BG100704A - New piperazine derivatives and methods for their preparation as well as of the compounds containing them - Google Patents

New piperazine derivatives and methods for their preparation as well as of the compounds containing them

Info

Publication number
BG100704A
BG100704A BG100704A BG10070496A BG100704A BG 100704 A BG100704 A BG 100704A BG 100704 A BG100704 A BG 100704A BG 10070496 A BG10070496 A BG 10070496A BG 100704 A BG100704 A BG 100704A
Authority
BG
Bulgaria
Prior art keywords
hydrogen
preparation
methods
well
compounds containing
Prior art date
Application number
BG100704A
Other languages
Bulgarian (bg)
Other versions
BG61875B1 (en
Inventor
Eui- Hwan CHO
Sun - Gan CHUNG
Joong-Young Kim
Sun - Hwan LEE
Ho - Seok KWON
Byung-Chul Kim
Jae-Myeong Kong
Jae - Eung LEE
Dong - Wook KANG
Original Assignee
Samjin Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019950043607A external-priority patent/KR0162710B1/en
Priority claimed from PCT/KR1996/000005 external-priority patent/WO1996021648A1/en
Application filed by Samjin Pharmaceutical Co., Ltd. filed Critical Samjin Pharmaceutical Co., Ltd.
Publication of BG100704A publication Critical patent/BG100704A/en
Publication of BG61875B1 publication Critical patent/BG61875B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Abstract

The invention relates to a new compound having the general formula and to acid adjoining of its salts in which formula R1 and R2 mean, reapectively, hydrogen, C1-C8 alkyl or optionally substituted C3-C6-member cycloalkyl containing C3-C6; R3, R4, R5, R6 & R7 being, respectively, hydrogen, halogen, hydroxy, nitro, C1-C4 lower ester, C1-C4 lower alkyl, C1-C4 lower alkoxy, aryl, arylalkoxy or unsaturated aline, l being an integer from 0 to 7, m and n are, respectively, integers from 0 to 1, W is carbon or nitrogen, X - oxygen, sulphur, optionally substituted imine, Y is nitrogen or oxygen, and Z is hydrogen, C1-C8 alkoxy, aryloxy, C1-C4 alkylamine, cycloamine containing N1-N5 or oxogroup. The compounds have strogly expressed antitumour effect and low toxicity, for this reason being new antitumour substances.
BG100704A 1995-01-10 1996-07-08 New piperazine derivatives and methods for their preparation as well as of the compounds containing them BG61875B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19950000399 1995-01-10
KR1019950043607A KR0162710B1 (en) 1995-01-10 1995-11-24 New piperazine derivatives and method for the preparation thereof
PCT/KR1996/000005 WO1996021648A1 (en) 1995-01-11 1996-01-10 New piperazine derivatives and methods for the preparation thereof and compositions containing the same

Publications (2)

Publication Number Publication Date
BG100704A true BG100704A (en) 1997-09-30
BG61875B1 BG61875B1 (en) 1998-08-31

Family

ID=26630861

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100704A BG61875B1 (en) 1995-01-10 1996-07-08 New piperazine derivatives and methods for their preparation as well as of the compounds containing them

Country Status (2)

Country Link
BG (1) BG61875B1 (en)
RU (1) RU2126001C1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI341836B (en) * 2004-03-11 2011-05-11 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
TWI691493B (en) * 2009-06-29 2020-04-21 美商阿吉歐斯製藥公司 Therapeutic compounds and compositions

Also Published As

Publication number Publication date
RU2126001C1 (en) 1999-02-10
BG61875B1 (en) 1998-08-31

Similar Documents

Publication Publication Date Title
CA2184919A1 (en) New Piperazine Derivatives and Methods for the Preparation Thereof and Compositions Containing the Same
PL325341A1 (en) Derivatives od piperazine and method of obtaining them
DE69416501D1 (en) 2-PROPYLVALERIC ACID AND 2-PROPYLVALERIAN ACID AMIDE DERIVATIVES AND THE USE THEREOF AS AN ANTI-CONVULSIVE AGENT
HUP0102404A2 (en) N-acyl cyclic amine derivatives, process for producing them and pharmaceutical compositions containing them
IL104305A0 (en) Piperazine derivatives,their preparation and pharmaceutical compositions containing them
IL150650A0 (en) Piperidine derivatives and pharmaceutical compositions containing the same
NZ240050A (en) Substituted piperazine derivatives; pharmaceutical compositions and preparatory processes
NZ518144A (en) Piperazine Compounds
RU93005332A (en) DERIVATIVES 4,1-BENZOXAZEPINA, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT
DE69332792T2 (en) 4,1-Benzoxazepine derivatives as squalene synthetase inhibitors and their use for the treatment of hypercholesteremia and as fungicides
DE3876813T2 (en) 3 (2H) PYRIDAZINONE, METHOD FOR THE PRODUCTION THEREOF AND ITS CONTAINER AGAINST SRS-A.
BG100704A (en) New piperazine derivatives and methods for their preparation as well as of the compounds containing them
PH24762A (en) 1,6-naphthyridine derivatives, pharmaceutical compositions and method of use
HK1032916A1 (en) N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agents
MX9603308A (en) New piperazine derivatives and methods for the preparation thereof and compositions containing the same.
MY132324A (en) New piperazine derivatives and methods for the preperation thereof and compositions containing the same
RU96120092A (en) NEW PIPERAZIN DERIVATIVES AND METHODS OF THEIR PRODUCTION AND CONTAINING THEIR COMPOSITIONS
ES2006336A6 (en) 2,3-Dihydro-3-phenyl-benzofuran-2-one acetamide derivatives, processes for their preparation and pharmaceutical compositions containing them.
IL49666A (en) 3-imino-1,3,4,5-tetrahydro-2,4-benzothiazepines,their production and pharmaceutical compositions containing them
ES8302712A1 (en) Imidazobenzodiazepines