RO82014B - Procedeu pentru prepararea unor derivati de 4-chinolona cu activitate antihipertensiva - Google Patents
Procedeu pentru prepararea unor derivati de 4-chinolona cu activitate antihipertensivaInfo
- Publication number
- RO82014B RO82014B RO105404A RO10540481A RO82014B RO 82014 B RO82014 B RO 82014B RO 105404 A RO105404 A RO 105404A RO 10540481 A RO10540481 A RO 10540481A RO 82014 B RO82014 B RO 82014B
- Authority
- RO
- Romania
- Prior art keywords
- preparation
- general formula
- quinolone derivatives
- antihypertensive action
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de 4-chinolona cu formula generala I: (vezi formula) în care n este 0 sau 2, R este alchil cu 1...3 atomi de carbon si R1 este hidrogen, alchil cu 1...4 atomi de carbon, metoxi, halogen sau trifluormetil, constînd din aceea ca un compus cu formula generala II: (vezi formula) în care X este o grupa aleasa dintre clor si acetoxi, iar R si R1 au semnificatiile de mai sus, rectioneaza cu un compus cu formula generala III: (vezi formula) în care n este 0 sau 2 si reprezinta un metal alcalin, în prezenta unui solvent ales dintre metanol, acetona apoasa si dimetilformamida la o temperatura cuprinsa între 0 degree C si temperatura de reflux.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8031162 | 1980-09-26 | ||
| GB8031106 | 1980-09-26 | ||
| GB8118879 | 1981-06-19 | ||
| GB8119062 | 1981-06-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO82014B true RO82014B (ro) | 1983-05-30 |
| RO82014A RO82014A (ro) | 1983-06-01 |
Family
ID=27449208
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO81105404A RO82014A (ro) | 1980-09-26 | 1981-09-25 | Procedeu pentru prepararea unor derivati de 4-chinolina cu activitateantihipertensiva |
| RO110630A RO85318B (ro) | 1980-09-26 | 1981-09-25 | Procedeu pentru prepararea unor derivati de 4-chinolona cu activitate antihipertensiva |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO110630A RO85318B (ro) | 1980-09-26 | 1981-09-25 | Procedeu pentru prepararea unor derivati de 4-chinolona cu activitate antihipertensiva |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US4442109A (ro) |
| AT (1) | AT379388B (ro) |
| AU (1) | AU549078B2 (ro) |
| BG (2) | BG36495A3 (ro) |
| CA (1) | CA1146943A (ro) |
| CH (1) | CH650254A5 (ro) |
| DD (1) | DD201890A5 (ro) |
| DE (1) | DE3138121A1 (ro) |
| DK (1) | DK152674C (ro) |
| ES (2) | ES8302662A1 (ro) |
| FI (1) | FI812997L (ro) |
| FR (1) | FR2491064A1 (ro) |
| GR (1) | GR75797B (ro) |
| IE (1) | IE51542B1 (ro) |
| IL (1) | IL63845A (ro) |
| IT (1) | IT1189449B (ro) |
| LU (1) | LU83649A1 (ro) |
| NL (1) | NL8104394A (ro) |
| NO (1) | NO154052C (ro) |
| NZ (1) | NZ198414A (ro) |
| PH (1) | PH18605A (ro) |
| PT (1) | PT73666B (ro) |
| RO (2) | RO82014A (ro) |
| SE (1) | SE457533B (ro) |
| YU (2) | YU230181A (ro) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT79031B (en) * | 1983-08-20 | 1986-08-22 | Boots Co Plc | Therapeutic agents |
| DE3578374D1 (de) * | 1984-01-13 | 1990-08-02 | Boots Co Ltd | Verwendung von chinolonen fuer die herstellung eines arzneimittels zur behandlung von herzerkrankungen. |
| DE3576686D1 (de) * | 1984-08-15 | 1990-04-26 | Boots Co Ltd | Chinolinone, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen praeparate. |
| GB8515207D0 (en) * | 1985-06-15 | 1985-07-17 | Boots Co Plc | Therapeutic agents |
| GB8515209D0 (en) * | 1985-06-15 | 1985-07-17 | Boots Co Plc | Therapeutic agents |
| GB8627698D0 (en) * | 1986-11-20 | 1986-12-17 | Boots Co Plc | Therapeutic agents |
| GB8726950D0 (en) * | 1987-11-18 | 1987-12-23 | Boots Co Plc | Chemical process |
| GB8804016D0 (en) * | 1988-02-22 | 1988-03-23 | Boots Co Plc | Therapeutic agents |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3121725A (en) * | 1960-07-18 | 1964-02-18 | Phillips Petroleum Co | N-heterocyclic sulfides, sulfoxides, sulfones, and n-oxides of said sulfoxides and sulfones |
| US3801644A (en) * | 1971-08-25 | 1974-04-02 | Warner Lambert Co | Substituted-o-hydroxy-omega-(methylsulfinyl)acetophenones and process for producing same |
| US3772301A (en) * | 1971-11-22 | 1973-11-13 | Warner Lambert Co | (4-substituted)4-(methylsulfinyl)methylcarbostyrils |
| US4343805A (en) * | 1978-12-16 | 1982-08-10 | John Wyeth & Brother Limited | Heterocyclic compounds |
| GB2038825B (en) * | 1978-12-16 | 1983-02-09 | Wyeth John & Brother Ltd | Heterocyclic compounds substituted by heterocyclyl-alkyl-thio groups |
| NZ193167A (en) * | 1979-03-27 | 1984-08-24 | Boots Co Plc | Quinoline derivatives and pharmaceutical compositions |
| ZA801575B (en) * | 1979-03-27 | 1981-03-25 | Boots Co Ltd | Therapeutic agents |
| US4302360A (en) * | 1980-01-11 | 1981-11-24 | Agency Of Industrial Science & Technology | Catalyst for catalytic combustion of hydrogen |
-
1981
- 1981-09-02 IE IE2033/81A patent/IE51542B1/en unknown
- 1981-09-14 PT PT73666A patent/PT73666B/pt unknown
- 1981-09-14 PH PH26202A patent/PH18605A/en unknown
- 1981-09-16 IL IL63845A patent/IL63845A/xx unknown
- 1981-09-18 GR GR66095A patent/GR75797B/el unknown
- 1981-09-18 FR FR8117630A patent/FR2491064A1/fr active Granted
- 1981-09-21 AU AU75524/81A patent/AU549078B2/en not_active Ceased
- 1981-09-21 US US06/303,948 patent/US4442109A/en not_active Expired - Fee Related
- 1981-09-21 US US06/304,165 patent/US4447435A/en not_active Expired - Fee Related
- 1981-09-21 NZ NZ198414A patent/NZ198414A/xx unknown
- 1981-09-23 BG BG062845A patent/BG36495A3/xx unknown
- 1981-09-23 CA CA000386485A patent/CA1146943A/en not_active Expired
- 1981-09-23 BG BG053612A patent/BG36344A3/xx unknown
- 1981-09-24 NL NL8104394A patent/NL8104394A/nl not_active Application Discontinuation
- 1981-09-24 DE DE19813138121 patent/DE3138121A1/de not_active Ceased
- 1981-09-24 LU LU83649A patent/LU83649A1/fr unknown
- 1981-09-24 YU YU02301/81A patent/YU230181A/xx unknown
- 1981-09-25 RO RO81105404A patent/RO82014A/ro unknown
- 1981-09-25 RO RO110630A patent/RO85318B/ro unknown
- 1981-09-25 ES ES505786A patent/ES8302662A1/es not_active Expired
- 1981-09-25 SE SE8105689A patent/SE457533B/sv not_active IP Right Cessation
- 1981-09-25 AT AT0412181A patent/AT379388B/de not_active IP Right Cessation
- 1981-09-25 NO NO813263A patent/NO154052C/no unknown
- 1981-09-25 DK DK424781A patent/DK152674C/da active
- 1981-09-25 IT IT49370/81A patent/IT1189449B/it active
- 1981-09-25 CH CH6235/81A patent/CH650254A5/fr not_active IP Right Cessation
- 1981-09-25 FI FI812997A patent/FI812997L/fi not_active Application Discontinuation
- 1981-09-28 DD DD81233630A patent/DD201890A5/de unknown
-
1982
- 1982-07-27 ES ES514411A patent/ES8306111A1/es not_active Expired
-
1983
- 1983-07-01 YU YU01446/83A patent/YU144683A/xx unknown
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