DK539589A - Fremgangsmaade til fremstilling af 3-oxo-4-azasteroider - Google Patents

Fremgangsmaade til fremstilling af 3-oxo-4-azasteroider

Info

Publication number
DK539589A
DK539589A DK539589A DK539589A DK539589A DK 539589 A DK539589 A DK 539589A DK 539589 A DK539589 A DK 539589A DK 539589 A DK539589 A DK 539589A DK 539589 A DK539589 A DK 539589A
Authority
DK
Denmark
Prior art keywords
formula
preparing
azasteroids
oxo
procedure
Prior art date
Application number
DK539589A
Other languages
English (en)
Other versions
DK170734B1 (da
DK539589D0 (da
Inventor
Apurba Bhattacharya
Ulf H Dolling
Joseph S Amato
John M Williams
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK539589D0 publication Critical patent/DK539589D0/da
Publication of DK539589A publication Critical patent/DK539589A/da
Application granted granted Critical
Publication of DK170734B1 publication Critical patent/DK170734B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK539589A 1988-10-31 1989-10-30 Fremgangsmåde og mellemprodukt til brug ved fremstilling af 3-oxo-4-azasteroider DK170734B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/264,652 US5237061A (en) 1988-10-31 1988-10-31 Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US26465288 1988-10-31

Publications (3)

Publication Number Publication Date
DK539589D0 DK539589D0 (da) 1989-10-30
DK539589A true DK539589A (da) 1990-05-01
DK170734B1 DK170734B1 (da) 1995-12-27

Family

ID=23007023

Family Applications (1)

Application Number Title Priority Date Filing Date
DK539589A DK170734B1 (da) 1988-10-31 1989-10-30 Fremgangsmåde og mellemprodukt til brug ved fremstilling af 3-oxo-4-azasteroider

Country Status (11)

Country Link
US (1) US5237061A (da)
EP (1) EP0367502B1 (da)
JP (1) JPH0714959B2 (da)
AT (1) ATE127809T1 (da)
CA (1) CA1326013C (da)
CY (1) CY2078B1 (da)
DE (1) DE68924237T2 (da)
DK (1) DK170734B1 (da)
ES (1) ES2078909T3 (da)
HK (1) HK1002707A1 (da)
IE (1) IE67802B1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2050824A1 (en) * 1990-09-24 1992-03-25 John M. Williams Process for making 3-oxo-4-aza-androst-1-ene 17-.beta.-ketones
US5061801A (en) * 1990-09-24 1991-10-29 Merck & Co., Inc. Intermediate for making 3-oxo-4-aza-androst-1-ene 17β-ketones
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5470976A (en) * 1994-09-07 1995-11-28 Merck & Co., Inc. Process for the stereoselective reduction of steroid enelactams
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
GB9727522D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Process for preparing carboxamido-4-azasteroids
ES2153789B1 (es) 1999-07-05 2001-10-16 Raga Consultores S L Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides
US6182013B1 (en) * 1999-07-23 2001-01-30 Schlumberger Technology Corporation Methods and apparatus for dynamically estimating the location of an oil-water interface in a petroleum reservoir
AU6991101A (en) * 2000-09-07 2002-03-22 Reddys Lab Ltd Dr Novel polymorphic form of 17-beta-(n-ter.butyl carbamoyl)-4-aza-5-alpha-androst-1-en-3-one and a process for preparing it
MXPA03002031A (es) 2000-09-07 2004-12-13 Reddys Lab Ltd Dr Forma polimorfica novedosa de 17-beta-(n-tercbutil carbamoil)-4-aza-5-alfa-androst-1-en-3-ona y proceso para preparar la misma.
EP1790653A3 (en) * 2000-09-07 2010-06-02 Dr. Reddy's Laboratories Ltd. Novel polymorphic form of 17-beta-(n-ter.butyl carbamoyl)-4-aza-5-alpha-androst-1-en-3-one and a process for preparing it
US6645974B2 (en) 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
US7149749B2 (en) * 2002-06-03 2006-12-12 International Business Machines Corporation Method of inserting and deleting leaves in tree table structures
ES2206065B1 (es) 2002-10-31 2005-08-16 Ragactives, S.L. Procedimiento para la obtencion de la forma polimorfica i de finasterida.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602099A (en) * 1973-04-02 1986-07-22 Merrell Dow Pharmaceuticals Inc. Antirhinovirus agents
SE7701916L (sv) * 1976-04-27 1977-10-28 Sandoz Ag Organiska foreningar, deras framstellning och anvendning
US4197308A (en) * 1976-11-12 1980-04-08 The Upjohn Company Analgesic N-(2-heterocyclic-amino cycloaliphatic) benzamides
US4179453A (en) * 1978-04-13 1979-12-18 Merck & Co., Inc. Process for preparing 17β-carboxy-5-androsten-3-ones
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4220775A (en) * 1979-03-15 1980-09-02 Merck & Co., Inc. Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
US4460509A (en) * 1981-08-19 1984-07-17 Beth Israel Medical Center Chemical synthesis
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
US4859681A (en) * 1984-02-27 1989-08-22 Merck & Co., Inc. 17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors
FR2571727B1 (fr) * 1984-10-16 1987-06-12 Roussel Uclaf Nouveaux produits steroides comportant, en position 23, un radical dihydro oxazolyle, leur procede de preparation, leur application a la preparation de produits de la serie des 20 cetopregnanes et intermediaires de cette application
DE3780778T2 (de) * 1986-11-20 1993-01-14 Merck & Co Inc Topisches arzneimittel enthaltend 17-beta-methoxy-carbonyl-4-methyl-4-aza-5-alpha-androst-1-en-3-one.
US4845104A (en) * 1986-11-20 1989-07-04 Merck & Co., Inc. Oxidized analogs of 17β-N-monosubstituted-carbamoyl-4-aza-5-α-androstan-3-ones
NZ225100A (en) * 1987-06-29 1991-09-25 Merck & Co Inc Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates

Also Published As

Publication number Publication date
ATE127809T1 (de) 1995-09-15
JPH0714959B2 (ja) 1995-02-22
EP0367502B1 (en) 1995-09-13
JPH02172999A (ja) 1990-07-04
CA1326013C (en) 1994-01-11
DK170734B1 (da) 1995-12-27
ES2078909T3 (es) 1996-01-01
EP0367502A1 (en) 1990-05-09
DK539589D0 (da) 1989-10-30
IE893483L (en) 1990-04-30
HK1002707A1 (en) 1998-09-11
DE68924237D1 (de) 1995-10-19
DE68924237T2 (de) 1996-04-25
CY2078B1 (en) 1998-10-16
US5237061A (en) 1993-08-17
IE67802B1 (en) 1996-05-01

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

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