FI102965B1 - Kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö - Google Patents

Kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö

Info

Publication number
FI102965B1
FI102965B1 FI915488A FI915488A FI102965B1 FI 102965 B1 FI102965 B1 FI 102965B1 FI 915488 A FI915488 A FI 915488A FI 915488 A FI915488 A FI 915488A FI 102965 B1 FI102965 B1 FI 102965B1
Authority
FI
Finland
Prior art keywords
substituted
condensed heterocyclic
preparation
whole number
heterocyclic compounds
Prior art date
Application number
FI915488A
Other languages
English (en)
Swedish (sv)
Other versions
FI915488A0 (fi
FI102965B (fi
FI915488A (fi
Inventor
Giichi Goto
Yuji Ishihara
Masaomi Miyamoto
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FI915488A0 publication Critical patent/FI915488A0/fi
Publication of FI915488A publication Critical patent/FI915488A/fi
Application granted granted Critical
Publication of FI102965B publication Critical patent/FI102965B/fi
Publication of FI102965B1 publication Critical patent/FI102965B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)
  • Hydrogenated Pyridines (AREA)
FI915488A 1990-11-22 1991-11-21 Kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö FI102965B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP31989790 1990-11-22
JP7028691 1991-01-14
JP20935891 1991-08-21
JP24376891 1991-09-24

Publications (4)

Publication Number Publication Date
FI915488A0 FI915488A0 (fi) 1991-11-21
FI915488A FI915488A (fi) 1992-05-23
FI102965B FI102965B (fi) 1999-03-31
FI102965B1 true FI102965B1 (fi) 1999-03-31

Family

ID=27465225

Family Applications (2)

Application Number Title Priority Date Filing Date
FI915488A FI102965B1 (fi) 1990-11-22 1991-11-21 Kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö
FI982436A FI982436A0 (fi) 1990-11-22 1998-11-10 Kondensoituneet heterosykliset yhdisteet

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI982436A FI982436A0 (fi) 1990-11-22 1998-11-10 Kondensoituneet heterosykliset yhdisteet

Country Status (19)

Country Link
US (1) US5273974A (fi)
EP (1) EP0487071B1 (fi)
JP (1) JP2650537B2 (fi)
KR (1) KR100211437B1 (fi)
CN (1) CN1036458C (fi)
AT (1) ATE124695T1 (fi)
AU (1) AU643337B2 (fi)
CA (1) CA2055947C (fi)
DE (1) DE69111029T2 (fi)
DK (1) DK0487071T3 (fi)
ES (1) ES2074205T3 (fi)
FI (2) FI102965B1 (fi)
GR (1) GR3017366T3 (fi)
HU (2) HU214573B (fi)
IE (1) IE68346B1 (fi)
NO (1) NO179868C (fi)
NZ (1) NZ240676A (fi)
RU (1) RU2095361C1 (fi)
TW (1) TW197435B (fi)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
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US5965574A (en) * 1996-08-13 1999-10-12 Chen; Yuhpyng Liang Heteroaryl amines as novel acetylcholinesterase inhibitors
TW263504B (fi) * 1991-10-03 1995-11-21 Pfizer
US5462934A (en) * 1992-03-09 1995-10-31 Takeda Chemical Industries Condensed heterocyclic ketone derivatives and their use
TW218875B (fi) * 1992-03-09 1994-01-11 Takeda Pharm Industry Co Ltd
DE69329084T2 (de) 1992-04-24 2000-12-21 Takeda Chemical Industries Ltd Benzoxazepin-Derivate als Cholinesterase-Inhibitoren
TW248556B (fi) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
US5620973A (en) * 1993-11-30 1997-04-15 Takeda Chemical Industries, Ltd. Tetracyclic condensed heterocyclic compounds and their use
JPH10506615A (ja) * 1994-07-27 1998-06-30 ザ、プロクター、エンド、ギャンブル、カンパニー 抗炎症剤として有用なジヒドロベンゾフラン及び関連化合物
US5656661A (en) * 1994-07-27 1997-08-12 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US6251938B1 (en) 1996-12-18 2001-06-26 Teva Pharmaceutical Industries, Ltd., Phenylethylamine derivatives
CA2275425C (en) 1996-12-18 2009-08-04 Michael Chorev Aminoindan derivatives
EP0952826B1 (en) * 1997-01-17 2001-11-14 Takeda Chemical Industries, Ltd. Idebenone containing combination agent for treating alzheimer's disease
US5962535A (en) * 1997-01-17 1999-10-05 Takeda Chemical Industries, Ltd. Composition for alzheimer's disease
US6534496B1 (en) 1997-04-17 2003-03-18 Takeda Chemical Industries, Inc. Thermogenic composition and benzazepine thermogenics
EP1079816A2 (en) * 1998-04-23 2001-03-07 Takeda Chemical Industries, Ltd. Pharmaceutical composition for neurotrophic action
NZ510685A (en) 1998-09-30 2003-10-31 Takeda Chemical Industries Ltd Drugs for improving vesical excretory strength
WO2000051985A1 (fr) * 1999-03-03 2000-09-08 Eisai Co., Ltd. Fluorures de derives de piperidine substitues en position 4
WO2002002530A1 (fr) * 2000-07-04 2002-01-10 Takeda Chemical Industries, Ltd. Antagoniste de gpr14
US20040053826A1 (en) * 2000-08-10 2004-03-18 Yoshio Matsumoto Uses of polypeptides
CN1317276C (zh) * 2000-09-29 2007-05-23 中国科学院上海药物研究所 一类吲哚基哌啶类化合物及其制备方法和用途
NZ533774A (en) 2001-12-28 2006-08-31 Takeda Pharmaceutical Preventatives/remedies for urinary disturbance
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
MXPA04012534A (es) 2002-06-14 2005-04-19 Toyama Chemical Co Ltd Composicion farmaceutica para mejorar la funcion cerebral y metodo para mejorar la funcion cerebral.
DK1572215T3 (da) 2002-12-20 2010-01-11 Glaxo Group Ltd Benzo[D]azepin-derivater til behandling af neurologiske lidelser
US20080045500A1 (en) * 2004-07-01 2008-02-21 Eisai R&D Management Co., Ltd. Nerve Regeneration Stimulator
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
AU2006326642B2 (en) * 2005-12-09 2012-05-03 Technion Research And Development Foundation Ltd. Use of low-dose ladostigil for neuroprotection
TW200744576A (en) * 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
MX2011000460A (es) * 2008-07-18 2011-03-15 Takeda Pharmaceutical Derivados de benzazepina y su uso como antagonistas de histamina h3.
CA2789014C (en) 2010-02-09 2019-01-15 Michela Gallagher Methods and compositions for improving cognitive function
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
ES2881081T3 (es) 2013-03-15 2021-11-26 Agenebio Inc Procedimientos y composiciones para mejorar la función cognitiva
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
US10925834B2 (en) 2015-05-22 2021-02-23 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
CN109880635B (zh) * 2019-03-19 2021-02-02 石家庄晶奥量新材料有限公司 含有二苯并呋喃并含氧杂环类液晶化合物和组合物及应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
US4208417A (en) * 1978-06-29 1980-06-17 Pharmindustrie Indole derivatives and their use as anxiolytics
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
CA2023492A1 (en) * 1989-08-31 1991-03-01 Barry Clifford Lange Herbicidal glutarimides
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines

Also Published As

Publication number Publication date
ATE124695T1 (de) 1995-07-15
JPH05140149A (ja) 1993-06-08
FI915488A0 (fi) 1991-11-21
NO179868C (no) 1997-01-02
AU643337B2 (en) 1993-11-11
FI982436A (fi) 1998-11-10
FI102965B (fi) 1999-03-31
RU2095361C1 (ru) 1997-11-10
HU211130A9 (en) 1995-10-30
NO179868B (no) 1996-09-23
HU214573B (hu) 2000-04-28
FI982436A0 (fi) 1998-11-10
DE69111029T2 (de) 1995-12-14
HU913643D0 (en) 1992-02-28
GR3017366T3 (en) 1995-12-31
EP0487071A1 (en) 1992-05-27
IE914053A1 (en) 1992-06-03
NO914558L (no) 1992-05-25
DE69111029D1 (de) 1995-08-10
EP0487071B1 (en) 1995-07-05
CN1036458C (zh) 1997-11-19
KR920009823A (ko) 1992-06-25
KR100211437B1 (ko) 1999-08-02
TW197435B (fi) 1993-01-01
CA2055947C (en) 2002-03-12
NZ240676A (en) 1993-05-26
CA2055947A1 (en) 1992-05-23
US5273974A (en) 1993-12-28
ES2074205T3 (es) 1995-09-01
AU8804591A (en) 1992-05-28
NO914558D0 (no) 1991-11-21
IE68346B1 (en) 1996-06-12
JP2650537B2 (ja) 1997-09-03
HUT59676A (en) 1992-06-29
CN1062143A (zh) 1992-06-24
DK0487071T3 (da) 1995-10-30
FI915488A (fi) 1992-05-23

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