ES2001024A6 - Procedimiento para preparar derivados de dihidro-quinolinona y agentes terapeuticos que los contienen. - Google Patents

Procedimiento para preparar derivados de dihidro-quinolinona y agentes terapeuticos que los contienen.

Info

Publication number
ES2001024A6
ES2001024A6 ES8600407A ES8600407A ES2001024A6 ES 2001024 A6 ES2001024 A6 ES 2001024A6 ES 8600407 A ES8600407 A ES 8600407A ES 8600407 A ES8600407 A ES 8600407A ES 2001024 A6 ES2001024 A6 ES 2001024A6
Authority
ES
Spain
Prior art keywords
preparation
medicaments
intermediates
processes
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600407A
Other languages
English (en)
Inventor
Rainer Henning
Ulrich Lerch
Joachim Kaiser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES2001024A6 publication Critical patent/ES2001024A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EL PROCEDIMIENTO DESCRITO PREPARA COMPUESTOS DE FORMULA I: SIENDO: R(1), R(2), R(3), R(4) Y R(5), ENTRE OTROS, HIDROGENO Y ALQUILO, M 1-4, N 0 O'' 1, P 0-4 Y R(6) DIFERENTES DERIVADOS ALQUILAMINICOS, Y SUS SALES, HACIENDO REACCIONAR EN CONDICIONES DE SUSTITUCION NUCLEOFILA UN COMPUESTO DE FORMULA (II) DONDE R(1), R(1)'', R(1)'''', R(2), R(3), R(4), R(4)'', R(5), M, N Y P TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA I, E Y ES UN GRUPO LABIL DESALOJABLE NUCLEOFILICAMENTE, CON UNO DE LOS COMPUESTOS DE FORMULAS IIIA, IIIB, IIIC O IIID DONDE R(7), R(8), R(9), R(10), R(11) Y R(12) PUEDEN SER, ENTRE OTROS, HIDROGENO, (CICLO)ALQUILO O FENILO. LOS COMPUESTOS OBTENIDOS SON ESPECIALMENTE UTILES COMO ANTAGONISTAS DEL CALCIO EN EL SISTEMA CARDIOCIRCULATORIO DEHUMANOS Y ANIMALES.
ES8600407A 1985-07-20 1986-07-18 Procedimiento para preparar derivados de dihidro-quinolinona y agentes terapeuticos que los contienen. Expired ES2001024A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853526044 DE3526044A1 (de) 1985-07-20 1985-07-20 Dihydrochinolinon-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung, sowie zwischenprodukte zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES2001024A6 true ES2001024A6 (es) 1988-04-16

Family

ID=6276332

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600407A Expired ES2001024A6 (es) 1985-07-20 1986-07-18 Procedimiento para preparar derivados de dihidro-quinolinona y agentes terapeuticos que los contienen.

Country Status (14)

Country Link
US (1) US4778793A (es)
EP (1) EP0212216A1 (es)
JP (1) JPS6222767A (es)
KR (1) KR870001166A (es)
AU (1) AU6031086A (es)
DE (1) DE3526044A1 (es)
DK (1) DK162092C (es)
ES (1) ES2001024A6 (es)
FI (1) FI862971A7 (es)
HU (1) HUT43569A (es)
IL (1) IL79456A0 (es)
NO (1) NO862917L (es)
PT (1) PT83014B (es)
ZA (1) ZA865332B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9125515D0 (en) * 1991-11-29 1992-01-29 Merck Sharp & Dohme Therapeutic agents
CA2134448A1 (en) * 1992-05-01 1993-11-02 Yoshinori Kyotani Quinoline derivative or salt thereof and remedy for cardiac diseases containing the same
CA2121148A1 (en) * 1992-08-19 1994-03-03 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
CA2196672A1 (en) * 1994-08-04 1996-02-15 You Sup Chung Amine derivatives, processes for producing same, and use thereof as antiarrhythmic drugs
US7960548B2 (en) * 2005-04-29 2011-06-14 The Ohio State University Research Foundation Keratinocyte growth factor receptor—tyrosine specific inhibitors for the prevention of cancer metastatis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1216878B (de) * 1963-04-02 1966-05-18 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins
US3330823A (en) * 1964-12-16 1967-07-11 Squibb & Sons Inc N-amino-loweralkylene-benzo-lactams
US3551413A (en) * 1969-03-12 1970-12-29 Squibb & Sons Inc Benzo-lactams
GB1305278A (es) * 1970-03-12 1973-01-31
US4006148A (en) * 1975-08-06 1977-02-01 Imc Chemical Group, Inc. Carbostyril derivatives used as coccidiostats

Also Published As

Publication number Publication date
PT83014A (de) 1986-08-01
HUT43569A (en) 1987-11-30
DK162092C (da) 1992-02-24
NO862917D0 (no) 1986-07-18
EP0212216A1 (de) 1987-03-04
DK343486D0 (da) 1986-07-18
ZA865332B (en) 1987-02-25
FI862971A0 (fi) 1986-07-17
AU6031086A (en) 1987-01-22
IL79456A0 (en) 1986-10-31
JPS6222767A (ja) 1987-01-30
NO862917L (no) 1987-01-21
PT83014B (pt) 1989-01-30
DK162092B (da) 1991-09-16
DE3526044A1 (de) 1987-01-22
KR870001166A (ko) 1987-03-11
DK343486A (da) 1987-01-21
FI862971A7 (fi) 1987-01-21
US4778793A (en) 1988-10-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102