MD663G2 - Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente - Google Patents

Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente

Info

Publication number
MD663G2
MD663G2 MD95-0431A MD950431A MD663G2 MD 663 G2 MD663 G2 MD 663G2 MD 950431 A MD950431 A MD 950431A MD 663 G2 MD663 G2 MD 663G2
Authority
MD
Moldova
Prior art keywords
compounds
heteroatoms
formula
saturated
possibly
Prior art date
Application number
MD95-0431A
Other languages
English (en)
Russian (ru)
Other versions
MD663F1 (ro
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD663F1 publication Critical patent/MD663F1/ro
Publication of MD663G2 publication Critical patent/MD663G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Compuşii cu formula generală (I):în care fie că R1 şi R2, care sunt identici sau diferiţi, reprezintă atom de hidrogen sau radical de hidrocarbură, saturat sau nesaturat, conţinând până la 24 atomi de carbon, fiind eventual întrerupt prin unul sau mai mulţi heteroatomi şi având una sau mai multe grupări funcţionale; fie că R1 şi R2, împreună cu atomul de azot, cuplat cu ei, formează un inel heterociclic, ce conţine eventual unul sau mai mulţi heteroatomi, selectaţi dintre azot, oxigen sau sulf; fie că R1 şi R2, luaţi împreună, formează un radical (a), în care R'1 şi R'2, care sunt identici sau diferiţi, reprezintă atom de hidrogen sau radical de hidrocarbură, saturat sau nesaturat, conţinând până la 23 atomi de carbon, fiind eventual întrerupt prin unul sau mai mulţi heteroatomi şi conţinând una sau mai multe grupări funcţionale, şi Z reprezintă un atom de hidrogen sau un rest de acid carboxilic, conţinând până la 18 atomi de carbon, precum şi sărurile lor aditive cu acizii compuşilor cu formula (I). Compuşii cu formula (I) posedă proprietăţi antibiotice valoroase.
MD95-0431A 1994-04-08 1995-04-06 Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente MD663G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
MD663F1 MD663F1 (ro) 1997-01-31
MD663G2 true MD663G2 (ro) 1997-07-31

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0431A MD663G2 (ro) 1994-04-08 1995-04-06 Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente

Country Status (49)

Country Link
US (2) US5656607A (ro)
EP (1) EP0676409B1 (ro)
JP (1) JP3000023B2 (ro)
KR (1) KR100317148B1 (ro)
CN (1) CN1059445C (ro)
AP (1) AP587A (ro)
AT (1) ATE234853T1 (ro)
AU (1) AU684939B2 (ro)
BG (1) BG61916B1 (ro)
BR (1) BR9506147A (ro)
CA (1) CA2164638C (ro)
CO (1) CO4370097A1 (ro)
CZ (1) CZ296005B6 (ro)
DE (1) DE69529934T2 (ro)
DK (1) DK0676409T3 (ro)
DZ (1) DZ1869A1 (ro)
EE (1) EE04498B1 (ro)
ES (1) ES2189820T3 (ro)
FI (1) FI111264B (ro)
FR (1) FR2718450B1 (ro)
GB (1) GB2288174A (ro)
GE (1) GEP19991836B (ro)
HR (1) HRP950217B1 (ro)
HU (1) HU215396B (ro)
IL (1) IL112954A (ro)
IS (1) IS1865B (ro)
JO (1) JO1850B1 (ro)
LV (1) LV11182B (ro)
MA (1) MA23501A1 (ro)
MD (1) MD663G2 (ro)
MY (1) MY114672A (ro)
NO (1) NO308361B1 (ro)
NZ (1) NZ284498A (ro)
OA (1) OA10200A (ro)
PE (1) PE2896A1 (ro)
PL (1) PL180837B1 (ro)
PT (1) PT676409E (ro)
RO (1) RO115634B1 (ro)
RU (1) RU2141965C1 (ro)
SA (1) SA97170757A (ro)
SI (1) SI0676409T1 (ro)
SK (1) SK284079B6 (ro)
SV (1) SV1995000018A (ro)
TN (1) TNSN95026A1 (ro)
TW (1) TW316908B (ro)
UA (1) UA44705C2 (ro)
WO (1) WO1995027720A1 (ro)
YU (1) YU49221B (ro)
ZA (1) ZA952059B (ro)

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FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
AU710532B2 (en) * 1996-05-07 1999-09-23 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
CA2263972C (en) * 1996-09-04 2008-01-29 Abbott Laboratories 6-o-substituted ketolides having antibacterial activity
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
WO1998040392A1 (fr) * 1997-03-10 1998-09-17 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
US6140479A (en) * 1997-03-24 2000-10-31 Taisho Pharmaceuticals Co., Ltd. Erythromycin a derivatives
WO1998051696A1 (en) * 1997-05-09 1998-11-19 Pfizer Products Inc. Erythromycin derivatives
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WO1998056800A1 (en) * 1997-06-11 1998-12-17 Pfizer Products Inc. 9-oxime erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
ATE298761T1 (de) * 1998-09-22 2005-07-15 Pfizer Prod Inc Carbamat- und carbazatketolidantibiotika
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
ES2273964T3 (es) 1998-12-10 2007-05-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
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HRP20160222T1 (hr) * 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
NZ602544A (en) 2010-03-22 2014-11-28 Cempra Pharmaceuticals Inc Crystalline forms of a macrolide, and uses therefor
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
HK1205939A1 (en) 2012-03-27 2015-12-31 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CA3130061C (en) 2013-04-04 2024-05-28 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

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EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

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AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
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FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
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Also Published As

Publication number Publication date
FI955913A7 (fi) 1995-12-08
EE04498B1 (et) 2005-06-15
RO115634B1 (ro) 2000-04-28
FR2718450A1 (fr) 1995-10-13
HU9503505D0 (en) 1996-02-28
ES2189820T3 (es) 2003-07-16
SV1995000018A (es) 1997-10-24
TNSN95026A1 (fr) 1996-02-06
IS4309A (is) 1995-11-17
CN1059445C (zh) 2000-12-13
SA97170757A (ar) 2005-12-03
OA10200A (fr) 1996-12-18
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
MA23501A1 (fr) 1995-12-31
AP9500743A0 (en) 1995-07-31
SK284079B6 (sk) 2004-09-08
YU21695A (sh) 1997-12-05
DE69529934T2 (de) 2003-09-04
EP0676409A1 (fr) 1995-10-11
JP3000023B2 (ja) 2000-01-17
UA44705C2 (uk) 2002-03-15
DK0676409T3 (da) 2003-06-23
FR2718450B1 (fr) 1997-01-10
AU2310795A (en) 1995-10-30
RU2141965C1 (ru) 1999-11-27
TW316908B (ro) 1997-10-01
IS1865B (is) 2003-05-02
CN1126997A (zh) 1996-07-17
DE69529934D1 (de) 2003-04-24
KR100317148B1 (ko) 2002-06-22
FI955913A0 (fi) 1995-12-08
ZA952059B (en) 1996-03-13
SK154695A3 (en) 1996-10-02
HRP950217B1 (en) 2004-06-30
IL112954A (en) 2000-07-16
CA2164638C (fr) 2003-12-30
NO954942D0 (no) 1995-12-06
CZ296005B6 (cs) 2005-12-14
GEP19991836B (en) 1999-11-05
PE2896A1 (es) 1996-02-12
GB2288174A (en) 1995-10-11
NO954942L (no) 1996-02-07
ATE234853T1 (de) 2003-04-15
HUT73772A (en) 1996-09-30
BR9506147A (pt) 1996-04-16
US5656607A (en) 1997-08-12
WO1995027720A1 (fr) 1995-10-19
LV11182B (en) 1997-04-20
AU684939B2 (en) 1998-01-08
NZ284498A (en) 1997-07-27
AP587A (en) 1997-04-29
FI111264B (fi) 2003-06-30
PT676409E (pt) 2003-08-29
US5760233A (en) 1998-06-02
SI0676409T1 (en) 2003-06-30
LV11182A (lv) 1996-04-20
CZ322395A3 (en) 1996-08-14
CA2164638A1 (fr) 1995-10-19
PL311871A1 (en) 1996-03-18
BG100150A (bg) 1996-06-28
HRP950217A2 (en) 1997-08-31
JPH07278177A (ja) 1995-10-24
GB9506856D0 (en) 1995-05-24
MY114672A (en) 2002-12-31
DZ1869A1 (fr) 2002-02-17
NO308361B1 (no) 2000-09-04
YU49221B (sh) 2004-11-25
CO4370097A1 (es) 1996-10-07
BG61916B1 (bg) 1998-09-30
MD663F1 (ro) 1997-01-31
HU215396B (hu) 1998-12-28
PL180837B1 (pl) 2001-04-30
EE9500080A (et) 1996-12-16
IL112954A0 (en) 1995-06-29

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FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20150406

MM4A Patent for invention definitely lapsed due to non-payment of fees