RO90953B - Procedeu pentru prepararea unor derivati de 2-oxindol-1-carboxamida - Google Patents

Procedeu pentru prepararea unor derivati de 2-oxindol-1-carboxamida

Info

Publication number
RO90953B
RO90953B RO118054A RO11805485A RO90953B RO 90953 B RO90953 B RO 90953B RO 118054 A RO118054 A RO 118054A RO 11805485 A RO11805485 A RO 11805485A RO 90953 B RO90953 B RO 90953B
Authority
RO
Romania
Prior art keywords
oxindole
carboxamide derivatives
preparing
methylthio
trifluoromethyl
Prior art date
Application number
RO118054A
Other languages
English (en)
Other versions
RO90953A (ro
Inventor
Thomas Charles Crowford
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of RO90953A publication Critical patent/RO90953A/ro
Publication of RO90953B publication Critical patent/RO90953B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de 2-oxindol-1-carboxamida cu formula generala I : în care x este hidrogen, fluor, clor, metil, metoxi, trifluormetil, metiltio, nitro, benzoil, acetil si 2 tenoil, Y este hidrogen, fluor, clor, metil, metoxi, metiltio, trifluormetil si fenil sau X si Y luati împreuna formeaza o grupa 5,6-metilen-dioxi sau o catena cu formula:........................
RO118054A 1984-03-19 1985-03-19 Procedeu pentru prepararea unor derivati de 2-oxindol-1-carboxamida RO90953B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59066784A 1984-03-19 1984-03-19
US68488984A 1984-12-21 1984-12-21

Publications (2)

Publication Number Publication Date
RO90953A RO90953A (ro) 1987-02-27
RO90953B true RO90953B (ro) 1987-02-28

Family

ID=27080914

Family Applications (1)

Application Number Title Priority Date Filing Date
RO118054A RO90953B (ro) 1984-03-19 1985-03-19 Procedeu pentru prepararea unor derivati de 2-oxindol-1-carboxamida

Country Status (29)

Country Link
EP (1) EP0155828B1 (ro)
JP (1) JPH03178963A (ro)
KR (1) KR860001874B1 (ro)
AR (1) AR247885A1 (ro)
AU (1) AU552119B2 (ro)
BG (1) BG44203A3 (ro)
CA (1) CA1250832A (ro)
CS (1) CS250680B2 (ro)
CY (1) CY1667A (ro)
DE (1) DE3579716D1 (ro)
DK (2) DK163662C (ro)
EG (1) EG17274A (ro)
ES (1) ES541373A0 (ro)
FI (1) FI85265C (ro)
GR (1) GR850669B (ro)
HK (1) HK75992A (ro)
HU (1) HU194825B (ro)
IE (1) IE57741B1 (ro)
IL (1) IL74630A (ro)
MA (1) MA20379A1 (ro)
NO (1) NO168639C (ro)
NZ (1) NZ211487A (ro)
OA (1) OA07967A (ro)
PH (1) PH20843A (ro)
PL (1) PL145873B1 (ro)
PT (1) PT80116B (ro)
RO (1) RO90953B (ro)
YU (1) YU43869B (ro)
ZW (1) ZW4885A1 (ro)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE63543T1 (de) * 1984-02-07 1991-06-15 Pfizer 2-oxindolzwischenprodukte.
US4686224A (en) * 1984-10-31 1987-08-11 Pfizer Inc. Oxindole antiinflammatory agents
DE3621761A1 (de) * 1986-06-28 1988-01-07 Bayer Ag Indolylpropionsaeuren
RO105052B1 (en) * 1987-02-02 1994-12-01 Pfizer Producing process for the crystalline sodium salt, anhydre, of 5-chlorine-3-(2-tenoil)-2-oxindol-1-carboxamide
GB8720693D0 (en) * 1987-09-03 1987-10-07 Glaxo Group Ltd Chemical compounds
US4952703A (en) * 1989-05-25 1990-08-28 Pfizer Inc. Intermediates for making 2-oxindole-1-carboxamides
HUP9600855A3 (en) * 1996-04-03 1998-04-28 Egyt Gyogyszervegyeszeti Gyar Process for producing tenidap
US7186745B2 (en) 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3767653A (en) * 1971-06-28 1973-10-23 Squibb & Sons Inc Thiazines

Also Published As

Publication number Publication date
IL74630A (en) 1988-04-29
DE3579716D1 (de) 1990-10-25
HUT37397A (en) 1985-12-28
HK75992A (en) 1992-10-09
NO168639B (no) 1991-12-09
NO851059L (no) 1985-09-20
PH20843A (en) 1987-05-08
CS250680B2 (en) 1987-05-14
AU4005885A (en) 1985-09-26
PT80116B (pt) 1987-10-20
GR850669B (ro) 1985-07-25
JPH0525875B2 (ro) 1993-04-14
DK64591D0 (da) 1991-04-11
KR850006174A (ko) 1985-10-02
RO90953A (ro) 1987-02-27
ES8603409A1 (es) 1985-12-16
CA1253490C (ro) 1989-05-02
EG17274A (en) 1989-06-30
AR247885A1 (es) 1995-04-28
FI85265B (fi) 1991-12-13
PT80116A (en) 1985-04-01
DK64591A (da) 1991-04-11
IE850683L (en) 1985-09-19
EP0155828A3 (en) 1986-02-05
DK165179B (da) 1992-10-19
EP0155828A2 (en) 1985-09-25
ES541373A0 (es) 1985-12-16
MA20379A1 (fr) 1985-10-01
PL252433A1 (en) 1985-12-03
DK163662C (da) 1992-08-31
FI851068A0 (fi) 1985-03-18
BG44203A3 (en) 1988-10-14
DK121485D0 (da) 1985-03-18
JPH03178963A (ja) 1991-08-02
YU42885A (en) 1987-10-31
NO168639C (no) 1992-03-18
DK121485A (da) 1985-09-20
HU194825B (en) 1988-03-28
EP0155828B1 (en) 1990-09-19
FI851068L (fi) 1985-09-20
AU552119B2 (en) 1986-05-22
DK163662B (da) 1992-03-23
ZW4885A1 (en) 1985-06-26
PL145873B1 (en) 1988-11-30
IE57741B1 (en) 1993-03-24
CA1250832A (en) 1989-03-07
OA07967A (fr) 1987-01-31
DK165179C (da) 1993-03-01
YU43869B (en) 1989-12-31
IL74630A0 (en) 1985-06-30
NZ211487A (en) 1988-11-29
KR860001874B1 (ko) 1986-10-24
CY1667A (en) 1993-05-14
FI85265C (fi) 1992-03-25

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