ES2038205T3 - Reduccion de ceto mejorada de productos intermedios de carbaciclina. - Google Patents
Reduccion de ceto mejorada de productos intermedios de carbaciclina.Info
- Publication number
- ES2038205T3 ES2038205T3 ES198787730147T ES87730147T ES2038205T3 ES 2038205 T3 ES2038205 T3 ES 2038205T3 ES 198787730147 T ES198787730147 T ES 198787730147T ES 87730147 T ES87730147 T ES 87730147T ES 2038205 T3 ES2038205 T3 ES 2038205T3
- Authority
- ES
- Spain
- Prior art keywords
- atoms
- residue
- coor
- carbacicline
- ceto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- NZTVVUIIJPWANB-UHFFFAOYSA-N 3,3a,4,5,6,6a-hexahydro-2h-pentalen-1-one Chemical class C1CCC2C(=O)CCC21 NZTVVUIIJPWANB-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE ALFA-HIDROXIBICICLO [3,3,0] OCTANO, DE FORMULA (I), DONDE A ES EL RESTO O-X-O- CON X COMO ALQUILO DE CADENA RECTA O RAMIFICADA CON 1-7 ATOMOS DE C O LOS RESTOS =CH-(CH2)3-COOR'', =CH-CH2-O-CH2-COOR'' O =CH-(CH2)3-=-CH2-CH2-COOR'' CON R'' COMO C1-C7-ALQUILO, R ES EL RESTO (III) CON R" COMO HIDROGENO O FENILO O EL RESTO -SIR1R2R3, DONDE R1, R2 Y R3 PUEDEN SER IGUALES O DIFERENTES Y SON UN GRUPO ALQUILO DE CADENA RECTA O RAMIFICADA CON 1-7 ATOMOS DE C O FENILO; B ES UN GRUPO TRANS-CH=C(X) CON X COMO HIDROGENO O BROMO, ESTANDO LA CONFIGURACION TRANS SOBRE LA CADENA C, Y D ES UN GRUPO ALQUILO CON 1-10 ATOMOS DE C, UN GRUPO ALQUENILO CON 1-10 ATOMOS DE C O UN GRUP ALQUINILO CON 1-10 ATOMOS DE C. LOS DRIVADOS CETO-BICICLO [3,3,0] DE FORMULA (II) SE REDUCEN EN PRESENCIA DE SALES DE CERIO-III.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863638761 DE3638761A1 (de) | 1986-11-13 | 1986-11-13 | Verbesserte ketoreduktion von carbacyclinzwischenprodukten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2038205T3 true ES2038205T3 (es) | 1993-07-16 |
Family
ID=6313861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198787730147T Expired - Lifetime ES2038205T3 (es) | 1986-11-13 | 1987-11-12 | Reduccion de ceto mejorada de productos intermedios de carbaciclina. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5200530A (es) |
| EP (1) | EP0268548B1 (es) |
| JP (1) | JP2596575B2 (es) |
| AT (1) | ATE66472T1 (es) |
| AU (1) | AU610101B2 (es) |
| CA (1) | CA1326238C (es) |
| CS (1) | CS271479B2 (es) |
| DD (1) | DD265623A5 (es) |
| DE (2) | DE3638761A1 (es) |
| ES (1) | ES2038205T3 (es) |
| GR (1) | GR3002974T3 (es) |
| HU (1) | HU199447B (es) |
| IE (1) | IE59349B1 (es) |
| WO (1) | WO1988003527A1 (es) |
| ZA (1) | ZA878504B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3638757A1 (de) * | 1986-11-13 | 1988-05-26 | Schering Ag | Neues verfahren zur herstellung von optisch aktiven carbacyclin-zwischenstufen |
| DE3835162A1 (de) * | 1988-10-13 | 1990-04-19 | Schering Ag | (1s,2s,3r,5r)-2-((3s)-2-halogen-3-hydroxy-1-alken(inyl))-3-trialkylsilyloxy-7,7-(2,2-dimethyl-trimethylendioxy)-bicyclo-(3.3.0)-octan-verbindungen und verfahren zu deren herstellung |
| FR2763777B1 (fr) | 1997-05-22 | 1999-08-13 | Sgs Thomson Microelectronics | Circuit de commande d'une membrane vibrante |
| WO2004094343A1 (en) * | 2003-04-22 | 2004-11-04 | Biocon Limited | NOVEL PROCESS FOR STEREOSELECTIVE REDUCTION OF ß-KETOESTERS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3225288A1 (de) * | 1982-07-02 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS60172941A (ja) * | 1984-02-16 | 1985-09-06 | Sankyo Co Ltd | カルバサイクリン類 |
| ES8705382A1 (es) * | 1983-07-26 | 1987-05-01 | Sankyo Co | Un procedimiento para la preparacion de nuevos derivados de carbaciclina. |
| US4522949A (en) * | 1983-10-20 | 1985-06-11 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful as cardiovascular agents |
| DE3405181A1 (de) * | 1984-02-10 | 1985-08-22 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
-
1986
- 1986-11-13 DE DE19863638761 patent/DE3638761A1/de not_active Withdrawn
-
1987
- 1987-11-05 DD DD87308710A patent/DD265623A5/de not_active IP Right Cessation
- 1987-11-06 CS CS877982A patent/CS271479B2/cs not_active IP Right Cessation
- 1987-11-12 ZA ZA878504A patent/ZA878504B/xx unknown
- 1987-11-12 ES ES198787730147T patent/ES2038205T3/es not_active Expired - Lifetime
- 1987-11-12 CA CA000551617A patent/CA1326238C/en not_active Expired - Lifetime
- 1987-11-12 AT AT87730147T patent/ATE66472T1/de not_active IP Right Cessation
- 1987-11-12 US US07/772,762 patent/US5200530A/en not_active Expired - Lifetime
- 1987-11-12 EP EP87730147A patent/EP0268548B1/de not_active Expired - Lifetime
- 1987-11-12 HU HU875805A patent/HU199447B/hu unknown
- 1987-11-12 IE IE304887A patent/IE59349B1/en not_active IP Right Cessation
- 1987-11-12 AU AU82363/87A patent/AU610101B2/en not_active Ceased
- 1987-11-12 DE DE8787730147T patent/DE3772332D1/de not_active Expired - Lifetime
- 1987-11-12 JP JP62506740A patent/JP2596575B2/ja not_active Expired - Lifetime
- 1987-11-12 WO PCT/DE1987/000519 patent/WO1988003527A1/de unknown
-
1991
- 1991-10-23 GR GR91401608T patent/GR3002974T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5200530A (en) | 1993-04-06 |
| WO1988003527A1 (en) | 1988-05-19 |
| DE3772332D1 (de) | 1991-09-26 |
| CS798287A2 (en) | 1989-09-12 |
| HU199447B (en) | 1990-02-28 |
| IE873048L (en) | 1988-05-13 |
| DD265623A5 (de) | 1989-03-08 |
| DE3638761A1 (de) | 1988-05-26 |
| IE59349B1 (en) | 1994-02-09 |
| GR3002974T3 (en) | 1993-01-25 |
| AU610101B2 (en) | 1991-05-16 |
| EP0268548A2 (de) | 1988-05-25 |
| JPH01501390A (ja) | 1989-05-18 |
| EP0268548B1 (de) | 1991-08-21 |
| CS271479B2 (en) | 1990-10-12 |
| ATE66472T1 (de) | 1991-09-15 |
| CA1326238C (en) | 1994-01-18 |
| JP2596575B2 (ja) | 1997-04-02 |
| AU8236387A (en) | 1988-06-01 |
| EP0268548A3 (en) | 1988-06-22 |
| HUT46901A (en) | 1988-12-28 |
| ZA878504B (en) | 1988-05-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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