MA20380A1 - Procede de production d'un 2-oxindole-1-carboxamide et produit obtenu - Google Patents

Procede de production d'un 2-oxindole-1-carboxamide et produit obtenu

Info

Publication number
MA20380A1
MA20380A1 MA20604A MA20604A MA20380A1 MA 20380 A1 MA20380 A1 MA 20380A1 MA 20604 A MA20604 A MA 20604A MA 20604 A MA20604 A MA 20604A MA 20380 A1 MA20380 A1 MA 20380A1
Authority
MA
Morocco
Prior art keywords
alkyl
optionally substituted
oxindole
bicyclo
compounds
Prior art date
Application number
MA20604A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA20380A1 publication Critical patent/MA20380A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
MA20604A 1984-03-19 1985-03-18 Procede de production d'un 2-oxindole-1-carboxamide et produit obtenu MA20380A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59065984A 1984-03-19 1984-03-19
US06/684,634 US4556672A (en) 1984-03-19 1984-12-21 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents

Publications (1)

Publication Number Publication Date
MA20380A1 true MA20380A1 (fr) 1985-10-01

Family

ID=27080909

Family Applications (1)

Application Number Title Priority Date Filing Date
MA20604A MA20380A1 (fr) 1984-03-19 1985-03-18 Procede de production d'un 2-oxindole-1-carboxamide et produit obtenu

Country Status (36)

Country Link
US (1) US4556672A (fr)
EP (1) EP0156603B1 (fr)
JP (1) JPH04235165A (fr)
KR (1) KR860001873B1 (fr)
AT (1) ATE45731T1 (fr)
AU (1) AU549927B2 (fr)
BG (1) BG60347B2 (fr)
CA (2) CA1251441A (fr)
CS (1) CS249539B2 (fr)
CY (1) CY1668A (fr)
DE (1) DE3572481D1 (fr)
DK (1) DK162090C (fr)
EG (1) EG17795A (fr)
ES (1) ES8603408A1 (fr)
FI (2) FI82042C (fr)
GR (1) GR850668B (fr)
HK (1) HK78392A (fr)
HU (1) HU196178B (fr)
IE (1) IE57743B1 (fr)
IL (3) IL85130A (fr)
LV (1) LV5618A3 (fr)
MA (1) MA20380A1 (fr)
MY (1) MY101987A (fr)
NL (1) NL940025I2 (fr)
NO (1) NO165799C (fr)
NZ (2) NZ224134A (fr)
OA (1) OA07966A (fr)
PH (2) PH21323A (fr)
PL (1) PL145951B1 (fr)
PT (1) PT80117B (fr)
RO (1) RO90952B (fr)
SI (1) SI8510440A8 (fr)
SU (1) SU1445556A3 (fr)
UA (1) UA6343A1 (fr)
YU (1) YU43870B (fr)
ZW (1) ZW4785A1 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
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US4686224A (en) * 1984-10-31 1987-08-11 Pfizer Inc. Oxindole antiinflammatory agents
US4678802A (en) * 1985-07-09 1987-07-07 Pfizer Inc. 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
EP0208510B1 (fr) * 1985-07-09 1991-09-11 Pfizer Inc. Oxindole-3-carboxamines substituées utilisées analgésiques et anti-inflammatoires
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
US5036099A (en) * 1987-02-02 1991-07-30 Pfizer Inc. Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide
US4761485A (en) * 1987-03-11 1988-08-02 Pfizer Inc. Synthetic method for indol-2(3H)-ones
US4885370A (en) * 1987-03-11 1989-12-05 Pfizer Inc. Synthetic method for indol-2(3H)-ones
GB8720693D0 (en) * 1987-09-03 1987-10-07 Glaxo Group Ltd Chemical compounds
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4853409A (en) * 1988-04-13 1989-08-01 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
US4861794A (en) * 1988-04-13 1989-08-29 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
EP0365194B1 (fr) * 1988-10-18 1995-08-02 Pfizer Inc. Prodrogues de 3-aryl-2-oxindole-1-carboxamide antiinflammatoires
WO1990004393A1 (fr) * 1988-10-18 1990-05-03 Pfizer Inc. Promedicaments de 3-acyle-2-indoxyle-1-carboxamides anti-inflammatoires
HU215112B (hu) * 1989-01-10 1998-12-28 Pfizer Inc. Eljárás gyulladáscsökkentő 1-heteroaril-3-acil-2-oxindol-származékok előállítására
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5059693A (en) * 1989-10-06 1991-10-22 Pfizer Inc. Process for making 3-aroyl-2-oxindole-1-carboxamides
IL95880A (en) * 1989-10-13 1995-12-31 Pfizer Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis
WO1991009598A1 (fr) * 1990-01-05 1991-07-11 Pfizer Inc. Derives de l'azaoxindole
US5008283A (en) * 1990-03-19 1991-04-16 Pfizer Inc. Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5006547A (en) * 1990-03-19 1991-04-09 Pfizer Inc. Tenidap as an inhibitor of the release of elastase by neutrophils
US5064851A (en) * 1990-07-24 1991-11-12 Pfizer Inc. 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
US5122534A (en) * 1991-02-08 1992-06-16 Pfizer Inc. Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
DE4111305C2 (de) * 1991-04-08 1994-12-01 Mack Chem Pharm Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
DE4111306C2 (de) * 1991-04-08 1994-06-01 Mack Chem Pharm Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind
US5210212A (en) * 1991-06-25 1993-05-11 Pfizer Inc Process for 5-fluoro-6-chlorooxindole
US5166401A (en) * 1991-06-25 1992-11-24 Pfizer Inc Intermediates for 5-fluoro-6-chlorooxindole
TW438798B (en) * 1992-10-07 2001-06-07 Pfizer 3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions
US5288743A (en) * 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
DK0680321T3 (da) * 1993-01-22 1999-06-14 Pfizer Lysinsalt af 6-chlor-5-fluor-3-(2-thenoyl)-2-oxindol-1-carboxamid
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US5270331A (en) * 1993-01-26 1993-12-14 Pfizer, Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
DE69305999T2 (de) * 1993-02-09 1997-03-06 Pfizer Inc., New York, N.Y. Oxindol 1-[n-(alkoxycarbonyl)]carboxamide und 1-[n-carboxamido]carboxamide als antiinflammatorische wirkstoffe
ES2076106B1 (es) * 1993-08-26 1996-06-16 Pfizer Composiciones farmaceuticas a base de 2-oxindol-1-carboxamidas 3-sustituidas
US5449788A (en) * 1994-01-28 1995-09-12 Catalytica, Inc. Process for preparing 2-oxindole-1-carboxamides
EP0679396A1 (fr) * 1994-03-02 1995-11-02 Pfizer Inc. Utilisation de dérivés oxindol-2-carboxamides-1,3-substitués pour la fabrication d'un médicament destiné au traiter des dommages du myocardes causés par une ischémie et les dommages du myocardes induits par les cytokines
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US5545656A (en) * 1995-04-05 1996-08-13 Pfizer Inc. 2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
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IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
IT1318673B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Farmaci per le disfunzioni sessuali.
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102911105B (zh) * 2012-11-12 2013-12-04 辽宁科技大学 一种3-芳酰基吲哚化合物的合成方法
CA2981066A1 (fr) * 2015-03-31 2016-10-06 Monsanto Technology Llc Procedes de preparation de chlorure de 2-thiophenecarbonyle
WO2016179157A1 (fr) 2015-05-05 2016-11-10 Carafe Drug Innovation, Llc 5-hydroxyoxindoles substitués et leur utilisation en tant qu'analgésiques et réducteurs de fièvre
BR112018069255A2 (pt) 2016-03-24 2019-01-22 Monsanto Technology Llc processos para a preparação de ácidos heteroaril carboxílicos

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Also Published As

Publication number Publication date
HUT37398A (en) 1985-12-28
DK162090C (da) 1992-02-24
CA1288422C (fr) 1991-09-03
HK78392A (en) 1992-10-23
IL74631A0 (en) 1985-06-30
FI82449B (fi) 1990-11-30
FI82449C (fi) 1991-03-11
YU43870B (en) 1989-12-31
FI82042C (fi) 1991-01-10
DK121385D0 (da) 1985-03-18
DE3572481D1 (en) 1989-09-28
IE850684L (en) 1985-09-19
GR850668B (fr) 1985-07-16
NZ211486A (en) 1988-10-28
KR850006173A (ko) 1985-10-02
FI894540A (fi) 1989-09-26
PH21470A (en) 1987-10-28
PL145951B1 (en) 1988-12-31
PH21323A (en) 1987-09-28
IL85130A0 (en) 1988-06-30
NZ224134A (en) 1988-10-28
YU44085A (en) 1988-02-29
NO851054L (no) 1985-09-20
MY101987A (en) 1992-02-29
AU549927B2 (en) 1986-02-20
DK121385A (da) 1985-09-20
FI894540A0 (fi) 1989-09-26
DK162090B (da) 1991-09-16
IE57743B1 (en) 1993-03-24
ES541372A0 (es) 1985-12-16
EP0156603A3 (en) 1986-02-12
CA1251441A (fr) 1989-03-21
EG17795A (en) 1990-08-30
KR860001873B1 (ko) 1986-10-24
CS249539B2 (en) 1987-03-12
HU196178B (en) 1988-10-28
FI851069A0 (fi) 1985-03-18
OA07966A (fr) 1987-01-31
EP0156603B1 (fr) 1989-08-23
NO165799C (no) 1991-04-10
PL252434A1 (en) 1985-12-03
CY1668A (en) 1993-05-14
LV5618A3 (lv) 1994-05-10
US4556672A (en) 1985-12-03
JPH0561269B2 (fr) 1993-09-06
IL85130A (en) 1988-07-31
NL940025I2 (nl) 2000-01-03
UA6343A1 (uk) 1994-12-29
ZW4785A1 (en) 1985-06-19
JPH04235165A (ja) 1992-08-24
RO90952B (ro) 1987-03-01
NO165799B (no) 1991-01-02
AU4005985A (en) 1985-09-26
EP0156603A2 (fr) 1985-10-02
BG60347B2 (bg) 1994-09-30
FI851069L (fi) 1985-09-20
PT80117A (en) 1985-04-01
ATE45731T1 (de) 1989-09-15
SU1445556A3 (ru) 1988-12-15
RO90952A (fr) 1987-02-27
NL940025I1 (nl) 1995-02-01
IL74631A (en) 1988-07-31
PT80117B (pt) 1987-10-20
FI82042B (fi) 1990-09-28
SI8510440A8 (sl) 1996-06-30
ES8603408A1 (es) 1985-12-16

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