ES8505685A1 - Un procedimiento para preparar compuestos de espiro (2h-1,4-benzodioxepin-3(5h)4'-piperidina y -3'-pirrolidina) - Google Patents
Un procedimiento para preparar compuestos de espiro (2h-1,4-benzodioxepin-3(5h)4'-piperidina y -3'-pirrolidina)Info
- Publication number
- ES8505685A1 ES8505685A1 ES525013A ES525013A ES8505685A1 ES 8505685 A1 ES8505685 A1 ES 8505685A1 ES 525013 A ES525013 A ES 525013A ES 525013 A ES525013 A ES 525013A ES 8505685 A1 ES8505685 A1 ES 8505685A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- benzodioxepin
- spiro
- piperidine
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE ESPIRO2H-1,4-BENZODIOXEPIN-3(5H)4-PIPERIDINA Y -3-PIRROLIDINA.CONSISTE EN CICLIZAR UN COMPUESTO DE FORMULA (II) EN PRESENCIA DE UNA BASE, COMO TERC-BUTOXIDO POTASICO O HIDRURO DE SODIO, EN UN DISOLVENTE COMO SULFOXIDO DE DIMETILO O THF, A UNA TEMPERATURA ENTRE LA TEMPERATURA AMBIENTE Y LA TEMPERATURA DE REFLUJO, PARA OBTENER UN COMPUESTO DE FORMULA (II) Y SUS SALES FARMACEUTICAMENTE ACEDPTABLES. SIENDO: R1, GRUPO ALQUILO DE C 1 A 5 DE CADENA RECTA O RAMIFICADA, GRUPO ALQUILO DE C 1 A 5 DE CADENA RECTA O RAMIFICADA SUSTITUIDO EN POSICION TERMINAL Y OTROS; R2, H CUANDO NF0; R3, R4, H O UN ALQUILO DE C 1 A 3 DE CADENA RECTA; X, HAL, -NO2 Y OTROS; HAL, HALOGENO; R, H, METILO Y OTROS; M 0, 1 O 2 Y N 0, O 1.SE UTILIZAN EN EL TRATAMIENTO DE LA HIPERTENSION EN MAMIFEROS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/410,155 US4405631A (en) | 1982-08-20 | 1982-08-20 | Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'pyrrolidine] compounds and their use as antihypertensive agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8505685A1 true ES8505685A1 (es) | 1985-06-01 |
| ES525013A0 ES525013A0 (es) | 1985-06-01 |
Family
ID=23623465
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525013A Granted ES525013A0 (es) | 1982-08-20 | 1983-08-18 | Un procedimiento para preparar compuestos de espiro (2h-1,4-benzodioxepin-3(5h)4'-piperidina y -3'-pirrolidina) |
| ES540841A Granted ES540841A0 (es) | 1982-08-20 | 1985-03-01 | Un procedimiento compuesto de espiro 2h-1,4-benzodioxepin-3 (5h)4'-piperidina y -3'-pirrolidina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES540841A Granted ES540841A0 (es) | 1982-08-20 | 1985-03-01 | Un procedimiento compuesto de espiro 2h-1,4-benzodioxepin-3 (5h)4'-piperidina y -3'-pirrolidina |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4405631A (es) |
| EP (1) | EP0102034B1 (es) |
| JP (1) | JPS5953489A (es) |
| KR (1) | KR840005729A (es) |
| AT (1) | ATE33656T1 (es) |
| AU (1) | AU576473B2 (es) |
| CA (1) | CA1210764A (es) |
| DE (1) | DE3376327D1 (es) |
| DK (1) | DK381983A (es) |
| ES (2) | ES525013A0 (es) |
| FI (1) | FI832959A (es) |
| GR (1) | GR78667B (es) |
| HU (1) | HU191874B (es) |
| IL (1) | IL69525A0 (es) |
| MA (1) | MA19881A1 (es) |
| NO (1) | NO833001L (es) |
| NZ (1) | NZ205320A (es) |
| PH (1) | PH18839A (es) |
| PT (1) | PT77223B (es) |
| ZA (1) | ZA836127B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4521537A (en) * | 1982-08-20 | 1985-06-04 | Hoechst-Roussel Pharmaceuticals Incorporated | Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds and their use as antihypertensive agents |
| US4472580A (en) * | 1982-08-20 | 1984-09-18 | Hoechst-Roussel Pharmaceuticals Incorporated | Spiro (2H-1,4-benzodioxepin-3 (5H)4-piperidine and -3-pyrrolidine) compounds and their use as anti-hypertensive agents |
| US4751223A (en) * | 1986-10-14 | 1988-06-14 | Hoechst-Roussel Pharmaceuticals, Inc. | Antiinflammatory and analgesic aminoalkyl tetracyclic benzodiazepines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1312894A (fr) * | 1962-01-29 | 1962-12-21 | Geigy Ag J R | Nouveaux composés hétérocycliques à 2 atomes d'oxygène dans le cycle et leur préparation |
| CH469736A (de) * | 1966-06-28 | 1969-03-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen Heterospiroalkanen |
| US3679666A (en) * | 1969-04-03 | 1972-07-25 | Hoffmann La Roche | 4-(4-hydroxypiperidino)-4'-fluorobutyrophenones |
-
1982
- 1982-08-20 US US06/410,155 patent/US4405631A/en not_active Expired - Fee Related
-
1983
- 1983-08-17 GR GR72231A patent/GR78667B/el unknown
- 1983-08-18 AT AT83108156T patent/ATE33656T1/de not_active IP Right Cessation
- 1983-08-18 EP EP83108156A patent/EP0102034B1/en not_active Expired
- 1983-08-18 FI FI832959A patent/FI832959A/fi not_active Application Discontinuation
- 1983-08-18 ES ES525013A patent/ES525013A0/es active Granted
- 1983-08-18 KR KR1019830003853A patent/KR840005729A/ko not_active Application Discontinuation
- 1983-08-18 DE DE8383108156T patent/DE3376327D1/de not_active Expired
- 1983-08-18 PH PH29413A patent/PH18839A/en unknown
- 1983-08-18 NZ NZ205320A patent/NZ205320A/en unknown
- 1983-08-19 AU AU18169/83A patent/AU576473B2/en not_active Ceased
- 1983-08-19 IL IL69525A patent/IL69525A0/xx unknown
- 1983-08-19 NO NO833001A patent/NO833001L/no unknown
- 1983-08-19 PT PT77223A patent/PT77223B/pt unknown
- 1983-08-19 JP JP58150473A patent/JPS5953489A/ja active Pending
- 1983-08-19 DK DK381983A patent/DK381983A/da not_active Application Discontinuation
- 1983-08-19 ZA ZA836127A patent/ZA836127B/xx unknown
- 1983-08-19 HU HU832920A patent/HU191874B/hu unknown
- 1983-08-19 CA CA000434928A patent/CA1210764A/en not_active Expired
- 1983-08-20 MA MA20103A patent/MA19881A1/fr unknown
-
1985
- 1985-03-01 ES ES540841A patent/ES540841A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AU576473B2 (en) | 1988-09-01 |
| IL69525A0 (en) | 1983-11-30 |
| PT77223B (en) | 1986-03-18 |
| MA19881A1 (fr) | 1984-04-01 |
| DK381983A (da) | 1984-02-21 |
| EP0102034A1 (en) | 1984-03-07 |
| NO833001L (no) | 1984-02-21 |
| AU1816983A (en) | 1984-02-23 |
| KR840005729A (ko) | 1984-11-16 |
| PH18839A (en) | 1985-10-10 |
| CA1210764A (en) | 1986-09-02 |
| ES525013A0 (es) | 1985-06-01 |
| EP0102034B1 (en) | 1988-04-20 |
| FI832959A (fi) | 1984-02-21 |
| ES8602800A1 (es) | 1985-12-01 |
| FI832959A0 (fi) | 1983-08-18 |
| DE3376327D1 (en) | 1988-05-26 |
| ES540841A0 (es) | 1985-12-01 |
| JPS5953489A (ja) | 1984-03-28 |
| HU191874B (en) | 1987-04-28 |
| DK381983D0 (da) | 1983-08-19 |
| ZA836127B (en) | 1984-04-25 |
| NZ205320A (en) | 1987-05-29 |
| GR78667B (es) | 1984-09-27 |
| ATE33656T1 (de) | 1988-05-15 |
| US4405631A (en) | 1983-09-20 |
| PT77223A (en) | 1983-09-01 |
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