RO81944B - Procedeu de preparare a unor imidodisulfamide - Google Patents
Procedeu de preparare a unor imidodisulfamideInfo
- Publication number
- RO81944B RO81944B RO103970A RO10397081A RO81944B RO 81944 B RO81944 B RO 81944B RO 103970 A RO103970 A RO 103970A RO 10397081 A RO10397081 A RO 10397081A RO 81944 B RO81944 B RO 81944B
- Authority
- RO
- Romania
- Prior art keywords
- methyl
- chlorine
- formula
- represents hydrogen
- trifluoromethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
Abstract
Inventia se refera la un procedeu pentru prepararea unor imidosulfamide cu formula generala I: (vezi formula) în care X reprezinta hidrogen, metil, brom sau clor si Y reprezinta un radical benzenaminosulfonil cu formula: (vezi formula) în care R reprezinta hidrogen sau metil, R1 reprezinta hidrogen, clor, nitro, metil, trifluormetil sau metoxi si R2 reprezinta clor R1 sa reprezinte clor, metil sau trifluormetil si cînd R2 reprezinta metil R1 sa reprezinte metil, constînd din aceea ca o tetrahidroizochinolina cu formula generala II: (vezi formula) în care substituentii X si Y au semnificatiile de mai sus reactioneaza cu bis, (clorsulfonil) imida, în prezenta trietilaminei în calitate de baza organica nenucleofila, si a acetronilului ca solvent la temperaturi cuprinse între 0 degree C si temperatura camerei, produsul cu formula generala I putînd sa fie transformat prin metode în sine cunoscute, în saruri de metale alcaline.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14002180A | 1980-04-14 | 1980-04-14 | |
US06/159,340 US4315935A (en) | 1980-04-14 | 1980-06-13 | N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use |
Publications (2)
Publication Number | Publication Date |
---|---|
RO81944B true RO81944B (ro) | 1983-05-30 |
RO81944A RO81944A (ro) | 1983-06-01 |
Family
ID=26837794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO81103970A RO81944A (ro) | 1980-04-14 | 1981-04-08 | Procedeu de preparare a unor imidodisulfamide |
Country Status (25)
Country | Link |
---|---|
US (1) | US4315935A (ro) |
EP (1) | EP0038177B1 (ro) |
KR (1) | KR850000272B1 (ro) |
AR (1) | AR229160A1 (ro) |
AU (1) | AU536754B2 (ro) |
BG (1) | BG35328A3 (ro) |
CA (1) | CA1162545A (ro) |
CS (1) | CS222695B2 (ro) |
DD (1) | DD158240A5 (ro) |
DE (1) | DE3160805D1 (ro) |
DK (1) | DK149846C (ro) |
ES (1) | ES501195A0 (ro) |
FI (1) | FI74702C (ro) |
GR (1) | GR75217B (ro) |
IE (1) | IE51220B1 (ro) |
IL (1) | IL62631A (ro) |
MX (1) | MX6697E (ro) |
NO (1) | NO811278L (ro) |
NZ (1) | NZ196773A (ro) |
PL (1) | PL125404B1 (ro) |
PT (1) | PT72828B (ro) |
RO (1) | RO81944A (ro) |
SU (1) | SU1017169A3 (ro) |
YU (1) | YU98081A (ro) |
ZW (1) | ZW8381A1 (ro) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1582884A (en) * | 1977-05-19 | 1981-01-14 | Beecham Group Ltd | Clavulanic acid derivatives their preparation and use |
ZA804670B (en) * | 1979-08-03 | 1981-07-29 | Beecham Group Ltd | Derivatives of clavulanic acid, a process for their preparation and their use |
NZ199061A (en) * | 1980-12-09 | 1984-10-19 | Beecham Group Ltd | 9-(n-tetrazolyl)-deoxyclavulanic acids,salts,esters,and pharmaceutical compositions |
NZ199200A (en) * | 1980-12-23 | 1984-07-31 | Beecham Group Ltd | Clavulanic acid derivatives and pharmaceutical compositions |
US4385047A (en) * | 1981-01-05 | 1983-05-24 | Smithkline Beckman Corporation | Antiallergic imidodisulfamides |
US4456757A (en) * | 1981-03-20 | 1984-06-26 | Asahi Kasei Kogyo Kabushiki Kaisha | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
US4350698A (en) * | 1981-09-25 | 1982-09-21 | Smithkline Corporation | Antiallergic imidosulfamides |
US4536510A (en) * | 1983-07-22 | 1985-08-20 | Smith Kline Beckman Corporation | Method of antagonizing the effects of thromboxane |
US4678783B1 (en) * | 1983-11-04 | 1995-04-04 | Asahi Chemical Ind | Substituted isoquinolinesulfonyl compounds |
GB8717374D0 (en) * | 1987-07-22 | 1987-08-26 | Smith Kline French Lab | Pharmaceutically active compounds |
DE19719817A1 (de) * | 1997-05-13 | 1998-11-19 | Hoechst Ag | Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren |
CA2408913A1 (en) | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
US20070043231A1 (en) * | 2005-08-22 | 2007-02-22 | Amer Hammami | Process for preparing sulfonylimides and derivatives thereof |
JP5630048B2 (ja) | 2009-03-31 | 2014-11-26 | セントラル硝子株式会社 | イミド酸化合物の製造方法 |
JP5471045B2 (ja) | 2009-06-03 | 2014-04-16 | セントラル硝子株式会社 | イミド酸塩の製造方法 |
AR080374A1 (es) * | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida |
TW201300358A (zh) | 2011-03-14 | 2013-01-01 | 大正製藥股份有限公司 | 含氮縮合雜環化合物 |
CN103524387A (zh) * | 2013-10-25 | 2014-01-22 | 中国海洋石油总公司 | 一种双氟磺酰亚胺锂盐的制备方法 |
CN109721037B (zh) | 2019-03-11 | 2019-12-24 | 上海如鲲新材料有限公司 | 一种双氟磺酰亚胺盐的新工艺 |
CN115010102B (zh) * | 2022-06-29 | 2024-01-26 | 山东凯盛新材料股份有限公司 | 一种双氟磺酰亚胺的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1384530A (en) * | 1971-07-29 | 1975-02-19 | Fisons Ltd | Chromone derivatives |
AT352135B (de) * | 1975-07-30 | 1979-09-10 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer homophthalimide und ihrer salze |
AU506657B2 (en) * | 1975-12-10 | 1980-01-17 | Wellcome Foundation Limited, The | Isoquinoline derivatives |
US4192877A (en) * | 1977-08-01 | 1980-03-11 | Massachusetts General Hospital | Neuromuscular blocking agents |
US4252818A (en) * | 1979-08-02 | 1981-02-24 | Merck & Co., Inc. | Novel benzopyran derivatives |
-
1980
- 1980-06-13 US US06/159,340 patent/US4315935A/en not_active Expired - Lifetime
-
1981
- 1981-04-08 RO RO81103970A patent/RO81944A/ro unknown
- 1981-04-08 AU AU69200/81A patent/AU536754B2/en not_active Ceased
- 1981-04-08 CS CS812653A patent/CS222695B2/cs unknown
- 1981-04-08 CA CA000375005A patent/CA1162545A/en not_active Expired
- 1981-04-08 FI FI811082A patent/FI74702C/fi not_active IP Right Cessation
- 1981-04-09 NZ NZ196773A patent/NZ196773A/xx unknown
- 1981-04-09 EP EP81301551A patent/EP0038177B1/en not_active Expired
- 1981-04-09 ES ES501195A patent/ES501195A0/es active Granted
- 1981-04-09 PT PT72828A patent/PT72828B/pt unknown
- 1981-04-09 DE DE8181301551T patent/DE3160805D1/de not_active Expired
- 1981-04-09 DK DK160681A patent/DK149846C/da not_active IP Right Cessation
- 1981-04-10 ZW ZW83/81A patent/ZW8381A1/xx unknown
- 1981-04-10 IL IL62631A patent/IL62631A/xx unknown
- 1981-04-10 PL PL1981230622A patent/PL125404B1/pl unknown
- 1981-04-10 BG BG8151608A patent/BG35328A3/xx unknown
- 1981-04-13 GR GR64670A patent/GR75217B/el unknown
- 1981-04-13 SU SU813277099A patent/SU1017169A3/ru active
- 1981-04-13 NO NO811278A patent/NO811278L/no unknown
- 1981-04-13 IE IE829/81A patent/IE51220B1/en unknown
- 1981-04-13 KR KR1019810001251A patent/KR850000272B1/ko not_active IP Right Cessation
- 1981-04-14 AR AR284964A patent/AR229160A1/es active
- 1981-04-14 YU YU00980/81A patent/YU98081A/xx unknown
- 1981-04-14 MX MX819405U patent/MX6697E/es unknown
- 1981-04-14 DD DD81229225A patent/DD158240A5/de unknown
Also Published As
Publication number | Publication date |
---|---|
SU1017169A3 (ru) | 1983-05-07 |
CS222695B2 (en) | 1983-07-29 |
IL62631A (en) | 1984-05-31 |
KR830005148A (ko) | 1983-08-03 |
PT72828B (en) | 1982-03-30 |
US4315935A (en) | 1982-02-16 |
AU6920081A (en) | 1981-10-22 |
BG35328A3 (en) | 1984-03-15 |
IE51220B1 (en) | 1986-11-12 |
NO811278L (no) | 1981-10-15 |
DD158240A5 (de) | 1983-01-05 |
YU98081A (en) | 1983-10-31 |
PL125404B1 (en) | 1983-05-31 |
DK160681A (da) | 1981-10-15 |
EP0038177A1 (en) | 1981-10-21 |
FI74702C (fi) | 1988-03-10 |
IE810829L (en) | 1981-10-14 |
CA1162545A (en) | 1984-02-21 |
ES8207145A1 (es) | 1982-09-01 |
AU536754B2 (en) | 1984-05-24 |
PL230622A1 (ro) | 1981-12-23 |
EP0038177B1 (en) | 1983-08-31 |
KR850000272B1 (ko) | 1985-03-15 |
RO81944A (ro) | 1983-06-01 |
GR75217B (ro) | 1984-07-13 |
AR229160A1 (es) | 1983-06-30 |
DK149846B (da) | 1986-10-13 |
ES501195A0 (es) | 1982-09-01 |
PT72828A (en) | 1981-05-01 |
MX6697E (es) | 1985-10-21 |
DE3160805D1 (en) | 1983-10-06 |
ZW8381A1 (en) | 1981-07-08 |
DK149846C (da) | 1987-06-29 |
FI811082L (fi) | 1981-10-15 |
FI74702B (fi) | 1987-11-30 |
NZ196773A (en) | 1983-07-15 |
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