ATE97410T1 - 6-amino-6-desoxyfumagillole, ihre herstellung und ihre verwendung. - Google Patents
6-amino-6-desoxyfumagillole, ihre herstellung und ihre verwendung.Info
- Publication number
- ATE97410T1 ATE97410T1 AT90104176T AT90104176T ATE97410T1 AT E97410 T1 ATE97410 T1 AT E97410T1 AT 90104176 T AT90104176 T AT 90104176T AT 90104176 T AT90104176 T AT 90104176T AT E97410 T1 ATE97410 T1 AT E97410T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibiting activity
- linkage
- optionally substituted
- compound
- present
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006020 2-methyl-1-propenyl group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5353589 | 1989-03-06 | ||
| EP90104176A EP0386667B1 (de) | 1989-03-06 | 1990-03-03 | 6-Amino-6-desoxyfumagillole, ihre Herstellung und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE97410T1 true ATE97410T1 (de) | 1993-12-15 |
Family
ID=12945499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90104176T ATE97410T1 (de) | 1989-03-06 | 1990-03-03 | 6-amino-6-desoxyfumagillole, ihre herstellung und ihre verwendung. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0386667B1 (de) |
| AT (1) | ATE97410T1 (de) |
| CA (1) | CA2011448C (de) |
| DE (1) | DE69004598T2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69114782T2 (de) * | 1990-08-08 | 1996-04-18 | Takeda Chemical Industries Ltd | Intravaskulär embolisierendes Mittel mit Gehalt an einem die Angiogenesis hemmenden Stoff. |
| DE69231457T2 (de) * | 1991-06-21 | 2001-05-23 | Takeda Chemical Industries Ltd | Zyklodextrin-Zusammensetzung enthaltend Fumagillol-Derivate |
| ATE161716T1 (de) | 1992-08-07 | 1998-01-15 | Takeda Chemical Industries Ltd | Herstellung von mikrokapseln, die wasserlösliche arzneimittel enthalten |
| DE69311278T2 (de) * | 1992-12-16 | 1997-10-30 | Takeda Chemical Industries Ltd | Stabile pharmazeutische Zubereitung mit Fumagillolderivaten |
| US6117455A (en) | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
| DE69519685T2 (de) * | 1994-09-30 | 2001-08-02 | Takeda Chemical Industries, Ltd. | Oral anzuwendende arzneizubereitung mit verzögerter wirkstoffabgabe |
| US5710148A (en) * | 1995-03-06 | 1998-01-20 | Senju Pharmaceuticals Co., Ltd. | Corneal opacification inhibitory composition |
| US5837281A (en) | 1995-03-17 | 1998-11-17 | Takeda Chemical Industries, Ltd. | Stabilized interface for iontophoresis |
| US5908400A (en) * | 1996-06-20 | 1999-06-01 | Hisamitsu Pharmaceutical Co., Inc. | Device structure for iontophoresis |
| US6207704B1 (en) | 1997-06-09 | 2001-03-27 | Massachusetts Institute Of Technology | Type 2 methionine aminopeptidase [MetAP2] inhibitors and uses thereof |
| KR100357542B1 (ko) * | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 푸마질롤 유도체 및 그 제조방법 |
| KR100357541B1 (ko) * | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 5-데메톡시 푸마질롤 유도체 및 그 제조방법 |
| JP4414517B2 (ja) | 1999-09-01 | 2010-02-10 | 久光製薬株式会社 | イオントフォレーシス用デバイス構造体 |
| US20070161570A1 (en) * | 2000-11-01 | 2007-07-12 | Praecis Pharmaceuticals, Inc. | Methionine aminopeptidase-2 inhibitors and methods of use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1258967A (de) * | 1968-04-16 | 1972-01-05 |
-
1990
- 1990-03-03 EP EP90104176A patent/EP0386667B1/de not_active Expired - Lifetime
- 1990-03-03 DE DE90104176T patent/DE69004598T2/de not_active Expired - Fee Related
- 1990-03-03 AT AT90104176T patent/ATE97410T1/de not_active IP Right Cessation
- 1990-03-05 CA CA002011448A patent/CA2011448C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69004598T2 (de) | 1994-03-24 |
| DE69004598D1 (de) | 1993-12-23 |
| EP0386667B1 (de) | 1993-11-18 |
| EP0386667A1 (de) | 1990-09-12 |
| CA2011448C (en) | 2000-06-27 |
| CA2011448A1 (en) | 1990-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |