ES8604392A1 - Un procedimiento para preparar derivados de pirazinona. - Google Patents

Un procedimiento para preparar derivados de pirazinona.

Info

Publication number
ES8604392A1
ES8604392A1 ES538037A ES538037A ES8604392A1 ES 8604392 A1 ES8604392 A1 ES 8604392A1 ES 538037 A ES538037 A ES 538037A ES 538037 A ES538037 A ES 538037A ES 8604392 A1 ES8604392 A1 ES 8604392A1
Authority
ES
Spain
Prior art keywords
compounds
6alkyl
group
independently hydrogen
pyrazinone compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538037A
Other languages
English (en)
Other versions
ES538037A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Original Assignee
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd, GlaxoSmithKline LLC filed Critical Smith Kline and French Laboratories Ltd
Publication of ES8604392A1 publication Critical patent/ES8604392A1/es
Publication of ES538037A0 publication Critical patent/ES538037A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PIRAZINONA, DE FORMULA GENERAL (I), EN LA QUE R1 ES CIANO; Y R2, R3 Y R4 SON INDEPENDIENTEMENTE ENTRE SI HIDROGENO O ALQUILO DE C1C4, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON UNA FUENTE DE CIANURO, EN DONDE R2, R3 Y R4 TIENEN LOS SIGNIFICADOS YA MENCIONADOS; Y XC ES UN ION CONTRARIO, Y A CONTINUACION SE ELIMINAN LOS GRUPOS PROTECTORES. DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES POR SU ACTIVIDAD INOTROPICA POSITIVA Y POR SU ACTIVIDAD VASODILATADORA.
ES538037A 1983-12-02 1984-11-28 Un procedimiento para preparar derivados de pirazinona. Expired ES8604392A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838332313A GB8332313D0 (en) 1983-12-02 1983-12-02 Chemical compounds

Publications (2)

Publication Number Publication Date
ES8604392A1 true ES8604392A1 (es) 1986-01-16
ES538037A0 ES538037A0 (es) 1986-01-16

Family

ID=10552775

Family Applications (1)

Application Number Title Priority Date Filing Date
ES538037A Expired ES8604392A1 (es) 1983-12-02 1984-11-28 Un procedimiento para preparar derivados de pirazinona.

Country Status (10)

Country Link
US (1) US4632924A (es)
EP (1) EP0146282A3 (es)
JP (1) JPS60132967A (es)
AU (1) AU3601784A (es)
DK (1) DK564284A (es)
ES (1) ES8604392A1 (es)
GB (1) GB8332313D0 (es)
GR (1) GR81105B (es)
PT (1) PT79570B (es)
ZA (1) ZA849274B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8332313D0 (en) * 1983-12-02 1984-01-11 Smith Kline French Lab Chemical compounds
SK34398A3 (en) * 1995-09-22 1998-11-04 Sumitomo Chemical Co Pyrazin-2-one derivative, method for inhibiting undesirable weeds and use of derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3745161A (en) * 1970-04-20 1973-07-10 Merck & Co Inc Phenyl-hydroxy-pyrazine carboxylic acids and derivatives
EP0052442B1 (en) * 1980-11-14 1985-09-11 Imperial Chemical Industries Plc Heterocyclic compounds
ZA827641B (en) * 1981-11-12 1983-09-28 Ici Plc Thiadiazine, oxadiazine and triazine derivatives which possess cardiotonic and/or antihypertensive activity
US4402958A (en) * 1981-11-19 1983-09-06 American Cyanamid Company Novel (substituted phenyl)-1,2,4-triazolo (4,3-A)pyrazines and novel 2-hydrazino-(substituted phenyl)pyrazine intermediates
EP0096517A3 (en) * 1982-06-05 1985-04-03 Smith Kline & French Laboratories Limited Aryl pyrazinones
US4489074A (en) * 1982-11-12 1984-12-18 Imperial Chemical Industries, Plc 1,3,4-Thiadiazin-2-ones
JPS59144772A (ja) * 1983-02-08 1984-08-18 Ube Ind Ltd 液晶性ピラジン誘導体およびその製法
GB8332313D0 (en) * 1983-12-02 1984-01-11 Smith Kline French Lab Chemical compounds

Also Published As

Publication number Publication date
JPS60132967A (ja) 1985-07-16
PT79570B (en) 1986-11-14
US4632924A (en) 1986-12-30
ZA849274B (en) 1986-07-30
GB8332313D0 (en) 1984-01-11
AU3601784A (en) 1985-06-06
EP0146282A2 (en) 1985-06-26
DK564284D0 (da) 1984-11-28
GR81105B (en) 1985-04-01
PT79570A (en) 1984-12-01
DK564284A (da) 1985-06-03
EP0146282A3 (en) 1986-03-26
ES538037A0 (es) 1986-01-16

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