MD663G2 - Производные эритромицина, способих получения и использование в качестве медикаментов - Google Patents

Производные эритромицина, способих получения и использование в качестве медикаментов

Info

Publication number
MD663G2
MD663G2 MD95-0431A MD950431A MD663G2 MD 663 G2 MD663 G2 MD 663G2 MD 950431 A MD950431 A MD 950431A MD 663 G2 MD663 G2 MD 663G2
Authority
MD
Moldova
Prior art keywords
compounds
heteroatoms
formula
saturated
possibly
Prior art date
Application number
MD95-0431A
Other languages
English (en)
Romanian (ro)
Other versions
MD663F1 (ro
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD663F1 publication Critical patent/MD663F1/xx
Publication of MD663G2 publication Critical patent/MD663G2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Соединения общей формулы (1)в которой:либо R1 и R2 идентичные или разные, представляют собой атом водорода или углеводородный радикал, насыщенный или ненасыщенный, содержащий до 24 атомов углерода и, в случае необходимости, прерванный одним или несколькими гетероатомами и имеющий одну или несколько функциональных групп; либо R1 и R2, вместе с атомом азота, к которому они присоединены, образуют гетероциклическое кольцо, содержащее один или несколько гетероатомов, выбранных из азота, кислорода или серы; либо R1 и R2, взятые вместе, образуют радикал (а), в котором R'1 и R'2 идентичные или разные, представляют собой атом водорода или углеводородный радикал, насыщенный или ненасыщенный, содержащий до 23 атомов углерода и прерванный одним или несколькими гетероатомами и содержащий одну или несколько функциональных групп, и Z представляет собой атом водорода или остаток карбоновой кислоты, содержащий до 18 атомов углерода, а также их аддитивные соли с кислотами соединений формулы (1).Соединения формулы (1) обладают ценными свойствами антибиотиков.
MD95-0431A 1994-04-08 1995-04-06 Производные эритромицина, способих получения и использование в качестве медикаментов MD663G2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
MD663F1 MD663F1 (ro) 1997-01-31
MD663G2 true MD663G2 (ru) 1997-07-31

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0431A MD663G2 (ru) 1994-04-08 1995-04-06 Производные эритромицина, способих получения и использование в качестве медикаментов

Country Status (49)

Country Link
US (2) US5656607A (ru)
EP (1) EP0676409B1 (ru)
JP (1) JP3000023B2 (ru)
KR (1) KR100317148B1 (ru)
CN (1) CN1059445C (ru)
AP (1) AP587A (ru)
AT (1) ATE234853T1 (ru)
AU (1) AU684939B2 (ru)
BG (1) BG61916B1 (ru)
BR (1) BR9506147A (ru)
CA (1) CA2164638C (ru)
CO (1) CO4370097A1 (ru)
CZ (1) CZ296005B6 (ru)
DE (1) DE69529934T2 (ru)
DK (1) DK0676409T3 (ru)
DZ (1) DZ1869A1 (ru)
EE (1) EE04498B1 (ru)
ES (1) ES2189820T3 (ru)
FI (1) FI111264B (ru)
FR (1) FR2718450B1 (ru)
GB (1) GB2288174A (ru)
GE (1) GEP19991836B (ru)
HR (1) HRP950217B1 (ru)
HU (1) HU215396B (ru)
IL (1) IL112954A (ru)
IS (1) IS1865B (ru)
JO (1) JO1850B1 (ru)
LV (1) LV11182B (ru)
MA (1) MA23501A1 (ru)
MD (1) MD663G2 (ru)
MY (1) MY114672A (ru)
NO (1) NO308361B1 (ru)
NZ (1) NZ284498A (ru)
OA (1) OA10200A (ru)
PE (1) PE2896A1 (ru)
PL (1) PL180837B1 (ru)
PT (1) PT676409E (ru)
RO (1) RO115634B1 (ru)
RU (1) RU2141965C1 (ru)
SA (1) SA97170757A (ru)
SI (1) SI0676409T1 (ru)
SK (1) SK284079B6 (ru)
SV (1) SV1995000018A (ru)
TN (1) TNSN95026A1 (ru)
TW (1) TW316908B (ru)
UA (1) UA44705C2 (ru)
WO (1) WO1995027720A1 (ru)
YU (1) YU49221B (ru)
ZA (1) ZA952059B (ru)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
CZ349698A3 (cs) * 1996-05-07 1999-04-14 Abbott Laboratories 3-deskladinoso-2,3-anhydroerythromycinové deriváty
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (ru) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-0-замещённые кетолиды с антибактериальной активностью
ATE299508T1 (de) * 1996-09-04 2005-07-15 Abbott Lab 6-o-substituierte ketoliden mit antibakteriellen wirkung
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998042720A1 (fr) * 1997-03-24 1998-10-01 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
US6162794A (en) * 1997-05-09 2000-12-19 Pfizer Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
ID24529A (id) * 1997-06-11 2000-07-20 Pfizer Prod Inc Turunan-turunan 9-oksima eritromisin
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
ES2243066T3 (es) 1998-09-22 2005-11-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
ES2273964T3 (es) 1998-12-10 2007-05-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
MXPA01010521A (es) 1999-04-16 2003-08-19 Johnson & Johnson Antibacteriales de cetolidos.
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
EP1171446B1 (en) * 1999-04-16 2006-09-20 Kosan Biosciences, Inc. Macrolide antiinfective agents
IL145739A0 (en) * 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
AU2002316550A1 (en) 2001-07-03 2003-01-21 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
JP2006508643A (ja) 2002-07-01 2006-03-16 アーキオン ライフ サイエンシーズ エルエルシー ディー／ビー／エー バイオ−テクニカル リソーセズ ディビジョン グルコサミンおよびｎ−アセチルグルコサミン製造のためのプロセスおよび材料
CA2801100A1 (en) * 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Macrolides and processes for their preparation
US7332476B2 (en) * 2003-04-25 2008-02-19 Novartis Ag Pyridyl substituted ketolide antibiotics
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
AU2008316830B2 (en) * 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN102245195B (zh) 2008-10-24 2016-01-13 森普拉制药公司 使用含三唑的大环内酯的生物防御
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN102724874B (zh) 2009-09-10 2018-06-01 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
CN108570083A (zh) 2010-03-22 2018-09-25 森普拉制药公司 大环内脂的结晶形式及其用途
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
CA2905975A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
JP6675973B2 (ja) 2013-03-15 2020-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド抗菌薬を調製するための集束的な方法
MX377459B (es) 2013-04-04 2025-03-10 Harvard College Macrolidos y metodos para su preparacion y uso.
US10633407B2 (en) * 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
HK1250371A1 (zh) 2015-03-25 2018-12-14 President And Fellows Of Harvard College 具有修饰的脱氧糖胺糖的大环内酯及其用途
MD1222Z (ru) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Способ обработки посадочного материала цветов перед посадкой
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Also Published As

Publication number Publication date
ES2189820T3 (es) 2003-07-16
EE04498B1 (et) 2005-06-15
EE9500080A (et) 1996-12-16
YU21695A (sh) 1997-12-05
DE69529934T2 (de) 2003-09-04
MD663F1 (ro) 1997-01-31
WO1995027720A1 (fr) 1995-10-19
US5760233A (en) 1998-06-02
NO954942D0 (no) 1995-12-06
EP0676409A1 (fr) 1995-10-11
CZ322395A3 (en) 1996-08-14
JPH07278177A (ja) 1995-10-24
FI111264B (fi) 2003-06-30
US5656607A (en) 1997-08-12
IL112954A0 (en) 1995-06-29
HRP950217A2 (en) 1997-08-31
MA23501A1 (fr) 1995-12-31
KR100317148B1 (ko) 2002-06-22
CN1059445C (zh) 2000-12-13
IS4309A (is) 1995-11-17
NO308361B1 (no) 2000-09-04
RU2141965C1 (ru) 1999-11-27
BG61916B1 (bg) 1998-09-30
CO4370097A1 (es) 1996-10-07
SV1995000018A (es) 1997-10-24
LV11182A (lv) 1996-04-20
FR2718450A1 (fr) 1995-10-13
AU684939B2 (en) 1998-01-08
PL180837B1 (pl) 2001-04-30
TW316908B (ru) 1997-10-01
ZA952059B (en) 1996-03-13
NO954942L (no) 1996-02-07
MY114672A (en) 2002-12-31
SI0676409T1 (en) 2003-06-30
HRP950217B1 (en) 2004-06-30
PT676409E (pt) 2003-08-29
GB2288174A (en) 1995-10-11
SK154695A3 (en) 1996-10-02
UA44705C2 (uk) 2002-03-15
GEP19991836B (en) 1999-11-05
NZ284498A (en) 1997-07-27
AP9500743A0 (en) 1995-07-31
DE69529934D1 (de) 2003-04-24
RO115634B1 (ro) 2000-04-28
PL311871A1 (en) 1996-03-18
IS1865B (is) 2003-05-02
DZ1869A1 (fr) 2002-02-17
IL112954A (en) 2000-07-16
AU2310795A (en) 1995-10-30
TNSN95026A1 (fr) 1996-02-06
CZ296005B6 (cs) 2005-12-14
DK0676409T3 (da) 2003-06-23
YU49221B (sh) 2004-11-25
FI955913A7 (fi) 1995-12-08
GB9506856D0 (en) 1995-05-24
CA2164638A1 (fr) 1995-10-19
BG100150A (bg) 1996-06-28
FR2718450B1 (fr) 1997-01-10
JP3000023B2 (ja) 2000-01-17
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
FI955913A0 (fi) 1995-12-08
SA97170757A (ar) 2005-12-03
BR9506147A (pt) 1996-04-16
OA10200A (fr) 1996-12-18
CN1126997A (zh) 1996-07-17
LV11182B (en) 1997-04-20
CA2164638C (fr) 2003-12-30
HU9503505D0 (en) 1996-02-28
PE2896A1 (es) 1996-02-12
AP587A (en) 1997-04-29
HU215396B (hu) 1998-12-28
SK284079B6 (sk) 2004-09-08
ATE234853T1 (de) 2003-04-15
HUT73772A (en) 1996-09-30

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IF99 Valid patent on 19990615

Free format text: EXPIRES: 20150406

MM4A Patent for invention definitely lapsed due to non-payment of fees