DE3785315D1 - Erythromycin-a-derivate und verfahren zu ihrer herstellung. - Google Patents

Erythromycin-a-derivate und verfahren zu ihrer herstellung.

Info

Publication number
DE3785315D1
DE3785315D1 DE8787311097T DE3785315T DE3785315D1 DE 3785315 D1 DE3785315 D1 DE 3785315D1 DE 8787311097 T DE8787311097 T DE 8787311097T DE 3785315 T DE3785315 T DE 3785315T DE 3785315 D1 DE3785315 D1 DE 3785315D1
Authority
DE
Germany
Prior art keywords
group
lower alkyl
erythromycin
together form
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787311097T
Other languages
English (en)
Other versions
DE3785315T2 (de
Inventor
Shigeo Morimoto
Tohru Matsunaga
Takashi Adachi
Masato Kashimura
Toshifumi Asaka
Kaoru Sota
Yoshiaki Watanabe
Kazuto Sekiuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of DE3785315D1 publication Critical patent/DE3785315D1/de
Application granted granted Critical
Publication of DE3785315T2 publication Critical patent/DE3785315T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8787311097T 1986-12-17 1987-12-16 Erythromycin-a-derivate und verfahren zu ihrer herstellung. Expired - Lifetime DE3785315T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30065386 1986-12-17

Publications (2)

Publication Number Publication Date
DE3785315D1 true DE3785315D1 (de) 1993-05-13
DE3785315T2 DE3785315T2 (de) 1993-07-22

Family

ID=17887449

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787311097T Expired - Lifetime DE3785315T2 (de) 1986-12-17 1987-12-16 Erythromycin-a-derivate und verfahren zu ihrer herstellung.

Country Status (5)

Country Link
US (1) US4990602A (de)
EP (1) EP0272110B1 (de)
KR (1) KR960000434B1 (de)
AT (1) ATE87925T1 (de)
DE (1) DE3785315T2 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
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US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
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US5858986A (en) * 1996-07-29 1999-01-12 Abbott Laboratories Crystal form I of clarithromycin
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US5929219A (en) * 1997-09-10 1999-07-27 Abbott Laboratories 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
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US6124269A (en) * 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
US6046171A (en) * 1997-10-29 2000-04-04 Abbott Laboratories 6,11-bridged erythromycin derivatives
US5852180A (en) * 1997-11-17 1998-12-22 Abbott Laboratories Chemical synthesis of 6-O-alkyl erythromycin A
WO1999028333A1 (en) * 1997-12-01 1999-06-10 Abbott Laboratories Chemical synthesis of 6-o-alkyl erythromycin c
US5892008A (en) * 1997-12-16 1999-04-06 Abbott Laboratories Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
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CN1098272C (zh) * 1999-05-06 2003-01-08 王凌峰 克拉霉素抗生素药物合成
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US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6569836B2 (en) 1999-12-02 2003-05-27 Abbott Laboratories 6-O-alkyl-2-nor-2-substituted ketolide derivatives
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DE60022230T2 (de) * 1999-12-16 2006-01-26 Teva Pharmaceutical Industries Ltd. Verfahren zur herstllung von clarithromycin polymorphen und polymorph iv
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DE60111438T2 (de) * 2000-03-15 2006-05-18 Hanmi Pharm. Co., Ltd. Verfahren zur Herstellung von einer kristallinen Form II von Clarythromycin
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US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
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US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
CN1659178A (zh) * 2002-05-13 2005-08-24 英安塔制药有限公司 6、11二环红霉素衍生物
US7064110B2 (en) * 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
US6878691B2 (en) * 2002-05-13 2005-04-12 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6841664B2 (en) 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
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WO2005070918A1 (en) * 2002-05-13 2005-08-04 Enanta Pharmaceuticals, Inc. Process for the preparation of t-11 bicyclic erythromycin derivatives
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US6843854B2 (en) 2002-05-31 2005-01-18 Purdue Research Foundation Method and apparatus for separating a component from a mixture
US6812216B2 (en) * 2002-06-25 2004-11-02 Enanta Pharmaceuticals, Inc. 11-C-substituted derivatives of clarithromycin
US6750204B2 (en) 2002-06-25 2004-06-15 Enanta Pharmaceuticals, Inc. 11-C-substituted ketolides
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
JP2006528190A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
JP2006528185A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
JP2006528189A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質産物、その使用法および製剤
WO2005016311A1 (en) * 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
CA2535398C (en) 2003-08-12 2013-11-12 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
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US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
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AU2003304705A1 (en) * 2003-12-24 2005-08-03 Enanta Pharmaceuticals, Inc. 11-csubsituted erythromycin derivatives
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
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US20060111560A1 (en) * 2004-11-01 2006-05-25 Glenmark Pharmaceuticals Limited Process for the preparation of crystalline form II of clarithromycin
WO2007029265A2 (en) * 2005-04-29 2007-03-15 Kopran Research Laboratories Ltd A process for preparing clarithromycin and clarithromycin intermediate
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US7547679B2 (en) * 2005-05-10 2009-06-16 Glaxosmithkline Istrazivacki Center Zagreb D.O.O Ether linked macrolides useful for the treatment of microbial infections
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US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
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US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
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CN101875678B (zh) 2009-04-30 2012-06-27 浙江华义医药有限公司 一种制备克拉霉素的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (de) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Verfahren zur behandlung von malaria, tuberkulose und mac-erkrankungen
CN102250180B (zh) * 2010-05-18 2015-07-22 上海医药工业研究院 2’,4”-o-二(三甲基硅基)-红霉素a衍生物和克拉霉素制备方法
CN102250173B (zh) * 2010-05-18 2015-07-08 上海医药工业研究院 一种6-o-甲基红霉素a衍生物和克拉霉素的制备方法
AU2011255464C1 (en) * 2010-05-20 2017-02-23 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
EP2613630A4 (de) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc Wasserstoffbindung zur formung von fluorketoliden zur behandlung von krankheiten
EP2830632A4 (de) 2012-03-27 2015-10-21 Cempra Pharmaceuticals Inc Parenterale formulierungen zur verabreichung von makrolid-antibiotika
CN103880901A (zh) * 2012-12-23 2014-06-25 菏泽市方明制药有限公司 一种克拉霉素中间甲化物的制备方法
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN105418709A (zh) * 2015-12-18 2016-03-23 山东理工职业学院 一种制备克拉霉素杂质的方法
CN106749462A (zh) * 2016-11-11 2017-05-31 杭州新桂实业有限公司 一种高效绿色克拉霉素中间体合成工艺
CN115286654B (zh) * 2022-07-07 2023-07-18 浙江国邦药业有限公司 一种克拉霉素中间体的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
EP0201166B1 (de) * 1985-03-12 1990-02-07 Beecham Group Plc Erythromycin-Derivate
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
US4640910A (en) * 1985-11-12 1987-02-03 Abbott Laboratories Erythromycin A silylated compounds and method of use

Also Published As

Publication number Publication date
KR960000434B1 (ko) 1996-01-06
EP0272110A2 (de) 1988-06-22
ATE87925T1 (de) 1993-04-15
DE3785315T2 (de) 1993-07-22
US4990602A (en) 1991-02-05
KR880007524A (ko) 1988-08-27
EP0272110A3 (en) 1989-10-25
EP0272110B1 (de) 1993-04-07

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