ES8302662A1 - Un procedimiento para la preparacion de una quinolona - Google Patents

Un procedimiento para la preparacion de una quinolona

Info

Publication number
ES8302662A1
ES8302662A1 ES505786A ES505786A ES8302662A1 ES 8302662 A1 ES8302662 A1 ES 8302662A1 ES 505786 A ES505786 A ES 505786A ES 505786 A ES505786 A ES 505786A ES 8302662 A1 ES8302662 A1 ES 8302662A1
Authority
ES
Spain
Prior art keywords
treating hypertension
quinolinones
methylsulfinylmethyl
methylthiomethyl
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505786A
Other languages
English (en)
Other versions
ES505786A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Co PLC
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co PLC filed Critical Boots Co PLC
Publication of ES8302662A1 publication Critical patent/ES8302662A1/es
Publication of ES505786A0 publication Critical patent/ES505786A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Abstract

PROCEDIMIENTO DE OBTENCION DE QUINOLONAS. CONSISTE EN HACER REACCIONAR EL COMPUESTO (I) EN QUE X ES UN GRUPO ELIMINABLE CON EL ANION METILTIOLATO DE CH S<068> O EL ANION METALNOSULFINATO CH SO <068>. SE OBTIENE EL COMPUESTO (II) EN QUE N ES 0 O 2; R ES ALCOHILO INFERIOR; R ES HIDROGENO, ALCOHILO INFERIOR, METOXI, METILTIO, HALOGENO O TRIFLUOROMETILO. ACTIVIDAD ANTI-HIPERTONSORA, REDUCIENDOLA LA PRESION SANGUINEA EN MAMIFEROS HIPERTENSOS.
ES505786A 1980-09-26 1981-09-25 Un procedimiento para la preparacion de una quinolona Granted ES505786A0 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8031106 1980-09-26
GB8031162 1980-09-26
GB8119062 1981-06-19
GB8118879 1981-06-19

Publications (2)

Publication Number Publication Date
ES8302662A1 true ES8302662A1 (es) 1982-12-01
ES505786A0 ES505786A0 (es) 1982-12-01

Family

ID=27449208

Family Applications (2)

Application Number Title Priority Date Filing Date
ES505786A Granted ES505786A0 (es) 1980-09-26 1981-09-25 Un procedimiento para la preparacion de una quinolona
ES514411A Expired ES8306111A1 (es) 1980-09-26 1982-07-27 "un procedimiento para la preparacion de una quinolona".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES514411A Expired ES8306111A1 (es) 1980-09-26 1982-07-27 "un procedimiento para la preparacion de una quinolona".

Country Status (25)

Country Link
US (2) US4442109A (es)
AT (1) AT379388B (es)
AU (1) AU549078B2 (es)
BG (2) BG36344A3 (es)
CA (1) CA1146943A (es)
CH (1) CH650254A5 (es)
DD (1) DD201890A5 (es)
DE (1) DE3138121A1 (es)
DK (1) DK152674C (es)
ES (2) ES505786A0 (es)
FI (1) FI812997L (es)
FR (1) FR2491064A1 (es)
GR (1) GR75797B (es)
IE (1) IE51542B1 (es)
IL (1) IL63845A (es)
IT (1) IT1189449B (es)
LU (1) LU83649A1 (es)
NL (1) NL8104394A (es)
NO (1) NO154052C (es)
NZ (1) NZ198414A (es)
PH (1) PH18605A (es)
PT (1) PT73666B (es)
RO (2) RO85318B (es)
SE (1) SE457533B (es)
YU (2) YU230181A (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT79031B (en) * 1983-08-20 1986-08-22 Boots Co Plc Therapeutic agents
EP0149519B1 (en) * 1984-01-13 1990-06-27 The Boots Company PLC Use of quinolones for the manufacture of a composition for the treatment of heart failure.
DE3576686D1 (de) * 1984-08-15 1990-04-26 Boots Co Ltd Chinolinone, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen praeparate.
GB8515207D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8515209D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3121725A (en) * 1960-07-18 1964-02-18 Phillips Petroleum Co N-heterocyclic sulfides, sulfoxides, sulfones, and n-oxides of said sulfoxides and sulfones
US3801644A (en) * 1971-08-25 1974-04-02 Warner Lambert Co Substituted-o-hydroxy-omega-(methylsulfinyl)acetophenones and process for producing same
US3772301A (en) * 1971-11-22 1973-11-13 Warner Lambert Co (4-substituted)4-(methylsulfinyl)methylcarbostyrils
US4343805A (en) * 1978-12-16 1982-08-10 John Wyeth & Brother Limited Heterocyclic compounds
GB2038825B (en) * 1978-12-16 1983-02-09 Wyeth John & Brother Ltd Heterocyclic compounds substituted by heterocyclyl-alkyl-thio groups
ZA801575B (en) * 1979-03-27 1981-03-25 Boots Co Ltd Therapeutic agents
NZ193167A (en) * 1979-03-27 1984-08-24 Boots Co Plc Quinoline derivatives and pharmaceutical compositions
US4302360A (en) * 1980-01-11 1981-11-24 Agency Of Industrial Science & Technology Catalyst for catalytic combustion of hydrogen

Also Published As

Publication number Publication date
CH650254A5 (fr) 1985-07-15
IL63845A (en) 1985-02-28
LU83649A1 (fr) 1983-02-22
NO813263L (no) 1982-03-29
NO154052B (no) 1986-04-01
FR2491064B1 (es) 1984-03-16
US4447435A (en) 1984-05-08
FI812997L (fi) 1982-03-27
IT1189449B (it) 1988-02-04
AT379388B (de) 1985-12-27
DK152674C (da) 1988-08-22
NO154052C (no) 1986-07-16
DK152674B (da) 1988-04-11
BG36344A3 (en) 1984-10-15
FR2491064A1 (fr) 1982-04-02
DD201890A5 (de) 1983-08-17
IT8149370A0 (it) 1981-09-25
RO85318A (ro) 1984-09-29
AU7552481A (en) 1982-04-01
CA1146943A (en) 1983-05-24
GR75797B (es) 1984-08-02
ES514411A0 (es) 1983-05-01
US4442109A (en) 1984-04-10
IE51542B1 (en) 1987-01-07
ATA412181A (de) 1985-05-15
IE812033L (en) 1982-03-02
NZ198414A (en) 1983-11-18
YU230181A (en) 1983-12-31
YU144683A (en) 1983-12-31
RO82014A (ro) 1983-06-01
SE8105689L (sv) 1982-03-27
RO85318B (ro) 1984-10-30
DK424781A (da) 1982-03-27
IL63845A0 (en) 1981-12-31
BG36495A3 (en) 1984-11-15
DE3138121A1 (de) 1982-04-15
RO82014B (ro) 1983-05-30
ES505786A0 (es) 1982-12-01
PT73666B (en) 1982-11-22
NL8104394A (nl) 1982-04-16
SE457533B (sv) 1989-01-09
PT73666A (en) 1981-10-01
AU549078B2 (en) 1986-01-16
ES8306111A1 (es) 1983-05-01
PH18605A (en) 1985-08-21

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