RO81652B - Procedeu pentru prepararea unor dibenzimidazoazepine - Google Patents

Procedeu pentru prepararea unor dibenzimidazoazepine

Info

Publication number
RO81652B
RO81652B RO103617A RO10361781A RO81652B RO 81652 B RO81652 B RO 81652B RO 103617 A RO103617 A RO 103617A RO 10361781 A RO10361781 A RO 10361781A RO 81652 B RO81652 B RO 81652B
Authority
RO
Romania
Prior art keywords
alkoxy
carbon atoms
halogen
alkyl
general formula
Prior art date
Application number
RO103617A
Other languages
English (en)
Other versions
RO81652A (ro
Inventor
Gerhard Walther
S. Claus Schneider
Karl-Heinz Weber
Armin Fugner
Original Assignee
C.H. Boehringer Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn filed Critical C.H. Boehringer Sohn
Publication of RO81652A publication Critical patent/RO81652A/ro
Publication of RO81652B publication Critical patent/RO81652B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor benzimidazoazepine cu formula generala I: (vezi form. in desc.) în care R1, R2, R3 si R4 reprezinta hidrogen, halogen, alchil sau alcoxi, cu respectiv 1 pîna la 6 atomi de carbon, R5 si R6 reprezinta hidrogen, halogen, alchil sau alcoxi, cu respectiv 1 pîna la 6 atomi de carbon, alchenil cu 3 pîna la 6 atomi de carbon, R5 si R6 reprezinta, de asemenea, împreuna cu atomul de azot un radical pirolidino, piperidino sau morfolino si X reprezinta O, S sau CH2 prin reactia unui compus cu formula generala II: (vezi form. in desc.) în care Y reprezinta halogen de exemplu clor, alcoxi sau alchiltio cu o amida, reactia avînd loc în stare topita sau prin adaugarea de solventi uzuali alesi dintre alcanoli inferiori, cetone alifatice, eteri inferiori, hidrocarburi alifatice sau aromatice, la temperaturi pîna la temperatura de fierbere a solventului.
RO103617A 1980-03-08 1981-03-07 Procedeu pentru prepararea unor dibenzimidazoazepine RO81652B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803008944 DE3008944A1 (de) 1980-03-08 1980-03-08 Dibenzimidazoazepine, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
RO81652A RO81652A (ro) 1983-04-29
RO81652B true RO81652B (ro) 1983-04-30

Family

ID=6096617

Family Applications (1)

Application Number Title Priority Date Filing Date
RO103617A RO81652B (ro) 1980-03-08 1981-03-07 Procedeu pentru prepararea unor dibenzimidazoazepine

Country Status (29)

Country Link
US (1) US4313931A (ro)
EP (1) EP0035749B1 (ro)
JP (1) JPS56139484A (ro)
AU (1) AU535359B2 (ro)
BG (1) BG33886A3 (ro)
CA (1) CA1150253A (ro)
CS (2) CS221288B2 (ro)
DD (1) DD156708A5 (ro)
DE (2) DE3008944A1 (ro)
DK (1) DK154299C (ro)
ES (1) ES8301481A1 (ro)
FI (1) FI70898C (ro)
GB (1) GB2071095B (ro)
GR (1) GR74805B (ro)
HK (1) HK63186A (ro)
HU (1) HU180628B (ro)
IE (1) IE51015B1 (ro)
IL (1) IL62309A (ro)
MX (1) MX6869E (ro)
NO (1) NO162073C (ro)
NZ (1) NZ196446A (ro)
PH (1) PH15839A (ro)
PL (1) PL132141B1 (ro)
PT (1) PT72631B (ro)
RO (1) RO81652B (ro)
SU (1) SU1015829A3 (ro)
UA (1) UA8041A1 (ro)
YU (1) YU42557B (ro)
ZA (1) ZA811500B (ro)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3134672A1 (de) * 1981-09-02 1983-03-17 Boehringer Ingelheim KG, 6507 Ingelheim Heterocyclische verbindungen, ihre herstellung und verwendung
JPS60500176A (ja) * 1982-12-30 1985-02-07 ビ−チヤム　グル−プ　ピ−エルシ− 四環式化合物
DE4102148A1 (de) * 1991-01-25 1992-07-30 Boehringer Ingelheim Kg Verfahren zur herstellung von 3-amino-9,13b-dihydro-1h-dibenz-(c,f)imidazol(1,5-a)azepin-hydrochlorid
DE19542281C2 (de) * 1995-11-14 1997-12-04 Boehringer Ingelheim Kg Verwendung von Epinastin für die Behandlung der Migräne
DE19954516A1 (de) * 1999-11-12 2001-05-17 Boehringer Ingelheim Int Epinastin-haltige Lösungen
DE19958460A1 (de) * 1999-12-03 2001-06-07 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Epinastine-Hydrochlorid in der hochschmelzenden Kristallmodifikation
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
DE10152973A1 (de) * 2001-10-26 2003-05-08 Boehringer Ingelheim Int Neue trockene und wässrige Epinastin-Sirup-Formulierung
JP4298212B2 (ja) * 2002-03-29 2009-07-15 大日本印刷株式会社 塩酸エピナスチン高融点型結晶の製造法
US7196193B2 (en) * 2002-04-11 2007-03-27 Konica Minolta Chemical Co., Ltd. Method for preparing 6-aminomethyl-6, 11-dihydro-5h-dibenz[b,e]azepine
JP4514017B2 (ja) * 2003-03-27 2010-07-28 大日本印刷株式会社 塩酸エピナスチンの製造方法
WO2006058022A1 (en) 2004-11-24 2006-06-01 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
US8758816B2 (en) * 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
EP1901724A1 (en) * 2005-07-08 2008-03-26 Senju Pharmaceutical Co., Ltd. Percutaneously absorptive ophthalmic preparation comprising epinastine
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
KR101386530B1 (ko) 2006-12-29 2014-04-18 케이피엑스 라이프사이언스 주식회사 순도 및 수율이 향상된3-아미노-9,13ｂ디하이드로-1Ｈ-디벤즈-[ｃ,ｆ]이미다조[1,5-ａ]-아제핀 염산염의 제조방법
WO2009063504A2 (en) * 2007-09-24 2009-05-22 Usv Limited Novel crystal modification of epinastine or salts thereof and process for preparation thereof
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
JP2010120960A (ja) * 2010-02-17 2010-06-03 Dainippon Printing Co Ltd 塩酸エピナスチンの製造方法
JP6006634B2 (ja) * 2011-12-28 2016-10-12 東和薬品株式会社 イソウレア化合物を用いるエピナスチンの製造方法
CN103172638B (zh) * 2013-03-13 2015-09-16 北京朗依制药有限公司 一种盐酸依匹斯汀的制备方法
CN104098575B (zh) * 2013-04-15 2016-06-01 四川科瑞德凯华制药有限公司 一种盐酸依匹斯汀晶型及其制备方法和用途
KR102041389B1 (ko) * 2017-12-12 2019-11-27 (주)프론트바이오 N-(9,13b-디하이드로-1H-디벤조[c,f]이미다조[1,5-a]아제핀-3-일)-2-하이드록시벤즈아미드 및 2-((9,13b-디하이드로-1H-디벤조[c,f]이미다조[1,5-a]아제핀-3-일) 카바모일)페닐 아세테이트의 화합물, 이의 제조방법 및 이를 포함하는 항염증 및 진통제 조성물
KR102080239B1 (ko) 2019-08-06 2020-02-21 한양대학교 에리카산학협력단 에피나스틴의 신규 제조방법
CN115974882A (zh) * 2023-02-08 2023-04-18 广州艾格生物科技有限公司 一种盐酸依匹斯汀杂质的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789410A (fr) * 1971-10-05 1973-01-15 Akzo Nv Nieuwe imidazolidine derivaten
NL7202963A (ro) * 1972-03-07 1973-09-11
NL7414038A (nl) * 1974-10-28 1976-05-03 Akzo Nv Nieuwe tetracyclische pyrrolidino derivaten.

Also Published As

Publication number Publication date
PT72631B (fr) 1982-12-30
DK103581A (da) 1981-09-09
HU180628B (en) 1983-03-28
JPH0366311B2 (ro) 1991-10-16
YU56881A (en) 1983-10-31
IE810485L (en) 1981-09-08
DE3163938D1 (en) 1984-07-12
PT72631A (fr) 1981-04-01
NO810762L (no) 1981-09-09
US4313931A (en) 1982-02-02
PH15839A (en) 1983-04-08
GB2071095A (en) 1981-09-16
PL132141B1 (en) 1985-02-28
IL62309A (en) 1984-06-29
NO162073C (no) 1989-11-01
MX6869E (es) 1986-09-11
DK154299C (da) 1989-03-28
NO162073B (no) 1989-07-24
AU535359B2 (en) 1984-03-15
CA1150253A (en) 1983-07-19
ZA811500B (en) 1982-11-24
FI810712L (fi) 1981-09-09
RO81652A (ro) 1983-04-29
GB2071095B (en) 1983-06-02
GR74805B (ro) 1984-07-12
IE51015B1 (en) 1986-09-03
ES500150A0 (es) 1982-12-01
BG33886A3 (en) 1983-05-16
FI70898B (fi) 1986-07-18
JPS56139484A (en) 1981-10-30
DK154299B (da) 1988-10-31
NZ196446A (en) 1984-07-06
FI70898C (fi) 1986-10-27
ES8301481A1 (es) 1982-12-01
EP0035749A1 (de) 1981-09-16
PL230036A1 (ro) 1982-05-24
YU42557B (en) 1988-10-31
AU6815881A (en) 1981-09-17
CS410491A3 (en) 1992-05-13
CS221288B2 (en) 1983-04-29
EP0035749B1 (de) 1984-06-06
IL62309A0 (en) 1981-05-20
UA8041A1 (uk) 1995-12-26
HK63186A (en) 1986-09-05
DE3008944A1 (de) 1981-09-24
DD156708A5 (de) 1982-09-15
SU1015829A3 (ru) 1983-04-30

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