RO90952B - Procedeu pentru prepararea unor derivati de 2-oxindol - Google Patents

Procedeu pentru prepararea unor derivati de 2-oxindol

Info

Publication number
RO90952B
RO90952B RO118055A RO11805585A RO90952B RO 90952 B RO90952 B RO 90952B RO 118055 A RO118055 A RO 118055A RO 11805585 A RO11805585 A RO 11805585A RO 90952 B RO90952 B RO 90952B
Authority
RO
Romania
Prior art keywords
preparation
methoxy
chlorine
fluorine
hydrogen
Prior art date
Application number
RO118055A
Other languages
English (en)
Other versions
RO90952A (ro
Inventor
Saul Bernard Kadin
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of RO90952A publication Critical patent/RO90952A/ro
Publication of RO90952B publication Critical patent/RO90952B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de 2-oxindol cu formula generala I : în care X este un atom de hidrogen, clor, fluor sau brom sau o grupa trifluormetil, metil, metoxi, metultio, nitro, fenil, bonzoil, tenoil sau acetil, Y este un atom de hidrogen, fluor, clor, o grupa metoxi sau metil sau X si Y formeaza împreuna o grupa metilendioxi sau o catena cu formula : ......................
RO118055A 1984-03-19 1985-03-19 Procedeu pentru prepararea unor derivati de 2-oxindol RO90952B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59065984A 1984-03-19 1984-03-19
US06/684,634 US4556672A (en) 1984-03-19 1984-12-21 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents

Publications (2)

Publication Number Publication Date
RO90952A RO90952A (ro) 1987-02-27
RO90952B true RO90952B (ro) 1987-03-01

Family

ID=27080909

Family Applications (1)

Application Number Title Priority Date Filing Date
RO118055A RO90952B (ro) 1984-03-19 1985-03-19 Procedeu pentru prepararea unor derivati de 2-oxindol

Country Status (36)

Country Link
US (1) US4556672A (ro)
EP (1) EP0156603B1 (ro)
JP (1) JPH04235165A (ro)
KR (1) KR860001873B1 (ro)
AT (1) ATE45731T1 (ro)
AU (1) AU549927B2 (ro)
BG (1) BG60347B2 (ro)
CA (2) CA1251441A (ro)
CS (1) CS249539B2 (ro)
CY (1) CY1668A (ro)
DE (1) DE3572481D1 (ro)
DK (1) DK162090C (ro)
EG (1) EG17795A (ro)
ES (1) ES541372A0 (ro)
FI (2) FI82042C (ro)
GR (1) GR850668B (ro)
HK (1) HK78392A (ro)
HU (1) HU196178B (ro)
IE (1) IE57743B1 (ro)
IL (3) IL74631A (ro)
LV (1) LV5618A3 (ro)
MA (1) MA20380A1 (ro)
MY (1) MY101987A (ro)
NL (1) NL940025I2 (ro)
NO (1) NO165799C (ro)
NZ (2) NZ224134A (ro)
OA (1) OA07966A (ro)
PH (2) PH21323A (ro)
PL (1) PL145951B1 (ro)
PT (1) PT80117B (ro)
RO (1) RO90952B (ro)
SI (1) SI8510440A8 (ro)
SU (1) SU1445556A3 (ro)
UA (1) UA6343A1 (ro)
YU (1) YU43870B (ro)
ZW (1) ZW4785A1 (ro)

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Also Published As

Publication number Publication date
PH21323A (en) 1987-09-28
ES8603408A1 (es) 1985-12-16
SU1445556A3 (ru) 1988-12-15
FI82449C (fi) 1991-03-11
FI894540L (fi) 1989-09-26
IL74631A0 (en) 1985-06-30
CS249539B2 (en) 1987-03-12
ATE45731T1 (de) 1989-09-15
CY1668A (en) 1993-05-14
DK121385D0 (da) 1985-03-18
JPH0561269B2 (ro) 1993-09-06
GR850668B (ro) 1985-07-16
KR850006173A (ko) 1985-10-02
EP0156603A3 (en) 1986-02-12
NO165799C (no) 1991-04-10
MA20380A1 (fr) 1985-10-01
NL940025I2 (nl) 2000-01-03
IE57743B1 (en) 1993-03-24
RO90952A (ro) 1987-02-27
EP0156603A2 (en) 1985-10-02
FI851069A0 (fi) 1985-03-18
BG60347B2 (bg) 1994-09-30
UA6343A1 (uk) 1994-12-29
KR860001873B1 (ko) 1986-10-24
CA1251441A (en) 1989-03-21
DK162090B (da) 1991-09-16
CA1288422C (en) 1991-09-03
HK78392A (en) 1992-10-23
NL940025I1 (nl) 1995-02-01
NO165799B (no) 1991-01-02
OA07966A (fr) 1987-01-31
ZW4785A1 (en) 1985-06-19
PL252434A1 (en) 1985-12-03
AU4005985A (en) 1985-09-26
ES541372A0 (es) 1985-12-16
IL74631A (en) 1988-07-31
HU196178B (en) 1988-10-28
IE850684L (en) 1985-09-19
DK162090C (da) 1992-02-24
LV5618A3 (lv) 1994-05-10
YU44085A (en) 1988-02-29
IL85130A (en) 1988-07-31
EG17795A (en) 1990-08-30
JPH04235165A (ja) 1992-08-24
HUT37398A (en) 1985-12-28
FI82042B (fi) 1990-09-28
YU43870B (en) 1989-12-31
PL145951B1 (en) 1988-12-31
FI851069L (fi) 1985-09-20
US4556672A (en) 1985-12-03
IL85130A0 (en) 1988-06-30
SI8510440A8 (sl) 1996-06-30
DK121385A (da) 1985-09-20
PT80117A (en) 1985-04-01
FI82042C (fi) 1991-01-10
EP0156603B1 (en) 1989-08-23
NZ224134A (en) 1988-10-28
PH21470A (en) 1987-10-28
NO851054L (no) 1985-09-20
FI894540A0 (fi) 1989-09-26
DE3572481D1 (en) 1989-09-28
NZ211486A (en) 1988-10-28
FI82449B (fi) 1990-11-30
AU549927B2 (en) 1986-02-20
PT80117B (pt) 1987-10-20
MY101987A (en) 1992-02-29

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