ES8403897A1 - Procedimiento para la fabricacion de nuevos derivados de la amino-3 quinuclidina - Google Patents
Procedimiento para la fabricacion de nuevos derivados de la amino-3 quinuclidinaInfo
- Publication number
- ES8403897A1 ES8403897A1 ES524128A ES524128A ES8403897A1 ES 8403897 A1 ES8403897 A1 ES 8403897A1 ES 524128 A ES524128 A ES 524128A ES 524128 A ES524128 A ES 524128A ES 8403897 A1 ES8403897 A1 ES 8403897A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- aminoquinuclidin
- preparation
- therapeutical agents
- new derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE LA AMINO-3 QUINUCLIDINA, DE FORMULA GENERAL (I), EN LA QUE X REPRESENTA UN ATOMO DE AZUFRE O DE OXIGENO; R REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO O UN GRUPO BENCILO; Y AR REPRESENTA UN NUCLEO FENILO SUSTITUIDO POR UN ATOMO DE HALOGENO O UN NUCLEO FENILO, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN CONDENSAR LOS ACIDOS DE FORMULA: AR-COOH CON LOS DERIVADOS DE LA AMINO-3 QUINUCLIDINA, DE FORMULA (II), EN LA CUAL R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO DE 1A 4 ATOMOS DE CARBONO O BENCILO.DE APLICACION EN TERAPEUTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8211670A FR2529548A1 (fr) | 1982-07-02 | 1982-07-02 | Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8403897A1 true ES8403897A1 (es) | 1984-04-16 |
ES524128A0 ES524128A0 (es) | 1984-04-16 |
Family
ID=9275643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES524128A Granted ES524128A0 (es) | 1982-07-02 | 1983-07-01 | Procedimiento para la fabricacion de nuevos derivados de la amino-3 quinuclidina |
Country Status (9)
Country | Link |
---|---|
US (1) | US4657911A (es) |
EP (1) | EP0099789B1 (es) |
JP (1) | JPS5921684A (es) |
AU (1) | AU562210B2 (es) |
CA (1) | CA1265802A (es) |
DE (1) | DE3372769D1 (es) |
ES (1) | ES524128A0 (es) |
FR (1) | FR2529548A1 (es) |
ZA (1) | ZA834704B (es) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI74707C (fi) * | 1982-06-29 | 1988-03-10 | Sandoz Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror. |
JPS5936675A (ja) * | 1982-07-13 | 1984-02-28 | サンド・アクチエンゲゼルシヤフト | 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド |
US5175173A (en) * | 1983-12-22 | 1992-12-29 | Sun Jung Hui | Carboxamides useful as antiemetic or antipsychotic agents |
US4888353A (en) * | 1986-02-28 | 1989-12-19 | Erbamont, Inc. | Carboxamides useful as antiemetic or antipsychotic agents |
US4593034A (en) * | 1984-04-06 | 1986-06-03 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides |
US4605652A (en) * | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
US4870181A (en) * | 1985-02-04 | 1989-09-26 | A. H. Robins Company, Incorporated | Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides |
GB8511988D0 (en) * | 1985-05-11 | 1985-06-19 | Beecham Group Plc | Compounds |
GB8520616D0 (en) * | 1985-08-16 | 1985-09-25 | Beecham Group Plc | Compounds |
GB8525844D0 (en) * | 1985-10-19 | 1985-11-20 | Beecham Group Plc | Compounds |
US4722834A (en) * | 1986-03-05 | 1988-02-02 | A. H. Robins Company, Incorporated | Method of using 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide-N-oxides to control emesis caused by anticancer drugs |
US4717563A (en) * | 1986-03-05 | 1988-01-05 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs |
HU895334D0 (en) * | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
US4772459A (en) * | 1986-09-09 | 1988-09-20 | Erbamont, Inc. | Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein |
EP0272052B1 (en) * | 1986-12-16 | 1992-07-08 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Anxiolytic-N-(1-Azabicyclo[2.2.2]Oct-3-yl) Benzamides and Thobenzamides |
US5246941A (en) | 1986-12-17 | 1993-09-21 | Glaxo Group Limited | Method for the treatment of depression |
FR2610323B1 (fr) * | 1987-02-04 | 1989-06-23 | Delalande Sa | Enantiomeres de configuration absolue s de derives amide de l'amino-3 quinuclidine, leur procede de preparation et leur application en therapeutique |
US5237066A (en) * | 1987-02-04 | 1993-08-17 | Delande S.A. | Enantiomers of absolute configuration S of amide derivatives of 3-aminoquinuclidine, the process for preparing them and their application in therapy |
GB8718345D0 (en) * | 1987-08-03 | 1987-09-09 | Fordonal Sa | N-substituted benzamides |
GB8720805D0 (en) * | 1987-09-04 | 1987-10-14 | Naylor R J | 2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides |
EP0311724A1 (en) * | 1987-10-16 | 1989-04-19 | Synthelabo | Anxiolytic-R-N-(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides |
FR2625678B1 (fr) * | 1988-01-13 | 1991-06-07 | Delalande Sa | Agents anorexigenes a base de n-(quinuclidin-3-yl)-benzamides ou thiobenzamides |
US4863919A (en) * | 1988-02-01 | 1989-09-05 | A. H. Robins Company, Incorporated | Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes |
DE3878235T2 (de) * | 1988-08-04 | 1993-06-03 | Synthelabo | Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.)oct-3-yl)benzamide und thiobenzamide. |
WO1990005525A1 (en) * | 1988-11-23 | 1990-05-31 | Pfizer Inc. | Quinuclidine derivatives as substance p antagonists |
GB8904551D0 (en) * | 1989-02-28 | 1989-04-12 | Glaxo Group Ltd | Chemical compounds |
US5290938A (en) * | 1989-09-15 | 1994-03-01 | Chiron Laboratories A.S. | Preparation of S-(-)- and R-(+)-N-(quinuclidinyl-3)-amide |
NO168529C (no) * | 1989-09-15 | 1992-03-04 | Chiron Lab As | Fremgangsmaate for fremstilling av s-(-) og r-(+)-n-(quinuclidinyl-3)-amider. |
US5070095A (en) * | 1990-12-12 | 1991-12-03 | A. H. Robins Company, Incorporated | Substituted 4-(amidino)benzamides of 1-azabicyclo[2.2.2]octan-3- and -4-amine as gastric prokinetic, antiemetic, and anxiolytic agents |
GB9027487D0 (en) * | 1990-12-19 | 1991-02-06 | Beecham Group Plc | Pharmaceuticals |
US5084460A (en) * | 1990-12-24 | 1992-01-28 | A. H. Robins Company, Incorporated | Methods of therapeutic treatment with N-(3-ouinuclidinyl)-2-hydroxybenzamides and thiobenzamides |
US5138060A (en) * | 1991-01-03 | 1992-08-11 | Pfizer Inc. | Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines |
US5273972A (en) * | 1992-03-26 | 1993-12-28 | A. H. Robins Company, Incorporated | [(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates |
US5236931A (en) * | 1992-03-26 | 1993-08-17 | A. H. Robins Company, Incorporated | 2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol |
FR2719842B1 (fr) * | 1994-05-10 | 1996-06-07 | Synthelabo | Sels quaternaires de dérivés de 1-azabicyclo [2.2.2] octane, leur préparation et leur application en thérapeutique. |
US5723103A (en) * | 1994-12-09 | 1998-03-03 | Vanderbilt University | Substituted benzamides and radioligand analogs and methods of use |
SE0000540D0 (sv) * | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
JP2004506735A (ja) | 2000-08-18 | 2004-03-04 | ファルマシア・アンド・アップジョン・カンパニー | 疾患治療用キヌクリジン置換アリール化合物 |
AU2001282873A1 (en) | 2000-08-18 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
US6492385B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
WO2002015662A2 (en) | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists |
WO2002017358A2 (en) | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists) |
PE20021019A1 (es) | 2001-04-19 | 2002-11-13 | Upjohn Co | Grupos azabiciclicos sustituidos |
JP2005504059A (ja) * | 2001-08-24 | 2005-02-10 | ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー | 疾患を処置するための置換アリール7−アザ[2.2.1]ビシクロヘプタン |
JP2005522456A (ja) | 2002-02-15 | 2005-07-28 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | Cns関連障害治療のためのアザビシクロ置換ベンゾイルアミドおよびチオアミド |
EP1478646A1 (en) * | 2002-02-20 | 2004-11-24 | PHARMACIA & UPJOHN COMPANY | Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity |
JP2005537297A (ja) | 2002-08-01 | 2005-12-08 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | アルファ−7nachr活性を有する1h−ピラゾールおよび1h−ピロール−アザビシクロ化合物 |
JP2007515478A (ja) * | 2003-12-22 | 2007-06-14 | アストラゼネカ・アクチエボラーグ | ニコチン性アセチルコリンレセプターリガンド |
WO2008028903A2 (en) | 2006-09-04 | 2008-03-13 | Neurosearch A/S | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
WO2008119710A1 (en) * | 2007-03-30 | 2008-10-09 | Neurosearch A/S | Two-phase test method for characterizing the effect of a chemical compound on a test animal and maze for carrying out the method |
ES2432618T3 (es) | 2009-05-20 | 2013-12-04 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular |
JP5955767B2 (ja) | 2009-05-20 | 2016-07-20 | インセルム(インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル) | 損傷性前庭障害の処置における使用のためのセロトニン5−ht3受容体拮抗薬 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE331841B (es) * | 1967-05-23 | 1971-01-18 | Astra Ab | |
US3534053A (en) * | 1967-05-24 | 1970-10-13 | American Home Prod | Quinuclidine derivatives |
US3702324A (en) * | 1970-06-24 | 1972-11-07 | Stanford Research Inst | 3,4,5-trimethoxybenzamides of substituted anilines and of alkylpiperidines |
FR2183565B1 (es) * | 1972-05-10 | 1975-12-26 | Cerm Cent Europ Rech Mauvernay | |
CH614709A5 (es) * | 1975-09-25 | 1979-12-14 | Ciba Geigy Ag | |
NL7611713A (nl) * | 1975-11-03 | 1977-05-05 | Thomae Gmbh Dr K | Werkwijze voor de bereiding van verbindingen en preparaten met waardevolle farmacologische eigen- schappen. |
FR2329226A1 (fr) * | 1975-11-03 | 1977-05-27 | Ipa Ind Plastique Aquitain | Porte-documents ou pochette |
US4203989A (en) * | 1979-04-30 | 1980-05-20 | G. D. Searle & Co. | Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds |
-
1982
- 1982-07-02 FR FR8211670A patent/FR2529548A1/fr active Granted
-
1983
- 1983-06-28 ZA ZA834704A patent/ZA834704B/xx unknown
- 1983-06-29 EP EP83401338A patent/EP0099789B1/fr not_active Expired
- 1983-06-29 DE DE8383401338T patent/DE3372769D1/de not_active Expired
- 1983-06-29 US US06/509,022 patent/US4657911A/en not_active Expired - Lifetime
- 1983-06-30 CA CA000431637A patent/CA1265802A/en not_active Expired - Lifetime
- 1983-07-01 AU AU16507/83A patent/AU562210B2/en not_active Expired
- 1983-07-01 ES ES524128A patent/ES524128A0/es active Granted
- 1983-07-02 JP JP58120912A patent/JPS5921684A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2529548B1 (es) | 1985-04-19 |
AU562210B2 (en) | 1987-06-04 |
CA1265802A (en) | 1990-02-13 |
JPH0587516B2 (es) | 1993-12-16 |
EP0099789B1 (fr) | 1987-07-29 |
FR2529548A1 (fr) | 1984-01-06 |
ZA834704B (en) | 1984-03-28 |
AU1650783A (en) | 1984-01-05 |
US4657911A (en) | 1987-04-14 |
JPS5921684A (ja) | 1984-02-03 |
ES524128A0 (es) | 1984-04-16 |
DE3372769D1 (en) | 1987-09-03 |
EP0099789A1 (fr) | 1984-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040214 |