KR910007935A - 세고리형 카르바페넴 화합물 - Google Patents

세고리형 카르바페넴 화합물 Download PDF

Info

Publication number
KR910007935A
KR910007935A KR1019900016125A KR900016125A KR910007935A KR 910007935 A KR910007935 A KR 910007935A KR 1019900016125 A KR1019900016125 A KR 1019900016125A KR 900016125 A KR900016125 A KR 900016125A KR 910007935 A KR910007935 A KR 910007935A
Authority
KR
South Korea
Prior art keywords
group
ring
compound
substituted
formula
Prior art date
Application number
KR1019900016125A
Other languages
English (en)
Inventor
미찌유끼 센다이
테쓰오 미와
Original Assignee
우메모또 요시마사
다께다이야꾸힝고오교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우메모또 요시마사, 다께다이야꾸힝고오교 가부시끼가이샤 filed Critical 우메모또 요시마사
Publication of KR910007935A publication Critical patent/KR910007935A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D497/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

세고리형 카르바페넴 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기 식(I)의 화합물 또는 그 제약학적 허용 가능한 염.
    [상기식중, R1은 수소원자 또는 치환될 수 있는 탄화수소기이고, COOR2은 에스테르화될 수 있는 카르복시기이며, 고리B는 치환될 수 있는 고리기이다]
  2. 제1항에 있어서, 고리B가 산소원자, 임의로 산화되는 황원자, 질소원자, 2가 고리형 탄화수소기, 2가 헤테로고리기, 카르보닐기 및/또는 카르본이미도일기를 고리구성원소로 가지며 치환될 수 있는 5~8원 고리인 화합물.
  3. 제1항에 있어서, 고리B가 S, O 및/또는 N의 1 또는 2헤테로 원자(들)를 고리 구성원자로 갖는 5~7원 헤테로고리인 화합물.
  4. 제1항에 있어서, 고리 B가 5~7원 탄소고리인 화합물.
  5. 제1항에 있어서, R1이 1-히드록시에틸기인 화합물.
  6. 제1항에 있어서, (5S, 6S, 7S)-5-[(R)-1-히드록시에틸]-4-옥소-8-옥사-3-아자트리시클로[5·4·0·03,6]운데스-1-엔-2-카르복실산인 화합물.
  7. 제1항에 있어서, (10S, 11S, 12S)-5-[2-(이미노메틸아미노)에톡시-12-[(R)-1-히드록시에틸]-13-옥소-14-아자테트라시클로[8·5·02,7·011,14]펜타데카-2-4,6,15(1)-테트라엔-15-카르복실산인 화합물.
  8. 제1항에 있어서, (5S, 6S, 7S)-5-[(R)-1-히드록시에틸]-9-이미노에틸-4-옥소-3,9-디아자트리시클로[5·4·0·03,6]운데스-1-엔-2-카르복실산인 화합물.
  9. 하기식(II)의 화합물을 고리화시킨 후 필요에 따라 보호기(들)를 제거함을 특징으로 하는, 하기 식(I)의 화합물 또는 그의 제약학상 허용 가능한 염의 제조방법.
    [상기식중, R1은 수소원자 또는 치환될 수 있는 탄화수소기이고, COOR2은 에스테르화될 수 있는 카르복시기이며, 고리B는 치환될 수 있는 고리기이며, =Y 및 =Z는 각각 서로 반응하여 이중경합을 형성하는 기이다.]
  10. 하기식(III) 또는 (III')의 화합물을 고리화시킨 후 필요에 따라 보호기(들)를 제거함을 특징으로 하는 하기식(I")의 화합물의 제조방법.
    [상기식중, R1은 수소원자 또는 치환될 수 있는 탄화수소기이고, COOR2은 에스테르화될 수 있는 카르복시기이며, 고리B'는 S, 0 및 N의 1~3 헤테로원자(들)를 고리구성원자로 함유할 수 있고 치환될 수 있는 5~7원 고리기이고, R8은 히드록시기, 메르캅토기, 아미노기 및 단일치환 아미노기, 카르복시기 및 치환 옥시카르보닐기에서 선택된 작용기를 가지고, 탄소사슬 사이에 S, O 및 N중에서 선택되는 1 또는 2개의 헤테로원자(들)를 가지며 치환될 수 있는 저급 알킬기이며, R9은 이탈기, 또는 히드록시기, 카르복시기 및 치환 옥시카르보닐기에서 선택되는 작용기, 또는 탄소사슬 사이에 S, O 및 N중에서 선택되는 1또는 2개 헤테로원자(들)를 가지며 치환될 수 있는 이탈기 또는 상기 작용기를 갖는 저급 알킬기이다.]
  11. 유효 항균량의 하기 식(I)의 화합물 또는 그의 제약학상 허용 가능한 염, 및 제약학상 허용 가능한 담체를 함유함을 특징으로 하는 항균제.
    [상기식중, R1은 수소원자 또는 치환될 수 있는 탄화수소기이고, COOR2은 에스테르화될 수 있는 카르복시기이며, 고리B는 치환될 수 있는 고리기이다.]
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900016125A 1989-10-11 1990-10-11 세고리형 카르바페넴 화합물 KR910007935A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP1-264345 1989-10-11
JP26434589 1989-10-11
JP17711890 1990-07-03
JP90-177118 1990-07-03

Publications (1)

Publication Number Publication Date
KR910007935A true KR910007935A (ko) 1991-05-30

Family

ID=26497770

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900016125A KR910007935A (ko) 1989-10-11 1990-10-11 세고리형 카르바페넴 화합물

Country Status (10)

Country Link
US (1) US5393751A (ko)
EP (1) EP0422596B1 (ko)
KR (1) KR910007935A (ko)
AT (1) ATE124699T1 (ko)
AU (1) AU636913B2 (ko)
CA (1) CA2027237A1 (ko)
DE (1) DE69020676T2 (ko)
HU (1) HU210141B (ko)
IE (1) IE903586A1 (ko)
NO (1) NO904377L (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR200450569Y1 (ko) * 2008-03-03 2010-10-12 전오근 회전하는 갑판이 구비되며 돛의 양력을 이용하여 항주하는레저기구

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ285778B6 (cs) * 1989-09-08 1999-11-17 Glaxo S.P.A. Kyselina 10-(1-hydroxyethyl)-11-oxo-1-azatricyklo/7,2,0,03,8/-undec-2en-2-karboxylová a její deriváty, způsob jejich výroby, použití pro výrobu farmaceutických prostředků a farmaceutické prostředky s jejich obsahem
GB9015485D0 (en) * 1990-07-13 1990-08-29 Glaxo Spa Heterocyclic derivatives
IL99248A (en) * 1990-08-21 1996-01-31 Glaxo Spa Acid esters 01-) 1-Hydroxyethyl (-11-oxo-1-azatricycloundec-2-n-2-carboxylic acid, their preparation and pharmaceutical preparations
GB9104832D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
GB9104838D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
GB9104769D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
EP0507313A1 (en) * 1991-04-05 1992-10-07 Takeda Chemical Industries, Ltd. Polycyclic carbapenem compounds, their production and use
TW198035B (ko) * 1991-05-29 1993-01-11 Hoechst Ag
GB9218240D0 (en) * 1992-08-27 1992-10-14 Glaxo Spa Heterocyclic compounds
GB9218781D0 (en) * 1992-09-04 1992-10-21 Glaxo Spa Heterocyclic derivatives
GB9305805D0 (en) * 1993-03-20 1993-05-05 Glaxo Spa Chemical process
GB9305806D0 (en) * 1993-03-20 1993-05-05 Glaxo Spa Chemical compounds
US5372993A (en) * 1993-06-10 1994-12-13 Merck & Co., Inc. Bridged carbapenem compounds, compositions containing such compounds and methods of use
US5374630A (en) * 1993-06-10 1994-12-20 Merck & Co., Inc. Bridged carbapenem antibacterial compounds
US5384317A (en) * 1993-08-02 1995-01-24 Merck & Co., Inc. Bridged biphenyl carbapenem compounds, compositions containing such compounds and methods of use
US5401735A (en) * 1993-08-02 1995-03-28 Merck & Co., Inc. Bridged biphenyl carbapenem antibacterial compounds
US20020147333A1 (en) 1993-10-29 2002-10-10 Smithkline Beecham P.L.C. 2-(pyrazol-3-yl)carbapenem derivatives
GB9406074D0 (en) * 1994-03-26 1994-05-18 Glaxo Spa Chemical process
US5688786A (en) * 1994-04-01 1997-11-18 Microcide Pharmaceuticals, Inc. β-lactam antibiotics
US5698547A (en) * 1994-04-01 1997-12-16 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
AU682287B2 (en) * 1995-05-10 1997-09-25 Morton International, Inc. Latent mercaptans as multi-functional additives for halogen-containing polymer compositions
WO1996038450A1 (en) * 1995-05-31 1996-12-05 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US6410775B1 (en) * 1995-06-07 2002-06-25 La Jolla Pharmaceutical Company APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies
GB9516118D0 (en) * 1995-08-05 1995-10-04 Glaxo Spa Chemical process
US6531466B2 (en) 1996-11-14 2003-03-11 Glaxosmithkline Spa Tricyclic carbapenem compounds
GB9623684D0 (en) * 1996-11-14 1997-01-08 Glaxo Wellcome Spa Chemical compounds
JPH10168057A (ja) * 1996-12-12 1998-06-23 Takasago Internatl Corp シクロヘキシルアゼチジノン誘導体の製造法
SI9600371B (sl) 1996-12-18 2005-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Etilidenski derivati tricikličnih karbapenemov
TW498096B (en) * 1997-07-09 2002-08-11 Morton Int Inc Stabilizer composition comprising a blocked mercaptan and polymer composition comprising said stabilizer composition
AU716724B2 (en) * 1998-03-26 2000-03-02 Morton International, Inc. A latent mercaptan as a heat stabilizer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600713A (en) * 1979-12-03 1986-07-15 Merck & Co., Inc. 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids
US4374848A (en) * 1981-09-14 1983-02-22 Merck & Co., Inc. 6-(1-Hydroxyethyl)cyclonocardicin
EP0366641B1 (en) * 1988-10-24 2000-07-05 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial quinolonyl lactam esters
CZ285778B6 (cs) * 1989-09-08 1999-11-17 Glaxo S.P.A. Kyselina 10-(1-hydroxyethyl)-11-oxo-1-azatricyklo/7,2,0,03,8/-undec-2en-2-karboxylová a její deriváty, způsob jejich výroby, použití pro výrobu farmaceutických prostředků a farmaceutické prostředky s jejich obsahem

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR200450569Y1 (ko) * 2008-03-03 2010-10-12 전오근 회전하는 갑판이 구비되며 돛의 양력을 이용하여 항주하는레저기구

Also Published As

Publication number Publication date
DE69020676D1 (de) 1995-08-10
HU906402D0 (en) 1991-04-29
AU6379290A (en) 1991-04-18
DE69020676T2 (de) 1995-12-14
NO904377L (no) 1991-04-12
EP0422596A2 (en) 1991-04-17
NO904377D0 (no) 1990-10-10
ATE124699T1 (de) 1995-07-15
AU636913B2 (en) 1993-05-13
EP0422596A3 (en) 1992-03-11
HU210141B (en) 1995-02-28
JPH04178389A (ja) 1992-06-25
EP0422596B1 (en) 1995-07-05
IE903586A1 (en) 1991-04-24
HUT56370A (en) 1991-08-28
CA2027237A1 (en) 1991-04-12
US5393751A (en) 1995-02-28

Similar Documents

Publication Publication Date Title
KR910007935A (ko) 세고리형 카르바페넴 화합물
KR920702348A (ko) 퀴놀론 카르복실산 유도체
ATE97895T1 (de) Cannabinol-derivate und immuntest.
KR930004306A (ko) 피롤리딜티오카르바페넴 유도체
ES2094204T3 (es) Derivados de piperazina.
KR930016402A (ko) 항-hiv 활성을 갖는 이미다졸 유도체
DE69024397D1 (de) Diaminoethylen-Verbindungen
DE69132651D1 (de) Schwefel enthaltende heterocyclische Verbindungen
ES2065994T3 (es) Beta-dicetonas substituidas.
ATE19063T1 (de) Verfahren zur herstellung von trithiocarbonsaeurediestern.
DK384485A (da) 1,6-naphthyridinderivater med kardilaterende virkning
ES539160A0 (es) Un procedimiento para preparar derivados de penem
KR870004992A (ko) 세팔로스포린 유도체의 제조방법
KR930702339A (ko) 에폭시숙시남산 유도체
GR3007087T3 (ko)
ATE92492T1 (de) Verfahren zur herstellung von 2-betasubstituierten-methyl-penicillinderivaten.
KR890008151A (ko) 키놀린 카르복산의 유도체
ATE110384T1 (de) Makrolid-derivate.
ES523797A0 (es) Procedimiento para la obtencion de b-lactamantibioticos.
KR920002613A (ko) 이환성 함유 황화합물
KR890003690A (ko) 우레아 유도체
KR860004055A (ko) 치료제용의 티오포름아미드 유도체의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
SUBM Surrender of laid-open application requested