司 酮基内酯类化合物，其用途和制备方法以及药用组合物
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6140479A (en) * 1997-03-24 2000-10-31 Taisho Pharmaceuticals Co., Ltd. Erythromycin a derivatives
US6162794A (en) * 1997-05-09 2000-12-19 Pfizer Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
BR9810021A (pt) * 1997-06-11 2000-09-19 Pfizer Prod Inc Derivados 9-oxima-eritromicina
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
DE69926005T2 (de) 1998-09-22 2006-05-18 Pfizer Products Inc., Groton Carbamat- und carbazatketolidantibiotika
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
WO2000034297A1 (en) 1998-12-10 2000-06-15 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
BR0010680A (pt) * 1999-04-16 2002-02-19 Kosan Biosciences Inc Agentes antiinfecciosos de macrolìdeo
WO2000062783A2 (en) 1999-04-16 2000-10-26 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
AP2001002302A0 (en) * 1999-05-24 2001-10-25 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
US6756359B2 (en) 2001-07-03 2004-06-29 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
CN105039464A (zh) 2002-07-01 2015-11-11 阿基昂生命科学公司,以生物技术资源部的名义经营 用于生产葡糖胺和n-乙酰氨基葡糖的方法和物质
EP3738591A3 (en) * 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
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CA2523134A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Pyridyl substituted ketolide antibiotics
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CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN108310000A (zh) 2009-09-10 2018-07-24 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
US8975386B2 (en) 2010-03-22 2015-03-10 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
SG11201405895UA (en) 2012-03-27 2014-10-30 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
MX356772B (es) 2013-03-15 2018-06-13 Cempra Pharmaceuticals Inc Procesos convergentes para la preparacion de agentes antibacterianos macrolidos.
EP2988597B1 (en) 2013-04-04 2022-06-08 President and Fellows of Harvard College Macrolides and methods of their preparation and use
CA2963815A1 (en) * 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

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EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

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AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
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FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
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EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Also Published As

Publication number Publication date
CN1059445C (zh) 2000-12-13
FI955913A0 (fi) 1995-12-08
SA97170757A (ar) 2005-12-03
HRP950217B1 (en) 2004-06-30
HU215396B (hu) 1998-12-28
RU2141965C1 (ru) 1999-11-27
FR2718450A1 (fr) 1995-10-13
WO1995027720A1 (fr) 1995-10-19
BR9506147A (pt) 1996-04-16
NO954942D0 (no) 1995-12-06
US5760233A (en) 1998-06-02
MY114672A (en) 2002-12-31
BG100150A (bg) 1996-06-28
HRP950217A2 (en) 1997-08-31
GEP19991836B (en) 1999-11-05
PE2896A1 (es) 1996-02-12
LV11182A (lv) 1996-04-20
AU684939B2 (en) 1998-01-08
CZ296005B6 (cs) 2005-12-14
TNSN95026A1 (fr) 1996-02-06
OA10200A (fr) 1996-12-18
YU49221B (sh) 2004-11-25
ES2189820T3 (es) 2003-07-16
AU2310795A (en) 1995-10-30
IS1865B (is) 2003-05-02
RO115634B1 (ro) 2000-04-28
DZ1869A1 (fr) 2002-02-17
LV11182B (en) 1997-04-20
CZ322395A3 (en) 1996-08-14
YU21695A (sh) 1997-12-05
DE69529934T2 (de) 2003-09-04
AP587A (en) 1997-04-29
NZ284498A (en) 1997-07-27
DE69529934D1 (de) 2003-04-24
MD663F1 (ro) 1997-01-31
SV1995000018A (es) 1997-10-24
CA2164638C (fr) 2003-12-30
CN1126997A (zh) 1996-07-17
NO308361B1 (no) 2000-09-04
ATE234853T1 (de) 2003-04-15
HUT73772A (en) 1996-09-30
GB9506856D0 (en) 1995-05-24
IS4309A (is) 1995-11-17
ZA952059B (en) 1996-03-13
IL112954A0 (en) 1995-06-29
FI111264B (fi) 2003-06-30
EP0676409A1 (fr) 1995-10-11
FR2718450B1 (fr) 1997-01-10
FI955913A7 (fi) 1995-12-08
BG61916B1 (bg) 1998-09-30
GB2288174A (en) 1995-10-11
PL311871A1 (en) 1996-03-18
EE04498B1 (et) 2005-06-15
TW316908B (ro) 1997-10-01
EE9500080A (et) 1996-12-16
CA2164638A1 (fr) 1995-10-19
SK154695A3 (en) 1996-10-02
HU9503505D0 (en) 1996-02-28
MA23501A1 (fr) 1995-12-31
PL180837B1 (pl) 2001-04-30
DK0676409T3 (da) 2003-06-23
US5656607A (en) 1997-08-12
AP9500743A0 (en) 1995-07-31
JP3000023B2 (ja) 2000-01-17
IL112954A (en) 2000-07-16
NO954942L (no) 1996-02-07
SK284079B6 (sk) 2004-09-08
PT676409E (pt) 2003-08-29
CO4370097A1 (es) 1996-10-07
UA44705C2 (uk) 2002-03-15
EP0676409B1 (fr) 2003-03-19
SI0676409T1 (en) 2003-06-30
JPH07278177A (ja) 1995-10-24
JO1850B1 (en) 1995-12-27
KR100317148B1 (ko) 2002-06-22

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IF99 Valid patent on 19990615

Free format text: EXPIRES: 20150406

MM4A Patent for invention definitely lapsed due to non-payment of fees