RO82936B1 - Derivati 1-oxa-4-azaspiro(4, 5)decanici si procedeu pentru prepararea acestora - Google Patents
Derivati 1-oxa-4-azaspiro(4, 5)decanici si procedeu pentru prepararea acestoraInfo
- Publication number
- RO82936B1 RO82936B1 RO106052A RO10605281A RO82936B1 RO 82936 B1 RO82936 B1 RO 82936B1 RO 106052 A RO106052 A RO 106052A RO 10605281 A RO10605281 A RO 10605281A RO 82936 B1 RO82936 B1 RO 82936B1
- Authority
- RO
- Romania
- Prior art keywords
- oxa
- azaspiro
- derivatives
- benzene
- toluene
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- XVMSFILGAMDHEY-UHFFFAOYSA-N 6-(4-aminophenyl)sulfonylpyridin-3-amine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1 XVMSFILGAMDHEY-UHFFFAOYSA-N 0.000 abstract 1
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 abstract 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- HFNQLYDPNAZRCH-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O.OC(O)=O HFNQLYDPNAZRCH-UHFFFAOYSA-N 0.000 abstract 1
- -1 dichloroacetyl Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- 239000008096 xylene Substances 0.000 abstract 1
Landscapes
- Indole Compounds (AREA)
Abstract
Inventia se refera la derivati 1-oxa-4-azaspiro 4,5 decanici care au structura chimica corespunzatoare formulei generale I: (vezi formula) în care R este hidrogen sau izobutilen si sînt compusi solizi de culoare alba, cu punct de topire cuprins între 109 si 123 degree C si la procedeul de preparare al acestora constînd din aceea ca etanolamina se trateata cu ciclohexanona sau -izobutildenciclohexanona, la temperatura de reflux, într-un solvent ce formeaza azeotropul cu apa ales dintre benzen, toluen si xilen, raportul molar între reactanti fiind de 1:1......1:2, dupa care 1-oxa-4-aza-6R-spiro [4,5] decanul obtinut, în care R are semnificatiile de mai sus, se acileaza cu clorura de dicloracetil eventual într-un solvent ales dintre eter etilic, benzen, toluen, clorura de metilen, cloroform si piridina, în prezenta unui acceptor de aicid clorhidric ales dintre o amina tertiara si un hidroxid sau carrbonat de netal alcalin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO106052A RO82936B1 (ro) | 1981-12-21 | 1981-12-21 | Derivati 1-oxa-4-azaspiro(4, 5)decanici si procedeu pentru prepararea acestora |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO106052A RO82936B1 (ro) | 1981-12-21 | 1981-12-21 | Derivati 1-oxa-4-azaspiro(4, 5)decanici si procedeu pentru prepararea acestora |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO82936A2 RO82936A2 (ro) | 1984-01-14 |
| RO82936B1 true RO82936B1 (ro) | 1984-01-30 |
Family
ID=20110788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO106052A RO82936B1 (ro) | 1981-12-21 | 1981-12-21 | Derivati 1-oxa-4-azaspiro(4, 5)decanici si procedeu pentru prepararea acestora |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO82936B1 (ro) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116283812A (zh) * | 2023-03-04 | 2023-06-23 | 徐州彰梁生化科技有限公司 | 一种苯叉酰胺生产工艺 |
-
1981
- 1981-12-21 RO RO106052A patent/RO82936B1/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO82936A2 (ro) | 1984-01-14 |
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