MD663G2 - Производные эритромицина, способих получения и использование в качестве медикаментов - Google Patents

Производные эритромицина, способих получения и использование в качестве медикаментов

Info

Publication number
MD663G2
MD663G2 MD95-0431A MD950431A MD663G2 MD 663 G2 MD663 G2 MD 663G2 MD 950431 A MD950431 A MD 950431A MD 663 G2 MD663 G2 MD 663G2
Authority
MD
Moldova
Prior art keywords
carbon atoms
hydrogen atom
heteroatoms
formula
saturated
Prior art date
Application number
MD95-0431A
Other languages
English (en)
Romanian (ro)
Other versions
MD663F1 (ro
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD663F1 publication Critical patent/MD663F1/xx
Publication of MD663G2 publication Critical patent/MD663G2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Соединения общей формулы (1)в которой:либо R1 и R2 идентичные или разные, представляют собой атом водорода или углеводородный радикал, насыщенный или ненасыщенный, содержащий до 24 атомов углерода и, в случае необходимости, прерванный одним или несколькими гетероатомами и имеющий одну или несколько функциональных групп; либо R1 и R2, вместе с атомом азота, к которому они присоединены, образуют гетероциклическое кольцо, содержащее один или несколько гетероатомов, выбранных из азота, кислорода или серы; либо R1 и R2, взятые вместе, образуют радикал (а), в котором R'1 и R'2 идентичные или разные, представляют собой атом водорода или углеводородный радикал, насыщенный или ненасыщенный, содержащий до 23 атомов углерода и прерванный одним или несколькими гетероатомами и содержащий одну или несколько функциональных групп, и Z представляет собой атом водорода или остаток карбоновой кислоты, содержащий до 18 атомов углерода, а также их аддитивные соли с кислотами соединений формулы (1).Соединения формулы (1) обладают ценными свойствами антибиотиков.
MD95-0431A 1994-04-08 1995-04-06 Производные эритромицина, способих получения и использование в качестве медикаментов MD663G2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
MD663F1 MD663F1 (ro) 1997-01-31
MD663G2 true MD663G2 (ru) 1997-07-31

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0431A MD663G2 (ru) 1994-04-08 1995-04-06 Производные эритромицина, способих получения и использование в качестве медикаментов

Country Status (49)

Country Link
US (2) US5656607A (ru)
EP (1) EP0676409B1 (ru)
JP (1) JP3000023B2 (ru)
KR (1) KR100317148B1 (ru)
CN (1) CN1059445C (ru)
AP (1) AP587A (ru)
AT (1) ATE234853T1 (ru)
AU (1) AU684939B2 (ru)
BG (1) BG61916B1 (ru)
BR (1) BR9506147A (ru)
CA (1) CA2164638C (ru)
CO (1) CO4370097A1 (ru)
CZ (1) CZ296005B6 (ru)
DE (1) DE69529934T2 (ru)
DK (1) DK0676409T3 (ru)
DZ (1) DZ1869A1 (ru)
EE (1) EE04498B1 (ru)
ES (1) ES2189820T3 (ru)
FI (1) FI111264B (ru)
FR (1) FR2718450B1 (ru)
GB (1) GB2288174A (ru)
GE (1) GEP19991836B (ru)
HR (1) HRP950217B1 (ru)
HU (1) HU215396B (ru)
IL (1) IL112954A (ru)
IS (1) IS1865B (ru)
JO (1) JO1850B1 (ru)
LV (1) LV11182B (ru)
MA (1) MA23501A1 (ru)
MD (1) MD663G2 (ru)
MY (1) MY114672A (ru)
NO (1) NO308361B1 (ru)
NZ (1) NZ284498A (ru)
OA (1) OA10200A (ru)
PE (1) PE2896A1 (ru)
PL (1) PL180837B1 (ru)
PT (1) PT676409E (ru)
RO (1) RO115634B1 (ru)
RU (1) RU2141965C1 (ru)
SA (1) SA97170757A (ru)
SI (1) SI0676409T1 (ru)
SK (1) SK284079B6 (ru)
SV (1) SV1995000018A (ru)
TN (1) TNSN95026A1 (ru)
TW (1) TW316908B (ru)
UA (1) UA44705C2 (ru)
WO (1) WO1995027720A1 (ru)
YU (1) YU49221B (ru)
ZA (1) ZA952059B (ru)

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FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
DK0922050T3 (da) * 1996-05-07 2003-11-24 Abbott Lab 3-Descladinose-2,3-anhydroerythromycin-derivater
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
IL128681A0 (en) * 1996-09-04 2000-01-31 Abbott Lab 6-O substituted ketolides having antibacterial activity
UA51730C2 (ru) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-0-замещённые кетолиды с антибактериальной активностью
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US6165986A (en) * 1997-03-10 2000-12-26 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6140479A (en) * 1997-03-24 2000-10-31 Taisho Pharmaceuticals Co., Ltd. Erythromycin a derivatives
US6162794A (en) * 1997-05-09 2000-12-19 Pfizer Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
IL132767A0 (en) * 1997-06-11 2001-03-19 Pfizer Prod Inc 9-Oxime erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
EP1115732B1 (en) * 1998-09-22 2005-06-29 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
ATE344269T1 (de) 1998-12-10 2006-11-15 Pfizer Prod Inc Carbamat und carbazat ketolid antibiotika
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
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CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011032052A1 (en) 2009-09-10 2011-03-17 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
EP2550286B1 (en) 2010-03-22 2015-12-09 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
PL2571506T3 (pl) 2010-05-20 2017-10-31 Cempra Pharmaceuticals Inc Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
IN2014DN08939A (ru) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
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JP2017531663A (ja) 2014-10-08 2017-10-26 プレジデント アンド フェローズ オブ ハーバード カレッジ １４員ケトライドならびにそれらの調製および使用の方法
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
MD1222Z (ru) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Способ обработки посадочного материала цветов перед посадкой
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

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Also Published As

Publication number Publication date
NZ284498A (en) 1997-07-27
CA2164638C (fr) 2003-12-30
YU49221B (sh) 2004-11-25
SI0676409T1 (en) 2003-06-30
DK0676409T3 (da) 2003-06-23
LV11182B (en) 1997-04-20
IS1865B (is) 2003-05-02
PL311871A1 (en) 1996-03-18
IL112954A0 (en) 1995-06-29
NO308361B1 (no) 2000-09-04
WO1995027720A1 (fr) 1995-10-19
ZA952059B (en) 1996-03-13
CZ296005B6 (cs) 2005-12-14
CN1126997A (zh) 1996-07-17
FI955913A0 (fi) 1995-12-08
RU2141965C1 (ru) 1999-11-27
UA44705C2 (uk) 2002-03-15
MD663F1 (ro) 1997-01-31
IL112954A (en) 2000-07-16
NO954942D0 (no) 1995-12-06
TW316908B (ru) 1997-10-01
FR2718450B1 (fr) 1997-01-10
HRP950217A2 (en) 1997-08-31
HU9503505D0 (en) 1996-02-28
BG100150A (bg) 1996-06-28
MA23501A1 (fr) 1995-12-31
GB2288174A (en) 1995-10-11
RO115634B1 (ro) 2000-04-28
NO954942L (no) 1996-02-07
YU21695A (sh) 1997-12-05
AP9500743A0 (en) 1995-07-31
GB9506856D0 (en) 1995-05-24
ES2189820T3 (es) 2003-07-16
DE69529934T2 (de) 2003-09-04
OA10200A (fr) 1996-12-18
AP587A (en) 1997-04-29
CN1059445C (zh) 2000-12-13
HU215396B (hu) 1998-12-28
PT676409E (pt) 2003-08-29
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
GEP19991836B (en) 1999-11-05
AU2310795A (en) 1995-10-30
TNSN95026A1 (fr) 1996-02-06
LV11182A (lv) 1996-04-20
JP3000023B2 (ja) 2000-01-17
CA2164638A1 (fr) 1995-10-19
PL180837B1 (pl) 2001-04-30
US5760233A (en) 1998-06-02
IS4309A (is) 1995-11-17
KR100317148B1 (ko) 2002-06-22
DZ1869A1 (fr) 2002-02-17
SK284079B6 (sk) 2004-09-08
FI111264B (fi) 2003-06-30
PE2896A1 (es) 1996-02-12
DE69529934D1 (de) 2003-04-24
BR9506147A (pt) 1996-04-16
EE9500080A (et) 1996-12-16
EE04498B1 (et) 2005-06-15
SA97170757A (ar) 2005-12-03
MY114672A (en) 2002-12-31
HRP950217B1 (en) 2004-06-30
CO4370097A1 (es) 1996-10-07
CZ322395A3 (en) 1996-08-14
SV1995000018A (es) 1997-10-24
SK154695A3 (en) 1996-10-02
FR2718450A1 (fr) 1995-10-13
EP0676409A1 (fr) 1995-10-11
US5656607A (en) 1997-08-12
ATE234853T1 (de) 2003-04-15
HUT73772A (en) 1996-09-30
BG61916B1 (bg) 1998-09-30
AU684939B2 (en) 1998-01-08
FI955913A (fi) 1995-12-08
JPH07278177A (ja) 1995-10-24

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