RO87859B - Procedeu pentru prepararea unor derivati de inidazopirimidina pirezina si triazina - Google Patents
Procedeu pentru prepararea unor derivati de inidazopirimidina pirezina si triazinaInfo
- Publication number
- RO87859B RO87859B RO112929A RO11292983A RO87859B RO 87859 B RO87859 B RO 87859B RO 112929 A RO112929 A RO 112929A RO 11292983 A RO11292983 A RO 11292983A RO 87859 B RO87859 B RO 87859B
- Authority
- RO
- Romania
- Prior art keywords
- alkyl
- imidazopyrimidin
- triazine
- derivatives
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procedeul de preparare a unor derivati de imidazopirimidina, pirazina si triazina cu formula generala (I) în care unul sau doua din simbolurile A1, A2, A3 si A4 reprezinta azot si restul simbolurilor A1, A2, A3 si A4 sunt Ch, cu conditia ca atunci cînd A4 este azot, unul din simbolurile A1, A2 si A3 este azot si cu conditia ca unul din acestea sa poata fi OX, unde X este halogen, R1 reprezinta o grupa de metoxi si R2 reprezinta metoxi, metil-sulfinil sau metisulfonil, consta în aceea ca o aminacu formula generala II: (vezi formula) în care simbolurile A1, A2, A3 si A4 sunt definite ca mai sus, reactioneaza cu o alfa-halocetona cu formula generala (III): (vezi formula) în care substituentii R1, R2 si X sunt definiti ca mai sus, în dimetilformamida sau acetat de etil, la o temperatura cuprinsa între 20 degree si 60 degree C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45356582A | 1982-12-27 | 1982-12-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
RO87859A RO87859A (ro) | 1985-12-30 |
RO87859B true RO87859B (ro) | 1985-12-31 |
Family
ID=23801082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO112929A RO87859B (ro) | 1982-12-27 | 1983-12-19 | Procedeu pentru prepararea unor derivati de inidazopirimidina pirezina si triazina |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0113236B1 (ro) |
JP (1) | JPS59130886A (ro) |
KR (1) | KR840007003A (ro) |
AT (1) | ATE26719T1 (ro) |
AU (1) | AU2288383A (ro) |
CA (1) | CA1262460A (ro) |
CS (1) | CS997783A2 (ro) |
DD (1) | DD210689A5 (ro) |
DE (1) | DE3371081D1 (ro) |
DK (1) | DK595483A (ro) |
ES (1) | ES528275A0 (ro) |
FI (1) | FI834773A (ro) |
GB (1) | GB2132203B (ro) |
GR (1) | GR81509B (ro) |
IL (1) | IL70495A0 (ro) |
NZ (1) | NZ206622A (ro) |
PL (1) | PL245275A1 (ro) |
PT (1) | PT77844B (ro) |
RO (1) | RO87859B (ro) |
SU (1) | SU1255052A3 (ro) |
ZA (1) | ZA839398B (ro) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MC1673A1 (fr) * | 1984-06-27 | 1986-06-03 | Wellcome Found | Derives aryliques de composes imidazoliques,leur preparation et leur emploi pour la preparation des medicaments |
DE3446812A1 (de) * | 1984-12-21 | 1986-06-26 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
DE3446778A1 (de) * | 1984-12-21 | 1986-07-03 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
PT2280706E (pt) | 2008-05-14 | 2013-02-19 | Otsuka Pharma Co Ltd | Composições compreendendo derivados de benzeno que activam lipase de lipoproteína |
CN110483499A (zh) * | 2009-11-05 | 2019-11-22 | 圣母大学 | 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1026321B (de) * | 1955-05-26 | 1958-03-20 | Ind Chimica Profarmaco S R L | Verfahren zur Herstellung von (2, 3, 2', 3')-Imidazol-1, 2, 4-triazinen |
GB1442707A (en) * | 1973-07-07 | 1976-07-14 | Yoshitomi Pharmaceutical | Substituted phenylalkanoic acids and their derivatives and pharma ceutical compositions thereof |
US4166851A (en) * | 1977-05-16 | 1979-09-04 | Merck & Co., Inc. | Certain imidazo(1,2a)pyridine derivatives |
US4151210A (en) * | 1977-06-23 | 1979-04-24 | Ciba-Geigy Corporation | Process for the production of phenylalkyl sulphones |
DE2923602A1 (de) * | 1978-06-23 | 1980-01-10 | Sandoz Ag | Verwendung von substituierten alkylarylsulfoxiden und phenylarylsulfoxiden als photoinitiatoren |
FR2502622A1 (fr) * | 1981-03-25 | 1982-10-01 | Synthelabo | Derives d'imidazo (1,2-a) pyrimidines, leur preparation et leur application en therapeutique |
FR2510576A1 (fr) * | 1981-07-29 | 1983-02-04 | Synthelabo | Derives de phenyl-2 imidazo (1,2-a) pyrimidine, leur preparation et leur application en therapeutique |
-
1983
- 1983-12-19 ZA ZA839398A patent/ZA839398B/xx unknown
- 1983-12-19 NZ NZ206622A patent/NZ206622A/en unknown
- 1983-12-19 RO RO112929A patent/RO87859B/ro unknown
- 1983-12-19 PT PT77844A patent/PT77844B/pt unknown
- 1983-12-20 GR GR73288A patent/GR81509B/el unknown
- 1983-12-20 IL IL70495A patent/IL70495A0/xx unknown
- 1983-12-20 CA CA000443849A patent/CA1262460A/en not_active Expired
- 1983-12-21 DE DE8383307816T patent/DE3371081D1/de not_active Expired
- 1983-12-21 ES ES528275A patent/ES528275A0/es active Granted
- 1983-12-21 GB GB08334096A patent/GB2132203B/en not_active Expired
- 1983-12-21 EP EP83307816A patent/EP0113236B1/en not_active Expired
- 1983-12-21 AT AT83307816T patent/ATE26719T1/de not_active IP Right Cessation
- 1983-12-22 PL PL24527583A patent/PL245275A1/xx unknown
- 1983-12-22 DD DD83258473A patent/DD210689A5/de unknown
- 1983-12-23 DK DK595483A patent/DK595483A/da not_active Application Discontinuation
- 1983-12-23 FI FI834773A patent/FI834773A/fi not_active Application Discontinuation
- 1983-12-23 AU AU22883/83A patent/AU2288383A/en not_active Abandoned
- 1983-12-26 KR KR1019830006176A patent/KR840007003A/ko not_active Application Discontinuation
- 1983-12-26 SU SU833679907A patent/SU1255052A3/ru active
- 1983-12-27 CS CS839977A patent/CS997783A2/cs unknown
- 1983-12-27 JP JP58252289A patent/JPS59130886A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA1262460A (en) | 1989-10-24 |
DE3371081D1 (en) | 1987-05-27 |
DD210689A5 (de) | 1984-06-20 |
IL70495A0 (en) | 1984-03-30 |
NZ206622A (en) | 1986-03-14 |
AU2288383A (en) | 1984-07-05 |
PT77844A (en) | 1984-01-01 |
EP0113236A1 (en) | 1984-07-11 |
CS997783A2 (en) | 1985-06-13 |
ATE26719T1 (de) | 1987-05-15 |
SU1255052A3 (ru) | 1986-08-30 |
GB2132203B (en) | 1986-04-09 |
RO87859A (ro) | 1985-12-30 |
ES8506712A1 (es) | 1985-08-01 |
PL245275A1 (en) | 1985-03-26 |
FI834773A (fi) | 1984-06-28 |
DK595483A (da) | 1984-06-28 |
PT77844B (en) | 1986-05-08 |
JPS59130886A (ja) | 1984-07-27 |
KR840007003A (ko) | 1984-12-04 |
GB2132203A (en) | 1984-07-04 |
ES528275A0 (es) | 1985-08-01 |
FI834773A0 (fi) | 1983-12-23 |
GB8334096D0 (en) | 1984-02-01 |
EP0113236B1 (en) | 1987-04-22 |
ZA839398B (en) | 1985-08-28 |
DK595483D0 (da) | 1983-12-23 |
GR81509B (ro) | 1984-12-11 |
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