MD663G2 - Erythromycin derivatives,method for their preparation and use thereof as drugs - Google Patents

Erythromycin derivatives,method for their preparation and use thereof as drugs

Info

Publication number
MD663G2
MD663G2 MD95-0431A MD950431A MD663G2 MD 663 G2 MD663 G2 MD 663G2 MD 950431 A MD950431 A MD 950431A MD 663 G2 MD663 G2 MD 663G2
Authority
MD
Moldova
Prior art keywords
carbon atoms
hydrogen atom
heteroatoms
formula
saturated
Prior art date
Application number
MD95-0431A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD663F1 (en
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD663F1 publication Critical patent/MD663F1/en
Publication of MD663G2 publication Critical patent/MD663G2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Compounds of general formula (I),wherein R1, and R2 which are the same or different, are a hydrogen atom or a saturated or unsaturated hydrocarbon radical having up to 24 carbon atoms and being optionally interrupted by one or more heteroatoms provided with one or more functional groupings; or R1 and R2, taken together with the nitrogen atom to which they are attached, from a heterocyclic ring optionally containing one or more heteroatoms selected from nitrogen, oxigen and sulphur; or R1 and R2 taken together, forma radical (a) in which R'1 and R'2 which are the same or different, are hydrogen atom or saturated or unsaturated hydrocarbon radical, having up to 23 carbon atoms and being optinally interrupted by one or more heteroatoms and provided with one or more functional groupings, and Z is a hydrogen atom or a carboxylic acid residue having up to 18 carbon atoms; as well as acid addition salts there of formula (I) The compunds of formula (I) have valuable antibiotic properties.
MD95-0431A 1994-04-08 1995-04-06 Erythromycin derivatives,method for their preparation and use thereof as drugs MD663G2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (en) 1994-04-08 1994-04-08 New erythromycin derivatives, their preparation process and their use as drugs.
PCT/FR1995/000441 WO1995027720A1 (en) 1994-04-08 1995-04-06 Novel erythromycin derivatives, method for preparing same and use thereof as drugs

Publications (2)

Publication Number Publication Date
MD663F1 MD663F1 (en) 1997-01-31
MD663G2 true MD663G2 (en) 1997-07-31

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0431A MD663G2 (en) 1994-04-08 1995-04-06 Erythromycin derivatives,method for their preparation and use thereof as drugs

Country Status (49)

Country Link
US (2) US5656607A (en)
EP (1) EP0676409B1 (en)
JP (1) JP3000023B2 (en)
KR (1) KR100317148B1 (en)
CN (1) CN1059445C (en)
AP (1) AP587A (en)
AT (1) ATE234853T1 (en)
AU (1) AU684939B2 (en)
BG (1) BG61916B1 (en)
BR (1) BR9506147A (en)
CA (1) CA2164638C (en)
CO (1) CO4370097A1 (en)
CZ (1) CZ296005B6 (en)
DE (1) DE69529934T2 (en)
DK (1) DK0676409T3 (en)
DZ (1) DZ1869A1 (en)
EE (1) EE04498B1 (en)
ES (1) ES2189820T3 (en)
FI (1) FI111264B (en)
FR (1) FR2718450B1 (en)
GB (1) GB2288174A (en)
GE (1) GEP19991836B (en)
HR (1) HRP950217B1 (en)
HU (1) HU215396B (en)
IL (1) IL112954A (en)
IS (1) IS1865B (en)
JO (1) JO1850B1 (en)
LV (1) LV11182B (en)
MA (1) MA23501A1 (en)
MD (1) MD663G2 (en)
MY (1) MY114672A (en)
NO (1) NO308361B1 (en)
NZ (1) NZ284498A (en)
OA (1) OA10200A (en)
PE (1) PE2896A1 (en)
PL (1) PL180837B1 (en)
PT (1) PT676409E (en)
RO (1) RO115634B1 (en)
RU (1) RU2141965C1 (en)
SA (1) SA97170757A (en)
SI (1) SI0676409T1 (en)
SK (1) SK284079B6 (en)
SV (1) SV1995000018A (en)
TN (1) TNSN95026A1 (en)
TW (1) TW316908B (en)
UA (1) UA44705C2 (en)
WO (1) WO1995027720A1 (en)
YU (1) YU49221B (en)
ZA (1) ZA952059B (en)

Families Citing this family (49)

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FR2732023B1 (en) * 1995-03-22 1997-04-30 Roussel Uclaf NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2742757B1 (en) 1995-12-22 1998-01-30 Roussel Uclaf NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2745289B1 (en) * 1996-02-28 1998-05-29 Roussel Uclaf NOVEL DERIVATIVES OF CARBOXYLIC ACID 1 (2H) QUINOLEIN, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION TO THE SYNTHESIS OF PRODUCTS WITH ANTIBIOTIC PROPERTIES
PT922050E (en) * 1996-05-07 2003-12-31 Abbott Lab 3-DESCLADINOSE-2,3-ANYDROERITROMYCIN DERIVATIVES
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (en) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc NEW PROCESS FOR ISOMERIZATION OF RADICAL METHYL IN 10 FROM ERYTHROMYCIN DERIVATIVES
FR2751656B1 (en) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
UA51730C2 (en) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-0-substituted ketolides having antibacterial activity
ATE296832T1 (en) * 1996-09-04 2005-06-15 Abbott Lab 6-O-SUBSTITUTED KETOLIDES WITH ANTIBACTERIAL ACTION
FR2757168B1 (en) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2760017B1 (en) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc NOVEL ERYTROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6140479A (en) * 1997-03-24 2000-10-31 Taisho Pharmaceuticals Co., Ltd. Erythromycin a derivatives
AU6932098A (en) * 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
KR20010013660A (en) * 1997-06-11 2001-02-26 실버스타인 아써 에이. 9-oxime erythromycin derivatives
FR2771008B1 (en) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc USE OF KETOLIDES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR PREVENTING ARTERIAL THROMBOTIC COMPLICATIONS LINKED TO ATHEROSCLEROSIS
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AU5299499A (en) 1998-09-22 2000-04-10 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (en) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
TR200102129T2 (en) 1998-12-10 2002-01-21 Pfizer Products Inc. Carbamate and carbazate ketolid antibiotics.
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (en) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6395710B1 (en) * 1999-04-16 2002-05-28 Kosan Biosciences, Inc. Macrolide antiinfective agents
MXPA01010521A (en) 1999-04-16 2003-08-19 Johnson & Johnson Ketolide antibacterials.
WO2000071557A1 (en) * 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
JP2006508643A (en) 2002-07-01 2006-03-16 アーキオン ライフ サイエンシーズ エルエルシー ディー／ビー／エー バイオ−テクニカル リソーセズ ディビジョン Processes and materials for the production of glucosamine and N-acetylglucosamine
US7601695B2 (en) * 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
WO2004096823A2 (en) * 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives
CA2523134A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Pyridyl substituted ketolide antibiotics
AU2008316830B2 (en) * 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
DK2358379T3 (en) * 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
CA2793884C (en) 2010-03-22 2019-09-10 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
DK2571506T3 (en) 2010-05-20 2017-08-28 Cempra Pharmaceuticals Inc PROCEDURES FOR THE MANUFACTURE OF MACROLIDES AND KETOLIDES AND INTERMEDIATES
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc Hydrogen bond forming fluoro ketolides for treating diseases
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (en) 2013-03-15 2015-12-23 森普拉制药公司 Convergent processes for preparing macrolide antibacterial agents
CA3130061C (en) 2013-04-04 2024-05-28 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
CA2963815A1 (en) * 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
CA2980315A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
MD1222Z (en) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Process for treating planting material of flowers before planting
JP7199722B2 (en) 2019-12-25 2023-01-06 旭精工株式会社 Coin transport sorting mechanism and coin identification transport device provided with the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (en) * 1992-11-05 1994-05-11 Roussel Uclaf Erythromycin derivatives, their process of preparation and their application as medicaments

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DE2842759A1 (en) * 1978-09-30 1980-04-10 Merck Patent Gmbh BASIC AETHER, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
FR2692579B1 (en) * 1992-06-19 1995-06-02 Roussel Uclaf New picromycin derivatives, their preparation process and their use as medicines.
FR2697524B1 (en) * 1992-11-05 1994-12-23 Roussel Uclaf New erythromycin derivatives, their preparation process and their use as drugs.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (en) * 1993-03-09 1995-04-28 Roussel Uclaf New erythromycin derivatives, their preparation process and their use as drugs.

Patent Citations (1)

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EP0596802A1 (en) * 1992-11-05 1994-05-11 Roussel Uclaf Erythromycin derivatives, their process of preparation and their application as medicaments

Also Published As

Publication number Publication date
EP0676409B1 (en) 2003-03-19
AU2310795A (en) 1995-10-30
FI111264B (en) 2003-06-30
BG100150A (en) 1996-06-28
ATE234853T1 (en) 2003-04-15
EP0676409A1 (en) 1995-10-11
CO4370097A1 (en) 1996-10-07
US5656607A (en) 1997-08-12
CN1126997A (en) 1996-07-17
LV11182B (en) 1997-04-20
CA2164638A1 (en) 1995-10-19
ZA952059B (en) 1996-03-13
RU2141965C1 (en) 1999-11-27
HRP950217B1 (en) 2004-06-30
HRP950217A2 (en) 1997-08-31
IS4309A (en) 1995-11-17
NO954942L (en) 1996-02-07
AU684939B2 (en) 1998-01-08
NO954942D0 (en) 1995-12-06
SV1995000018A (en) 1997-10-24
PE2896A1 (en) 1996-02-12
JP3000023B2 (en) 2000-01-17
GB9506856D0 (en) 1995-05-24
EE9500080A (en) 1996-12-16
NZ284498A (en) 1997-07-27
OA10200A (en) 1996-12-18
UA44705C2 (en) 2002-03-15
SK154695A3 (en) 1996-10-02
AP9500743A0 (en) 1995-07-31
FI955913A0 (en) 1995-12-08
CZ322395A3 (en) 1996-08-14
JPH07278177A (en) 1995-10-24
LV11182A (en) 1996-04-20
SA97170757A (en) 2005-12-03
US5760233A (en) 1998-06-02
HU9503505D0 (en) 1996-02-28
BG61916B1 (en) 1998-09-30
MA23501A1 (en) 1995-12-31
DE69529934T2 (en) 2003-09-04
IS1865B (en) 2003-05-02
GB2288174A (en) 1995-10-11
TNSN95026A1 (en) 1996-02-06
NO308361B1 (en) 2000-09-04
CN1059445C (en) 2000-12-13
RO115634B1 (en) 2000-04-28
JO1850B1 (en) 1995-12-27
YU21695A (en) 1997-12-05
PL180837B1 (en) 2001-04-30
PT676409E (en) 2003-08-29
GEP19991836B (en) 1999-11-05
MY114672A (en) 2002-12-31
IL112954A0 (en) 1995-06-29
ES2189820T3 (en) 2003-07-16
DE69529934D1 (en) 2003-04-24
HUT73772A (en) 1996-09-30
YU49221B (en) 2004-11-25
DZ1869A1 (en) 2002-02-17
KR100317148B1 (en) 2002-06-22
DK0676409T3 (en) 2003-06-23
SI0676409T1 (en) 2003-06-30
TW316908B (en) 1997-10-01
PL311871A1 (en) 1996-03-18
BR9506147A (en) 1996-04-16
AP587A (en) 1997-04-29
SK284079B6 (en) 2004-09-08
IL112954A (en) 2000-07-16
FI955913A (en) 1995-12-08
CA2164638C (en) 2003-12-30
EE04498B1 (en) 2005-06-15
FR2718450B1 (en) 1997-01-10
HU215396B (en) 1998-12-28
FR2718450A1 (en) 1995-10-13
CZ296005B6 (en) 2005-12-14
WO1995027720A1 (en) 1995-10-19
MD663F1 (en) 1997-01-31

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Legal Events

Date Code Title Description
FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20150406

MM4A Patent for invention definitely lapsed due to non-payment of fees